FI79107C - Foerfarande foer framstaellning av stabil -form av prazosinhydroklorid. - Google Patents

Foerfarande foer framstaellning av stabil -form av prazosinhydroklorid. Download PDF

Info

Publication number
FI79107C
FI79107C FI842544A FI842544A FI79107C FI 79107 C FI79107 C FI 79107C FI 842544 A FI842544 A FI 842544A FI 842544 A FI842544 A FI 842544A FI 79107 C FI79107 C FI 79107C
Authority
FI
Finland
Prior art keywords
prazosin hydrochloride
prazosin
water
hydrochloride
hydrate
Prior art date
Application number
FI842544A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI842544L (fi
FI842544A0 (fi
FI79107B (fi
Inventor
Stig Olof Engelbert Lindholm
Original Assignee
Orion Yhtymae Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Orion Yhtymae Oy filed Critical Orion Yhtymae Oy
Publication of FI842544A0 publication Critical patent/FI842544A0/fi
Priority to FI842544A priority Critical patent/FI79107C/fi
Priority to DE19843429415 priority patent/DE3429415A1/de
Priority to GB08424999A priority patent/GB2160861B/en
Priority to US06/660,871 priority patent/US4739055A/en
Priority to AU34510/84A priority patent/AU566814B2/en
Priority to IL73267A priority patent/IL73267A/xx
Priority to NZ209962A priority patent/NZ209962A/en
Priority to IT23292/84A priority patent/IT1224142B/it
Priority to NL8403250A priority patent/NL8403250A/nl
Priority to FR8416401A priority patent/FR2567124B1/fr
Priority to PT79411A priority patent/PT79411B/pt
Priority to CH5142/84A priority patent/CH661045A5/de
Priority to BE0/213911A priority patent/BE900925A/fr
Priority to JP59227640A priority patent/JPS6115881A/ja
Priority to LU85616A priority patent/LU85616A1/fr
Priority to AT0344184A priority patent/AT389117B/de
Priority to ZA85910A priority patent/ZA85910B/xx
Publication of FI842544L publication Critical patent/FI842544L/fi
Priority to US07/153,780 priority patent/US4873330A/en
Application granted granted Critical
Publication of FI79107B publication Critical patent/FI79107B/fi
Publication of FI79107C publication Critical patent/FI79107C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
FI842544A 1984-06-25 1984-06-25 Foerfarande foer framstaellning av stabil -form av prazosinhydroklorid. FI79107C (fi)

Priority Applications (18)

Application Number Priority Date Filing Date Title
FI842544A FI79107C (fi) 1984-06-25 1984-06-25 Foerfarande foer framstaellning av stabil -form av prazosinhydroklorid.
DE19843429415 DE3429415A1 (de) 1984-06-25 1984-08-09 Wasserfreie, stabile und kristalline form von prazosinhydrochlorid und verfahren zu dessen herstellung
GB08424999A GB2160861B (en) 1984-06-25 1984-10-03 Prazosin hydrochloride
US06/660,871 US4739055A (en) 1984-06-25 1984-10-15 Anhydrous, stable, crystalline δ-form of prazosin hydrochloride
AU34510/84A AU566814B2 (en) 1984-06-25 1984-10-19 Anhydrous stable crystalline s-form of prazosin hydrochloride
IL73267A IL73267A (en) 1984-06-25 1984-10-19 Anhydrous,stable,crystalline delta-form of prazosin hydrochloride and a process for its preparation
NZ209962A NZ209962A (en) 1984-06-25 1984-10-23 Stable, crystalline form of prazosin hydrochloride
IT23292/84A IT1224142B (it) 1984-06-25 1984-10-24 Forma delta cristallina, stabile, anidra di idrocloruro di prazosin e nuovo procedimento per la preparazione di detta forma delta cristallina
NL8403250A NL8403250A (nl) 1984-06-25 1984-10-25 Watervrije, stabiele, kristallijne delta-vorm van prazosine-hydrochloride, alsmede werkwijze voor de bereiding daarvan.
PT79411A PT79411B (en) 1984-06-25 1984-10-26 Process for preparing a novel anhydrous stable crystalline delta-form of prazosina hydrochloride
FR8416401A FR2567124B1 (fr) 1984-06-25 1984-10-26 Nouvelle forme d cristalline, stable, anhydre du chlorhydrate de prazosine et nouveau procede pour la preparation de cette forme d cristalline
CH5142/84A CH661045A5 (de) 1984-06-25 1984-10-26 Wasserfreie, stabile kristalline form von prazosinhydrochlorid und verfahren zu dessen herstellung.
BE0/213911A BE900925A (fr) 1984-06-25 1984-10-29 Nouvelle forme cristalline alpha, anhydre et stable, du chlorhydrate de prazosine et nouveau procede de fabrication de celle-ci.
JP59227640A JPS6115881A (ja) 1984-06-25 1984-10-29 無水の安定したプラゾシン塩酸塩のδ型結晶体および該δ型結晶体の製造法
LU85616A LU85616A1 (fr) 1984-06-25 1984-10-29 Nouvelle forme cristalline delta;anhydre et stable,du chlorhydrate de prazosine et nouveau procede de fabrication de celle-ci
AT0344184A AT389117B (de) 1984-06-25 1984-10-30 Verfahren zur herstellung einer neuen, wasserfreien und stabilen deltakristallform von prazosinhydrochlorid
ZA85910A ZA85910B (en) 1984-06-25 1985-02-06 A novel anhydrous,stable,crystalline o-form of prazosin hydrochloride and a novel process for the preparation of said crystalline o-form
US07/153,780 US4873330A (en) 1984-06-25 1988-02-08 A process for the preparation of anhydrous, stable, crystalline delta-form of prazosin hydrochloride

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FI842544 1984-06-25
FI842544A FI79107C (fi) 1984-06-25 1984-06-25 Foerfarande foer framstaellning av stabil -form av prazosinhydroklorid.

Publications (4)

Publication Number Publication Date
FI842544A0 FI842544A0 (fi) 1984-06-25
FI842544L FI842544L (fi) 1985-12-26
FI79107B FI79107B (fi) 1989-07-31
FI79107C true FI79107C (fi) 1989-11-10

Family

ID=8519293

Family Applications (1)

Application Number Title Priority Date Filing Date
FI842544A FI79107C (fi) 1984-06-25 1984-06-25 Foerfarande foer framstaellning av stabil -form av prazosinhydroklorid.

Country Status (17)

Country Link
US (2) US4739055A (en:Method)
JP (1) JPS6115881A (en:Method)
AT (1) AT389117B (en:Method)
AU (1) AU566814B2 (en:Method)
BE (1) BE900925A (en:Method)
CH (1) CH661045A5 (en:Method)
DE (1) DE3429415A1 (en:Method)
FI (1) FI79107C (en:Method)
FR (1) FR2567124B1 (en:Method)
GB (1) GB2160861B (en:Method)
IL (1) IL73267A (en:Method)
IT (1) IT1224142B (en:Method)
LU (1) LU85616A1 (en:Method)
NL (1) NL8403250A (en:Method)
NZ (1) NZ209962A (en:Method)
PT (1) PT79411B (en:Method)
ZA (1) ZA85910B (en:Method)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3683760D1 (de) * 1986-03-21 1992-03-12 Heumann Pharma Gmbh & Co Kristalline, wasserfreie sigma -form von 2-(4-(2-furoyl-(2-piperazin)-1-yl)-4-amino-6,7-dimethoxychinazolinhydrochlorid und verfahren zu ihrer herstellung.
JP2756846B2 (ja) * 1989-12-28 1998-05-25 住化ファインケム株式会社 無水のε型結晶体２―〔４―（２―フロイル）ピペラジン―１―イル〕―４―アミノ―６，７―ジメトキシキナゾリン塩酸塩及びその製造方法
JPH07206857A (ja) * 1993-12-28 1995-08-08 Synthelabo Sa アルフゾシン塩酸塩の二水和物
EP1953162B9 (de) * 2001-02-24 2012-10-31 Boehringer Ingelheim Pharma GmbH & Co. KG Xanthinderivate, deren Herstellung und deren Verwendung als Arzneimittel
US7407955B2 (en) 2002-08-21 2008-08-05 Boehringer Ingelheim Pharma Gmbh & Co., Kg 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions
US7501426B2 (en) * 2004-02-18 2009-03-10 Boehringer Ingelheim International Gmbh 8-[3-amino-piperidin-1-yl]-xanthines, their preparation and their use as pharmaceutical compositions
DE102004054054A1 (de) 2004-11-05 2006-05-11 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Herstellung chiraler 8-(3-Amino-piperidin-1-yl)-xanthine
DE102005035891A1 (de) * 2005-07-30 2007-02-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg 8-(3-Amino-piperidin-1-yl)-xanthine, deren Herstellung und deren Verwendung als Arzneimittel
EP1852108A1 (en) * 2006-05-04 2007-11-07 Boehringer Ingelheim Pharma GmbH & Co.KG DPP IV inhibitor formulations
PE20080251A1 (es) * 2006-05-04 2008-04-25 Boehringer Ingelheim Int Usos de inhibidores de dpp iv
EP2016079A1 (de) 2006-05-04 2009-01-21 Boehringer Ingelheim International GmbH Polymorphe
JP5769966B2 (ja) * 2007-08-17 2015-08-26 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｆａｂ関連疾患治療用プリン誘導体
AR071175A1 (es) 2008-04-03 2010-06-02 Boehringer Ingelheim Int Composicion farmaceutica que comprende un inhibidor de la dipeptidil-peptidasa-4 (dpp4) y un farmaco acompanante
PE20100156A1 (es) * 2008-06-03 2010-02-23 Boehringer Ingelheim Int Tratamiento de nafld
UY32030A (es) 2008-08-06 2010-03-26 Boehringer Ingelheim Int "tratamiento para diabetes en pacientes inapropiados para terapia con metformina"
KR20190016601A (ko) 2008-08-06 2019-02-18 베링거 인겔하임 인터내셔날 게엠베하 메트포르민 요법이 부적합한 환자에서의 당뇨병 치료
ES2764251T3 (es) * 2008-08-15 2020-06-02 Boehringer Ingelheim Int Inhibidores de DPP-4 para uso en el tratamiento de curación de heridas en pacientes diabéticos
JP2012502081A (ja) 2008-09-10 2012-01-26 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 糖尿病及び関連症状の治療のための組み合わせ治療
US20200155558A1 (en) 2018-11-20 2020-05-21 Boehringer Ingelheim International Gmbh Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug
AU2009331471B2 (en) 2008-12-23 2015-09-03 Boehringer Ingelheim International Gmbh Salt forms of organic compound
AR074990A1 (es) 2009-01-07 2011-03-02 Boehringer Ingelheim Int Tratamiento de diabetes en pacientes con un control glucemico inadecuado a pesar de la terapia con metformina
JP2013512229A (ja) 2009-11-27 2013-04-11 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 遺伝子型が同定された糖尿病患者のリナグリプチン等のｄｄｐ−ｉｖ阻害薬による治療
EP2566469B1 (en) 2010-05-05 2022-12-21 Boehringer Ingelheim International GmbH Combination therapy
EP3366304B1 (en) 2010-06-24 2020-05-13 Boehringer Ingelheim International GmbH Diabetes therapy
AR083878A1 (es) 2010-11-15 2013-03-27 Boehringer Ingelheim Int Terapia antidiabetica vasoprotectora y cardioprotectora, linagliptina, metodo de tratamiento
DK2731947T3 (en) 2011-07-15 2019-04-23 Boehringer Ingelheim Int SUBSTITUTED DIMERIC QUINAZOLINE DERIVATIVE, PREPARATION AND USE thereof IN PHARMACEUTICAL COMPOSITIONS FOR TREATMENT OF TYPE I AND TYPE II DIABETES
US9555001B2 (en) 2012-03-07 2017-01-31 Boehringer Ingelheim International Gmbh Pharmaceutical composition and uses thereof
US20130303462A1 (en) 2012-05-14 2013-11-14 Boehringer Ingelheim International Gmbh Use of a dpp-4 inhibitor in podocytes related disorders and/or nephrotic syndrome
ES2929025T3 (es) 2012-05-14 2022-11-24 Boehringer Ingelheim Int Linagliptina, un derivado de xantina como inhibidor de dpp-4, para su uso en el tratamiento del SRIS y/o de la septicemia
WO2013174767A1 (en) 2012-05-24 2013-11-28 Boehringer Ingelheim International Gmbh A xanthine derivative as dpp -4 inhibitor for use in modifying food intake and regulating food preference
JP6615109B2 (ja) 2014-02-28 2019-12-04 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｄｐｐ−４阻害薬の医学的使用
CN109310697A (zh) 2016-06-10 2019-02-05 勃林格殷格翰国际有限公司 利格列汀和二甲双胍的组合

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE156532C (en:Method) *
US2969375A (en) * 1961-01-24 Certification of correction
NL54420C (en:Method) * 1937-05-25
GB1156973A (en) * 1965-07-06 1969-07-02 Quinazoline Derivatives
US3433788A (en) * 1966-04-27 1969-03-18 Union Carbide Corp Process for recovery of amines from aqueous solutions by solvent treatment and distillation
US3421983A (en) * 1967-03-07 1969-01-14 Lummus Co Azeotropic distillation of aqueous toluene diamine
US3511836A (en) * 1967-12-13 1970-05-12 Pfizer & Co C 2,4,6,7-tetra substituted quinazolines
US3743672A (en) * 1970-05-27 1973-07-03 Halcon International Inc Separation of water in alkylene glycol mono and diester purification by azeotropic distillation
GB1308718A (en) * 1970-07-01 1973-03-07 Sir Soc Italiana Resine Spa Method of separating vinyl acetate from liquid mixtures
IT956765B (it) * 1972-06-22 1973-10-10 Montedison Spa Procedimento per la purificazione di 1 3 diossolano
US3935213A (en) * 1973-12-05 1976-01-27 Pfizer Inc. Process for hypotensive 4-amino-2-(piperazin-1-yl) quinazoline derivatives
US4026894A (en) * 1975-10-14 1977-05-31 Abbott Laboratories Antihypertensive agents
US4001237A (en) * 1976-02-18 1977-01-04 Bristol-Myers Company Oxazole, isoxazole, thiazole and isothiazole amides
US4092315A (en) * 1976-03-01 1978-05-30 Pfizer Inc. Novel crystalline forms of prazosin hydrochloride
FI67699C (fi) * 1979-01-31 1985-05-10 Orion Yhtymae Oy Foerfarande foer framstaellning av 6,7-dimetoxi-4-amino-2-(4-(2-furoyl)-1-piperazinyl)kinazolinhydroklorid med blodtryckssaenkande verkan
FI64367C (fi) * 1980-02-26 1986-08-05 Orion Yhtymae Oy Foerfarande foer framstaellning av alfa-form av prazosinhydroklorid

Also Published As

Publication number Publication date
LU85616A1 (fr) 1985-06-04
FR2567124A1 (fr) 1986-01-10
FI842544L (fi) 1985-12-26
FR2567124B1 (fr) 1990-09-21
GB2160861B (en) 1987-11-18
IT1224142B (it) 1990-09-26
FI842544A0 (fi) 1984-06-25
AU566814B2 (en) 1987-10-29
FI79107B (fi) 1989-07-31
US4873330A (en) 1989-10-10
PT79411B (en) 1986-09-15
GB2160861A (en) 1986-01-02
JPH0481993B2 (en:Method) 1992-12-25
GB8424999D0 (en) 1984-11-07
ATA344184A (de) 1989-03-15
AU3451084A (en) 1986-01-02
BE900925A (fr) 1985-02-15
AT389117B (de) 1989-10-25
PT79411A (en) 1984-11-01
NZ209962A (en) 1987-06-30
DE3429415C2 (en:Method) 1990-05-03
DE3429415A1 (de) 1986-01-02
NL8403250A (nl) 1986-01-16
ZA85910B (en) 1985-09-25
US4739055A (en) 1988-04-19
CH661045A5 (de) 1987-06-30
JPS6115881A (ja) 1986-01-23
IL73267A0 (en) 1985-01-31
IL73267A (en) 1988-06-30
IT8423292A0 (it) 1984-10-24

Similar Documents

Publication Publication Date Title
FI79107C (fi) Foerfarande foer framstaellning av stabil -form av prazosinhydroklorid.
US4816455A (en) Crystalline, anhydrous sigma-form of 2-(4-(2-furoyl)-(2-piperazin)-1-yl)-4-amino-6,7-dimethoxy-quinazoline hydrochloride and a process for its preparation
EP1429757B1 (en) Crystalline forms of fluvastatin sodium
AU2002333271A1 (en) Crystalline forms of fluvastatin sodium
ES2216828T3 (es) Metodo para producir beta-aminoepoxido y beta-aminoalcohol n-protegido con una funcion carbamato.
CA2339283C (en) A process for the preparation of zofenopril calcium salt
WO2017036884A1 (en) A lesinurad, free form / lesinurad ethyl ester co-crystal
EP0145395B1 (en) Crystals of sodium cephemcarboxylate
CA2000184C (en) Trihydrates of sodium l- and d-2-pyrrolidone-5-carboxylate
JPS5918377B2 (ja) ソルビン酸の精製法
HU196979B (en) Process for producing basic thioether and salt
US5783688A (en) Purification of 3'-FDDU and resultant compositions
AU2002360951B8 (en) Method for preparing a glucosamine compound, and compound thus obtained
Crowell et al. The Effect of Aluminum Chloride on n-Propyl Chloride
GB2103206A (en) Process for preparing an imidazole derivative
JPS59106480A (ja) ジヒドロ−４，４−ジメチル−２，３−フランジオンの製法
CS216226B2 (en) Method of making the forms of hydrochloride 2-+l 4-+l2-furoyl+p-piperazin-1-yl+p-4-amino-6,7-dimethoxychinazoline
JPH0627097B2 (ja) ソルビン酸湿ケ−キの保存方法
MXPA01001253A (en) A process for the preparation of zofenopril calcium salt
FR2513254A1 (fr) Procede pour la preparation d'adenines n6,9-disubstituees
HK1058522A (en) Polymorphic forms/hydrates of n-[4-(3-chloro-4-fluorophenylamino)-7-(3-morpholin-4-ylpropoxy)-quinazolin-6-yl]-acrylamide dihydrochloride

Legal Events

Date Code Title Description
MM Patent lapsed
MM Patent lapsed

Owner name: ORION-YHTYMAE OY