FI781955A - Foerfarande foer framstaellning av farmakologiskt anvaendbara 1,2,3,6-tetrahydroisonikotinsyraderivater - Google Patents
Foerfarande foer framstaellning av farmakologiskt anvaendbara 1,2,3,6-tetrahydroisonikotinsyraderivaterInfo
- Publication number
- FI781955A FI781955A FI781955A FI781955A FI781955A FI 781955 A FI781955 A FI 781955A FI 781955 A FI781955 A FI 781955A FI 781955 A FI781955 A FI 781955A FI 781955 A FI781955 A FI 781955A
- Authority
- FI
- Finland
- Prior art keywords
- tetrahydroisonicotine
- syrader
- framework
- preparation
- animal products
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D211/78—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB2574077 | 1977-06-20 |
Publications (1)
Publication Number | Publication Date |
---|---|
FI781955A true FI781955A (fi) | 1978-12-21 |
Family
ID=10232513
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI781955A FI781955A (fi) | 1977-06-20 | 1978-06-19 | Foerfarande foer framstaellning av farmakologiskt anvaendbara 1,2,3,6-tetrahydroisonikotinsyraderivater |
FI781954A FI64376C (fi) | 1977-06-20 | 1978-06-19 | Foerfarande foer framstaellning av en farmakologiskt anvaendbar 4,5,6,7-tetrahydroisoxazolo(5,4-c)pyridin-3-ol |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI781954A FI64376C (fi) | 1977-06-20 | 1978-06-19 | Foerfarande foer framstaellning av en farmakologiskt anvaendbar 4,5,6,7-tetrahydroisoxazolo(5,4-c)pyridin-3-ol |
Country Status (14)
Country | Link |
---|---|
US (2) | US4278676A (it) |
EP (4) | EP0027279A1 (it) |
JP (2) | JPS5436290A (it) |
AT (1) | AT368505B (it) |
AU (2) | AU3724478A (it) |
CA (1) | CA1107736A (it) |
DK (2) | DK270378A (it) |
ES (2) | ES470913A1 (it) |
FI (2) | FI781955A (it) |
IE (1) | IE47200B1 (it) |
IT (2) | IT7868449A0 (it) |
NO (3) | NO782128L (it) |
NZ (1) | NZ187615A (it) |
ZA (2) | ZA783492B (it) |
Families Citing this family (46)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3145474A1 (de) * | 1980-11-27 | 1982-09-02 | Kefalas A/S, Koebenhavn-Valby | 3-substituierte 4,5,6,7-tetrahydroisoxazolo(5,4-c)pyridinverbindungen, verfahren zu ihrer herstellung und diese enthaltende arzneimittel |
DE3145473A1 (de) * | 1980-11-27 | 1982-08-26 | Kefalas A/S, Koebenhavn-Valby | 2-substituierte 4,5,6,7-tetrahydroisoxazolo (5,4-c) pyridin-3-on-verbindungen, verfahren zu ihrer herstellung und diese enthaltende arzneimittel |
EP0083378A1 (en) * | 1981-12-22 | 1983-07-13 | Chugai Seiyaku Kabushiki Kaisha | Tetrahydronicotinamide derivatives, a process for producing the same and a pharmaceutical composition comprising the same |
GB8314391D0 (en) * | 1983-05-24 | 1983-06-29 | Kefalas As | Heterocyclic compounds |
IT1228426B (it) * | 1987-07-20 | 1991-06-17 | Ausimont Spa | Perossiacidi eterociclici |
US4859666A (en) * | 1988-07-06 | 1989-08-22 | Bristol-Myers Company | THAZ derivatives for enhancement of cerebral function |
CN1043051C (zh) * | 1994-07-22 | 1999-04-21 | 国际壳牌研究有限公司 | 制备氢化石蜡的方法 |
US20050234093A1 (en) * | 2003-06-25 | 2005-10-20 | H. Lundbeck A/S | Treatment of depression and other affective disorders |
DK1641456T3 (da) | 2003-06-25 | 2010-06-21 | Lundbeck & Co As H | Gaboxadol til behandling af depression og andre affektive lidelser |
AR045540A1 (es) * | 2003-09-05 | 2005-11-02 | Lundbeck & Co As H | Metodo de elaboracion de 4,5,6,7 tetrahidroisoxazol [5,4-c] piridin-3-ol (thip) |
PT1691811E (pt) * | 2003-12-11 | 2014-10-30 | Sunovion Pharmaceuticals Inc | Combinação de um sedativo e de um modulador de neurotransmissores e métodos para melhorar a qualidade do sono e tratamento da depressão |
US20050137222A1 (en) * | 2003-12-18 | 2005-06-23 | H. Lundbeck A/S | Treatment of insomnia in human patients |
WO2005063248A1 (en) * | 2003-12-22 | 2005-07-14 | Sepracor Inc. | Modafinil combination therapy for improving sleep quality |
AU2004308962A1 (en) * | 2003-12-24 | 2005-07-14 | Sepracor Inc. | Melatonin combination therapy for improving sleep quality |
GB0402118D0 (en) * | 2004-01-30 | 2004-03-03 | Merck Sharp & Dohme | Polymorphic forms of a GABAA agonist |
EP1742624B1 (en) * | 2004-02-18 | 2010-01-06 | Sepracor, Inc. | Dopamine-agonist combination therapy with sedatives for improving sleep quality |
GB0417558D0 (en) * | 2004-08-06 | 2004-09-08 | Merck Sharp & Dohme | Novel combination therapy |
EP1848420A4 (en) * | 2005-01-28 | 2008-01-23 | Merck & Co Inc | POLYMORPHIC FORMS OF A GABAA AGONIST |
WO2006118897A1 (en) * | 2005-04-29 | 2006-11-09 | H.Lundbeck A/S | Acid and base salt forms of gaboxadol |
US7678363B2 (en) | 2005-08-26 | 2010-03-16 | Braincells Inc | Methods of treating psychiatric conditions comprising administration of muscarinic agents in combination with SSRIs |
EP2258359A3 (en) | 2005-08-26 | 2011-04-06 | Braincells, Inc. | Neurogenesis by muscarinic receptor modulation with sabcomelin |
EP1940389A2 (en) | 2005-10-21 | 2008-07-09 | Braincells, Inc. | Modulation of neurogenesis by pde inhibition |
US20070112017A1 (en) * | 2005-10-31 | 2007-05-17 | Braincells, Inc. | Gaba receptor mediated modulation of neurogenesis |
US20070203216A1 (en) * | 2006-02-14 | 2007-08-30 | Bjarke Ebert | Method of treating inflammatory diseases |
US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
MX2008014320A (es) | 2006-05-09 | 2009-03-25 | Braincells Inc | Neurogenesis mediada por el receptor de 5-hidroxitriptamina. |
EP2021000A2 (en) | 2006-05-09 | 2009-02-11 | Braincells, Inc. | Neurogenesis by modulating angiotensin |
EP2068872A1 (en) | 2006-09-08 | 2009-06-17 | Braincells, Inc. | Combinations containing a 4-acylaminopyridine derivative |
US20100193652A1 (en) * | 2009-02-02 | 2010-08-05 | William Stajos | Wall Display System And Method Of Providing The Same |
US20100216805A1 (en) | 2009-02-25 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
US8784835B2 (en) * | 2012-07-02 | 2014-07-22 | Trent Austin | Method for producing muscimol and/or reducing ibotenic acid from amanita tissue |
CN104974175A (zh) * | 2014-04-11 | 2015-10-14 | 天津药物研究院 | 一种氨甲基羟异恶唑类似物的制备方法 |
ES2876350T3 (es) | 2014-06-06 | 2021-11-12 | Ovid Therapeutics Inc | Métodos para aumentar la inhibición tónica y tratamiento del insomnio secundario |
ES2781978T3 (es) | 2015-03-24 | 2020-09-09 | H Lundbeck As | Fabricación de 4,5,6,7-tetrahidroisozaxolo[5,4-c]piridin-3-ol |
US9682069B2 (en) | 2015-07-17 | 2017-06-20 | Ovid Therapeutics Inc | Methods of treating Dravet syndrome |
CA2992734A1 (en) | 2015-07-17 | 2017-01-26 | Ovid Therapeutics, Inc. | Methods of treating developmental disorders with gaboxadol |
US9399034B1 (en) | 2015-08-11 | 2016-07-26 | Ovid Therapeutics Inc | Methods of sedation during critical care treatment |
EP4233861A3 (en) | 2016-08-11 | 2023-10-11 | Ovid Therapeutics, Inc. | Compositions for treatment of essential tremor |
US10071083B2 (en) | 2017-02-03 | 2018-09-11 | Ovid Therapeutics Inc | Use of gaboxadol in the treatment of tinnitus |
US20180338959A1 (en) | 2017-05-24 | 2018-11-29 | Ovid Therapeutics Inc. | Treatment of depressive disorders |
AU2018309049A1 (en) | 2017-08-04 | 2020-02-27 | Ovid Therapeutics Inc. | Use of gaboxadol in the treatment of diabetes and related conditions |
EP3833351A4 (en) | 2018-09-20 | 2021-10-13 | Ovid Therapeutics Inc. | USE OF GABOXADOL TO TREAT TOURETTE SYNDROME, TICKS, AND STUTTERS |
EP3883566A4 (en) | 2018-11-21 | 2022-09-07 | Certego Therapeutics Inc. | GABOXADOL FOR SUICIDE RISK REDUCTION AND RAPID DEPRESSION RELIEF |
CN113423399A (zh) | 2018-12-17 | 2021-09-21 | 奥维德医疗公司 | 加波沙朵用于治疗非24小时睡眠-觉醒障碍的用途 |
US11597726B2 (en) | 2020-05-20 | 2023-03-07 | Certego Therapeutics Inc. | Ring deuterated gaboxadol and its use for the treatment of psychiatric disorders |
CN114292224B (zh) * | 2022-03-07 | 2022-05-20 | 中国农业科学院农产品加工研究所 | 一种大麻二酚-2-(n-乙酰基)哌啶酸酯及其应用 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2784190A (en) * | 1952-03-28 | 1957-03-05 | Upjohn Co | Alkyl piperidinepropionates |
CA762455A (en) * | 1962-03-22 | 1967-07-04 | Dr. Karl Thomae Gesellschaft Mit Beschrankter Haftung | Pyrido-pyrimidines |
US3381016A (en) * | 1966-03-04 | 1968-04-30 | Upjohn Co | Isoxazolo[5, 4-b]pyridine derivatives and a method for their preparation |
DE2221770A1 (de) * | 1972-05-04 | 1973-11-15 | Bayer Ag | Verfahren zur herstellung von tetrahydropyridinen |
DK62791A (da) * | 1991-04-09 | 1992-11-09 | Tulip Int As | Fremgangsmaade til saltning af koed samt anlaeg til brug ved udoevelse af fremgangsmaaden |
-
1978
- 1978-06-15 DK DK270378A patent/DK270378A/da unknown
- 1978-06-15 DK DK270278A patent/DK270278A/da unknown
- 1978-06-19 IE IE1234/78A patent/IE47200B1/en unknown
- 1978-06-19 EP EP80106497A patent/EP0027279A1/en not_active Withdrawn
- 1978-06-19 ES ES470913A patent/ES470913A1/es not_active Expired
- 1978-06-19 NO NO782128A patent/NO782128L/no unknown
- 1978-06-19 FI FI781955A patent/FI781955A/fi not_active Application Discontinuation
- 1978-06-19 AU AU37244/78A patent/AU3724478A/en active Pending
- 1978-06-19 EP EP78100190A patent/EP0000167A1/en not_active Withdrawn
- 1978-06-19 FI FI781954A patent/FI64376C/fi not_active IP Right Cessation
- 1978-06-19 NZ NZ187615A patent/NZ187615A/xx unknown
- 1978-06-19 ZA ZA00783492A patent/ZA783492B/xx unknown
- 1978-06-19 ZA ZA00783493A patent/ZA783493B/xx unknown
- 1978-06-19 ES ES470912A patent/ES470912A1/es not_active Expired
- 1978-06-19 EP EP80106498A patent/EP0028017A1/en not_active Withdrawn
- 1978-06-19 US US05/917,118 patent/US4278676A/en not_active Expired - Lifetime
- 1978-06-19 EP EP78100191A patent/EP0000338B1/en not_active Expired
- 1978-06-19 NO NO782127A patent/NO152049C/no unknown
- 1978-06-20 JP JP7480078A patent/JPS5436290A/ja active Pending
- 1978-06-20 CA CA305,798A patent/CA1107736A/en not_active Expired
- 1978-06-20 JP JP7479978A patent/JPS5436275A/ja active Pending
- 1978-06-20 AU AU37298/78A patent/AU521040B2/en not_active Expired
- 1978-06-20 IT IT7868449A patent/IT7868449A0/it unknown
- 1978-06-20 AT AT0448678A patent/AT368505B/de not_active IP Right Cessation
- 1978-06-20 IT IT68450/78A patent/IT1159739B/it active
-
1979
- 1979-09-03 NO NO792839A patent/NO792839L/no unknown
- 1979-12-17 US US06/104,080 patent/US4301287A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
IT1159739B (it) | 1987-03-04 |
EP0000338B1 (en) | 1981-11-25 |
FI64376B (fi) | 1983-07-29 |
NO782128L (no) | 1978-12-21 |
IT7868450A0 (it) | 1978-06-20 |
NO792839L (no) | 1978-12-21 |
EP0028017A1 (en) | 1981-05-06 |
JPS5436290A (en) | 1979-03-16 |
ES470912A1 (es) | 1979-02-01 |
IT7868449A0 (it) | 1978-06-20 |
US4301287A (en) | 1981-11-17 |
CA1107736A (en) | 1981-08-25 |
DK270278A (da) | 1978-12-21 |
IE47200B1 (en) | 1984-01-11 |
EP0000338A2 (en) | 1979-01-24 |
AU3724478A (en) | 1980-01-03 |
NO152049B (no) | 1985-04-15 |
DK270378A (da) | 1978-12-21 |
EP0027279A1 (en) | 1981-04-22 |
ZA783493B (en) | 1979-06-27 |
ZA783492B (en) | 1979-06-27 |
EP0000338A3 (en) | 1979-06-27 |
JPS5436275A (en) | 1979-03-16 |
AU521040B2 (en) | 1982-03-11 |
FI781954A (fi) | 1978-12-21 |
NO152049C (no) | 1985-07-24 |
AU3729878A (en) | 1980-01-03 |
IE781234L (en) | 1978-12-20 |
ES470913A1 (es) | 1979-02-01 |
AT368505B (de) | 1982-10-25 |
NZ187615A (en) | 1981-12-15 |
FI64376C (fi) | 1983-11-10 |
ATA448678A (de) | 1982-02-15 |
EP0000167A1 (en) | 1979-01-10 |
US4278676A (en) | 1981-07-14 |
NO782127L (no) | 1978-12-21 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD | Application lapsed |
Owner name: FALCH, ERIK Owner name: KROGSGAARD-LARSEN, POVL |