FI78109B - Foerfarande foer framstaellning av antracyklinglykosider. - Google Patents
Foerfarande foer framstaellning av antracyklinglykosider. Download PDFInfo
- Publication number
- FI78109B FI78109B FI843110A FI843110A FI78109B FI 78109 B FI78109 B FI 78109B FI 843110 A FI843110 A FI 843110A FI 843110 A FI843110 A FI 843110A FI 78109 B FI78109 B FI 78109B
- Authority
- FI
- Finland
- Prior art keywords
- tai
- foer
- formula
- deoxy
- hydrochloridina
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
- C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Claims (5)
1 COCH3 1,0 OH ! 1. dm II NH R -i *2 jossa R^ on vetyatomi tai metoksiryhmä, R^ on bromi- tai klooriatomi ja R^ on trifluoroasetyyliryhmä, tai R^ on fluo-riatomi ja R^ on trikloroetoksikarbonyyliryhmä, ja tälle suoritetaan (R^-COCFg) lievä alkalinen hydrolyysi 0,1 N natriumhydroksidin vesiliuoksella tai (R =-C0-0-CH CC1 ) pel- w & 3 kistävä suojaryhmän poisto sinkkijauheella ja etikkahapolla asetonissa lämpötilassa 0°C, jolloin saadaan kaavan (A) (X=H) mukainen vapaa glykosidiemäs, joka eristetään hydrokloridina käsittelemällä sitä metanolisella kloorivedyllä, ja haluttaessa tämän annetaan reagoida kloroformiin liuotetun bromin kanssa niin, että saadaan vastaava 14-bromojohdannainen, josta natriumformiaatin vesiliuoksella suoritetulla hydrolyysil-lä saadaan kaavan (A) mukainen vapaa glykosidiemäs (X=0H), joka eristetään hydrokloridina. 14 78109 Analogiförfarande för fraaställning av en terapeutiskt verka nd e antracyklinglykosid enligt den älläänne foraeln (A)
0 OH
1. COCHjX I I I '''OH fe 0 OH ί (A) * I HH-s 2 "2 där X är en väteatoe eller en hydroxgrupp, R} är en väteato· eller en aetoxgrupp och R2 är en broa-, klor- eller fluor-atoa, kännetecknat därav, att en substitutlons-reaktion utförs aellan aed en 4·-epi-4*-o-trifluoroaetan-sulfonyl-N-skyddad daunorubicin enligt den allaänna foraeln (II) o OH cf3so2°- där Ri är ovan definierat och R3 är en trifluoroacetyl- eller trikloretoxkarbonylgrupp och soa är upplöst i en vatten-fri aetylenklorid (R3=-C0CF3 eller acetonitril <R3=-C0-0-CH2CCI3), och tetra(n-butyl)aaaoniuabroaid, tetra(n-butyl)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB8321676 | 1983-08-11 | ||
GB838321676A GB8321676D0 (en) | 1983-08-11 | 1983-08-11 | 4'-haloanthrocycline glycosides |
Publications (4)
Publication Number | Publication Date |
---|---|
FI843110A0 FI843110A0 (fi) | 1984-08-08 |
FI843110A FI843110A (fi) | 1985-02-12 |
FI78109B true FI78109B (fi) | 1989-02-28 |
FI78109C FI78109C (sv) | 1989-06-12 |
Family
ID=10547171
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI843110A FI78109C (sv) | 1983-08-11 | 1984-08-08 | Förfarande för framställning av antracyklinglykosider |
Country Status (19)
Country | Link |
---|---|
JP (1) | JPS6058997A (sv) |
AT (1) | AT384226B (sv) |
AU (1) | AU563396B2 (sv) |
BE (1) | BE900336A (sv) |
CA (1) | CA1250833A (sv) |
CH (1) | CH660740A5 (sv) |
CS (1) | CS270411B2 (sv) |
DE (1) | DE3428945A1 (sv) |
DK (1) | DK381884A (sv) |
FI (1) | FI78109C (sv) |
FR (1) | FR2554450B1 (sv) |
GB (2) | GB8321676D0 (sv) |
GR (1) | GR80046B (sv) |
HU (1) | HU194266B (sv) |
IT (1) | IT1209576B (sv) |
NL (1) | NL8402477A (sv) |
SE (1) | SE8404005L (sv) |
SU (1) | SU1579465A3 (sv) |
ZA (1) | ZA846147B (sv) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8414619D0 (en) * | 1984-06-08 | 1984-07-11 | Erba Farmitalia | Anthracyclines |
GB2159518A (en) * | 1984-06-08 | 1985-12-04 | Erba Farmitalia | New anthracyclines and process for manufacture |
DE3500017A1 (de) * | 1985-01-02 | 1986-07-10 | Farmitalia Carlo Erba S.p.A., Mailand/Milano | 4'-haloanthracyclinester |
GB2218087B (en) * | 1988-04-22 | 1991-01-30 | Erba Carlo Spa | 4-demethoxy-4'-deoxy-4'iodo anthracycline glycosides |
AU601857B2 (en) * | 1988-06-30 | 1990-09-20 | Pharmacia & Upjohn S.P.A. | A new antitumor agent obtained by microbial stereoselective reduction of 4'-deoxy-4'-iododoxorubicin |
MA21995A1 (fr) * | 1989-11-13 | 1991-07-01 | Menarini Farma Ind | Nouvelles fluoronaphthacenediones,leurs derives glycozyles et leurs procedes de fabrication . |
GB9418260D0 (en) * | 1994-09-09 | 1994-10-26 | Erba Carlo Spa | Anthracycline derivatives |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR892943A (fr) * | 1942-03-06 | 1944-05-24 | Ig Farbenindustrie Ag | Procédé pour épurer la dilactone gamma céto-pimélique |
US4345070A (en) * | 1980-09-29 | 1982-08-17 | Farmitalia Carlo Erba S.P.A. | Process for the preparation of 4'-deoxy-daunorubicin and 4'-deoxy-doxorubicin |
US4438105A (en) * | 1982-04-19 | 1984-03-20 | Farmaitalia Carlo Erba S.P.A | 4'-Iododerivatives of anthracycline glycosides |
-
1983
- 1983-08-11 GB GB838321676A patent/GB8321676D0/en active Pending
-
1984
- 1984-08-06 AT AT0253884A patent/AT384226B/de not_active IP Right Cessation
- 1984-08-06 IT IT8422232A patent/IT1209576B/it active
- 1984-08-06 DE DE3428945A patent/DE3428945A1/de not_active Withdrawn
- 1984-08-07 AU AU31685/84A patent/AU563396B2/en not_active Ceased
- 1984-08-07 FR FR8412467A patent/FR2554450B1/fr not_active Expired
- 1984-08-07 SE SE8404005A patent/SE8404005L/sv unknown
- 1984-08-07 GR GR80046A patent/GR80046B/el unknown
- 1984-08-07 SU SU843781800A patent/SU1579465A3/ru active
- 1984-08-08 FI FI843110A patent/FI78109C/sv not_active IP Right Cessation
- 1984-08-08 DK DK381884A patent/DK381884A/da not_active Application Discontinuation
- 1984-08-08 ZA ZA846147A patent/ZA846147B/xx unknown
- 1984-08-09 CS CS846052A patent/CS270411B2/cs unknown
- 1984-08-09 GB GB08420237A patent/GB2144744B/en not_active Expired
- 1984-08-09 JP JP59165760A patent/JPS6058997A/ja active Pending
- 1984-08-10 CH CH3853/84A patent/CH660740A5/de not_active IP Right Cessation
- 1984-08-10 NL NL8402477A patent/NL8402477A/nl unknown
- 1984-08-10 HU HU843055A patent/HU194266B/hu not_active IP Right Cessation
- 1984-08-10 BE BE0/213475A patent/BE900336A/fr not_active IP Right Cessation
- 1984-08-10 CA CA000460796A patent/CA1250833A/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
AT384226B (de) | 1987-10-12 |
CA1250833A (en) | 1989-03-07 |
NL8402477A (nl) | 1985-03-01 |
ZA846147B (en) | 1985-03-27 |
JPS6058997A (ja) | 1985-04-05 |
GB8321676D0 (en) | 1983-09-14 |
AU563396B2 (en) | 1987-07-09 |
IT1209576B (it) | 1989-08-30 |
GB2144744A (en) | 1985-03-13 |
SU1579465A3 (ru) | 1990-07-15 |
ATA253884A (de) | 1987-03-15 |
CS270411B2 (en) | 1990-06-13 |
CS605284A2 (en) | 1989-11-14 |
GB8420237D0 (en) | 1984-09-12 |
FI843110A0 (fi) | 1984-08-08 |
CH660740A5 (de) | 1987-06-15 |
HU194266B (en) | 1988-01-28 |
FI78109C (sv) | 1989-06-12 |
FI843110A (fi) | 1985-02-12 |
DE3428945A1 (de) | 1985-02-28 |
DK381884D0 (da) | 1984-08-08 |
SE8404005D0 (sv) | 1984-08-07 |
HUT35691A (en) | 1985-07-29 |
GR80046B (en) | 1984-12-10 |
GB2144744B (en) | 1986-12-03 |
DK381884A (da) | 1985-02-12 |
AU3168584A (en) | 1985-02-14 |
SE8404005L (sv) | 1985-02-12 |
BE900336A (fr) | 1985-02-11 |
FR2554450A1 (fr) | 1985-05-10 |
IT8422232A0 (it) | 1984-08-06 |
FR2554450B1 (fr) | 1987-01-30 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM | Patent lapsed |
Owner name: FARMITALIA CARLO ERBA S.P.A |