FI78082C - Foerfarande foer framstaellning av terapeutiskt aktiva 6(r)-/2-(8-acyloxi-2,6-dimetylpolyhydronaftyl-1)- etyl/-4(r)-hydroxi-3,4,5,6-tetrahydro-2h-pyranoner och 7-/8-acyloxi- 2,6-dimetylpolyhydronaftyl-1/-3(r),5(r)-dihydroxiheptansyror. - Google Patents

Foerfarande foer framstaellning av terapeutiskt aktiva 6(r)-/2-(8-acyloxi-2,6-dimetylpolyhydronaftyl-1)- etyl/-4(r)-hydroxi-3,4,5,6-tetrahydro-2h-pyranoner och 7-/8-acyloxi- 2,6-dimetylpolyhydronaftyl-1/-3(r),5(r)-dihydroxiheptansyror. Download PDF

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Publication number
FI78082C
FI78082C FI810287A FI810287A FI78082C FI 78082 C FI78082 C FI 78082C FI 810287 A FI810287 A FI 810287A FI 810287 A FI810287 A FI 810287A FI 78082 C FI78082 C FI 78082C
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FI
Finland
Prior art keywords
hydroxy
formula
pyran
tetrahydro
solution
Prior art date
Application number
FI810287A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI810287L (fi
FI78082B (fi
Inventor
Alvin K Willard
William F Hoffman
Robert L Smith
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27494171&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FI78082(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US06/175,232 external-priority patent/US4293496A/en
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of FI810287L publication Critical patent/FI810287L/fi
Publication of FI78082B publication Critical patent/FI78082B/fi
Application granted granted Critical
Publication of FI78082C publication Critical patent/FI78082C/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
FI810287A 1980-02-04 1981-02-02 Foerfarande foer framstaellning av terapeutiskt aktiva 6(r)-/2-(8-acyloxi-2,6-dimetylpolyhydronaftyl-1)- etyl/-4(r)-hydroxi-3,4,5,6-tetrahydro-2h-pyranoner och 7-/8-acyloxi- 2,6-dimetylpolyhydronaftyl-1/-3(r),5(r)-dihydroxiheptansyror. FI78082C (fi)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US11805180A 1980-02-04 1980-02-04
US11804980A 1980-02-04 1980-02-04
US11804980 1980-02-04
US11805180 1980-02-04
US17546080A 1980-08-05 1980-08-05
US17523280 1980-08-05
US17546080 1980-08-05
US06/175,232 US4293496A (en) 1980-02-04 1980-08-05 6(R)-[2-(8-Hydroxy-2,6-dimethylpolyhydronaphthyl-1)-ethyl]-4(R)-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-ones

Publications (3)

Publication Number Publication Date
FI810287L FI810287L (fi) 1981-08-05
FI78082B FI78082B (fi) 1989-02-28
FI78082C true FI78082C (fi) 1989-06-12

Family

ID=27494171

Family Applications (1)

Application Number Title Priority Date Filing Date
FI810287A FI78082C (fi) 1980-02-04 1981-02-02 Foerfarande foer framstaellning av terapeutiskt aktiva 6(r)-/2-(8-acyloxi-2,6-dimetylpolyhydronaftyl-1)- etyl/-4(r)-hydroxi-3,4,5,6-tetrahydro-2h-pyranoner och 7-/8-acyloxi- 2,6-dimetylpolyhydronaftyl-1/-3(r),5(r)-dihydroxiheptansyror.

Country Status (22)

Country Link
EP (1) EP0033538B1 (en:Method)
AU (1) AU548996B2 (en:Method)
CA (1) CA1199322A (en:Method)
CY (1) CY1404A (en:Method)
DD (1) DD155989A5 (en:Method)
DE (1) DE3173042D1 (en:Method)
DK (1) DK157292C (en:Method)
ES (1) ES499079A0 (en:Method)
FI (1) FI78082C (en:Method)
GR (1) GR74798B (en:Method)
HK (1) HK16488A (en:Method)
IE (1) IE51478B1 (en:Method)
IL (1) IL62044A (en:Method)
MA (1) MA19054A1 (en:Method)
MY (1) MY8700745A (en:Method)
NL (1) NL930009I2 (en:Method)
NO (2) NO154229C (en:Method)
NZ (1) NZ196172A (en:Method)
PT (1) PT72441B (en:Method)
RO (1) RO82367B (en:Method)
SG (1) SG61087G (en:Method)
YU (1) YU28181A (en:Method)

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US4503072A (en) * 1982-12-22 1985-03-05 Merck & Co., Inc. Antihypercholesterolemic compounds
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US5021451A (en) * 1988-11-14 1991-06-04 Hoffman-La Roche Inc. Method for inhibiting hyperproliferative diseases
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US5110825A (en) * 1989-12-28 1992-05-05 Shionogi & Co., Ltd. Benzofuran derivative
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NZ250609A (en) * 1992-12-28 1995-07-26 Sankyo Co Hexahydronaphthalene esters and ring closed lactones; preparation and medicaments
US6642268B2 (en) 1994-09-13 2003-11-04 G.D. Searle & Co. Combination therapy employing ileal bile acid transport inhibiting benzothipines and HMG Co-A reductase inhibitors
US6268392B1 (en) 1994-09-13 2001-07-31 G. D. Searle & Co. Combination therapy employing ileal bile acid transport inhibiting benzothiepines and HMG Co-A reductase inhibitors
NZ286920A (en) * 1995-07-03 1997-06-24 Sankyo Co Use of combination of hmg-coa reductase inhibitors and of insulin sensitizers for the prevention/treatment of arteriosclerosis or xanthoma
AU7271696A (en) * 1995-12-06 1997-06-27 Antibiotic Co Method of production of lovastatin
CA2185961A1 (en) 1996-09-19 1998-03-20 K.S. Keshava Murthy Process for producing simvastatin
US6083497A (en) 1997-11-05 2000-07-04 Geltex Pharmaceuticals, Inc. Method for treating hypercholesterolemia with unsubstituted polydiallylamine polymers
SI9800057A (sl) * 1998-02-26 1999-08-31 Krka, Tovarna Zdravil, D.D. Postopek za pripravo simvastatina in njegovih derivatov
CA2240983A1 (en) 1998-06-18 1999-12-18 Yong Tao Process to manufacture simvastatin and intermediates
ATE241386T1 (de) 1998-12-23 2003-06-15 Searle Llc Kombinationen von ileumgallensäuretransports inhibitoren und cholesteryl ester transfer protein inhibitoren
EP1340508A1 (en) 1998-12-23 2003-09-03 G.D. Searle LLC. Combinations of cholesteryl ester transfer protein inhibitors and nicotinic acid derivatives for cardiovascular indications
PT1140190E (pt) 1998-12-23 2003-02-28 Searle Llc Combinacoes de inibidores do transporte ileal dos acidos biliares e agentes sequestrantes dos acidos biliares usadas para problemas cardiovasculares
EP1140186B1 (en) 1998-12-23 2003-06-04 G.D. Searle LLC. Combinations of cholesteryl ester transfer protein inhibitors and fibric acid derivatives for cardiovascular indications
ES2203239T3 (es) 1998-12-23 2004-04-01 G.D. Searle Llc Combinaciones de inhibidores de la proteina de transferencia de ester de colesterilo y de agentes secuestrantes de acidos biliares para indicaciones cardiovasculares.
US6462091B1 (en) 1998-12-23 2002-10-08 G.D. Searle & Co. Combinations of cholesteryl ester transfer protein inhibitors and HMG coA reductase inhibitors for cardiovascular indications
WO2000038727A1 (en) 1998-12-23 2000-07-06 G.D. Searle Llc Combinations of ileal bile acid transport inhibitors and fibric acid derivatives for cardiovascular indications
WO2001068637A2 (en) 2000-03-10 2001-09-20 Pharmacia Corporation Method for the preparation of tetrahydrobenzothiepines
HUP0302929A3 (en) 2000-09-07 2004-10-28 Kaneka Corp Methods for crystallization of hydroxycarboxylic acids
BR0213501A (pt) 2001-11-02 2004-08-24 Searle Llc Compostos de benzotiepina mono- e di-fluorada como inibidores de transporte de ácido biliar co-dependente de sódio apical (asbt) e captação de taurocolato
CA2471639A1 (en) 2002-01-17 2003-07-31 Pharmacia Corporation Novel alkyl/aryl hydroxy or keto thiepines.
SI21187A (sl) 2002-03-26 2003-10-31 Krka, Tovarna Zdravil D.D., Novo Mesto Postopek za pripravo 4-oksitetrahidropiran-2-onov
KR20040092790A (ko) * 2003-04-29 2004-11-04 씨제이 주식회사 심바스타틴 중간체 제조방법
EP1741427A1 (en) 2005-07-06 2007-01-10 KRKA, D.D., Novo Mesto Pharmaceutical composition comprising simvastatin and ezetimibe
EP2359826B1 (en) 2006-07-05 2013-10-30 Takeda GmbH Combination of HMG-COA reductase inhibitor rosuvastatin with a phosphodiesterase 4 inhibitor, such as roflumilast, roflumilast-N-oxide for the treatment of inflammatory pulmonary diseases
WO2009013764A2 (en) * 2007-07-24 2009-01-29 Jubilant Organosys Limited Process for producing 6(r)-[2-(8'(s)-2 ',2 '-dimethylbutyryloxy-2'(s),6'(r)-dimethyl-1,2,6,7', 8',8a'(r)- hexahydronaphthyl-l'(s))ethyl]-4(r)-hydroxy-3,4,5,6- tetrahydro-2h-pyran-2-one
JOP20080381B1 (ar) 2007-08-23 2023-03-28 Amgen Inc بروتينات مرتبطة بمولدات مضادات تتفاعل مع بروبروتين كونفيرتاز سيتيليزين ككسين من النوع 9 (pcsk9)
ES2330184B1 (es) 2008-06-03 2010-07-05 Neuron Biopharma, S.A. Uso de estatinas como anticonvulsivantes, antiepilepticos y neuroprotectores.
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EP2204170A1 (en) 2008-12-01 2010-07-07 LEK Pharmaceuticals D.D. Pharmaceutical composition comprising ezetimibe and simvastatin
WO2010069593A1 (en) 2008-12-19 2010-06-24 Krka, D. D., Novo Mesto Use of amphiphilic compounds for controlled crystallization of statins and statin intermediates
EP2327682A1 (en) 2009-10-29 2011-06-01 KRKA, D.D., Novo Mesto Use of amphiphilic compounds for controlled crystallization of statins and statin intermediates
EP2216016A1 (en) 2009-02-06 2010-08-11 LEK Pharmaceuticals d.d. Process for the preparation of a pharmaceutical composition comprising ezetimibe
EP2241561A1 (en) * 2009-04-16 2010-10-20 Neuron Biopharma, S.A. Neuroprotective, hypocholesterolemic and antiepileptic compound
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Also Published As

Publication number Publication date
GR74798B (en:Method) 1984-07-12
AU6657381A (en) 1981-08-13
HK16488A (en) 1988-03-11
PT72441B (pt) 1984-08-01
RO82367A (ro) 1984-02-21
EP0033538A3 (en) 1982-02-24
NO1994001I1 (no) 1994-07-01
NL930009I1 (nl) 1993-04-01
NZ196172A (en) 1985-01-31
MA19054A1 (fr) 1981-10-01
FI810287L (fi) 1981-08-05
NL930009I2 (nl) 1993-09-16
RO82367B (ro) 1984-02-28
IE810204L (en) 1981-08-04
DK46181A (da) 1981-08-05
EP0033538B1 (en) 1985-11-27
NO154229B (no) 1986-05-05
DE3173042D1 (en) 1986-01-09
EP0033538A2 (en) 1981-08-12
NO810358L (no) 1981-08-05
AU548996B2 (en) 1986-01-09
IL62044A0 (en) 1981-03-31
CY1404A (en) 1988-04-22
MY8700745A (en) 1987-12-31
ES8609296A1 (es) 1985-10-16
DD155989A5 (de) 1982-07-21
PT72441A (pt) 1981-03-01
IE51478B1 (en) 1987-01-07
FI78082B (fi) 1989-02-28
DK157292B (da) 1989-12-04
NO154229C (no) 1986-08-13
DK157292C (da) 1990-05-07
IL62044A (en) 1987-03-31
CA1199322A (en) 1986-01-14
YU28181A (en) 1983-10-31
ES499079A0 (es) 1985-10-16
SG61087G (en) 1987-10-23

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ND Supplementary protection certificate (spc) granted
SPCG Supplementary protection certificate granted

Spc suppl protection certif: L14

Extension date: 20030406

MA Patent expired

Owner name: MERCK & CO., INC.