FI73442B - Foerfarande foer framstaellning av nya, terapeutiskt anvaendbara (6r,7r)-7-/2-(2-amino-4-tiazolyl)-2- hydroxiimino)acetamido/-3-//(substituerad-as-triazin-3-yl)tio/metyl/ -8-oxo-5-tia-1-azabicyklo/4.2.0/okt-2-en-2-karboxylsyror. - Google Patents
Foerfarande foer framstaellning av nya, terapeutiskt anvaendbara (6r,7r)-7-/2-(2-amino-4-tiazolyl)-2- hydroxiimino)acetamido/-3-//(substituerad-as-triazin-3-yl)tio/metyl/ -8-oxo-5-tia-1-azabicyklo/4.2.0/okt-2-en-2-karboxylsyror. Download PDFInfo
- Publication number
- FI73442B FI73442B FI813088A FI813088A FI73442B FI 73442 B FI73442 B FI 73442B FI 813088 A FI813088 A FI 813088A FI 813088 A FI813088 A FI 813088A FI 73442 B FI73442 B FI 73442B
- Authority
- FI
- Finland
- Prior art keywords
- strain
- methyl
- oxo
- formula
- triazin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
- C07D253/06—1,2,4-Triazines
- C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
- C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D253/075—Two hetero atoms, in positions 3 and 5
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cephalosporin Compounds (AREA)
- Saccharide Compounds (AREA)
Claims (4)
1. Förfarande för framställning av terapeutiskt an-vändbara (6R, 7R)-Ί-β- (2-amino-4-tiazolyl) -2- (hydroxiimino) -5 acetamidQ7-3-/7!l substituerad-as-triazin-3-yl) tiq7-metyl7-8-oxo-5-tia-azabicyklo/4.2. Q7okt-2-en-2-karboxylsyror, lätt hydrolyserbara estrar, lätt hydrolyserbara etrar och salter därav samt hydrater av förenlngar med formeln I och av de-ras estrar, etrar och salter, 10 H H HON=C-CONH —f-f'' N n i QJ-n^-cVS-x 1 H-IT^S' ^00H 15 * i vilken formel X är en 1,2,5,6-tetrahydro-2-metyl-5,6-dioxo-as-triazin-3-ylgrupp eller dess motsvarande tautomera form, 2,5-dihydro-6-hydroxi-2-metyl-5-oxo-as-triazin-3-yl-20 gruppen, varvid föreningarna är i form av syn-isomeren eller i form av en blandning, där syn-isomeren är övervägande, kännet ecknat därav, att en förening med formeln H H HON=C-CONH-f-N
25. I 1 <po )-N .^J-ch2-s-x II f*2 ° Αχ* Hai 1 11 1 där X betecknar samma som X eller X är en tili en lätt 30 hydrolyserbar eter företrad 2,5-dihydro-6-hydroxi-2-metyl- 5-oxo-as-triazin-3-ylgrupp och Hai är brom eller klor, eller ett sait eller ett karboxylskyddat derivat därav, varvid föreningen med formeln II, saltet eller det karboxylskydda-de derivatet därav i form av syn-isomeren eller i form av 35 en blandning, där syn-isomeren är övervägande, omsätts med tiourea och en eventuell skyddsgrupp avspjälkes; och, om
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FI864694A FI864694A (fi) | 1980-10-06 | 1986-11-18 | (6r,7r)-7-/4-halogen-2-(hydroxi-imino) -asetoasetamido/-8-oxo-3-(substiteurad tiometyl)-5-tia-1-azabicyklo/ 4.2.0/okt-2-en-2-karboxylsyraderivat. |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH745080 | 1980-10-06 | ||
| CH745080 | 1980-10-06 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI813088L FI813088L (fi) | 1982-04-07 |
| FI73442B true FI73442B (fi) | 1987-06-30 |
| FI73442C FI73442C (sv) | 1987-10-09 |
Family
ID=4325316
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI813088A FI73442C (sv) | 1980-10-06 | 1981-10-06 | Förfarande för framställning av nya, terapeutiskt användbara (6R,7R)- 7-/2-(2-amino-4-tiazolyl)-2- hydroxiimino)acetamido/-3-//(substituerad -as-triazin-3-yl)tio/metyl/ -8-oxo-5-tia-1-azabicyklo/4.2.0/okt-2-en-2 -karboxylsyror. |
Country Status (21)
| Country | Link |
|---|---|
| US (3) | US4412070A (sv) |
| EP (1) | EP0049499B1 (sv) |
| JP (3) | JPS5791989A (sv) |
| KR (1) | KR870000828B1 (sv) |
| AT (1) | ATE17729T1 (sv) |
| AU (1) | AU554552B2 (sv) |
| CA (1) | CA1168227A (sv) |
| DE (1) | DE3173642D1 (sv) |
| DK (1) | DK379581A (sv) |
| ES (1) | ES8206534A1 (sv) |
| FI (1) | FI73442C (sv) |
| GR (1) | GR75072B (sv) |
| HU (1) | HU185963B (sv) |
| IE (1) | IE51633B1 (sv) |
| IL (1) | IL63964A (sv) |
| MC (1) | MC1421A1 (sv) |
| NO (2) | NO813375L (sv) |
| NZ (1) | NZ198507A (sv) |
| PH (1) | PH20367A (sv) |
| PT (1) | PT73764B (sv) |
| ZA (1) | ZA816741B (sv) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4695565A (en) * | 1984-10-04 | 1987-09-22 | Merck & Co., Inc. | Antibacterial 7β-heterocyclic-cephem |
| EP0185220A3 (de) * | 1984-12-19 | 1987-09-02 | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft | Zwischenprodukte zur Herstellung von Cephalosporinen |
| JP2620743B2 (ja) * | 1992-12-02 | 1997-06-18 | 株式会社山一屋 | 垣形成用支柱 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4348518A (en) * | 1974-05-05 | 1982-09-07 | Hoffmann-La Roche Inc. | Cephalosporins |
| JPS6011713B2 (ja) * | 1976-09-08 | 1985-03-27 | 武田薬品工業株式会社 | セフアロスポリン誘導体およびその製造法 |
| DE2714880A1 (de) * | 1977-04-02 | 1978-10-26 | Hoechst Ag | Cephemderivate und verfahren zu ihrer herstellung |
| JPS5444695A (en) * | 1977-09-13 | 1979-04-09 | Fujisawa Pharmaceut Co Ltd | 3,7-disubstituted-3-cephem-4-carboxylic acid and its salt and their preparation |
| US4200745A (en) * | 1977-12-20 | 1980-04-29 | Eli Lilly And Company | 7[2-(2-Aminothiazol-4-yl)-2-alkoxyimino]acetamido 3[4-alkyl-5-oxo-6-hydroxy-3,4 dihydro 1,2,4-triazin 3-yl]thio methyl cephalosporins |
| CH641468A5 (de) * | 1978-05-30 | 1984-02-29 | Hoffmann La Roche | Cephemderivate. |
| MC1259A1 (fr) * | 1978-05-30 | 1980-01-14 | Hoffmann La Roche | Derives acyles |
| NL8100089A (nl) * | 1980-01-17 | 1981-08-17 | Rhone Poulenc Ind | Nieuwe thiolen en de bereiding daarvan. |
-
1981
- 1981-08-26 DK DK379581A patent/DK379581A/da not_active Application Discontinuation
- 1981-09-28 US US06/306,053 patent/US4412070A/en not_active Expired - Lifetime
- 1981-09-28 IL IL63964A patent/IL63964A/xx unknown
- 1981-09-29 AU AU75741/81A patent/AU554552B2/en not_active Ceased
- 1981-09-29 ZA ZA816741A patent/ZA816741B/xx unknown
- 1981-09-30 NZ NZ198507A patent/NZ198507A/en unknown
- 1981-10-01 PH PH26295A patent/PH20367A/en unknown
- 1981-10-02 EP EP81107866A patent/EP0049499B1/de not_active Expired
- 1981-10-02 DE DE8181107866T patent/DE3173642D1/de not_active Expired
- 1981-10-02 AT AT81107866T patent/ATE17729T1/de not_active IP Right Cessation
- 1981-10-02 PT PT73764A patent/PT73764B/pt unknown
- 1981-10-02 HU HU812848A patent/HU185963B/hu unknown
- 1981-10-02 MC MC811550A patent/MC1421A1/xx unknown
- 1981-10-05 GR GR66203A patent/GR75072B/el unknown
- 1981-10-05 IE IE2315/81A patent/IE51633B1/en unknown
- 1981-10-05 JP JP56157607A patent/JPS5791989A/ja active Granted
- 1981-10-05 NO NO813375A patent/NO813375L/no unknown
- 1981-10-05 CA CA000387271A patent/CA1168227A/en not_active Expired
- 1981-10-05 ES ES506022A patent/ES8206534A1/es not_active Expired
- 1981-10-06 FI FI813088A patent/FI73442C/sv not_active IP Right Cessation
- 1981-10-06 KR KR1019810003771A patent/KR870000828B1/ko active
-
1982
- 1982-08-24 NO NO822876A patent/NO822876L/no unknown
-
1983
- 1983-08-01 US US06/519,453 patent/US4520195A/en not_active Expired - Lifetime
-
1986
- 1986-01-31 JP JP61018289A patent/JPS61178993A/ja active Granted
-
1987
- 1987-04-01 US US07/033,430 patent/US4774330A/en not_active Expired - Fee Related
-
1990
- 1990-10-03 JP JP2266152A patent/JPH0786112B2/ja not_active Expired - Lifetime
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM | Patent lapsed |
Owner name: F HOFFMANN-LA ROCHE & CO |