FI73208C - Förfarande för framställning av 4-substituerade imidazolföreningar. - Google Patents

Förfarande för framställning av 4-substituerade imidazolföreningar. Download PDF

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Publication number
FI73208C
FI73208C FI771291A FI771291A FI73208C FI 73208 C FI73208 C FI 73208C FI 771291 A FI771291 A FI 771291A FI 771291 A FI771291 A FI 771291A FI 73208 C FI73208 C FI 73208C
Authority
FI
Finland
Prior art keywords
methyl
formula
mol
aminoethyl
lower alkyl
Prior art date
Application number
FI771291A
Other languages
English (en)
Finnish (fi)
Other versions
FI73208B (fi
FI771291A (fi
Inventor
Joseph James Lewis
Robert Lee Webb
Original Assignee
Smithkline Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/771,044 external-priority patent/US4119781A/en
Application filed by Smithkline Corp filed Critical Smithkline Corp
Publication of FI771291A publication Critical patent/FI771291A/fi
Publication of FI73208B publication Critical patent/FI73208B/fi
Application granted granted Critical
Publication of FI73208C publication Critical patent/FI73208C/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/84—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/88—Nitrogen atoms, e.g. allantoin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6503—Five-membered rings
    • C07F9/6506—Five-membered rings having the nitrogen atoms in positions 1 and 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Claims (6)

1. Förfarande för framställning av 4-(tio eller amino)-metyl-imidazoler med formeln r1_ch2r2 / \ n Y'H R3 1. väri R är väte eller lägre alkyl, R är -SCH2CH2NH2, NCN -SCH2CH2NHC ^^'nhch3 6 7 6 7 eller -NR°R/, väri R° och R vardera är väte, lägre alkyl eller tillsammans med den kväveatom tili vilken de är bundna, 73208 20 bildar en piperidin-, pyrrolidin- eller morfolinring, och R är väte, lägre alkyl, trifluormetyl, bensyl, amino eller 4 4 -SR , väri R är lägre alkyl, fenyl, bensyl, eller klorben-syl,kännetecknat av att man omsätter en för-ening med formeln 1 ® 5 Rv_ CH2P (R ) 2 'V \ χθ R3 13 5 väri R och R har den ovan angivna betydelsen, R är lägre alkyl eller fenyl och X är halogen, med en förening med for-2 2 mein R -H, väri R har den ovan angivna betydelsen, i ett organiskt lösningsmedel säsom metanol, etanol, propanol, butanol, aceton, acetonitril, dimetylformamid eller dimetyl-sulfoxid, vid en temperatur som är mellan omgivningstempera-turen och lösningsmedlets äterflödestemperatur, och under basiska betingelser erhällna med en bas med ett pKa-värde större än 12.
2. Förfarande enligt patentkravet 1, känneteck-n a t av att man framställer 4-(2-aminoetyl)tiometyl-5-metyl-2-metyltioimidazol.
3. Förfarande enligt patentkravet 1, känneteck-n a t av att man framställer 4-(2-aminoetyl)tiometyl-5-metylimidazol.
4. Förfarande enligt patentkravet 1, känneteck-n a t av att man som bas använder natriummetoxid eller natriumhydrid.
5. Förfarande enligt patentkravet l,känneteck-n a t av att reaktionen utföres vid en temperatur mellan ca 25°C och ca 200°C, varvid reaktionstiden är mellan ca 20 minuter och ca 24 timmar.
FI771291A 1977-02-22 1977-04-22 Förfarande för framställning av 4-substituerade imidazolföreningar. FI73208C (sv)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US05/771,044 US4119781A (en) 1975-10-29 1977-02-22 Process for preparing 4-substituted imidazole compounds
US77104477 1977-02-22

Publications (3)

Publication Number Publication Date
FI771291A FI771291A (fi) 1978-08-23
FI73208B FI73208B (fi) 1987-05-29
FI73208C true FI73208C (sv) 1987-09-10

Family

ID=25090518

Family Applications (1)

Application Number Title Priority Date Filing Date
FI771291A FI73208C (sv) 1977-02-22 1977-04-22 Förfarande för framställning av 4-substituerade imidazolföreningar.

Country Status (22)

Country Link
AR (1) AR217073A1 (sv)
AT (1) AT355015B (sv)
BE (1) BE853954R (sv)
CA (1) CA1084052A (sv)
CH (2) CH631167A5 (sv)
DE (1) DE2718715A1 (sv)
DK (1) DK168277A (sv)
ES (1) ES458153A1 (sv)
FI (1) FI73208C (sv)
FR (1) FR2381031A2 (sv)
GB (1) GB1582865A (sv)
HU (1) HU174840B (sv)
IE (1) IE45035B1 (sv)
IL (1) IL51898A (sv)
IN (1) IN148285B (sv)
IT (1) IT1078449B (sv)
LU (1) LU77200A1 (sv)
MX (1) MX4663E (sv)
NL (1) NL7704617A (sv)
NO (1) NO152903C (sv)
PT (1) PT66446B (sv)
SE (2) SE442199B (sv)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL57415A (en) * 1978-05-30 1984-08-31 Smith Kline French Lab Nitropyrrole compounds,process for preparing them and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
IL51898A (en) 1980-07-31
GB1582865A (en) 1981-01-14
NL7704617A (nl) 1978-08-24
FR2381031B2 (sv) 1982-09-17
FI73208B (fi) 1987-05-29
NO152903C (no) 1985-12-11
AR217073A1 (es) 1980-02-29
NO771453L (no) 1978-08-23
LU77200A1 (sv) 1977-08-17
ES458153A1 (es) 1978-04-01
NO152903B (no) 1985-09-02
IT1078449B (it) 1985-05-08
IE45035B1 (en) 1982-06-02
FR2381031A2 (fr) 1978-09-15
SE7704870L (sv) 1978-08-23
IN148285B (sv) 1981-01-03
DK168277A (da) 1978-08-23
CH631167A5 (en) 1982-07-30
SE442199B (sv) 1985-12-09
IE45035L (en) 1978-08-22
CH631168A5 (en) 1982-07-30
MX4663E (es) 1982-07-21
AT355015B (de) 1980-02-11
DE2718715A1 (de) 1978-08-31
IL51898A0 (en) 1977-06-30
FI771291A (fi) 1978-08-23
ATA289577A (de) 1979-07-15
PT66446A (en) 1977-05-01
HU174840B (hu) 1980-03-28
SE8008935L (sv) 1980-12-18
SE452887B (sv) 1987-12-21
CA1084052A (en) 1980-08-19
BE853954R (fr) 1977-10-26
PT66446B (en) 1978-09-22

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Legal Events

Date Code Title Description
MM Patent lapsed

Owner name: SMITHKLINE CORPORATION