FI71124B - Nya derivat av 2,4,6-trijodisoftalsyra foerfarande foer framstaellning av dessa samt roentgenkontrastmedel innehaollande desamma - Google Patents

Nya derivat av 2,4,6-trijodisoftalsyra foerfarande foer framstaellning av dessa samt roentgenkontrastmedel innehaollande desamma Download PDF

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Publication number
FI71124B
FI71124B FI802373A FI802373A FI71124B FI 71124 B FI71124 B FI 71124B FI 802373 A FI802373 A FI 802373A FI 802373 A FI802373 A FI 802373A FI 71124 B FI71124 B FI 71124B
Authority
FI
Finland
Prior art keywords
acid bis
methyl
triiodoisophthalic acid
water
alkyl
Prior art date
Application number
FI802373A
Other languages
English (en)
Finnish (fi)
Other versions
FI71124C (fi
FI802373A (fi
Inventor
Ernst Felder
Davide Pitre
Original Assignee
Bracco Ind Chimica Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bracco Ind Chimica Spa filed Critical Bracco Ind Chimica Spa
Publication of FI802373A publication Critical patent/FI802373A/fi
Application granted granted Critical
Publication of FI71124B publication Critical patent/FI71124B/fi
Publication of FI71124C publication Critical patent/FI71124C/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/28—Radicals substituted by nitrogen atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Polyamides (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Claims (6)

1. Som skuggivande komponenter i röntgenkontrastmedel användbara 5-(N-alkyl-«-hydroxiacyl-amino)-2,4,6-1rijod-Lso-ftalsyra-bis-(dihydroxialkylamider) med den allmänna formeln (I) (HO)^alkyl-NH-CO (HO) 2alkyl-NH CO ^ N CO-CH(OH)-R vari (HO^alkyl- betecknar 1 , 3-dihydroxί-isopropyl eller 2,3-dihydroxi-propyl, R betecknar väte eller metyl och R^ betecknar en alkylrest med 1-5 C-atomer.
2. Förening enligt patentkravet 1, kännetecknad av att R^ är metyl.
3. Förening enligt patentkravet 1, känetecknad av att den är 5-(N-metyl-hydroxiacetyl-amino)-2,4,6-trijod-iso-ftalsyra-bis-(2,3-dihydroxipropylamid).
4. Förening enligt patentkravet 1,kännetecknad av att den är 5-(N-metyl-α-hydroxipropionyl-amino)-2,4,6-trijod-isoftalsyra-bis-(1,3-dihydroxiisopropylamid).
5. Förfarande för framställning av som skuggivande komponenter i röntgenkontrastmedel användbara 5-(N-alkyl-a-hydroxiacyl-amino)- 2,4,6-trijod-isoftalsyra-bis-(dihydroxialkylamider) enligt patentkravet 1,kännetecknat av att en 5-a-hydroxiacyl-amino-2,4,6-trijod-isoftalsyra-bis-(dihydroxialkylamid) med den allmänna formeln (III)
FI802373A 1979-08-09 1980-07-29 Nya derivat av 2,4,6-trijodisoftalsyra foerfarande foer framstaellning av dessa samt roentgenkontrastmedel innehaollande desamma FI71124C (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT2502679 1979-08-08
IT25026/79A IT1193211B (it) 1979-08-09 1979-08-09 Derivati dell'acido 2,4,6-triiodo-isoftalico,metodo per la loro preparazione e mezzi di contrasto che li contengono

Publications (3)

Publication Number Publication Date
FI802373A FI802373A (fi) 1981-02-10
FI71124B true FI71124B (fi) 1986-08-14
FI71124C FI71124C (fi) 1986-11-24

Family

ID=11215461

Family Applications (1)

Application Number Title Priority Date Filing Date
FI802373A FI71124C (fi) 1979-08-09 1980-07-29 Nya derivat av 2,4,6-trijodisoftalsyra foerfarande foer framstaellning av dessa samt roentgenkontrastmedel innehaollande desamma

Country Status (19)

Country Link
US (1) US4352788A (sv)
EP (1) EP0026281B1 (sv)
JP (1) JPS5827264B2 (sv)
AR (2) AR225773A1 (sv)
AT (1) ATE1995T1 (sv)
AU (1) AU541428B2 (sv)
CA (1) CA1128065A (sv)
DE (1) DE3061347D1 (sv)
DK (1) DK158659C (sv)
ES (1) ES8106696A1 (sv)
FI (1) FI71124C (sv)
IE (1) IE50149B1 (sv)
IT (1) IT1193211B (sv)
MX (1) MX9202639A (sv)
NL (1) NL940024I2 (sv)
NO (1) NO150154C (sv)
PL (2) PL123167B1 (sv)
PT (1) PT71682B (sv)
YU (1) YU42352B (sv)

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IT1275429B (it) * 1995-05-18 1997-08-07 Zambon Spa Processo per la preparazione di un intermedio utile nella sintesi di composti organici
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IT1288114B1 (it) * 1996-06-13 1998-09-10 Fructamine Spa Processo per la purificazione di un intermedio
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CN102363600B (zh) * 2011-10-24 2013-07-17 江苏省原子医学研究所 一种碘美普尔的制备方法
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CN106316878B (zh) * 2015-06-15 2018-01-19 重庆常捷医药有限公司 一种碘美普尔杂质的制备方法
JP7012722B2 (ja) * 2016-12-05 2022-01-28 ブラッコ・イメージング・ソシエタ・ペル・アチオニ 放射線画像診断剤中間体の機械化学的合成
CN107253918A (zh) * 2017-07-27 2017-10-17 成都丽璟科技有限公司 一种制备碘美普尔的新方法
KR102128423B1 (ko) * 2018-09-17 2020-07-01 (주)유케이케미팜 조영제 이오메프롤의 제조방법
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Also Published As

Publication number Publication date
AR225773A1 (es) 1982-04-30
MX9202639A (es) 1992-06-30
FI71124C (fi) 1986-11-24
IE801684L (en) 1981-02-09
NL940024I2 (nl) 1999-06-01
FI802373A (fi) 1981-02-10
ES494076A0 (es) 1981-09-01
NL940024I1 (nl) 1995-01-16
PL126118B1 (en) 1983-07-30
DE3061347D1 (en) 1983-01-20
JPS5827264B2 (ja) 1983-06-08
YU201180A (en) 1983-02-28
DK158659B (da) 1990-07-02
ES8106696A1 (es) 1981-09-01
NO802373L (no) 1981-02-10
PT71682A (en) 1980-09-01
IT7925026A0 (it) 1979-08-09
NO150154C (no) 1984-08-29
EP0026281A1 (de) 1981-04-08
DK343980A (da) 1981-02-10
EP0026281B1 (de) 1982-12-15
NO150154B (no) 1984-05-21
AU6061680A (en) 1981-02-12
PT71682B (en) 1981-06-15
PL123167B1 (en) 1982-09-30
JPS5629553A (en) 1981-03-24
US4352788A (en) 1982-10-05
YU42352B (en) 1988-08-31
AU541428B2 (en) 1985-01-10
IT1193211B (it) 1988-06-15
AR225836A1 (es) 1982-04-30
IE50149B1 (en) 1986-02-19
PL226143A1 (sv) 1981-05-08
ATE1995T1 (de) 1982-12-15
CA1128065A (en) 1982-07-20
DK158659C (da) 1991-01-21

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Legal Events

Date Code Title Description
PC Transfer of assignment of patent

Owner name: BRACCO INTERNATIONAL B.V.

ND Supplementary protection certificate (spc) granted
SPCG Supplementary protection certificate granted

Spc suppl protection certif: L91

Extension date: 20050729

MA Patent expired

Owner name: BRACCO INTERNATIONAL B.V.