FI69063C - Foerfarande foer framstaellning av farmaceutiskt anvaendbart 1-(p-metoxibensoyl)-2-pyrrolidinon samt i detta som mellanprodukter anvaendbara 1-(p-hydroxibensoyl)-2-pyrrolidinon 4-(p-metoxibensoylamino)smoersyra och 2-pyrrolinonderivat - Google Patents
Foerfarande foer framstaellning av farmaceutiskt anvaendbart 1-(p-metoxibensoyl)-2-pyrrolidinon samt i detta som mellanprodukter anvaendbara 1-(p-hydroxibensoyl)-2-pyrrolidinon 4-(p-metoxibensoylamino)smoersyra och 2-pyrrolinonderivat Download PDFInfo
- Publication number
- FI69063C FI69063C FI790226A FI790226A FI69063C FI 69063 C FI69063 C FI 69063C FI 790226 A FI790226 A FI 790226A FI 790226 A FI790226 A FI 790226A FI 69063 C FI69063 C FI 69063C
- Authority
- FI
- Finland
- Prior art keywords
- pyrrolidinone
- methoxybenzoyl
- compound
- preparation
- formula
- Prior art date
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- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- 150000003235 pyrrolidines Chemical class 0.000 description 1
- 239000002516 radical scavenger Substances 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000011514 reflex Effects 0.000 description 1
- 238000007142 ring opening reaction Methods 0.000 description 1
- 210000003786 sclera Anatomy 0.000 description 1
- 238000004904 shortening Methods 0.000 description 1
- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 1
- 239000011877 solvent mixture Substances 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 238000000859 sublimation Methods 0.000 description 1
- 230000008022 sublimation Effects 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 description 1
- 150000003512 tertiary amines Chemical class 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 210000003437 trachea Anatomy 0.000 description 1
- 125000004665 trialkylsilyl group Chemical group 0.000 description 1
- JFJZZMVDLULRGK-URLMMPGGSA-O tubocurarine Chemical compound C([C@H]1[N+](C)(C)CCC=2C=C(C(=C(OC3=CC=C(C=C3)C[C@H]3C=4C=C(C(=CC=4CCN3C)OC)O3)C=21)O)OC)C1=CC=C(O)C3=C1 JFJZZMVDLULRGK-URLMMPGGSA-O 0.000 description 1
- 229960001844 tubocurarine Drugs 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 229940072358 xylocaine Drugs 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
- C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/36—Oxygen or sulfur atoms
- C07D207/38—2-Pyrrolones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/10—Compounds having one or more C—Si linkages containing nitrogen having a Si-N linkage
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- General Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Psychiatry (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hospice & Palliative Care (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH140378 | 1978-02-10 | ||
| CH140378 | 1978-02-10 | ||
| CH1198178 | 1978-11-22 | ||
| CH1198178 | 1978-11-22 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI790226A FI790226A (fi) | 1979-08-11 |
| FI69063B FI69063B (fi) | 1985-08-30 |
| FI69063C true FI69063C (fi) | 1985-12-10 |
Family
ID=25687541
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI790226A FI69063C (fi) | 1978-02-10 | 1979-01-24 | Foerfarande foer framstaellning av farmaceutiskt anvaendbart 1-(p-metoxibensoyl)-2-pyrrolidinon samt i detta som mellanprodukter anvaendbara 1-(p-hydroxibensoyl)-2-pyrrolidinon 4-(p-metoxibensoylamino)smoersyra och 2-pyrrolinonderivat |
Country Status (34)
| Country | Link |
|---|---|
| US (1) | US4369139A (xx) |
| EP (2) | EP0005143B1 (xx) |
| JP (1) | JPS6059907B2 (xx) |
| AR (1) | AR220739A1 (xx) |
| AT (1) | AT374787B (xx) |
| AU (1) | AU525514B2 (xx) |
| BG (1) | BG29281A3 (xx) |
| BR (1) | BR7900684A (xx) |
| CA (1) | CA1100515A (xx) |
| CS (1) | CS226182B2 (xx) |
| CU (1) | CU21107A3 (xx) |
| DD (1) | DD141828A5 (xx) |
| DE (1) | DE2963321D1 (xx) |
| DK (1) | DK155278C (xx) |
| EG (1) | EG13873A (xx) |
| ES (2) | ES477587A1 (xx) |
| FI (1) | FI69063C (xx) |
| GR (1) | GR71464B (xx) |
| HK (1) | HK6185A (xx) |
| HU (1) | HU177644B (xx) |
| IE (1) | IE47831B1 (xx) |
| IL (1) | IL56587A0 (xx) |
| IN (1) | IN150106B (xx) |
| MC (1) | MC1257A1 (xx) |
| MY (1) | MY8500340A (xx) |
| NO (1) | NO152046C (xx) |
| NZ (1) | NZ189571A (xx) |
| OA (1) | OA06180A (xx) |
| PH (1) | PH15491A (xx) |
| PL (1) | PL115958B1 (xx) |
| PT (1) | PT69206A (xx) |
| RO (1) | RO76615A (xx) |
| SU (1) | SU931104A3 (xx) |
| YU (1) | YU41330B (xx) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1131959B (it) * | 1979-08-09 | 1986-06-25 | Hoffmann La Roche | Derivati pirrolidinici |
| CH646149A5 (de) * | 1981-02-05 | 1984-11-15 | Hoffmann La Roche | Pyrrolidin-derivat. |
| US4398938A (en) * | 1982-05-20 | 1983-08-16 | Velsicol Chemical Corporation | N-Acylated lactams and their herbicidal compositions and method of use |
| DE3326724A1 (de) * | 1983-07-25 | 1985-02-07 | Boehringer Ingelheim KG, 6507 Ingelheim | In 1-stellung substituierte 4-hydroxymethyl-pyrrolidinone, verfahren zu ihrer herstellung, pharmazeutische zusammensetzungen und zwischenprodukte |
| DE3336024A1 (de) * | 1983-10-04 | 1985-04-18 | Boehringer Ingelheim KG, 6507 Ingelheim | 4-amino-l-benzyl-pyrrolidinone und ihre saeureadditionssalze, verfahren zu ihrer herstellung und arzneimittel |
| DE3420193A1 (de) * | 1984-05-30 | 1985-12-05 | Boehringer Ingelheim KG, 6507 Ingelheim | Neue substituierte pyrrolidinone, verfahren zu ihrer herstellung und arzneimittel |
| CH661174GA3 (xx) * | 1985-07-10 | 1987-07-15 | ||
| US4691853A (en) * | 1985-12-30 | 1987-09-08 | Technalytics, Inc. | Surgical stapler |
| US5173489A (en) * | 1986-04-10 | 1992-12-22 | The Dupont Merck Pharmaceutical Co. | α,α-disubstituted aromatics and heteroaromatics as cognition enhancers |
| US4760083A (en) * | 1986-04-10 | 1988-07-26 | E. I. Dupont De Nemours & Company | 3,3-disubstituted indolines |
| US5300642A (en) * | 1986-04-10 | 1994-04-05 | The Du Pont Merck Pharmaceutical Company | α, α-disubstituted aromatics and heteroaromatics as cognition enhancers |
| US4876259A (en) * | 1987-01-05 | 1989-10-24 | E. I. Du Pont De Nemours And Company | 3,3-disubstituted indolines |
| IT1215587B (it) * | 1987-06-26 | 1990-02-14 | Roussel Maestretti Spa | Derivati della 1-benzoil2-oxo 5-alcossi pirrolidina, loro procedimento di preparazione e loro impiego come sostanza medicinale. |
| CA1305148C (en) * | 1987-08-19 | 1992-07-14 | Hiromu Matsumura | Carbamoylpyrrolidone derivatives and drugs for senile dementia |
| US5202345A (en) * | 1987-08-19 | 1993-04-13 | Shionogi & Co., Ltd. | Carbamoylpyrrolidone derivatives and drugs for senile dementia |
| JP2585086B2 (ja) * | 1988-12-28 | 1997-02-26 | 大鵬薬品工業株式会社 | ジアザビシクロアルカン誘導体 |
| IT1231921B (it) * | 1989-06-12 | 1992-01-15 | Sigma Tau Ind Farmaceuti | 1-acil-2-pirrolidoni quali attivatori dei processi di apprendimento e della memoria e composizioni farmaceutiche comprendenti tali composti |
| JP2803882B2 (ja) * | 1990-02-20 | 1998-09-24 | 日清製粉株式会社 | １―フエノキシカルボニル―２―ピロリジノン誘導体 |
| JP3038032B2 (ja) * | 1991-03-25 | 2000-05-08 | 日清製粉株式会社 | 血小板凝集抑制薬 |
| ES2210060T3 (es) * | 1992-07-24 | 2004-07-01 | The Regents Of The University Of California | Farmacos que aumentan las respuestas sinapticas mediadas por receptores ampa. |
| US5852008A (en) * | 1995-01-24 | 1998-12-22 | The Regents Of The University Of California | Heteroatom substituted benzoyl derivatives that enhance synaptic response mediated by receptors |
| US5955505A (en) * | 1995-02-21 | 1999-09-21 | Nippon Suisan Kaisha, Ltd. | Glutamic acid receptor agonist |
| IT1318490B1 (it) * | 1999-04-27 | 2003-08-25 | Hoffmann La Roche | Agente per fare aumentare la cessione di acetilcolina cerebrale. |
| ATE431142T1 (de) | 2000-12-28 | 2009-05-15 | Hamilton Pharmaceuticals Inc | Arzneimittel zur behandlung und vermeidung neurogener schmerzen |
| US8858594B2 (en) * | 2008-12-22 | 2014-10-14 | Abbott Laboratories | Curved closure device |
| PL2604592T3 (pl) | 2011-12-12 | 2015-04-30 | Zakl Farmaceutyczne Polpharma Sa | Sposób oczyszczania aniracetamu przez krystalizacje z roztworów wodnych |
| CN109651222A (zh) * | 2018-12-21 | 2019-04-19 | 上海昊航化工有限公司 | 一种阿尼西坦的催化合成方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3697563A (en) * | 1970-06-29 | 1972-10-10 | Inst Chemioterapico Italiano S | (3,4,5-trimethoxy-benzamido)-alkanoic acids for prophylaxis and treatment of cardiac disorders |
| DE2413935A1 (de) * | 1974-03-20 | 1975-10-16 | Schering Ag | 4-(polyalkoxy-phenyl)-2-pyrrolidone |
| ES433723A1 (es) * | 1975-01-10 | 1976-11-16 | Lafarquim S A Lab | Procedimiento de obtencion de un derivado de 2-pirrolidi- nona. |
-
1978
- 1978-01-25 CU CU7835021A patent/CU21107A3/xx unknown
-
1979
- 1979-01-01 AR AR22073979D patent/AR220739A1/es active
- 1979-01-10 IN IN27/CAL/79A patent/IN150106B/en unknown
- 1979-01-11 CA CA319,509A patent/CA1100515A/en not_active Expired
- 1979-01-16 EG EG26/79A patent/EG13873A/xx active
- 1979-01-24 FI FI790226A patent/FI69063C/fi not_active IP Right Cessation
- 1979-01-25 PH PH22107A patent/PH15491A/en unknown
- 1979-02-05 NZ NZ189571A patent/NZ189571A/en unknown
- 1979-02-05 BR BR7900684A patent/BR7900684A/pt unknown
- 1979-02-05 AU AU43916/79A patent/AU525514B2/en not_active Expired
- 1979-02-05 IL IL56587A patent/IL56587A0/xx not_active IP Right Cessation
- 1979-02-07 HU HU79HO2135A patent/HU177644B/hu not_active IP Right Cessation
- 1979-02-08 MC MC791362A patent/MC1257A1/xx unknown
- 1979-02-08 OA OA56728A patent/OA06180A/xx unknown
- 1979-02-08 SU SU792719854A patent/SU931104A3/ru active
- 1979-02-08 YU YU283/79A patent/YU41330B/xx unknown
- 1979-02-08 BG BG7942414A patent/BG29281A3/xx unknown
- 1979-02-08 RO RO7996556A patent/RO76615A/ro unknown
- 1979-02-08 JP JP54012880A patent/JPS6059907B2/ja not_active Expired
- 1979-02-08 GR GR58300A patent/GR71464B/el unknown
- 1979-02-08 CS CS79881A patent/CS226182B2/cs unknown
- 1979-02-09 NO NO790434A patent/NO152046C/no unknown
- 1979-02-09 DE DE7979100379T patent/DE2963321D1/de not_active Expired
- 1979-02-09 ES ES477587A patent/ES477587A1/es not_active Expired
- 1979-02-09 PT PT7969206A patent/PT69206A/pt unknown
- 1979-02-09 IE IE246/79A patent/IE47831B1/en not_active IP Right Cessation
- 1979-02-09 EP EP79100379A patent/EP0005143B1/de not_active Expired
- 1979-02-09 AT AT0099579A patent/AT374787B/de not_active IP Right Cessation
- 1979-02-09 EP EP81106674A patent/EP0044088B1/de not_active Expired
- 1979-02-09 DD DD79210944A patent/DD141828A5/de unknown
- 1979-02-09 DK DK056379A patent/DK155278C/da not_active Application Discontinuation
- 1979-02-10 PL PL1979213340A patent/PL115958B1/pl unknown
- 1979-08-31 ES ES483756A patent/ES483756A1/es not_active Expired
-
1980
- 1980-07-14 US US06/168,906 patent/US4369139A/en not_active Expired - Lifetime
-
1985
- 1985-01-24 HK HK61/85A patent/HK6185A/xx unknown
- 1985-12-30 MY MY340/85A patent/MY8500340A/xx unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM | Patent lapsed | ||
| MM | Patent lapsed |
Owner name: F. HOFFMANN-LA ROCHE AG |