FI67390C - Foerfarande foer framstaellning av en inklusionskomplex av n-(1-fenyletyl)-3,3-difenylpropylamin eller dess hydroklorid me cyklodextrin - Google Patents

Foerfarande foer framstaellning av en inklusionskomplex av n-(1-fenyletyl)-3,3-difenylpropylamin eller dess hydroklorid me cyklodextrin Download PDF

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Publication number
FI67390C
FI67390C FI830011A FI830011A FI67390C FI 67390 C FI67390 C FI 67390C FI 830011 A FI830011 A FI 830011A FI 830011 A FI830011 A FI 830011A FI 67390 C FI67390 C FI 67390C
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FI
Finland
Prior art keywords
cyclodextrin
fendilin
hydrochloride
complex
diphenylpropylamine
Prior art date
Application number
FI830011A
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English (en)
Finnish (fi)
Other versions
FI67390B (fi
FI830011L (fi
FI830011A0 (fi
Inventor
Jozsef Szejtli
Agnes Stadler
Maria Vikmon
Dezsoe Korbonits
Sandor Virag
Istvan Turcsan
Pal Kiss
Original Assignee
Chinoin Gyogyszer Es Vegyeszet
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Publication date
Application filed by Chinoin Gyogyszer Es Vegyeszet filed Critical Chinoin Gyogyszer Es Vegyeszet
Publication of FI830011L publication Critical patent/FI830011L/fi
Publication of FI830011A0 publication Critical patent/FI830011A0/fi
Publication of FI67390B publication Critical patent/FI67390B/fi
Application granted granted Critical
Publication of FI67390C publication Critical patent/FI67390C/fi

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
    • C08B37/0012—Cyclodextrin [CD], e.g. cycle with 6 units (alpha), with 7 units (beta) and with 8 units (gamma), large-ring cyclodextrin or cycloamylose with 9 units or more; Derivatives thereof
    • C08B37/0015—Inclusion compounds, i.e. host-guest compounds, e.g. polyrotaxanes

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nanotechnology (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Medical Informatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Claims (12)

1. Förfarande för framställning av inklusionskomplexer av N/l-fenylety 17-3,3-difenylpropylamin eller dess hydroklorid 5 med cyklodextrin, kännetecknat därav, att man omsätter en N-/l-fenyletyl7-3,3-difenylpropylaminbas eller dess hydroklorid i ett vatten- och/eller etanolhaltigt medium vid 4-60°C under omröring vid ett förhällande av 1 mmol bas eller HC1-salt med 1-3 mmol cyklodextrin och, ifali önskvärt, Ί0 för framställning av hydroklorid-komplexet behandlar det er-hällna komplexet med saltsyra.
2. Förfarande enligt patentkravet 1, kännetecknat därav, att man använder Ν-/Ί-fenyletyl7~3,3-difenylpropylamin och cyklodextrin vid ett molförhällande av 1:3.
3. Förfarande enligt patentkravet 1, kännetecknat därav att man använder Ν-/Ί-fenylety17-3,3-difenylpropylamin och cyklodextrin vid ett molförhällande av 1:1.
4. Förfarande enligt patentkravet 1, kännetecknat därav, att man använder Ν-/Ϊ-fenylety1/-3,3-difenyl- 2o propylamin-hydroklorid och cyklodextrin vid ett molförhällande av 1:1.
5. Förfarande enligt nägot av patentkraven 1-4, k ä n -netecknat därav, att man genomför reaktionen i ett vattenhaltigt medium i närvaro av en vattenmängd av 1-20 ml 25 beräknat pä 1 mmol cyklodextrin.
6. Förfarande enligt nägot av patentkraven 1-4, k ä n -netecknat därav, att man genomför reaktionen i ett 5-32-volym-%: igt vatten-etano.l-haltigt medium.
7. Förfarande enligt patentkravet 1, känneteck- 30. a t därav, att man omsätter N-/l-fenylety17-3,3-difenylpropylamin med cyklodextrin.
8. Förfarande* enligt patentkravet 1, kännetecknat därav, att man omsätter N-/1-fenylety17-3,3-difenylpro-pylamin-hydroklorid med cyklodextrin. 35
9. Förfarande enligt patentkravet 1, känneteck nat därav, att man genomför komplexbildandet med hydroklorid av Ν-/Ί-fenylety17-3,3-difenylpropylamin, som har bildats in situ.
FI830011A 1981-05-12 1983-01-03 Foerfarande foer framstaellning av en inklusionskomplex av n-(1-fenyletyl)-3,3-difenylpropylamin eller dess hydroklorid me cyklodextrin FI67390C (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
HU811286A HU183430B (en) 1981-05-12 1981-05-12 Process for producing cyclodextrine inclusion complexes of n-bracket-1-phenylethyl-bracket closed-3,3-diphenylpropylamine or n-bracket-1-phenylethyl-bracket closed-3,3-diphenylpropylamine-hydrochloride
HU128681 1981-05-12
HU8200024 1982-05-12
PCT/HU1982/000024 WO1982004052A1 (en) 1981-05-12 1982-05-12 Method for the preparation of inclusion complexes derived from n-(1-phenyle-ethyle)-3,3-diphenyle-propylamine respectively from the hydrochloryde thereof and from cyclodextrine

Publications (4)

Publication Number Publication Date
FI830011L FI830011L (fi) 1983-01-03
FI830011A0 FI830011A0 (fi) 1983-01-03
FI67390B FI67390B (fi) 1984-11-30
FI67390C true FI67390C (fi) 1985-03-11

Family

ID=10953697

Family Applications (1)

Application Number Title Priority Date Filing Date
FI830011A FI67390C (fi) 1981-05-12 1983-01-03 Foerfarande foer framstaellning av en inklusionskomplex av n-(1-fenyletyl)-3,3-difenylpropylamin eller dess hydroklorid me cyklodextrin

Country Status (6)

Country Link
US (1) US4518588A (sv)
EP (1) EP0078820B1 (sv)
DE (1) DE3277816D1 (sv)
FI (1) FI67390C (sv)
HU (1) HU183430B (sv)
WO (1) WO1982004052A1 (sv)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0094157B1 (en) * 1982-04-30 1987-07-29 Takeda Chemical Industries, Ltd. Pharmaceutical composition and its use
JPS60202115A (ja) * 1984-03-27 1985-10-12 Ichiro Shibauchi エポキシ樹脂用硬化剤
HU193933B (en) * 1984-06-08 1987-12-28 Nitrokemia Ipartelepek Herbicide or plant growth stimulating agent comprising beta-cyclodextrin complex of benzolsulphonylurea derivative and process for preparing the active substances
IL76889A0 (en) * 1984-11-02 1986-02-28 Johnson Matthey Plc Solubilised platinum compound,method for the production thereof and pharmaceutical compositions containing the same
EP0261719A3 (en) * 1986-09-23 1990-10-10 Akzo N.V. Thermochemiluminescent cyclodextrin complexes
IT1204725B (it) * 1987-06-17 1989-03-10 Edmond Pharma Srl Complessi di inclusione del dipiridamolo con ciclodestrine
US4877774A (en) * 1987-09-09 1989-10-31 The United States Of America As Represented By The Department Of Health And Human Services Administration of steroid hormones
US5017566A (en) * 1987-12-30 1991-05-21 University Of Florida Redox systems for brain-targeted drug delivery
US5002935A (en) * 1987-12-30 1991-03-26 University Of Florida Improvements in redox systems for brain-targeted drug delivery
ATE109663T1 (de) * 1988-02-05 1994-08-15 Schering Ag Ultraschallkontrastmittel, verfahren zu deren herstellung und deren verwendung als diagnostika und therapeutika.
US5997856A (en) * 1988-10-05 1999-12-07 Chiron Corporation Method and compositions for solubilization and stabilization of polypeptides, especially proteins
US6011068A (en) * 1991-08-23 2000-01-04 Nps Pharmaceuticals, Inc. Calcium receptor-active molecules
US6313146B1 (en) 1991-08-23 2001-11-06 Nps Pharmaceuticals, Inc. Calcium receptor-active molecules
US6031003A (en) * 1991-08-23 2000-02-29 Nps Pharmaceuticals, Inc. Calcium receptor-active molecules
US5858684A (en) * 1991-08-23 1999-01-12 The Brigham And Women's Hospital, Inc. Method of screening calcium receptor-active molecules
US5688938A (en) * 1991-08-23 1997-11-18 The Brigham & Women's Hospital, Inc. Calcium receptor-active molecules
US5763569A (en) * 1991-08-23 1998-06-09 The Brigham And Women's Hospital, Inc Calcium receptor-active molecules
EP1296142B1 (en) * 1991-08-23 2005-12-07 Nps Pharmaceuticals, Inc. Screening method for calcium receptor active molecules
US6001884A (en) * 1991-08-23 1999-12-14 Nps Pharmaceuticals, Inc. Calcium receptor-active molecules
US5962314A (en) * 1993-02-23 1999-10-05 Nps Pharmaceuticals, Inc. Calcium receptor-active molecules
AU3075395A (en) * 1994-07-06 1996-01-25 Farmarc Nederland Bv Inclusion complexes of ranitidine
NZ297157A (en) 1994-10-21 1999-08-30 Nps Pharma Inc Amine derivatives with calcium ion receptor activity; medicaments containing such compounds
AU731146C (en) 1996-05-01 2005-02-03 Nps Pharmaceuticals, Inc. Inorganic ion receptor-active compounds
AU2001255709A1 (en) * 2000-05-11 2001-11-20 Eastman Chemical Company Acylated cyclodextrin guest inclusion complexes

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3553191A (en) * 1968-05-21 1971-01-05 Cpc International Inc Aminoethyl cyclodextrin and method of making same
HU176215B (en) * 1978-01-27 1981-01-28 Chinoin Gyogyszer Es Vegyeszet Process for preparing a cyclodextrin-indomethacin inclusion complex with a ratio of at about 2:1
US4352793A (en) * 1979-04-26 1982-10-05 Sumitomo Chemical Company, Limited Pharmaceutical composition comprising bencyclane fumarate and cyclodextrin
US4407795A (en) * 1981-07-16 1983-10-04 American Cyanamid Company Inclusion compound of p-hexadecylamino benzoic acid in cyclodextrin and method of use

Also Published As

Publication number Publication date
EP0078820A4 (de) 1984-11-23
FI67390B (fi) 1984-11-30
DE3277816D1 (en) 1988-01-21
FI830011L (fi) 1983-01-03
US4518588A (en) 1985-05-21
WO1982004052A1 (en) 1982-11-25
EP0078820A1 (de) 1983-05-18
HU183430B (en) 1984-05-28
EP0078820B1 (de) 1987-12-09
FI830011A0 (fi) 1983-01-03

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Owner name: CHINOIN GYOGYSZER ES VEGYESZETI TERMEKEK GYARA RT.