FI66881B - Foerfarande foer framstaellning av nya syraadditionssalter av 16beta-mono-kvaternaera ammoniumderivat av 2beta,16beta-bis-piperidino-5alfa-androstan - Google Patents

Foerfarande foer framstaellning av nya syraadditionssalter av 16beta-mono-kvaternaera ammoniumderivat av 2beta,16beta-bis-piperidino-5alfa-androstan Download PDF

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Publication number
FI66881B
FI66881B FI792745A FI792745A FI66881B FI 66881 B FI66881 B FI 66881B FI 792745 A FI792745 A FI 792745A FI 792745 A FI792745 A FI 792745A FI 66881 B FI66881 B FI 66881B
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FI
Finland
Prior art keywords
androstane
16beta
bis
mono
dipiperidino
Prior art date
Application number
FI792745A
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English (en)
Finnish (fi)
Other versions
FI66881C (fi
FI792745A (fi
Inventor
Ian Craig Carlyle
Thomas Sleigh
David Samuel Savage
Original Assignee
Akzo Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nv filed Critical Akzo Nv
Publication of FI792745A publication Critical patent/FI792745A/fi
Publication of FI66881B publication Critical patent/FI66881B/fi
Application granted granted Critical
Publication of FI66881C publication Critical patent/FI66881C/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Claims (3)

1. Förfarande för framställning av nya syraadditionssalter av 16/3-mono-kvaternära ammoniumderivat av 2 £>,16|0-bis-piperidino-5<X/-androstan, vilka har formeln I, rv dr 0*θ . Y ALK Θ ^©1 x A y h o i
1 H i vilken formel R är väte eller en grupp -OR2> R^ och R2 är lika eller olika acylgrupper, vilka är härledda frän en lägre alifatisk karboxylsyra (1-6 C), ALK star för en alkyl-, alkenyl- eller alkynylgrupp innehällande 1-4 kolatomer, och A^och X® är anjoner, vilka är härledda frän en farmaceutiskt godtagbar organisk eller oorganiskt syra, kännetecknat därav, att en 5«6 -androstanförening raed formeln II ^ /Ulj A® ' ALK II
1 H väri R, R^, R2, ALK och A© har samma betydelse som ovan, omsätts i ett lämpligt lösningsmedel med en organisk eller oorganisk syra, som har formeln HX, väri X motsvarar anjonen X® .
FI792745A 1978-09-05 1979-09-04 Foerfarande foer framstaellning av nya syraadditionssalter av 16beta-mono-kvaternaera ammoniumderivat av 2beta,16beta-bis-piperidino-5alfa-androstan FI66881C (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB7835667 1978-09-05
GB7835667 1978-09-05

Publications (3)

Publication Number Publication Date
FI792745A FI792745A (fi) 1980-03-06
FI66881B true FI66881B (fi) 1984-08-31
FI66881C FI66881C (fi) 1984-12-10

Family

ID=10499453

Family Applications (1)

Application Number Title Priority Date Filing Date
FI792745A FI66881C (fi) 1978-09-05 1979-09-04 Foerfarande foer framstaellning av nya syraadditionssalter av 16beta-mono-kvaternaera ammoniumderivat av 2beta,16beta-bis-piperidino-5alfa-androstan

Country Status (20)

Country Link
US (2) US4237126A (sv)
EP (1) EP0008824B1 (sv)
JP (1) JPS5535098A (sv)
AR (1) AR228728A1 (sv)
AT (1) ATE921T1 (sv)
AU (1) AU526270B2 (sv)
CA (1) CA1134813A (sv)
DE (1) DE2962627D1 (sv)
DK (1) DK159119C (sv)
ES (1) ES483894A1 (sv)
FI (1) FI66881C (sv)
GR (1) GR72520B (sv)
HU (1) HU181847B (sv)
IE (1) IE50376B1 (sv)
IL (1) IL58080A (sv)
NO (1) NO151367C (sv)
NZ (1) NZ191462A (sv)
PH (1) PH16041A (sv)
PT (1) PT70126A (sv)
ZA (1) ZA794371B (sv)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE50675B1 (en) * 1979-12-12 1986-06-11 Akzo Nv Bis-and mono-quaternary ammonium derivatives of 2beta,16beta-dipiperidino-5alpha-androstanes,processes for their preparation and pharmaceutical preparations
IE53463B1 (en) * 1981-06-15 1988-11-23 Akzo Nv Mono-and bisquaternary ammonium derivatives of 2 beta,16 beta-d-amino-5 alpha-androstane derivatives and pharmaceutical preparations containing same
GB8709565D0 (en) * 1987-04-23 1987-05-28 Akzo Nv 2beta,16beta-diaminoandrostanes
US5238957A (en) * 1988-07-07 1993-08-24 Presidenza Del Consiglio Dei Ministri-Uffico Del Ministro Per Il Coordinamento Delle Iniziative Per La Ricerca Scientifica E Tecnologica Esters of 2,2-dimethyl-cyclopropane-carboxylic acid
US5418226A (en) * 1992-04-22 1995-05-23 Akzo N.V. Monoquaternary 2,16-bispiperidinylandrostane derivatives
HU210076B (en) * 1992-11-02 1995-01-30 Tuba Process for producing androstane derivatives substituted with quaternisaeted amino group in 16-position and for producing pharmaceutical compositions containing them
GB9302455D0 (en) * 1993-02-08 1993-03-24 Lab Inpharm N V Process for preparing a pharmaceutical preparation having neuromuscular blocking activity
US5767112A (en) * 1994-10-21 1998-06-16 Poli Industria Chimica, S.P.A. Muscle relaxant pharmaceutical compositions
US5553456A (en) * 1995-05-17 1996-09-10 Ramco, Inc. Clathrate freeze desalination apparatus and method
IT1277700B1 (it) * 1995-12-22 1997-11-11 Poli Ind Chimica Spa Processo di preparazione di 2-beta, 16-beta-diamino 3-alfa, 17-beta- diacilossi 5-alfaandrostani, bloccanti neuromuscolari a struttura
HU0402017D0 (en) * 2004-10-07 2004-12-28 Richter Gedeon Vegyeszet Environment-friend process for the synthesis of quaternary ammonio-steroids
WO2006038047A1 (en) * 2004-10-07 2006-04-13 Richter Gedeon Vegyészeti Gyár Rt. Environment-friend process for the synthesis of quaternary ammonio-steroιds
CA2605138A1 (en) * 2005-04-15 2006-10-26 Lyotropic Therapeutics, Inc. Formulations of quaternary ammonium neuromuscular blocking agents
DE102005030423A1 (de) * 2005-06-30 2007-01-04 Inresa Arzneimittel Gmbh Neue Formulierung für Vecuroniumbromid
US8148398B2 (en) 2006-12-06 2012-04-03 Cornell Research Foundation, Inc. Intermediate duration neuromuscular blocking agents and antagonists thereof
WO2010107488A1 (en) 2009-03-17 2010-09-23 Cornell University Reversible nondepolarizing neuromuscular blockade agents and methods for their use
US9220700B2 (en) 2009-08-19 2015-12-29 Cornell University Cysteine for physiological injection
WO2022078483A1 (zh) * 2020-10-15 2022-04-21 江苏恩华络康药物研发有限公司 甾体季铵化合物及其制备方法、制剂和用途

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1138605A (en) * 1965-02-19 1969-01-01 Organon Labor Ltd Improvements in or relating to new 2-ß,16-ß-diamino-androstanes
GB1454749A (en) * 1972-11-29 1976-11-03 Akzo Nv 2beta, 16beta-diamino-androstanes and their preparation
HU171166B (hu) * 1975-07-15 1977-11-28 Richter Gedeon Vegyeszet Sposob poluchenija novykh ehpoksi-androstanov
US4177190A (en) * 1975-08-01 1979-12-04 Richter Gedeon Vegyeszeti Gyar Rt. Diamino-androstanes and a process for the preparation of the said compounds
HU172522B (hu) * 1975-08-01 1978-09-28 Richter Gedeon Vegyeszet Sposob poluchenija novykh proizvodnykh 2beta, 16beta-diamino-androstana i ikh chetvertichnykh solej

Also Published As

Publication number Publication date
JPS6245879B2 (sv) 1987-09-29
DE2962627D1 (en) 1982-06-09
ZA794371B (en) 1980-08-27
ES483894A1 (es) 1980-09-01
AU5034879A (en) 1980-03-13
CA1134813A (en) 1982-11-02
JPS5535098A (en) 1980-03-11
NZ191462A (en) 1982-03-16
IE791593L (en) 1980-03-05
HU181847B (en) 1983-11-28
DK159119B (da) 1990-09-03
US4237126A (en) 1980-12-02
US4297351A (en) 1981-10-27
GR72520B (sv) 1983-11-16
AR228728A1 (es) 1983-04-15
IL58080A0 (en) 1979-12-30
DK159119C (da) 1991-03-11
PT70126A (en) 1979-09-01
ATE921T1 (de) 1982-05-15
NO151367C (no) 1985-03-27
DK361779A (da) 1980-03-06
AU526270B2 (en) 1982-12-23
IE50376B1 (en) 1986-04-16
IL58080A (en) 1982-12-31
NO151367B (no) 1984-12-17
FI66881C (fi) 1984-12-10
EP0008824B1 (en) 1982-04-28
PH16041A (en) 1983-06-02
EP0008824A1 (en) 1980-03-19
NO792810L (no) 1980-03-06
FI792745A (fi) 1980-03-06

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Owner name: AKZO N.V.