FI66867C - Foerfarande foer framstaellning av nya farmakologiskt aktiva 3-alkylxantiner - Google Patents
Foerfarande foer framstaellning av nya farmakologiskt aktiva 3-alkylxantiner Download PDFInfo
- Publication number
- FI66867C FI66867C FI793224A FI793224A FI66867C FI 66867 C FI66867 C FI 66867C FI 793224 A FI793224 A FI 793224A FI 793224 A FI793224 A FI 793224A FI 66867 C FI66867 C FI 66867C
- Authority
- FI
- Finland
- Prior art keywords
- methyl
- preparation
- pyrimidinedione
- dione
- purine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
- C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cardiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicinal Preparation (AREA)
- Steroid Compounds (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE7810947A SE7810947L (sv) | 1978-10-20 | 1978-10-20 | 3-alkylxanthines |
SE7810947 | 1978-10-20 |
Publications (3)
Publication Number | Publication Date |
---|---|
FI793224A FI793224A (fi) | 1980-04-21 |
FI66867B FI66867B (fi) | 1984-08-31 |
FI66867C true FI66867C (fi) | 1984-12-10 |
Family
ID=20336145
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI793224A FI66867C (fi) | 1978-10-20 | 1979-10-17 | Foerfarande foer framstaellning av nya farmakologiskt aktiva 3-alkylxantiner |
Country Status (24)
Country | Link |
---|---|
US (2) | US4548818A (fr) |
EP (1) | EP0010531B1 (fr) |
JP (1) | JPS5557589A (fr) |
AT (1) | ATE1145T1 (fr) |
AU (1) | AU530717B2 (fr) |
CA (1) | CA1131632A (fr) |
DD (1) | DD146708A5 (fr) |
DE (1) | DE2963021D1 (fr) |
DK (1) | DK148884C (fr) |
ES (1) | ES485178A1 (fr) |
FI (1) | FI66867C (fr) |
GR (1) | GR72945B (fr) |
HK (1) | HK7785A (fr) |
HU (1) | HU180220B (fr) |
IE (1) | IE49184B1 (fr) |
NO (1) | NO152561C (fr) |
NZ (1) | NZ191870A (fr) |
PH (1) | PH16676A (fr) |
PL (1) | PL119413B1 (fr) |
PT (1) | PT70350A (fr) |
SE (1) | SE7810947L (fr) |
SG (1) | SG86084G (fr) |
SU (1) | SU952105A3 (fr) |
ZA (1) | ZA795113B (fr) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE7810947L (sv) * | 1978-10-20 | 1980-04-21 | Draco Ab | 3-alkylxanthines |
SE8002910L (sv) * | 1980-04-18 | 1981-10-19 | Draco Ab | 3,8-dialkylxantiner, forfarande for deras framstellning, beredning och metoder for behandling av kronisk obstruktiv luftvegssjukdom och kardiovaskulera sjukdomar |
CH643260A5 (fr) * | 1980-05-02 | 1984-05-30 | Nestle Sa | 1-allyl-3-butyl-8-methylxanthine, procede de preparation et utilisation dans un medicament. |
IT1200944B (it) * | 1982-08-10 | 1989-01-27 | Malesci Sas | Derivati xantinici,procedimento per la loro preparazione,composizione farmaceutiche che il contengono e loro impiego terapeutico |
US5338741A (en) * | 1986-10-27 | 1994-08-16 | Nestec S.A. | 1-hydroxyalkylxanthines and medicaments containing them |
IL92096A0 (en) | 1988-10-25 | 1990-07-12 | Abbott Lab | Carboxylic nucleoside analogs |
US5153352A (en) * | 1988-10-25 | 1992-10-06 | Bristol-Myers Squibb Company | Process for preparation of intermediates of carbocyclic nucleoside analogs |
US5246931A (en) * | 1988-10-25 | 1993-09-21 | Bristol-Myers Squibb Company | Carbocyclic nucleoside analogs |
US5321029A (en) * | 1988-11-14 | 1994-06-14 | Beecham-Wuelfing Gmbh & Co.K.G. | Xanthines |
GB8826595D0 (en) * | 1988-11-14 | 1988-12-21 | Beecham Wuelfing Gmbh & Co Kg | Active compounds |
IT1229195B (it) * | 1989-03-10 | 1991-07-25 | Poli Ind Chimica Spa | Derivati xantinici ad attivita' broncodilatatrice e loro applicazioni terapeutiche. |
US4988703A (en) * | 1989-05-22 | 1991-01-29 | Abbott Laboratories | Carbocyclic nucleoside analogs with antiviral activity |
CA2030112A1 (fr) * | 1989-11-24 | 1991-05-25 | Yasuo Ito | Compose de xanthine, methode de preparation et composition pharmaceutique contenant ledit compose |
FR2657257B1 (fr) * | 1990-01-19 | 1994-09-02 | Rhone Poulenc Sante | Procede de preparation de medicaments sous forme de perles. |
DK0502690T3 (da) * | 1991-03-05 | 2000-05-22 | Ajinomoto Kk | Cyclopropanderivat |
US5877179A (en) * | 1992-09-29 | 1999-03-02 | The United States Of America As Represented By The Department Of Health And Human Services | Xanthines for identifying CFTR--binding compounds useful for activating chloride conductance in animal cells |
US5504090A (en) * | 1994-03-30 | 1996-04-02 | Trustees Of The University Of Pennsylvania | Compositions and methods for the prevention and treatment of ischemia-reperfusion organ injury |
US5786360A (en) | 1996-11-19 | 1998-07-28 | Link Technology Incorporated | A1 adenosine receptor antagonists |
WO2000002861A1 (fr) | 1998-07-10 | 2000-01-20 | The United States Of America, Represented By Secretary, Department Of Health And Human Services | Antagonistes du recepteur de l'adenosine a¿3? |
ATE336492T1 (de) * | 2000-01-14 | 2006-09-15 | Us Gov Health & Human Serv | Methonocarbacycloalkylanaloga von nucleosiden |
US6623553B2 (en) * | 2001-04-20 | 2003-09-23 | John Russell | Printing process with edible inks |
AR039385A1 (es) | 2002-04-19 | 2005-02-16 | Astrazeneca Ab | Derivados de tioxantina como inhibidores de la mieloperoxidasa |
WO2004074247A2 (fr) * | 2003-02-19 | 2004-09-02 | Endacea, Inc. | Antagonistes du recepteur de l'adenosine a1 |
US7247639B2 (en) * | 2003-06-06 | 2007-07-24 | Endacea, Inc. | A1 adenosine receptor antagonists |
CA2528367A1 (fr) * | 2003-06-09 | 2004-12-23 | Endacea, Inc. | Antagonistes de recepteur d'adenosine a1 |
MY140748A (en) | 2004-12-06 | 2010-01-15 | Astrazeneca Ab | Novel pyrrolo [3,2-d] pyrimidin-4-one derivatives and their use in therapy |
DE102006020519A1 (de) * | 2006-05-03 | 2007-11-08 | Robert Bosch Gmbh | Vorrichtung zum Einfalten zumindest einer Lasche einer Verpackung |
TW200804383A (en) | 2006-06-05 | 2008-01-16 | Astrazeneca Ab | New compounds |
US7743683B2 (en) * | 2006-08-15 | 2010-06-29 | Umagination Labs, L.P. | Systems and methods of a power tool system with interchangeable functional attachments powered by a direct rotational drive |
US8518957B2 (en) | 2009-12-02 | 2013-08-27 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Methanocarba adenosine derivatives, pharmaceutical compositions, and method of reducing intraocular pressure |
EP3397640B1 (fr) * | 2015-12-29 | 2021-08-04 | INSERM - Institut National de la Santé et de la Recherche Médicale | Inhibiteurs de protéines bet dérivés de la xanthine |
Family Cites Families (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1245969B (de) * | 1967-08-03 | VEB Arzneimittelwerk Dresden, Radebeul | Verfahren zur Herstellung von Xanthinderivaten | |
DE864868C (de) * | 1943-10-02 | 1953-01-29 | Hellmut Dr Bredereck | Verfahren zur Herstellung von Purinverbindungen |
US2646432A (en) * | 1947-01-13 | 1953-07-21 | Mallinckrodt Chemical Works | Method of preparing 2, 6-diketopurines |
US2517410A (en) * | 1947-08-15 | 1950-08-01 | Searle & Co | Hydroxy alkyl xanthines and the production thereof |
GB683523A (en) * | 1948-08-18 | 1952-12-03 | Beecham Res Lab | The manufacture of purine derivatives |
US2781344A (en) * | 1953-05-04 | 1957-02-12 | Monsanto Chemicals | Formylation of amino-pyrimidines |
US2844576A (en) * | 1955-11-22 | 1958-07-22 | American Cyanamid Co | Preparation of purines |
BE592753A (fr) * | 1959-07-09 | 1900-01-01 | ||
GB982079A (en) * | 1962-05-01 | 1965-02-03 | Dresden Arzneimittel | Process for the production of xanthine derivatives |
GB1008454A (en) * | 1963-03-26 | 1965-10-27 | Dresden Arzneimittel | Pseudoxanthines |
JPS53890B2 (fr) * | 1972-04-22 | 1978-01-12 | ||
GB1435916A (en) * | 1972-05-11 | 1976-05-19 | Beecham Group Ltd | Pharmaceutical weight-reducing compositions |
JPS5125009U (fr) * | 1974-08-14 | 1976-02-24 | ||
FR2346244A1 (fr) * | 1976-03-30 | 1977-10-28 | Chamagne Pierre | Nouveau conditionnement pour la conservation de liquides alimentaires |
CA1077932A (fr) * | 1976-03-31 | 1980-05-20 | Berlex Laboratories, Inc. | Composes de la xanthine pour le traitement des bronchospasmes et des affections allergiques |
US4089959A (en) * | 1976-03-31 | 1978-05-16 | Cooper Laboratories, Inc. | Long-acting xanthine bronchodilators and antiallergy agents |
US4120947A (en) * | 1976-03-31 | 1978-10-17 | Cooper Laboratories, Inc. | Xanthine compounds and method of treating bronchospastic and allergic diseases |
JPS52133295U (fr) * | 1976-04-05 | 1977-10-11 | ||
JPS5618169Y2 (fr) * | 1976-09-20 | 1981-04-28 | ||
SE416810C (sv) * | 1977-10-14 | 1982-07-19 | Draco Ab | Forfarande for framstellning av xantinderivat med antiallergisk aktivitet |
SE7810947L (sv) * | 1978-10-20 | 1980-04-21 | Draco Ab | 3-alkylxanthines |
SE7810946L (sv) * | 1978-10-20 | 1980-04-21 | Draco Ab | Metod att behandla kronisk obstruktiv luftvegssjukdom |
US4338319A (en) * | 1979-11-27 | 1982-07-06 | Aktiebolaget Draco | Method for the treatment of chronic obstructive airway or cardiac diseases |
SE8002910L (sv) * | 1980-04-18 | 1981-10-19 | Draco Ab | 3,8-dialkylxantiner, forfarande for deras framstellning, beredning och metoder for behandling av kronisk obstruktiv luftvegssjukdom och kardiovaskulera sjukdomar |
-
1978
- 1978-10-20 SE SE7810947A patent/SE7810947L/xx not_active Application Discontinuation
-
1979
- 1979-09-26 ZA ZA00795113A patent/ZA795113B/xx unknown
- 1979-09-28 DE DE7979850090T patent/DE2963021D1/de not_active Expired
- 1979-09-28 AT AT79850090T patent/ATE1145T1/de not_active IP Right Cessation
- 1979-09-28 EP EP79850090A patent/EP0010531B1/fr not_active Expired
- 1979-10-05 CA CA337,077A patent/CA1131632A/fr not_active Expired
- 1979-10-11 SU SU792824353A patent/SU952105A3/ru active
- 1979-10-12 DK DK432179A patent/DK148884C/da active
- 1979-10-16 PH PH23182A patent/PH16676A/en unknown
- 1979-10-17 FI FI793224A patent/FI66867C/fi not_active IP Right Cessation
- 1979-10-17 AU AU51871/79A patent/AU530717B2/en not_active Ceased
- 1979-10-17 NZ NZ191870A patent/NZ191870A/en unknown
- 1979-10-18 IE IE1987/79A patent/IE49184B1/en unknown
- 1979-10-19 HU HU79DA367A patent/HU180220B/hu unknown
- 1979-10-19 GR GR60300A patent/GR72945B/el unknown
- 1979-10-19 NO NO793377A patent/NO152561C/no unknown
- 1979-10-19 PT PT70350A patent/PT70350A/pt unknown
- 1979-10-19 PL PL1979219065A patent/PL119413B1/pl unknown
- 1979-10-19 JP JP13584579A patent/JPS5557589A/ja active Granted
- 1979-10-19 DD DD79216348A patent/DD146708A5/de unknown
- 1979-10-19 ES ES485178A patent/ES485178A1/es not_active Expired
-
1981
- 1981-11-23 US US06/323,955 patent/US4548818A/en not_active Expired - Fee Related
-
1984
- 1984-07-25 US US06/634,650 patent/US4644001A/en not_active Expired - Fee Related
- 1984-11-29 SG SG860/84A patent/SG86084G/en unknown
-
1985
- 1985-01-31 HK HK77/85A patent/HK7785A/xx unknown
Also Published As
Publication number | Publication date |
---|---|
PL219065A1 (fr) | 1980-06-16 |
NO152561B (no) | 1985-07-08 |
NZ191870A (en) | 1984-07-06 |
EP0010531B1 (fr) | 1982-06-02 |
HU180220B (en) | 1983-02-28 |
US4644001A (en) | 1987-02-17 |
AU5187179A (en) | 1980-05-01 |
SU952105A3 (ru) | 1982-08-15 |
SE7810947L (sv) | 1980-04-21 |
DD146708A5 (de) | 1981-02-25 |
CA1131632A (fr) | 1982-09-14 |
PT70350A (en) | 1979-11-01 |
ATE1145T1 (de) | 1982-06-15 |
DK148884B (da) | 1985-11-04 |
FI793224A (fi) | 1980-04-21 |
DK148884C (da) | 1986-04-07 |
GR72945B (fr) | 1984-01-17 |
IE49184B1 (en) | 1985-08-21 |
ZA795113B (en) | 1980-10-29 |
SG86084G (en) | 1985-06-07 |
AU530717B2 (en) | 1983-07-28 |
IE791987L (en) | 1980-04-20 |
JPH0130834B2 (fr) | 1989-06-22 |
HK7785A (en) | 1985-02-08 |
PL119413B1 (en) | 1981-12-31 |
NO152561C (no) | 1985-10-16 |
DE2963021D1 (en) | 1982-07-22 |
DK432179A (da) | 1980-04-21 |
FI66867B (fi) | 1984-08-31 |
JPS5557589A (en) | 1980-04-28 |
NO793377L (no) | 1980-04-22 |
PH16676A (en) | 1983-12-13 |
EP0010531A1 (fr) | 1980-04-30 |
US4548818A (en) | 1985-10-22 |
ES485178A1 (es) | 1980-05-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM | Patent lapsed |
Owner name: AKTIEBOLAGET DRACO |