FI66388C - Foerfarande foer framstaellning av 7-(d-alfa-amino-alfa-(p-hydroxifenyl)acetamido)-3-(1,2,3-triazol-5-yltiometyl)-3-cefem-4-karboxylsyra-1,2-propylenglykolat - Google Patents

Foerfarande foer framstaellning av 7-(d-alfa-amino-alfa-(p-hydroxifenyl)acetamido)-3-(1,2,3-triazol-5-yltiometyl)-3-cefem-4-karboxylsyra-1,2-propylenglykolat Download PDF

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Publication number
FI66388C
FI66388C FI750002A FI750002A FI66388C FI 66388 C FI66388 C FI 66388C FI 750002 A FI750002 A FI 750002A FI 750002 A FI750002 A FI 750002A FI 66388 C FI66388 C FI 66388C
Authority
FI
Finland
Prior art keywords
hydroxyphenyl
amino
triazol
cephem
carboxylic acid
Prior art date
Application number
FI750002A
Other languages
English (en)
Finnish (fi)
Other versions
FI66388B (fi
FI750002A (de
Inventor
Murray Arthur Kaplan
Alphonse Peter Granatek
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of FI750002A publication Critical patent/FI750002A/fi
Publication of FI66388B publication Critical patent/FI66388B/fi
Application granted granted Critical
Publication of FI66388C publication Critical patent/FI66388C/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/36—Methylene radicals, substituted by sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
FI750002A 1974-01-07 1975-01-02 Foerfarande foer framstaellning av 7-(d-alfa-amino-alfa-(p-hydroxifenyl)acetamido)-3-(1,2,3-triazol-5-yltiometyl)-3-cefem-4-karboxylsyra-1,2-propylenglykolat FI66388C (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US43125174A 1974-01-07 1974-01-07
US43125174 1974-01-07
US05/534,114 US3970651A (en) 1974-01-07 1974-12-18 Crystalline cephalosporin derivative
US53411474 1974-12-18

Publications (3)

Publication Number Publication Date
FI750002A FI750002A (de) 1975-07-08
FI66388B FI66388B (fi) 1984-06-29
FI66388C true FI66388C (fi) 1984-10-10

Family

ID=27028950

Family Applications (1)

Application Number Title Priority Date Filing Date
FI750002A FI66388C (fi) 1974-01-07 1975-01-02 Foerfarande foer framstaellning av 7-(d-alfa-amino-alfa-(p-hydroxifenyl)acetamido)-3-(1,2,3-triazol-5-yltiometyl)-3-cefem-4-karboxylsyra-1,2-propylenglykolat

Country Status (17)

Country Link
US (1) US3970651A (de)
JP (1) JPS6020394B2 (de)
CA (1) CA1060886A (de)
CH (1) CH612978A5 (de)
DE (1) DE2500386C2 (de)
DK (1) DK152368C (de)
FI (1) FI66388C (de)
GB (1) GB1483416A (de)
HK (1) HK40981A (de)
HU (1) HU168901B (de)
IE (1) IE41883B1 (de)
IL (1) IL46390A (de)
KE (1) KE3150A (de)
MY (1) MY8200099A (de)
NL (1) NL185924C (de)
OA (1) OA04876A (de)
SE (1) SE422064B (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2400519A1 (fr) * 1977-08-17 1979-03-16 Roussel Uclaf Forme cristalline du sel de sodium d'un derive oximine de l'acide 7-amino-thiazolyl acetamido cephalosporanique, son procede de preparation et son application comme medicament
EP0052094A1 (de) * 1979-04-25 1982-05-19 BIOCHEMIE Gesellschaft m.b.H. N-Isopropoxycarbonylphenylglycine und ihre Herstellung
IT1233864B (it) * 1988-02-24 1992-04-21 Opos Biochimica Srl Procedimento per la fabbricazione dell'acido 7-(d-(-)-alfa-amino-alfa -(p-idrossifenil)acetamido)-3-(1,2,3-triazol-4(5)-il)tiometil-3-cefem -4-carbossilico 1,2,-propilenglicolato e intermedio alogenato di detto procedimento
US7790905B2 (en) * 2002-02-15 2010-09-07 Mcneil-Ppc, Inc. Pharmaceutical propylene glycol solvate compositions
US20100311701A1 (en) * 2002-02-15 2010-12-09 Transform Pharmaceuticals, Inc Pharmaceutical Co-Crystal Compositions
US7927613B2 (en) * 2002-02-15 2011-04-19 University Of South Florida Pharmaceutical co-crystal compositions
WO2003074474A2 (en) 2002-03-01 2003-09-12 University Of South Florida Multiple-component solid phases containing at least one active pharmaceutical ingredient
JP2006500377A (ja) * 2002-06-21 2006-01-05 トランスフォーム・ファーマシューティカルズ・インコーポレイテッド 改善された溶解性を有する医薬組成物
US8183290B2 (en) * 2002-12-30 2012-05-22 Mcneil-Ppc, Inc. Pharmaceutically acceptable propylene glycol solvate of naproxen
US7230097B2 (en) * 2003-03-10 2007-06-12 Lupin Ltd. Process for preparation of 7-[α-Amino (4-hydroxyphenyl) acetamido]-3-substituted-3-cephem-4-carboxylic acid
CA2570949A1 (en) * 2006-12-12 2008-06-12 Apotex Pharmachem Inc. Ibandronate sodium propylene glycol solvate and processes for the preparation thereof
US7834195B2 (en) * 2007-01-24 2010-11-16 Apotex Pharmachem Inc. Atorvastatin calcium propylene glycol solvates
PE20090185A1 (es) 2007-03-22 2009-02-28 Bristol Myers Squibb Co Formulaciones farmaceuticas que contienen un inhibidor sglt2

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1316964A (en) * 1969-07-24 1973-05-16 Glaxo Lab Ltd Antibiotics
US3855213A (en) * 1971-02-18 1974-12-17 Smith Kline French Lab 3-heterocyclic thiomethyl-cephalosporins
US3867380A (en) * 1971-02-18 1975-02-18 Smithkline Corp 3-Heterocyclic thiomethylcephalosporins

Also Published As

Publication number Publication date
MY8200099A (en) 1982-12-31
JPS6020394B2 (ja) 1985-05-21
NL185924C (nl) 1990-08-16
NL7500167A (nl) 1975-07-09
FI66388B (fi) 1984-06-29
DE2500386C2 (de) 1983-10-13
JPS50105813A (de) 1975-08-20
CH612978A5 (de) 1979-08-31
DE2500386A1 (de) 1975-07-17
GB1483416A (en) 1977-08-17
FI750002A (de) 1975-07-08
IL46390A (en) 1978-01-31
SE422064B (sv) 1982-02-15
NL185924B (nl) 1990-03-16
IE41883L (en) 1975-07-07
DK152368C (da) 1988-07-25
SE7500123L (de) 1975-07-08
KE3150A (en) 1981-08-28
IL46390A0 (en) 1976-06-30
HU168901B (de) 1976-08-28
DK152368B (da) 1988-02-22
DK692674A (de) 1975-09-01
IE41883B1 (en) 1980-04-23
OA04876A (fr) 1980-10-31
CA1060886A (en) 1979-08-21
US3970651A (en) 1976-07-20
HK40981A (en) 1981-08-28

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Owner name: BRISTOL-MYERS CO