IT1233864B - Procedimento per la fabbricazione dell'acido 7-(d-(-)-alfa-amino-alfa -(p-idrossifenil)acetamido)-3-(1,2,3-triazol-4(5)-il)tiometil-3-cefem -4-carbossilico 1,2,-propilenglicolato e intermedio alogenato di detto procedimento - Google Patents

Procedimento per la fabbricazione dell'acido 7-(d-(-)-alfa-amino-alfa -(p-idrossifenil)acetamido)-3-(1,2,3-triazol-4(5)-il)tiometil-3-cefem -4-carbossilico 1,2,-propilenglicolato e intermedio alogenato di detto procedimento

Info

Publication number
IT1233864B
IT1233864B IT8819513A IT1951388A IT1233864B IT 1233864 B IT1233864 B IT 1233864B IT 8819513 A IT8819513 A IT 8819513A IT 1951388 A IT1951388 A IT 1951388A IT 1233864 B IT1233864 B IT 1233864B
Authority
IT
Italy
Prior art keywords
alpha
procedure
thyometyl
propylenglyculate
cefem
Prior art date
Application number
IT8819513A
Other languages
English (en)
Other versions
IT8819513A0 (it
Inventor
Luigi Ratti
Leone Dall Asta
Original Assignee
Opos Biochimica Srl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Opos Biochimica Srl filed Critical Opos Biochimica Srl
Priority to IT8819513A priority Critical patent/IT1233864B/it
Publication of IT8819513A0 publication Critical patent/IT8819513A0/it
Priority to JP1041989A priority patent/JPH01258683A/ja
Priority to KR1019890002133A priority patent/KR890013030A/ko
Priority to US07/314,025 priority patent/US4965355A/en
Priority to CN89102027A priority patent/CN1024417C/zh
Application granted granted Critical
Publication of IT1233864B publication Critical patent/IT1233864B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/36—Methylene radicals, substituted by sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IT8819513A 1988-02-24 1988-02-24 Procedimento per la fabbricazione dell'acido 7-(d-(-)-alfa-amino-alfa -(p-idrossifenil)acetamido)-3-(1,2,3-triazol-4(5)-il)tiometil-3-cefem -4-carbossilico 1,2,-propilenglicolato e intermedio alogenato di detto procedimento IT1233864B (it)

Priority Applications (5)

Application Number Priority Date Filing Date Title
IT8819513A IT1233864B (it) 1988-02-24 1988-02-24 Procedimento per la fabbricazione dell'acido 7-(d-(-)-alfa-amino-alfa -(p-idrossifenil)acetamido)-3-(1,2,3-triazol-4(5)-il)tiometil-3-cefem -4-carbossilico 1,2,-propilenglicolato e intermedio alogenato di detto procedimento
JP1041989A JPH01258683A (ja) 1988-02-24 1989-02-23 ７―／Ｄ（−）アルフア―アミノ　アルフア―（ｐ―ヒドロキシフエニル）アセトアミド／―３―（１，２，３―トリアゾル―４（５）―チオメチル―３―セフエム―４―カルボン酸１，２プロピレングリコレートの製造びその製造のための新規中間体
KR1019890002133A KR890013030A (ko) 1988-02-24 1989-02-23 7-/D(-)-알파-아미노-알파-(p-히드록시페닐)아세트아미도/-3-(1,2,3-트리아졸-4(5)-티오메틸-3-세펨-4-카르복실산 1,2-프로필렌 글리콜레이트 제조공정 및 할로겐화된 공정용 중간 생성물
US07/314,025 US4965355A (en) 1988-02-24 1989-02-23 Process for the prepartion of cefatrizine 1,2-propylene glycolate
CN89102027A CN1024417C (zh) 1988-02-24 1989-02-24 3-三唑基-硫甲基头孢烯-4-羧酸1，2-丙二醇酯的制备方法

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT8819513A IT1233864B (it) 1988-02-24 1988-02-24 Procedimento per la fabbricazione dell'acido 7-(d-(-)-alfa-amino-alfa -(p-idrossifenil)acetamido)-3-(1,2,3-triazol-4(5)-il)tiometil-3-cefem -4-carbossilico 1,2,-propilenglicolato e intermedio alogenato di detto procedimento

Publications (2)

Publication Number Publication Date
IT8819513A0 IT8819513A0 (it) 1988-02-24
IT1233864B true IT1233864B (it) 1992-04-21

Family

ID=11158670

Family Applications (1)

Application Number Title Priority Date Filing Date
IT8819513A IT1233864B (it) 1988-02-24 1988-02-24 Procedimento per la fabbricazione dell'acido 7-(d-(-)-alfa-amino-alfa -(p-idrossifenil)acetamido)-3-(1,2,3-triazol-4(5)-il)tiometil-3-cefem -4-carbossilico 1,2,-propilenglicolato e intermedio alogenato di detto procedimento

Country Status (5)

Country Link
US (1) US4965355A (it)
JP (1) JPH01258683A (it)
KR (1) KR890013030A (it)
CN (1) CN1024417C (it)
IT (1) IT1233864B (it)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100404685B1 (ko) * 2001-02-26 2003-11-10 한미약품 주식회사 4-히드록시페닐글리신 무수물을 이용한 세팔로스포린화합물의 제조방법
KR20020069432A (ko) * 2001-02-26 2002-09-04 한미약품공업 주식회사 4-히드록시페닐글리신 유도체를 이용한 세팔로스포린화합물의 제조방법
CN103772414B (zh) * 2013-12-31 2016-03-09 福建省福抗药业股份有限公司 一种制备丙二醇头孢曲嗪的制备方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3970651A (en) * 1974-01-07 1976-07-20 Bristol-Myers Company Crystalline cephalosporin derivative

Also Published As

Publication number Publication date
CN1037902A (zh) 1989-12-13
JPH01258683A (ja) 1989-10-16
CN1024417C (zh) 1994-05-04
IT8819513A0 (it) 1988-02-24
KR890013030A (ko) 1989-09-20
US4965355A (en) 1990-10-23

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