FI63671C - Foerfarande foer bildande av en doseringsenhetsform av en hjaertmedicin - Google Patents
Foerfarande foer bildande av en doseringsenhetsform av en hjaertmedicin Download PDFInfo
- Publication number
- FI63671C FI63671C FI750964A FI750964A FI63671C FI 63671 C FI63671 C FI 63671C FI 750964 A FI750964 A FI 750964A FI 750964 A FI750964 A FI 750964A FI 63671 C FI63671 C FI 63671C
- Authority
- FI
- Finland
- Prior art keywords
- digoxin
- hjaertmedicin
- doseringsenhetsform
- weight
- foerfarande foer
- Prior art date
Links
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 18
- LTMHDMANZUZIPE-AMTYYWEZSA-N Digoxin Natural products O([C@H]1[C@H](C)O[C@H](O[C@@H]2C[C@@H]3[C@@](C)([C@@H]4[C@H]([C@]5(O)[C@](C)([C@H](O)C4)[C@H](C4=CC(=O)OC4)CC5)CC3)CC2)C[C@@H]1O)[C@H]1O[C@H](C)[C@@H](O[C@H]2O[C@@H](C)[C@H](O)[C@@H](O)C2)[C@@H](O)C1 LTMHDMANZUZIPE-AMTYYWEZSA-N 0.000 description 14
- LTMHDMANZUZIPE-PUGKRICDSA-N digoxin Chemical compound C1[C@H](O)[C@H](O)[C@@H](C)O[C@H]1O[C@@H]1[C@@H](C)O[C@@H](O[C@@H]2[C@H](O[C@@H](O[C@@H]3C[C@@H]4[C@]([C@@H]5[C@H]([C@]6(CC[C@@H]([C@@]6(C)[C@H](O)C5)C=5COC(=O)C=5)O)CC4)(C)CC3)C[C@@H]2O)C)C[C@@H]1O LTMHDMANZUZIPE-PUGKRICDSA-N 0.000 description 14
- 229960005156 digoxin Drugs 0.000 description 14
- LTMHDMANZUZIPE-UHFFFAOYSA-N digoxine Natural products C1C(O)C(O)C(C)OC1OC1C(C)OC(OC2C(OC(OC3CC4C(C5C(C6(CCC(C6(C)C(O)C5)C=5COC(=O)C=5)O)CC4)(C)CC3)CC2O)C)CC1O LTMHDMANZUZIPE-UHFFFAOYSA-N 0.000 description 14
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 12
- 239000002775 capsule Substances 0.000 description 10
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 9
- 239000004480 active ingredient Substances 0.000 description 9
- FXHOOIRPVKKKFG-UHFFFAOYSA-N N,N-Dimethylacetamide Chemical compound CN(C)C(C)=O FXHOOIRPVKKKFG-UHFFFAOYSA-N 0.000 description 7
- 229920001223 polyethylene glycol Polymers 0.000 description 7
- 239000003826 tablet Substances 0.000 description 7
- 239000002202 Polyethylene glycol Substances 0.000 description 6
- 239000007903 gelatin capsule Substances 0.000 description 5
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 4
- 239000002371 cardiac agent Substances 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 239000000600 sorbitol Substances 0.000 description 4
- 108010010803 Gelatin Proteins 0.000 description 3
- 229920002565 Polyethylene Glycol 400 Polymers 0.000 description 3
- MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 description 3
- 239000008273 gelatin Substances 0.000 description 3
- 229920000159 gelatin Polymers 0.000 description 3
- 235000019322 gelatine Nutrition 0.000 description 3
- 235000011852 gelatine desserts Nutrition 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 239000004014 plasticizer Substances 0.000 description 3
- 230000000747 cardiac effect Effects 0.000 description 2
- 239000002552 dosage form Substances 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 239000007791 liquid phase Substances 0.000 description 2
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- 239000002368 cardiac glycoside Substances 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 229930182478 glucoside Natural products 0.000 description 1
- 150000008131 glucosides Chemical class 0.000 description 1
- TZMQHOJDDMFGQX-UHFFFAOYSA-N hexane-1,1,1-triol Chemical compound CCCCCC(O)(O)O TZMQHOJDDMFGQX-UHFFFAOYSA-N 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 239000007935 oral tablet Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Molecular Biology (AREA)
- Hospice & Palliative Care (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1426574 | 1974-04-01 | ||
| GB14265/74A GB1508770A (en) | 1974-04-01 | 1974-04-01 | Pharmaceutical compositions |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI750964A7 FI750964A7 (env) | 1975-10-02 |
| FI63671B FI63671B (fi) | 1983-04-29 |
| FI63671C true FI63671C (fi) | 1983-08-10 |
Family
ID=10038031
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI750964A FI63671C (fi) | 1974-04-01 | 1975-04-01 | Foerfarande foer bildande av en doseringsenhetsform av en hjaertmedicin |
Country Status (12)
| Country | Link |
|---|---|
| JP (1) | JPS5644045B2 (env) |
| AT (1) | AT342777B (env) |
| AU (1) | AU500001B2 (env) |
| BE (1) | BE827349A (env) |
| CA (1) | CA1046410A (env) |
| DE (1) | DE2513601A1 (env) |
| DK (1) | DK137436B (env) |
| FI (1) | FI63671C (env) |
| FR (1) | FR2265353B1 (env) |
| GB (1) | GB1508770A (env) |
| NL (1) | NL7503881A (env) |
| SE (1) | SE408687B (env) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2380030A1 (fr) * | 1977-02-09 | 1978-09-08 | Christiaens Sa A | Composition pharmaceutique contenant de la gitoxine |
| ES2308955T5 (es) | 1993-09-28 | 2012-04-03 | R.P. Scherer Gmbh | Fabricación de cápsulas de gelatina blanda |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1481411A (en) * | 1973-07-20 | 1977-07-27 | Scherer Ltd R | Pharmaceutical compositions |
| NL7502121A (nl) * | 1974-02-22 | 1975-08-26 | Wellcome Found | Werkwijze ter vervaardiging van een farmaceu- tisch preparaat dat digoxin bevat. |
-
1974
- 1974-04-01 GB GB14265/74A patent/GB1508770A/en not_active Expired
-
1975
- 1975-03-27 DE DE19752513601 patent/DE2513601A1/de active Granted
- 1975-03-27 SE SE7503592A patent/SE408687B/xx not_active IP Right Cessation
- 1975-03-28 BE BE154915A patent/BE827349A/xx not_active IP Right Cessation
- 1975-04-01 CA CA223,484A patent/CA1046410A/en not_active Expired
- 1975-04-01 JP JP3968275A patent/JPS5644045B2/ja not_active Expired
- 1975-04-01 DK DK138675AA patent/DK137436B/da not_active IP Right Cessation
- 1975-04-01 AT AT244575A patent/AT342777B/de not_active IP Right Cessation
- 1975-04-01 FI FI750964A patent/FI63671C/fi not_active IP Right Cessation
- 1975-04-01 FR FR7510180A patent/FR2265353B1/fr not_active Expired
- 1975-04-01 AU AU79663/75A patent/AU500001B2/en not_active Expired
- 1975-04-01 NL NL7503881A patent/NL7503881A/xx not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| DE2513601C2 (env) | 1988-05-26 |
| FR2265353A1 (env) | 1975-10-24 |
| ATA244575A (de) | 1977-08-15 |
| FI750964A7 (env) | 1975-10-02 |
| DE2513601A1 (de) | 1975-10-02 |
| GB1508770A (en) | 1978-04-26 |
| NL7503881A (nl) | 1975-10-03 |
| AU7966375A (en) | 1976-10-07 |
| DK138675A (env) | 1975-10-02 |
| FI63671B (fi) | 1983-04-29 |
| JPS517117A (env) | 1976-01-21 |
| DK137436B (da) | 1978-03-06 |
| SE408687B (sv) | 1979-07-02 |
| DK137436C (env) | 1978-08-21 |
| AT342777B (de) | 1978-04-25 |
| BE827349A (fr) | 1975-09-29 |
| FR2265353B1 (env) | 1980-02-15 |
| CA1046410A (en) | 1979-01-16 |
| JPS5644045B2 (env) | 1981-10-16 |
| AU500001B2 (en) | 1979-05-10 |
| SE7503592L (env) | 1975-10-02 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Setty et al. | Development of fast dispersible aceclofenac tablets: effect of functionality of superdisintegrants | |
| US4198391A (en) | Pharmaceutical compositions | |
| RU2121344C1 (ru) | Лекарственная форма двухфазного действия с высвобождением для липофильных лекарственных препаратов и способ ее получения | |
| Nau et al. | A new model for embryotoxicity testing: teratogenicity and pharmacokinetics of valproic acid following constant-rate administration in the mouse using human therapeutic drug and metabolite concentrations | |
| KR850000975A (ko) | 발프로익산과 그 염의 혼합물을 토대로 한 조성물 | |
| US2736682A (en) | Method of making a prolonged action medicinal tablet | |
| KR840000228A (ko) | 조제성 혼합물에 있어서 건성분말의 제조방법 | |
| Chung et al. | Comparative pharmacokinetics of Theracurmin, a highly bioavailable curcumin, in healthy adult subjects | |
| DE19648576A1 (de) | Lutschtablette zur modifizierten Freisetzung von Wirkstoffen im Gastrointestinaltrakt | |
| FI57056B (fi) | Foerfarande foer framstaellning av enteralt hoegresorberbara produkter av i sig svaort resorberbara hjaertglykosider | |
| JPS61501202A (ja) | アセトアミノフェン・ゼラチンカプセル | |
| Usmanova et al. | AN UNDERSTANDING OF THE FORMULATION OF THE DRUG AND THE RELEASE OF THE ACTIVE SUBSTANCES OF THE DRUG | |
| EP0025686A2 (en) | Pharmaceutical composition containing paracetamol, treatment pack comprising said composition and method of reducing liver toxicity effect of paracetamol compositions | |
| FI63670B (fi) | Foerfarande foer framstaellning av digoxin innehaollande doseringsenheter | |
| FI63671B (fi) | Foerfarande foer bildande av en doseringsenhetsform av en hjaertmedicin | |
| JPH0840880A (ja) | 軟ゼラチンカプセル剤中のケトプロフエン溶液に基づく医薬製剤およびその調製法 | |
| CN109833309A (zh) | 美金刚缓释微片胶囊及其制备方法 | |
| US3312593A (en) | Anti-inflammatory compositions of aspirin and niacin | |
| Jamali et al. | Salicylate excretion in breast milk | |
| EP0414688B1 (en) | Process for regulating the absorption rate of drugs and a pharmaceutical formulation | |
| Woo et al. | Liquid-filled hard capsule formulation of choline alfoscerate: preparation and in vitro/in vivo evaluation | |
| AU2024208438A1 (en) | Self-emulsifying pharmaceutical composition, preparation method therefor, and application thereof | |
| CN114073683A (zh) | 一种维生素口溶膜剂及其制备方法 | |
| US2870060A (en) | Stable encapsulated solution of a salt of a dialkyl sulfosuccinate | |
| JPS6137731A (ja) | グアバ葉エキスを有効成分とする経口糖尿病薬 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM | Patent lapsed |
Owner name: R.P. SCHERER LIMITED |