FI63062C - Foerfarande foer framstaellning av de farmaceutiskt aktiva aminosockerderivaten trestatin a trestatin b och trestatin c - Google Patents

Foerfarande foer framstaellning av de farmaceutiskt aktiva aminosockerderivaten trestatin a trestatin b och trestatin c Download PDF

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Publication number
FI63062C
FI63062C FI790486A FI790486A FI63062C FI 63062 C FI63062 C FI 63062C FI 790486 A FI790486 A FI 790486A FI 790486 A FI790486 A FI 790486A FI 63062 C FI63062 C FI 63062C
Authority
FI
Finland
Prior art keywords
trestatin
höh
trestatins
isp
water
Prior art date
Application number
FI790486A
Other languages
English (en)
Finnish (fi)
Other versions
FI63062B (fi
FI790486A (fi
Inventor
Yasuji Suhara
Kiyoshi Ogawa
Kazuteru Yokose
Kimihiro Watanabe
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of FI790486A publication Critical patent/FI790486A/fi
Publication of FI63062B publication Critical patent/FI63062B/fi
Application granted granted Critical
Publication of FI63062C publication Critical patent/FI63062C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/99—Enzyme inactivation by chemical treatment
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
FI790486A 1978-02-14 1979-02-14 Foerfarande foer framstaellning av de farmaceutiskt aktiva aminosockerderivaten trestatin a trestatin b och trestatin c FI63062C (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB583478 1978-02-14
GB583478 1978-02-14

Publications (3)

Publication Number Publication Date
FI790486A FI790486A (fi) 1979-08-15
FI63062B FI63062B (fi) 1982-12-31
FI63062C true FI63062C (fi) 1983-04-11

Family

ID=9803510

Family Applications (1)

Application Number Title Priority Date Filing Date
FI790486A FI63062C (fi) 1978-02-14 1979-02-14 Foerfarande foer framstaellning av de farmaceutiskt aktiva aminosockerderivaten trestatin a trestatin b och trestatin c

Country Status (26)

Country Link
US (1) US4273765A (zh)
EP (1) EP0003616B1 (zh)
JP (1) JPS54163511A (zh)
AR (1) AR219150A1 (zh)
AT (1) AT367451B (zh)
AU (1) AU527318B2 (zh)
CA (1) CA1121290A (zh)
DE (2) DE2962165D1 (zh)
DK (1) DK149599C (zh)
ES (1) ES477653A1 (zh)
FI (1) FI63062C (zh)
FR (1) FR2416901A1 (zh)
GR (1) GR72817B (zh)
HU (1) HU181442B (zh)
IE (1) IE47916B1 (zh)
IL (1) IL56626A0 (zh)
LU (1) LU80906A1 (zh)
MC (1) MC1253A1 (zh)
NL (1) NL7901182A (zh)
NO (1) NO153011C (zh)
NZ (1) NZ189625A (zh)
PH (1) PH15084A (zh)
PT (1) PT69218A (zh)
SE (1) SE7901276L (zh)
YU (1) YU41437B (zh)
ZA (1) ZA79528B (zh)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3166093D1 (en) * 1981-01-05 1984-10-18 Takeda Chemical Industries Ltd N-substituted pseudo-aminosugars, their production and use
JPS57146713A (en) * 1981-03-09 1982-09-10 Akira Endo Hypoglycemic
US4595678A (en) * 1982-03-19 1986-06-17 Takeda Chemical Industries, Ltd. N-substituted pseudo-aminosugars and pharmaceutical compositions containing same
US4678812A (en) * 1986-05-30 1987-07-07 E. I. Du Pont De Nemours And Company Trehalose as stabilizer and tableting excipient
US4762857A (en) * 1986-05-30 1988-08-09 E. I. Du Pont De Nemours And Company Trehalose as stabilizer and tableting excipient
US4885361A (en) * 1987-07-31 1989-12-05 Hoffmann-La Roche Inc. Sulfated oligosaccharides
ATE132269T1 (de) * 1990-11-30 1996-01-15 Monoclonetics Int Verfahren zur diagnose chronischer niedriger rückenschmerzen und nackenschmerzen
TW381025B (en) * 1993-08-05 2000-02-01 Hoffmann La Roche Pharmaceutical composition containing a glucosidase inhibitor and a lipase inhibitor
IL186223A0 (en) * 2000-05-24 2008-01-20 Pfizer Treatment of rumen acidosis with ??-amylase inhibitors
US7022684B2 (en) * 2000-05-24 2006-04-04 Pfizer Inc. Treatment of rumen acidosis with α-amylase inhibitors
EP1689383B1 (en) 2003-11-19 2012-10-31 Metabasis Therapeutics, Inc. Novel phosphorus-containing thyromimetics
US7262318B2 (en) * 2004-03-10 2007-08-28 Pfizer, Inc. Substituted heteroaryl- and phenylsulfamoyl compounds
US20050288340A1 (en) * 2004-06-29 2005-12-29 Pfizer Inc Substituted heteroaryl- and phenylsulfamoyl compounds
AP2007003979A0 (en) * 2004-11-23 2007-06-30 Warner Lambert Co 7-(2h-pyrazol-3-yl)-3,5-dihyroxy-heptanoic acid derivatives as hmg co-a reductase inhibitors for thetreatment of lipidemia
US7741317B2 (en) 2005-10-21 2010-06-22 Bristol-Myers Squibb Company LXR modulators
US7888376B2 (en) 2005-11-23 2011-02-15 Bristol-Myers Squibb Company Heterocyclic CETP inhibitors
JP5498168B2 (ja) 2006-12-01 2014-05-21 ブリストル−マイヤーズ スクイブ カンパニー アテローム性動脈硬化および循環器疾患の治療のためのｃｅｔｐ阻害剤としてのｎ−（（３−ベンジル）−２，２−（ビス−フェニル）−プロパン−１−アミン誘導体
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
DK2170930T3 (da) 2007-06-04 2012-11-05 Synergy Pharmaceuticals Inc Agonister af guanylatcyclase, anvendelige til behandlingen af gastrointestinale sygdomme, inflammation, cancer og andre sygdomme
MX2010011183A (es) 2008-04-11 2010-12-15 Astellas Pharma Inc Compuesto de aminoazucar y proceso para su produccion.
CA2726917C (en) 2008-06-04 2018-06-26 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
CA2730603C (en) 2008-07-16 2019-09-24 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
US20120046364A1 (en) 2009-02-10 2012-02-23 Metabasis Therapeutics, Inc. Novel Sulfonic Acid-Containing Thyromimetics, and Methods for Their Use
CA2799708A1 (en) 2010-05-21 2011-11-24 Pfizer Inc. 2-phenyl benzoylamides
WO2012027331A1 (en) 2010-08-27 2012-03-01 Ironwood Pharmaceuticals, Inc. Compositions and methods for treating or preventing metabolic syndrome and related diseases and disorders
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
WO2012120414A2 (en) 2011-03-04 2012-09-13 Pfizer Inc. Edn3-like peptides and uses thereof
US20150050371A1 (en) 2012-03-09 2015-02-19 Biotropics Malaysia Berhad Extract Formulations of Rhodamnia Cinerea And Uses Thereof
WO2014151206A1 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
WO2014151200A2 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Compositions useful for the treatment of gastrointestinal disorders
BR112015026513A2 (pt) 2013-04-17 2017-07-25 Pfizer derivados de n-piperidin-3-ilbenzamida para tratar as doenças cardiovasculares
HRP20240805T1 (hr) 2013-06-05 2024-09-27 Bausch Health Ireland Limited Ultra-pročišćeni agonisti guanilat-ciklaze c, postupak njihove pripreme i uporabe
EP3186242B1 (en) 2014-08-29 2021-10-06 Tes Pharma S.r.l. Inhibitors of alpha-amino-beta-carboxymuconic acid semialdehyde decarboxylase
WO2016055901A1 (en) 2014-10-08 2016-04-14 Pfizer Inc. Substituted amide compounds
WO2018069532A1 (en) 2016-10-14 2018-04-19 Tes Pharma S.R.L. Inhibitors of alpha-amino-beta-carboxymuconic acid semialdehyde decarboxylase
AR117122A1 (es) 2018-11-20 2021-07-14 Tes Pharma S R L INHIBIDORES DE LA ÁCIDO a-AMINO-b-CARBOXIMUCÓNICO SEMIALDEHÍDO DESCARBOXILASA
CA3125765A1 (en) 2019-01-18 2020-07-23 Astrazeneca Ab Pcsk9 inhibitors and methods of use thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2064092C2 (de) * 1970-12-28 1983-06-01 Bayer Ag, 5090 Leverkusen Inhibitoren für Glykosidhydrolasen aus Actinomyceten
DE2347782C3 (de) * 1973-09-22 1979-10-11 Bayer Ag, 5090 Leverkusen Aminozuckerderivate, Verfahren zu ihrer Herstellung sowie diese Verbindungen enthaltende Arzneimittel
US4062950A (en) * 1973-09-22 1977-12-13 Bayer Aktiengesellschaft Amino sugar derivatives
US4065557A (en) * 1974-03-21 1977-12-27 Bayer Aktiengesellschaft Amino sugars and their use in improving the meat:fat ratio in animals
USRE29903E (en) 1975-03-19 1979-02-06 American Cyanamid Company Antibacterial antibiotics AM31α, AM31β and AM31γ
DE2614393C3 (de) * 1976-04-02 1980-04-03 Bayer Ag, 5090 Leverkusen Aminozucker-Derivate und diese Verbindungen enthaltende Arzneimittel

Also Published As

Publication number Publication date
AR219150A1 (es) 1980-07-31
FI63062B (fi) 1982-12-31
YU41437B (en) 1987-06-30
LU80906A1 (de) 1980-09-24
FI790486A (fi) 1979-08-15
EP0003616A3 (en) 1979-09-05
JPS54163511A (en) 1979-12-26
EP0003616B1 (de) 1982-02-24
ZA79528B (en) 1980-02-27
US4273765A (en) 1981-06-16
ATA108879A (de) 1981-11-15
DE2905649A1 (de) 1979-08-16
DK149599B (da) 1986-08-04
NO153011B (no) 1985-09-23
DK61179A (da) 1979-08-15
NL7901182A (nl) 1979-08-16
JPS643877B2 (zh) 1989-01-23
SE7901276L (sv) 1979-08-15
HU181442B (en) 1983-07-28
NO153011C (no) 1986-01-02
GR72817B (zh) 1983-12-06
CA1121290A (en) 1982-04-06
AU527318B2 (en) 1983-02-24
IL56626A0 (en) 1979-05-31
FR2416901B1 (zh) 1980-10-24
NO790469L (no) 1979-08-15
IE47916B1 (en) 1984-07-25
ES477653A1 (es) 1980-03-01
PH15084A (en) 1982-07-02
FR2416901A1 (fr) 1979-09-07
NZ189625A (en) 1981-05-01
PT69218A (en) 1979-03-01
IE790274L (en) 1979-08-14
MC1253A1 (fr) 1980-01-14
DK149599C (da) 1987-06-01
YU34879A (en) 1983-01-21
AU4402879A (en) 1979-08-23
DE2962165D1 (en) 1982-03-25
AT367451B (de) 1982-07-12
EP0003616A2 (de) 1979-08-22

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Owner name: F. HOFFMANN-LA ROCHE AG