FI60712C - Foerfarande foer framstaellning av 6-(m(6-halogennikotinoylamino)fenyl)-eller 6-(m-(6-halogenisonikotinoylamino)fenyl)-2,3,5,6-tetrahydroimidazo-(2,1-b)tiazol anvaendbar som maskmedel - Google Patents
Foerfarande foer framstaellning av 6-(m(6-halogennikotinoylamino)fenyl)-eller 6-(m-(6-halogenisonikotinoylamino)fenyl)-2,3,5,6-tetrahydroimidazo-(2,1-b)tiazol anvaendbar som maskmedel Download PDFInfo
- Publication number
- FI60712C FI60712C FI771362A FI771362A FI60712C FI 60712 C FI60712 C FI 60712C FI 771362 A FI771362 A FI 771362A FI 771362 A FI771362 A FI 771362A FI 60712 C FI60712 C FI 60712C
- Authority
- FI
- Finland
- Prior art keywords
- phenyl
- tai
- formula
- hai
- halo
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/80—Acids; Esters in position 3
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Claims (2)
1 J (I) r'conh—1 mukaisen 6-£m-(6-halogeeninikotinoyyliamino)fenyyliJ- tai 6-£m-(6-halogeeniisonikotinoyyliamino)fenyyliJ -2,3,5,6-tetrahydroimidatso f 2,1-b)tiatsolin dl- ja 1-muotojen ja niiden farmaseuttisesti hyväk-syttävien happoadditiosuolojen valmistamiseksi, jolloin R"1' kaavassa I on halogeenipyridyyliryhmä, jonka kaava on 6 Λ jossa Hai on F, Cl, Br tai I ja -CONH-ryhmä on liittynyt halogeeni-pyridyyliryhmän 3- tai 4-asemaan, tunnettu siitä, että saatetaan dl- tai 1-m-aminotetramisoli, jonka kaava on -N---- I (II) νη2-^^—kNA.sJ reagoimaan hapon kanssa, jonka kaava on C00H γΛ<3 Har^ir (III) is 6071 2 jossa Hai tarkoittaa samaa kuin edellä ja -COOH-ryhmä on liittynyt pyridiinirenkaan 3- tai 4-asemaan, tai sen happohalogenidin, aktivoidun esterin tai seka-anhydridin kanssa, minkä jälkeen haluttaessa (i) kaavan I mukaisen yhdisteen dl-muoto hajotetaan sinänsä tunnetulla tavalla d- ja 1-muodoiksi ja 1-muoto otetaan talteen, ja (ii) muutetaan kaavan I mukainen yhdiste farmaseuttisesti hyväksyttäväksi happoadditiosuolaksi saattamalla yhdiste reagoimaan sopivan hapon kanssa. 19 6071 2 FÖrfarande för framställning av dl- och 1-formerna av 6-/m-(6-halogennikotinoylamino)fenylj - eller 6-["m- (6-halogenisonikotionyl-amino)-fenylJ-2,3,5, 6-tetrahydroimidazo [2,1-bJtiazol med formeIn --N _ R1 CONH-1 ^_I J a> och farmaceutiskt godtagbara syraadditionssalt därav, användbara som maskmedel, varvid r"' i formeln I är en halogenpyridylgrupp med formeln sfJ^3 Hai väri Hai är F, Cl, Br eller I och -CONH-gruppen är bunden vid halogenpyr idylgruppens 3- eller 4-ställning, kännetecknat därav, att man bringar dl- eller 1-m-aminotetramisol med formeln ,_N _ nh2—L J—L λ αι) att reagera med en syra med formeln
4 COOH j^^-3 (III) Hai r ·
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB17883/76A GB1516938A (en) | 1976-05-01 | 1976-05-01 | Halopyridylamides of m-aminotetramisole and their use as anthelmintics |
| GB1788376 | 1976-05-01 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI771362A FI771362A (sv) | 1977-11-02 |
| FI60712B FI60712B (fi) | 1981-11-30 |
| FI60712C true FI60712C (fi) | 1982-03-10 |
Family
ID=10102899
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI771362A FI60712C (fi) | 1976-05-01 | 1977-04-28 | Foerfarande foer framstaellning av 6-(m(6-halogennikotinoylamino)fenyl)-eller 6-(m-(6-halogenisonikotinoylamino)fenyl)-2,3,5,6-tetrahydroimidazo-(2,1-b)tiazol anvaendbar som maskmedel |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US4112102A (sv) |
| JP (1) | JPS52133998A (sv) |
| AR (1) | AR215629A1 (sv) |
| AT (1) | AT355572B (sv) |
| BE (1) | BE854073A (sv) |
| CA (1) | CA1067082A (sv) |
| CH (1) | CH620218A5 (sv) |
| CS (1) | CS189598B2 (sv) |
| DD (1) | DD130149A5 (sv) |
| DE (1) | DE2718976A1 (sv) |
| DK (1) | DK142583B (sv) |
| ES (1) | ES458249A1 (sv) |
| FI (1) | FI60712C (sv) |
| FR (1) | FR2349592A1 (sv) |
| GB (1) | GB1516938A (sv) |
| IE (1) | IE45140B1 (sv) |
| IL (1) | IL51875A0 (sv) |
| LU (1) | LU77233A1 (sv) |
| NL (1) | NL162389C (sv) |
| NZ (1) | NZ183876A (sv) |
| PH (1) | PH11989A (sv) |
| PT (1) | PT66491B (sv) |
| SE (1) | SE432423B (sv) |
| YU (1) | YU102377A (sv) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0041322A1 (en) | 1980-05-30 | 1981-12-09 | Beecham Group Plc | m-Pyrazolylamido tetramisole derivatives, compositions thereof, processes for production of such compounds and compositions and their use in treating helminthiasis |
| WO2018231704A1 (en) * | 2017-06-12 | 2018-12-20 | Dow Agrosciences, Llc | 6-bromonicotinamide and processes of preparation |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL131034C (sv) * | 1964-05-11 | |||
| US3673205A (en) * | 1970-03-25 | 1972-06-27 | American Cyanamid Co | 6-(m-AMINO AND SUBSTITUTED-AMINO PHENYL)-2,3,5,6-TETRAHYDRO{8 2,1-b{9 THIAZOLES AND METHOD OF USE |
| GB1365515A (en) * | 1971-09-03 | 1974-09-04 | American Cyanamid Co | 6-tetrahydro imidazol/2 1-b/thiazoles |
| CA982136A (en) * | 1971-09-07 | 1976-01-20 | Larry D. Spicer | 6-(aminophenyl)-2,3,5,6-tetrahydro(2,1-b)thiazoles |
| JPS4839492A (sv) * | 1971-09-23 | 1973-06-09 | ||
| CH556871A (de) * | 1971-09-24 | 1974-12-13 | American Cyanamid Co | Verfahren zur herstellung von substituierten 6-phenylimidazo (2,1-b)thiazolen. |
| BE773062R (fr) * | 1971-09-24 | 1972-03-24 | American Cyanamid Co | Nouveaux phenyltetrahydrothiazoles, leur preparation et leurs utilisations therapeutiques |
-
1976
- 1976-05-01 GB GB17883/76A patent/GB1516938A/en not_active Expired
-
1977
- 1977-03-28 SE SE7703553A patent/SE432423B/sv unknown
- 1977-04-13 IL IL51875A patent/IL51875A0/xx unknown
- 1977-04-15 NZ NZ183876A patent/NZ183876A/xx unknown
- 1977-04-18 PH PH19684A patent/PH11989A/en unknown
- 1977-04-20 YU YU01023/77A patent/YU102377A/xx unknown
- 1977-04-26 CA CA276,958A patent/CA1067082A/en not_active Expired
- 1977-04-27 JP JP4900777A patent/JPS52133998A/ja active Granted
- 1977-04-28 DK DK186877AA patent/DK142583B/da unknown
- 1977-04-28 AR AR267385A patent/AR215629A1/es active
- 1977-04-28 PT PT66491A patent/PT66491B/pt unknown
- 1977-04-28 ES ES458249A patent/ES458249A1/es not_active Expired
- 1977-04-28 FI FI771362A patent/FI60712C/fi not_active IP Right Cessation
- 1977-04-28 DE DE19772718976 patent/DE2718976A1/de not_active Withdrawn
- 1977-04-28 DD DD7700198638A patent/DD130149A5/xx unknown
- 1977-04-28 BE BE177110A patent/BE854073A/xx not_active IP Right Cessation
- 1977-04-28 NL NL7704662.A patent/NL162389C/xx not_active IP Right Cessation
- 1977-04-28 CS CS772804A patent/CS189598B2/cs unknown
- 1977-04-29 IE IE866/77A patent/IE45140B1/en unknown
- 1977-04-29 CH CH539477A patent/CH620218A5/fr not_active IP Right Cessation
- 1977-04-29 AT AT305677A patent/AT355572B/de not_active IP Right Cessation
- 1977-04-29 LU LU77233A patent/LU77233A1/xx unknown
- 1977-04-29 FR FR7713038A patent/FR2349592A1/fr active Granted
- 1977-04-29 US US05/792,142 patent/US4112102A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DE2718976A1 (de) | 1977-11-17 |
| FI771362A (sv) | 1977-11-02 |
| NL7704662A (nl) | 1977-11-03 |
| DD130149A5 (de) | 1978-03-08 |
| IE45140B1 (en) | 1982-06-30 |
| ATA305677A (de) | 1979-08-15 |
| AR215629A1 (es) | 1979-10-31 |
| SE7703553L (sv) | 1977-11-02 |
| US4112102A (en) | 1978-09-05 |
| NL162389B (nl) | 1979-12-17 |
| JPS5713554B2 (sv) | 1982-03-17 |
| AT355572B (de) | 1980-03-10 |
| NL162389C (nl) | 1980-05-16 |
| SE432423B (sv) | 1984-04-02 |
| GB1516938A (en) | 1978-07-05 |
| PT66491B (en) | 1978-09-29 |
| IL51875A0 (en) | 1977-06-30 |
| YU102377A (en) | 1982-06-30 |
| CH620218A5 (sv) | 1980-11-14 |
| FR2349592A1 (fr) | 1977-11-25 |
| ES458249A1 (es) | 1978-06-01 |
| LU77233A1 (sv) | 1977-08-18 |
| DK186877A (sv) | 1977-11-02 |
| PH11989A (en) | 1978-10-05 |
| CA1067082A (en) | 1979-11-27 |
| DK142583B (da) | 1980-11-24 |
| PT66491A (en) | 1977-05-01 |
| JPS52133998A (en) | 1977-11-09 |
| DK142583C (sv) | 1981-07-27 |
| CS189598B2 (en) | 1979-04-30 |
| FR2349592B1 (sv) | 1980-09-19 |
| IE45140L (en) | 1977-11-01 |
| NZ183876A (en) | 1979-03-16 |
| BE854073A (fr) | 1977-10-28 |
| AU2437377A (en) | 1977-09-29 |
| FI60712B (fi) | 1981-11-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM | Patent lapsed |
Owner name: PFIZER CORPORATION |