FI60208C - Foerfarande foer framstaellning av antibiotiskt verksamma spiro-imidatzolidin-rifamyciner - Google Patents

Foerfarande foer framstaellning av antibiotiskt verksamma spiro-imidatzolidin-rifamyciner Download PDF

Info

Publication number
FI60208C
FI60208C FI761688A FI761688A FI60208C FI 60208 C FI60208 C FI 60208C FI 761688 A FI761688 A FI 761688A FI 761688 A FI761688 A FI 761688A FI 60208 C FI60208 C FI 60208C
Authority
FI
Finland
Prior art keywords
formula
deoxo
rifamycin
alkyl
filtered
Prior art date
Application number
FI761688A
Other languages
English (en)
Finnish (fi)
Other versions
FI761688A (fr
FI60208B (fi
Inventor
Leonardo Marsili
Vittorio Rossetti
Carmine Pasqualucci
Original Assignee
Erba Farmitalia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Erba Farmitalia filed Critical Erba Farmitalia
Publication of FI761688A publication Critical patent/FI761688A/fi
Application granted granted Critical
Publication of FI60208B publication Critical patent/FI60208B/fi
Publication of FI60208C publication Critical patent/FI60208C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pulmonology (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FI761688A 1975-06-13 1976-06-11 Foerfarande foer framstaellning av antibiotiskt verksamma spiro-imidatzolidin-rifamyciner FI60208C (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT755174A IT1056272B (it) 1975-06-13 1975-06-13 Prodotti derivati dalle amine aromatiche
IT517475 1975-06-13

Publications (3)

Publication Number Publication Date
FI761688A FI761688A (fr) 1976-12-14
FI60208B FI60208B (fi) 1981-08-31
FI60208C true FI60208C (fi) 1981-12-10

Family

ID=11118842

Family Applications (1)

Application Number Title Priority Date Filing Date
FI761688A FI60208C (fi) 1975-06-13 1976-06-11 Foerfarande foer framstaellning av antibiotiskt verksamma spiro-imidatzolidin-rifamyciner

Country Status (28)

Country Link
US (2) US4086225A (fr)
JP (1) JPS5236683A (fr)
AR (1) AR211127A1 (fr)
AU (1) AU497602B2 (fr)
BE (1) BE842883A (fr)
CA (1) CA1059123A (fr)
CH (1) CH625524A5 (fr)
CS (1) CS197271B1 (fr)
DK (1) DK145228C (fr)
ES (1) ES449187A1 (fr)
FI (1) FI60208C (fr)
FR (1) FR2314189A1 (fr)
GB (1) GB1542063A (fr)
HK (1) HK56083A (fr)
HU (1) HU171396B (fr)
IE (1) IE42998B1 (fr)
IL (1) IL49701A (fr)
IN (1) IN143526B (fr)
IT (1) IT1056272B (fr)
NL (1) NL177919C (fr)
NO (1) NO148848C (fr)
PH (1) PH16410A (fr)
PL (1) PL99493B1 (fr)
PT (1) PT65208B (fr)
SE (1) SE434057B (fr)
SU (1) SU680649A3 (fr)
YU (1) YU39768B (fr)
ZA (1) ZA763256B (fr)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1056272B (it) * 1975-06-13 1982-01-30 Archifar Ind Chim Trentino Prodotti derivati dalle amine aromatiche
DK345977A (da) * 1976-09-30 1978-03-31 Archifar Ind Chim Trentino G rifamycinforbindelser og fremgangsmaade til deres fremstillin
BE886395A (fr) * 1980-02-13 1981-03-16 Erba Farmitalia Derives de rifamycine
IT1201963B (it) * 1983-03-24 1989-02-02 Prodotti Antibiotici Spa Derivati delle rifamicine e procedimento per la loro preparazione
US4631290A (en) * 1985-08-29 1986-12-23 American Home Products Corporation Method of treating hepatitis
CA2138643A1 (fr) * 1993-05-05 1994-11-10 Jack S. Remington Utilisation de derives rifamycine pour la fabrication d'un medicament destine au traitement de la toxoplasmose
US5529994A (en) * 1993-05-05 1996-06-25 Palo Alto Medical Foundation Treatment for toxoplasmosis
EP0787494B1 (fr) * 1995-09-01 2004-06-09 Kaneka Corporation Utilisation des derivates de rifamycine pour la manufacture d'un medicament contre les maladies causées par une infection par helicobacter pylori
US5981522A (en) * 1995-09-01 1999-11-09 Kaneka Corporation Treatment of disease caused by infection of Helicobacter
CA2465846A1 (fr) * 2001-11-21 2003-06-05 Activbiotics, Inc. Agents therapeutiques cibles et leurs utilisations
WO2003051299A2 (fr) * 2001-12-13 2003-06-26 Activbiotics, Inc. Rifamycines au sulfhydryle et utilisations de ces dernieres
US7820652B2 (en) * 2003-09-24 2010-10-26 Activbiotics Pharma, Llc Regimen for the administration of rifamycin-class antibiotics
US7202246B2 (en) * 2004-06-09 2007-04-10 Cumbre Pharmaceuticals Inc. Spiro-rifamycin derivatives targeting RNA polymerase
ES2246155B1 (es) * 2004-07-19 2007-03-16 Universidad De Oviedo Nuevas espiropiperidilrifamicinas.
JP5368092B2 (ja) 2005-08-11 2013-12-18 ターガンタ セラピュティクス，インコーポレイティド ホスホン化リファマイシン類および骨と関節感染の予防と治療のためのその投与法
US7678791B2 (en) * 2006-07-12 2010-03-16 Cumbre Ip Ventures, L.P. Nitroheteroaryl-containing rifamycin derivatives
CN100569778C (zh) * 2006-12-05 2009-12-16 四川明欣药业有限责任公司 一种利福布汀结晶工艺
WO2009064792A1 (fr) * 2007-11-16 2009-05-22 Cumbre Pharmaceuticals Inc. Dérivés de rifamycine substituée par l'acide quinolone-carboxylique
EP2324041A4 (fr) 2008-08-13 2012-06-13 Targanta Therapeutics Corp Rifamycines phosphonées et leurs utilisations pour la prévention et le traitement d'infections des os et des articulations
US20150017673A1 (en) 2012-08-30 2015-01-15 James Sacchettini Compositions and methods for drug-sensitization or inhibition of a cancer cell
PH12013000351A1 (en) 2013-11-22 2015-05-25 Joselle A Macrohon A versatile queuing management system and method
US20170202850A1 (en) 2014-07-21 2017-07-20 Hiroaki Serizawa Ophthalmic compositions of rifamycins and uses thereof
CN106279205B (zh) * 2015-05-12 2020-07-21 重庆华邦胜凯制药有限公司 制备利福霉素s衍生物的方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL130099C (fr) * 1963-10-11
DE2626296C2 (de) * 1975-06-13 1986-11-27 Farmitalia Carlo Erba S.p.A., Mailand/Milano Rifamycin-Verbindung und Verfahren zu seiner Herstellung
IT1056272B (it) * 1975-06-13 1982-01-30 Archifar Ind Chim Trentino Prodotti derivati dalle amine aromatiche

Also Published As

Publication number Publication date
DK145228C (da) 1983-02-28
JPS6121957B2 (fr) 1986-05-29
YU140576A (en) 1982-06-30
PL99493B1 (pl) 1978-07-31
IN143526B (fr) 1977-12-17
CH625524A5 (fr) 1981-09-30
PH16410A (en) 1983-09-29
ES449187A1 (es) 1977-07-16
US4219478A (en) 1980-08-26
DK145228B (da) 1982-10-11
AU497602B2 (en) 1978-12-21
SU680649A3 (ru) 1979-08-15
SE7606640L (sv) 1976-12-14
NL7606370A (nl) 1976-12-15
GB1542063A (en) 1979-03-14
HK56083A (en) 1983-11-25
FI761688A (fr) 1976-12-14
NO148848B (no) 1983-09-19
AR211127A1 (es) 1977-10-31
PT65208B (en) 1977-11-23
IE42998L (en) 1976-12-13
US4086225A (en) 1978-04-25
FR2314189B1 (fr) 1980-10-31
YU39768B (en) 1985-04-30
CS197271B1 (en) 1980-04-30
NL177919C (nl) 1985-12-16
SE434057B (sv) 1984-07-02
NL177919B (nl) 1985-07-16
IT1056272B (it) 1982-01-30
CA1059123A (fr) 1979-07-24
IE42998B1 (en) 1980-12-03
IL49701A0 (en) 1976-08-31
IL49701A (en) 1979-10-31
NO148848C (no) 1983-12-28
HU171396B (hu) 1978-01-28
FI60208B (fi) 1981-08-31
DK258076A (da) 1976-12-14
AU1476976A (en) 1977-12-15
FR2314189A1 (fr) 1977-01-07
JPS5236683A (en) 1977-03-22
NO762026L (fr) 1976-12-14
ZA763256B (en) 1977-05-25
BE842883A (fr) 1976-10-01
PT65208A (en) 1976-07-01

Similar Documents

Publication Publication Date Title
FI60208C (fi) Foerfarande foer framstaellning av antibiotiskt verksamma spiro-imidatzolidin-rifamyciner
Shiozawa et al. Thiomarinol, a new hybrid antimicrobial antibiotic produced by a marine bacterium fermentation, isolation, structure, and antimicrobial activity
Rida et al. Synthesis of novel benzofuran and related benzimidazole derivatives for evaluation of in vitro anti-HIV-1, anticancer and antimicrobial activities
CH648316A5 (de) Camptothecinderivate und verfahren zu ihrer herstellung.
González et al. Synthesis and cytotoxic activity of pyrazino [1, 2-b]-isoquinolines, 1-(3-isoquinolyl) isoquinolines, and 6, 15-iminoisoquino [3, 2-b]-3-benzazocines
Dandia et al. Synthesis and biological evaluation of highly functionalized dispiro heterocycles
Marsili et al. New rifamycins modified at positions 3 and 4 synthesis, structure and biological evaluation
CN111233795A (zh) 一种手性γ-丁内酯类化合物及其衍生物的制备方法及其应用
Andreani et al. Potential Antitumor Agents, VII. 5‐Substituted 6‐Phenylimidazo [2, 1‐b] thiazoles
YANAGISAWA et al. Studies on Chemotherapeutic Agents. I. Syntheses of Quinoline and Naphthyridine Sulfonamide or Phosphonic Acid Derivatives
CZ20012640A3 (cs) Způsob přípravy alkylmerkaptomethylergolinových derivátů
DE1935459A1 (de) Carbinolalkylmercaptoverbindungen
DE2626296C2 (de) Rifamycin-Verbindung und Verfahren zu seiner Herstellung
Rinehart Jr et al. Synthesis of hydrazones and oximes of geldanaldehyde as potential polymerase inhibitors
Ostrowski et al. Selective Double Functionalization of meso‐Tetraphenylporphyrin Complexes on the Same Pyrrole Unit by Tandem Electrophilic/Nucleophilic Aromatic Substitution
GB1561299A (en) Rifamycin compounds
KR790001261B1 (ko) 리파 마이신 화합물의 제조방법
Komkov et al. Efficient methods for the synthesis of pyrido [2, 3-d] pyrimidin-5-ones from 4-amino-5-acetylpyrimidines
Muzaffar et al. Partial synthesis and antitubulin activity of minor colchicum alkaloids: N-acetoacetyl-deacetylcolchicine and 2-demethylspeciosine (Speciocolchine)
US4217276A (en) Rifamycin compounds
US4086344A (en) N,15-Didehydro-15-deoxo-3,15-epi(methano(alkylimino))rifamycins and antimicrobial compositions and methods employing them
Dorokhov et al. 3-[Amino (methylthio) methylene] pentane-2, 4-dione in the synthesis of functionalized pyridines
SI7611405A8 (sl) Postopek za pripravo rifamicinskih spojin
OHTSUKA et al. Tetronothiodin, a Novel Cholecystokinin Type-B Receptor Antagonist Produced by Streptomyces sp. NR0489 III. Structural Elucidation
KR820000498B1 (ko) 리파마이신 화합물의 제조방법

Legal Events

Date Code Title Description
MA Patent expired
MA Patent expired

Owner name: FARMITALIA CARLO ERBA S.R.L