FI60019C - Foerfarande foer framstaellning av antibakteriella 7-((alfa-(2-aminometyl-1-cyklohexenyl- och -1,4-cyklohexadienyl)-acetamido)-3-heterocyklisk-tiometyl-3-cefem-4-karbonsyror - Google Patents
Foerfarande foer framstaellning av antibakteriella 7-((alfa-(2-aminometyl-1-cyklohexenyl- och -1,4-cyklohexadienyl)-acetamido)-3-heterocyklisk-tiometyl-3-cefem-4-karbonsyror Download PDFInfo
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- FI60019C FI60019C FI2560/74A FI256074A FI60019C FI 60019 C FI60019 C FI 60019C FI 2560/74 A FI2560/74 A FI 2560/74A FI 256074 A FI256074 A FI 256074A FI 60019 C FI60019 C FI 60019C
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- salt
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- 238000000034 method Methods 0.000 claims description 13
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- ZGUNAGUHMKGQNY-UHFFFAOYSA-N alpha-phenylglycine Chemical compound OC(=O)C(N)C1=CC=CC=C1 ZGUNAGUHMKGQNY-UHFFFAOYSA-N 0.000 claims description 3
- 230000000844 anti-bacterial effect Effects 0.000 claims description 3
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- 125000000896 monocarboxylic acid group Chemical group 0.000 claims 3
- 241000277284 Salvelinus fontinalis Species 0.000 claims 1
- 150000001735 carboxylic acids Chemical class 0.000 claims 1
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- 238000002156 mixing Methods 0.000 description 1
- 239000012452 mother liquor Substances 0.000 description 1
- JBLLRCOZJMVOAE-HSQYWUDLSA-N n-[(2s)-1-[[(2s)-1-(1,3-benzothiazol-2-yl)-1-oxo-3-[(3s)-2-oxopyrrolidin-3-yl]propan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]-4-methoxy-1h-indole-2-carboxamide Chemical compound C([C@H](NC(=O)[C@H](CC(C)C)NC(=O)C=1NC=2C=CC=C(C=2C=1)OC)C(=O)C=1SC2=CC=CC=C2N=1)[C@@H]1CCNC1=O JBLLRCOZJMVOAE-HSQYWUDLSA-N 0.000 description 1
- FEMOMIGRRWSMCU-UHFFFAOYSA-N ninhydrin Chemical compound C1=CC=C2C(=O)C(O)(O)C(=O)C2=C1 FEMOMIGRRWSMCU-UHFFFAOYSA-N 0.000 description 1
- 239000012299 nitrogen atmosphere Substances 0.000 description 1
- 125000004433 nitrogen atom Chemical group N* 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 229940039748 oxalate Drugs 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000003208 petroleum Substances 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 229920001467 poly(styrenesulfonates) Polymers 0.000 description 1
- 229920000172 poly(styrenesulfonic acid) Polymers 0.000 description 1
- 229940005642 polystyrene sulfonic acid Drugs 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- OGLTVWOMSOKYCF-UHFFFAOYSA-N potassium 2H-triazole Chemical compound [K+].C1=CNN=N1 OGLTVWOMSOKYCF-UHFFFAOYSA-N 0.000 description 1
- 235000011181 potassium carbonates Nutrition 0.000 description 1
- TVPRCLHSULCNLV-UHFFFAOYSA-N pyridazin-3-one Chemical compound O=C1C=CC=N[N]1 TVPRCLHSULCNLV-UHFFFAOYSA-N 0.000 description 1
- JUJWROOIHBZHMG-UHFFFAOYSA-N pyridine Substances C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 239000012088 reference solution Substances 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
- UIIMBOGNXHQVGW-UHFFFAOYSA-N sodium;hydron;carbonate Chemical compound [Na+].OC(O)=O UIIMBOGNXHQVGW-UHFFFAOYSA-N 0.000 description 1
- 239000008279 sol Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 238000004611 spectroscopical analysis Methods 0.000 description 1
- IIACRCGMVDHOTQ-UHFFFAOYSA-M sulfamate Chemical compound NS([O-])(=O)=O IIACRCGMVDHOTQ-UHFFFAOYSA-M 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 229940095064 tartrate Drugs 0.000 description 1
- 150000003512 tertiary amines Chemical class 0.000 description 1
- WROMPOXWARCANT-UHFFFAOYSA-N tfa trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.OC(=O)C(F)(F)F WROMPOXWARCANT-UHFFFAOYSA-N 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 150000007970 thio esters Chemical class 0.000 description 1
- 125000003396 thiol group Chemical group [H]S* 0.000 description 1
- 125000005270 trialkylamine group Chemical group 0.000 description 1
- 150000004798 β-ketoamides Chemical class 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/06—1,2,3-Thiadiazoles; Hydrogenated 1,2,3-thiadiazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
- C07D285/125—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
- C07D285/125—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
- C07D285/135—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39436773 | 1973-09-04 | ||
| US394367A US3907786A (en) | 1973-09-04 | 1973-09-04 | 7-{8 {60 -(2-aminomethyl-1,4-cyclohexadienyl)acetamido{9 -3-heterocyclic-thiomethyl-3-cephem-4-carboxylic acids and salts |
| US41155973 | 1973-10-31 | ||
| US05/411,559 US3946000A (en) | 1973-10-31 | 1973-10-31 | 7-[α-(2-Aminomethyl-1-cyclohexenyl)-acetamido]-3-heterocyclic thiomethyl-3-cephem-4-carboxylic acids |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI256074A7 FI256074A7 (enrdf_load_stackoverflow) | 1975-03-05 |
| FI60019B FI60019B (fi) | 1981-07-31 |
| FI60019C true FI60019C (fi) | 1981-11-10 |
Family
ID=27014711
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI2560/74A FI60019C (fi) | 1973-09-04 | 1974-09-02 | Foerfarande foer framstaellning av antibakteriella 7-((alfa-(2-aminometyl-1-cyklohexenyl- och -1,4-cyklohexadienyl)-acetamido)-3-heterocyklisk-tiometyl-3-cefem-4-karbonsyror |
Country Status (13)
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1531598A (zh) * | 2001-04-19 | 2004-09-22 | ��ŷ�����¶����ǹɷ�����˾ | 制备头孢菌素衍生物的酶促方法 |
| CN112645883B (zh) * | 2020-12-23 | 2022-10-25 | 天和药业股份有限公司 | 一种3,6-二氯哒嗪的制备方法 |
-
1974
- 1974-08-22 CA CA207,550A patent/CA1037467A/en not_active Expired
- 1974-08-28 YU YU02338/74A patent/YU233874A/xx unknown
- 1974-08-30 NL NL7411569A patent/NL7411569A/xx not_active Application Discontinuation
- 1974-09-02 FR FR7429799A patent/FR2242103B1/fr not_active Expired
- 1974-09-02 FI FI2560/74A patent/FI60019C/fi active
- 1974-09-02 GB GB3825074A patent/GB1474790A/en not_active Expired
- 1974-09-03 SE SE7411146A patent/SE423714B/xx unknown
- 1974-09-03 DK DK466574A patent/DK143941C/da not_active IP Right Cessation
- 1974-09-03 IE IE1822/74A patent/IE39830B1/xx unknown
- 1974-09-04 CH CH1203174A patent/CH613458A5/xx not_active IP Right Cessation
- 1974-09-04 DE DE2442302A patent/DE2442302C2/de not_active Expired
- 1974-09-04 JP JP49100841A patent/JPS5924158B2/ja not_active Expired
- 1974-09-04 HU HUBI501A patent/HU169170B/hu unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5924158B2 (ja) | 1984-06-07 |
| DE2442302A1 (de) | 1975-03-06 |
| JPS5058089A (enrdf_load_stackoverflow) | 1975-05-20 |
| HU169170B (enrdf_load_stackoverflow) | 1976-10-28 |
| IE39830B1 (en) | 1979-01-03 |
| FR2242103B1 (enrdf_load_stackoverflow) | 1978-07-21 |
| GB1474790A (en) | 1977-05-25 |
| DK143941C (da) | 1982-04-13 |
| IE39830L (en) | 1975-03-04 |
| FI60019B (fi) | 1981-07-31 |
| CA1037467A (en) | 1978-08-29 |
| CH613458A5 (en) | 1979-09-28 |
| NL7411569A (nl) | 1975-03-06 |
| FI256074A7 (enrdf_load_stackoverflow) | 1975-03-05 |
| SE7411146L (enrdf_load_stackoverflow) | 1975-03-05 |
| AU7291474A (en) | 1976-03-11 |
| FR2242103A1 (enrdf_load_stackoverflow) | 1975-03-28 |
| DE2442302C2 (de) | 1982-11-18 |
| DK143941B (da) | 1981-11-02 |
| SE423714B (sv) | 1982-05-24 |
| DK466574A (enrdf_load_stackoverflow) | 1975-05-05 |
| YU233874A (en) | 1982-06-30 |
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