FI56829C - Nya diagnostiskt verksamma substrat med hoeg specifitet foer trypsin och andra enzymer av typen peptidylpeptidhydrolaser - Google Patents

Nya diagnostiskt verksamma substrat med hoeg specifitet foer trypsin och andra enzymer av typen peptidylpeptidhydrolaser Download PDF

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Publication number
FI56829C
FI56829C FI1308/73A FI130873A FI56829C FI 56829 C FI56829 C FI 56829C FI 1308/73 A FI1308/73 A FI 1308/73A FI 130873 A FI130873 A FI 130873A FI 56829 C FI56829 C FI 56829C
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FI
Finland
Prior art keywords
mmol
leu
arg
product
gel
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Application number
FI1308/73A
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English (en)
Finnish (fi)
Other versions
FI56829B (fi
Inventor
Karl Goeran Claeson
Birgitta Gunilla Karlsson
Lars-Gundro Svendsen
Original Assignee
Kabi Ab
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Application filed by Kabi Ab filed Critical Kabi Ab
Publication of FI56829B publication Critical patent/FI56829B/fi
Application granted granted Critical
Publication of FI56829C publication Critical patent/FI56829C/fi

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • C07K5/06008Dipeptides with the first amino acid being neutral
    • C07K5/06017Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/56Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2337/00N-linked chromogens for determinations of peptidases and proteinases
    • C12Q2337/10Anilides
    • C12Q2337/12Para-Nitroanilides p-NA
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90Enzymes; Proenzymes
    • G01N2333/914Hydrolases (3)
    • G01N2333/948Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/968Plasmin, i.e. fibrinolysin
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90Enzymes; Proenzymes
    • G01N2333/914Hydrolases (3)
    • G01N2333/948Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/974Thrombin
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90Enzymes; Proenzymes
    • G01N2333/914Hydrolases (3)
    • G01N2333/948Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/976Trypsin; Chymotrypsin
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/802Chromogenic or luminescent peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Neurosurgery (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
FI1308/73A 1972-05-02 1973-04-25 Nya diagnostiskt verksamma substrat med hoeg specifitet foer trypsin och andra enzymer av typen peptidylpeptidhydrolaser FI56829C (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE7205758A SE380258B (sv) 1972-05-02 1972-05-02 Nya diagnostiskt verksamma substrat med hog specificitet till trypsin och andra enzymer av typen peptidyl-peptid-hydrolaser
SE575872 1972-05-02

Publications (2)

Publication Number Publication Date
FI56829B FI56829B (fi) 1979-12-31
FI56829C true FI56829C (fi) 1980-04-10

Family

ID=20267173

Family Applications (1)

Application Number Title Priority Date Filing Date
FI1308/73A FI56829C (fi) 1972-05-02 1973-04-25 Nya diagnostiskt verksamma substrat med hoeg specifitet foer trypsin och andra enzymer av typen peptidylpeptidhydrolaser

Country Status (20)

Country Link
US (1) US3886136A (xx)
AT (1) AT324558B (xx)
AU (1) AU474908B2 (xx)
BE (1) BE798917A (xx)
CA (1) CA1019724A (xx)
CH (1) CH590475A5 (xx)
CS (1) CS172974B2 (xx)
DD (1) DD108282A5 (xx)
DE (1) DE2322115B2 (xx)
ES (1) ES414251A1 (xx)
FI (1) FI56829C (xx)
FR (1) FR2183170B1 (xx)
GB (1) GB1426385A (xx)
IL (2) IL42124A (xx)
IT (1) IT1051562B (xx)
NL (1) NL7306088A (xx)
NO (1) NO135362C (xx)
PL (1) PL89227B1 (xx)
SE (1) SE380258B (xx)
ZA (1) ZA732975B (xx)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2527932C2 (de) * 1974-07-02 1983-04-21 Pentapharm AG, 4052 Basel Säureadditionssalze von Tripeptidderivaten und deren Verwendung als Substrate zur Bestimmung von Plasmakallikrein
US4016259A (en) * 1974-07-26 1977-04-05 Research Corporation Contraceptive polypeptides
US4162941A (en) * 1974-12-05 1979-07-31 Ab Kabi Method for determining a proteolytic enzyme
CH622286A5 (xx) * 1975-06-23 1981-03-31 Pentapharm Ag
SE407405B (sv) * 1975-07-11 1979-03-26 Kabi Ab Nya kromogena trombinsubstrat
SE407571B (sv) * 1975-07-11 1979-04-02 Kabi Ab Nya kromogena enzymsubstrat for serinproteaser
US4061625A (en) * 1975-07-11 1977-12-06 Ab Kabi Novel chromogenic thrombin substrates
US4169015A (en) * 1975-07-11 1979-09-25 Ab Kabi Novel chromogenic thrombin substrates
CH634662A5 (de) * 1976-05-28 1983-02-15 Pentapharm Ag Verwendung von tripeptidderivaten zur quantitativen bestimmung von plasminogen-aktivatoren.
US4147692A (en) * 1977-02-26 1979-04-03 Ajinomoto Co., Inc. Novel dipeptide derivatives, and method of measuring enzymatic activity
SE7801373L (sv) * 1978-02-07 1979-08-08 Kabi Ab Lett spjelkbara substrat for kvantifiering av proteaser
IL60888A (en) * 1978-06-16 1984-07-31 Yeda Res & Dev Substrates and process for the quantitative assay of enzymes
US4336186A (en) * 1978-08-03 1982-06-22 Gargiulo Robert J Analytical fluorogenic substrates for proteolytic enzymes
US4275153A (en) * 1978-08-03 1981-06-23 American Hospital Supply Corporation Analytical fluorogenic substrates for proteolytic enzymes
US4161488A (en) * 1978-08-17 1979-07-17 Abbott Laboratories Enzymatic substrates
US4166825A (en) * 1978-08-17 1979-09-04 Abbott Laboratories Chromogenic substrates
JPS5559150A (en) * 1978-10-30 1980-05-02 Torii Yakuhin Kk Aminoacid derivative
US4289498A (en) * 1979-01-08 1981-09-15 Ortho Diagnostics, Inc. One-stage prothrombin assay and compositions useful therein
US4219497A (en) 1979-04-06 1980-08-26 Abbott Laboratories Chromogenic substrates
US4409140A (en) * 1979-04-23 1983-10-11 Smith Robert E Substrates and method for determining enzymes
EP0018002B1 (de) * 1979-04-24 1983-02-09 Marcel Jozefonvicz Neues Bestimmungsverfahren für Proteasen und Antiproteasen
DE2936543A1 (de) * 1979-09-10 1981-04-09 Behringwerke Ag, 3550 Marburg Chromogene verbindungen
US4308202A (en) * 1979-10-25 1981-12-29 Torii & Co., Ltd. Prolylphenylalanylarginine derivatives, process for producing same and method for measuring activity of enzymes using same
CA1161432A (en) * 1980-02-12 1984-01-31 Lars G. Svendsen Tripeptide derivatives and their application in assaying enzymes
ATE8130T1 (de) * 1980-08-25 1984-07-15 Kabivitrum Ab Peptidsubstrate zum bestimmen der proteaseaktivitaet.
JPS5753445A (en) * 1980-09-16 1982-03-30 Torii Yakuhin Kk Peptide compound
US4849353A (en) * 1980-09-30 1989-07-18 Cornell Research Foundation, Inc. Immunocapture of enzyme inhibitor, enzyme complexes and uses thereof
US4428874A (en) 1981-03-25 1984-01-31 Pentapharm A.G. Tripeptide derivatives
US4568636A (en) * 1981-03-25 1986-02-04 Pentapharm Ag Tripeptide derivatives
US4388233A (en) * 1981-05-15 1983-06-14 The Regents Of The University Of California Synthetic substrates for enzyme analysis
JPS5856695A (ja) * 1981-09-28 1983-04-04 Nitto Boseki Co Ltd 新規なトロンビン測定用基質
DE3139719A1 (de) * 1981-10-06 1983-04-21 Boehringer Mannheim Gmbh, 6800 Mannheim Verfahren zur bestimmung der aktivitaet von chymotrypsin oder trypsin im stuhl
JPS5863399A (ja) * 1981-10-14 1983-04-15 Nitto Boseki Co Ltd 新規なプラスミン測定用基質
ATE17262T1 (de) * 1981-11-02 1986-01-15 Pentapharm Ag Verfahren zur quantitativen bestimmung von blutgerinnungsfaktor xii in humanplasma.
US4448715A (en) * 1981-11-02 1984-05-15 University Of Miami Tagged pyroglu-L-Phe-L-Arg derivatives, substrates and assays for kallikrein
DE3244030A1 (de) * 1982-11-27 1984-05-30 Behringwerke Ag, 3550 Marburg Chromogene verbindungen, verfahren zu ihrer herstellung und ihre verwendung
FR2546164B1 (fr) * 1983-05-16 1987-07-17 Centre Nat Rech Scient Nouveaux derives de peptides, leur preparation et leur application comme inhibiteurs de l'elastase
JPS6117956A (ja) * 1984-07-04 1986-01-25 Nitto Boseki Co Ltd 新規な尿中カリクレイン測定用基質
US4897444A (en) * 1985-05-31 1990-01-30 The Research Foundation Of The State University Of New York Immobilized fluorogenic substrates for enzymes; and processes for their preparation
JPS62126196A (ja) * 1985-11-26 1987-06-08 Nitto Boseki Co Ltd 新規なα1−アンチトリプシン測定用化合物
US5399487A (en) * 1993-03-04 1995-03-21 Haematologic Technologies, Inc. 6-peptidylamino-1-naphthalenesulfonamides useful as fluorogenic proteolytic enzyme substrates
US6297024B1 (en) 1998-10-15 2001-10-02 Cell Activation, Inc. Methods for assessing complement activation
US6235494B1 (en) 1999-02-08 2001-05-22 The Scripps Research Institute Substrates for assessing mannan-binding protein-associated serine protease activity and methods using the substrates
US6455734B1 (en) 2000-08-09 2002-09-24 Magnesium Diagnostics, Inc. Antagonists of the magnesium binding defect as therapeutic agents and methods for treatment of abnormal physiological states

Also Published As

Publication number Publication date
NO135362C (xx) 1977-03-30
FR2183170A1 (xx) 1973-12-14
CH590475A5 (xx) 1977-08-15
PL89227B1 (xx) 1976-11-30
BE798917A (fr) 1973-08-16
SE380258B (sv) 1975-11-03
CA1019724A (en) 1977-10-25
AU5503973A (en) 1974-11-07
CS172974B2 (xx) 1977-01-28
FI56829B (fi) 1979-12-31
IT1051562B (it) 1981-05-20
ZA732975B (en) 1974-04-24
FR2183170B1 (xx) 1977-02-11
AU474908B2 (en) 1976-08-05
US3886136A (en) 1975-05-27
NO135362B (xx) 1976-12-20
DE2322115A1 (de) 1973-11-22
NL7306088A (xx) 1973-11-06
DE2322115B2 (de) 1980-01-10
DD108282A5 (xx) 1974-09-12
AT324558B (de) 1975-09-10
IL42124A (en) 1977-02-28
GB1426385A (en) 1976-02-25
ES414251A1 (es) 1976-06-16
IL42124A0 (en) 1973-06-29

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