FI56536C - Mot aktivitetsfoerlust stabiliserat ureaspreparat - Google Patents
Mot aktivitetsfoerlust stabiliserat ureaspreparat Download PDFInfo
- Publication number
- FI56536C FI56536C FI770294A FI770294A FI56536C FI 56536 C FI56536 C FI 56536C FI 770294 A FI770294 A FI 770294A FI 770294 A FI770294 A FI 770294A FI 56536 C FI56536 C FI 56536C
- Authority
- FI
- Finland
- Prior art keywords
- urease
- activity
- stabilized
- mot
- ureaspreparat
- Prior art date
Links
- 108010046334 Urease Proteins 0.000 description 28
- 230000000694 effects Effects 0.000 description 24
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 description 12
- 238000002360 preparation method Methods 0.000 description 12
- 229920002307 Dextran Polymers 0.000 description 11
- 241000282326 Felis catus Species 0.000 description 9
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 8
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 8
- 239000000203 mixture Substances 0.000 description 8
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 7
- 108090000790 Enzymes Proteins 0.000 description 7
- 102000004190 Enzymes Human genes 0.000 description 7
- 108010024636 Glutathione Proteins 0.000 description 6
- 235000013877 carbamide Nutrition 0.000 description 6
- 238000004108 freeze drying Methods 0.000 description 6
- 229960003180 glutathione Drugs 0.000 description 6
- 238000011282 treatment Methods 0.000 description 6
- 210000002700 urine Anatomy 0.000 description 6
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 5
- 239000004202 carbamide Substances 0.000 description 5
- 239000003381 stabilizer Substances 0.000 description 5
- 239000003513 alkali Substances 0.000 description 4
- 229910021529 ammonia Inorganic materials 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- 210000002966 serum Anatomy 0.000 description 3
- 230000006641 stabilisation Effects 0.000 description 3
- 238000011105 stabilization Methods 0.000 description 3
- ZPLCXHWYPWVJDL-UHFFFAOYSA-N 4-[(4-hydroxyphenyl)methyl]-1,3-oxazolidin-2-one Chemical compound C1=CC(O)=CC=C1CC1NC(=O)OC1 ZPLCXHWYPWVJDL-UHFFFAOYSA-N 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 239000003086 colorant Substances 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 239000012535 impurity Substances 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 239000007793 ph indicator Substances 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 1
- CDOUZKKFHVEKRI-UHFFFAOYSA-N 3-bromo-n-[(prop-2-enoylamino)methyl]propanamide Chemical compound BrCCC(=O)NCNC(=O)C=C CDOUZKKFHVEKRI-UHFFFAOYSA-N 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 229920005654 Sephadex Polymers 0.000 description 1
- 102000007562 Serum Albumin Human genes 0.000 description 1
- 108010071390 Serum Albumin Proteins 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 239000012876 carrier material Substances 0.000 description 1
- 238000006555 catalytic reaction Methods 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 238000004440 column chromatography Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 1
- 235000018417 cysteine Nutrition 0.000 description 1
- 235000019329 dioctyl sodium sulphosuccinate Nutrition 0.000 description 1
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- DNJIEGIFACGWOD-UHFFFAOYSA-N ethyl mercaptane Natural products CCS DNJIEGIFACGWOD-UHFFFAOYSA-N 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 230000002452 interceptive effect Effects 0.000 description 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 239000002808 molecular sieve Substances 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 229920002689 polyvinyl acetate Polymers 0.000 description 1
- 239000011118 polyvinyl acetate Substances 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 235000010413 sodium alginate Nutrition 0.000 description 1
- 229940005550 sodium alginate Drugs 0.000 description 1
- 239000000661 sodium alginate Substances 0.000 description 1
- URGAHOPLAPQHLN-UHFFFAOYSA-N sodium aluminosilicate Chemical compound [Na+].[Al+3].[O-][Si]([O-])=O.[O-][Si]([O-])=O URGAHOPLAPQHLN-UHFFFAOYSA-N 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 125000003396 thiol group Chemical group [H]S* 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- 150000003672 ureas Chemical class 0.000 description 1
- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 description 1
- DGVVWUTYPXICAM-UHFFFAOYSA-N β‐Mercaptoethanol Chemical compound OCCS DGVVWUTYPXICAM-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/58—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving urea or urease
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
- C12N9/80—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Enzymes And Modification Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2612726 | 1976-03-25 | ||
| DE2612726A DE2612726C3 (de) | 1976-03-25 | 1976-03-25 | Stabilisierte Urease |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI770294A7 FI770294A7 (it) | 1977-09-26 |
| FI56536B FI56536B (fi) | 1979-10-31 |
| FI56536C true FI56536C (fi) | 1980-02-11 |
Family
ID=5973424
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI770294A FI56536C (fi) | 1976-03-25 | 1977-01-28 | Mot aktivitetsfoerlust stabiliserat ureaspreparat |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US4188465A (it) |
| JP (1) | JPS6027516B2 (it) |
| AR (1) | AR210632A1 (it) |
| AT (1) | AT349651B (it) |
| AU (1) | AU509593B2 (it) |
| BE (1) | BE852791A (it) |
| BR (1) | BR7701770A (it) |
| CA (1) | CA1086615A (it) |
| CH (1) | CH629535A5 (it) |
| DD (1) | DD129692A5 (it) |
| DE (1) | DE2612726C3 (it) |
| FI (1) | FI56536C (it) |
| FR (1) | FR2345460A1 (it) |
| GB (1) | GB1517146A (it) |
| HU (1) | HU179124B (it) |
| IT (1) | IT1076016B (it) |
| NL (1) | NL188169C (it) |
| SE (1) | SE428475B (it) |
| SU (1) | SU743600A3 (it) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4378430A (en) * | 1979-09-11 | 1983-03-29 | Modrovich Ivan Endre | Method of forming stabilized urease solutions |
| US4465770A (en) * | 1979-09-11 | 1984-08-14 | Modrovich Ivan Endre | Stabilized enzymic solutions for determining urea |
| US4282316A (en) * | 1979-09-11 | 1981-08-04 | Modrovich Ivan Endre | Stabilized enzymic solutions for determining urea |
| US4350659A (en) * | 1981-07-30 | 1982-09-21 | Corning Glass Works | Stabilization of sensitive biologically active intermediate metabolites such as folic acid derivatives |
| FI863968A0 (fi) * | 1985-02-11 | 1986-10-01 | Travenol Genentech Diagnostics | Stabiliserade enzymsubstratloesningar. |
| AU2003296492A1 (en) * | 2002-12-11 | 2004-06-30 | Instrumentation Laboratory Company | Multi-analyte reference solutions |
| US20040154933A1 (en) * | 2003-02-11 | 2004-08-12 | Instrumentation Laboratory Company | Polymeric membranes for use in electrochemical sensors |
| US20040256227A1 (en) * | 2003-02-11 | 2004-12-23 | Jungwon Shin | Electrochemical urea sensors and methods of making the same |
| US20050176650A1 (en) * | 2004-02-09 | 2005-08-11 | Xanodyne Pharmacal, Inc. | Stable parenteral formulation of levomepromazine and a method for stabilizing said formulation |
| US9017664B2 (en) | 2006-12-15 | 2015-04-28 | Lifebond Ltd. | Gelatin-transglutaminase hemostatic dressings and sealants |
| WO2009153750A2 (en) * | 2008-06-18 | 2009-12-23 | Lifebond Ltd | Improved cross-linked compositions |
| EP2303344A2 (en) * | 2008-06-18 | 2011-04-06 | Lifebond Ltd | Methods and devices for use with sealants |
| EP2543394A1 (en) * | 2008-06-18 | 2013-01-09 | Lifebond Ltd | A method for enzymatic cross-linking of a protein |
| DE102009057050A1 (de) * | 2009-12-04 | 2011-06-09 | Torsten Beel | Urin-Indikator-Mittel |
| BR112012015029A2 (pt) | 2009-12-22 | 2017-06-27 | Lifebond Ltd | matriz reticulada, método para controlar a formação de uma matriz, método ou matriz, método para vedar um tecido contra vazamento de um fluído corporal, agente hemostático ou vedante cirúrgico, composição para vedar um ferimento, uso da composição, composição para um veículo para entrega localizada de fármaco, composição para engenharia de tecido, e método para modificar uma composição |
| WO2012017415A2 (en) | 2010-08-05 | 2012-02-09 | Lifebond Ltd. | Dry composition wound dressings and adhesives |
| EP2606147B1 (de) | 2010-08-20 | 2014-10-15 | Cytonet GmbH & Co. KG | Verfahren zur isolierung von harnstoff unter entfernung von störendem co2 |
| US11998654B2 (en) | 2018-07-12 | 2024-06-04 | Bard Shannon Limited | Securing implants and medical devices |
| WO2024263102A1 (en) * | 2023-06-20 | 2024-12-26 | Awak Technologies Pte Ltd | Immobilised urease formulations with improved shelf life |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1321659A (fr) * | 1961-03-20 | 1963-03-22 | Albert L Chaney Chemical Lab | Méthode de dosage de l'azote dans les fluides biologiques |
| USRE26125E (en) * | 1962-05-08 | 1966-12-13 | Reagents and analysis of nitrogen | |
| US3527674A (en) * | 1966-06-30 | 1970-09-08 | Calbiochem | Reagent material and method for urea assay |
| US3542649A (en) * | 1967-04-07 | 1970-11-24 | Hoffmann La Roche | Color developing composition consisting of an enzyme,a salicylate and a hypochlorite donor |
| DE1758581C3 (de) * | 1968-06-29 | 1974-01-10 | Demag Ag, 4100 Duisburg | Stützvorrichtung für ein metallurgisches Gefäß, insbesondere für einen Stahlwerkskonverter |
| ZA733611B (en) * | 1972-10-11 | 1974-04-24 | Merck Patent Gmbh | Indicator for the determination of urea |
| DE2329174C2 (de) * | 1973-06-07 | 1975-07-24 | Boehringer Mannheim Gmbh, 6800 Mannheim | Verfahren zur quantitativen Bestimmung von Blutammoniak |
-
1976
- 1976-03-25 DE DE2612726A patent/DE2612726C3/de not_active Expired
-
1977
- 1977-01-07 AT AT05477A patent/AT349651B/de not_active IP Right Cessation
- 1977-01-12 AR AR266169A patent/AR210632A1/es active
- 1977-01-24 CA CA270,368A patent/CA1086615A/en not_active Expired
- 1977-01-24 IT IT19581/77A patent/IT1076016B/it active
- 1977-01-24 NL NLAANVRAGE7700686,A patent/NL188169C/xx not_active IP Right Cessation
- 1977-01-28 FI FI770294A patent/FI56536C/fi not_active IP Right Cessation
- 1977-02-15 SU SU772453752A patent/SU743600A3/ru active
- 1977-03-21 SE SE7703206A patent/SE428475B/xx not_active IP Right Cessation
- 1977-03-22 FR FR7708519A patent/FR2345460A1/fr active Granted
- 1977-03-22 GB GB11994/77A patent/GB1517146A/en not_active Expired
- 1977-03-23 BR BR7701770A patent/BR7701770A/pt unknown
- 1977-03-23 CH CH369777A patent/CH629535A5/de not_active IP Right Cessation
- 1977-03-23 AU AU23562/77A patent/AU509593B2/en not_active Expired
- 1977-03-23 DD DD7700198026A patent/DD129692A5/xx unknown
- 1977-03-23 BE BE176043A patent/BE852791A/xx not_active IP Right Cessation
- 1977-03-24 HU HU77BO1657A patent/HU179124B/hu unknown
- 1977-03-24 JP JP52032754A patent/JPS6027516B2/ja not_active Expired
- 1977-03-25 US US05/781,222 patent/US4188465A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| FR2345460B1 (it) | 1982-12-17 |
| AR210632A1 (es) | 1977-08-31 |
| FI56536B (fi) | 1979-10-31 |
| SE428475B (sv) | 1983-07-04 |
| HU179124B (en) | 1982-08-28 |
| NL188169B (nl) | 1991-11-18 |
| SE7703206L (sv) | 1977-09-26 |
| FI770294A7 (it) | 1977-09-26 |
| AT349651B (de) | 1979-04-25 |
| CA1086615A (en) | 1980-09-30 |
| DD129692A5 (de) | 1978-02-01 |
| US4188465A (en) | 1980-02-12 |
| AU2356277A (en) | 1978-09-28 |
| NL7700686A (nl) | 1977-09-27 |
| ATA5477A (de) | 1978-09-15 |
| GB1517146A (en) | 1978-07-12 |
| DE2612726A1 (de) | 1977-10-06 |
| DE2612726C3 (de) | 1979-03-15 |
| JPS6027516B2 (ja) | 1985-06-29 |
| BR7701770A (pt) | 1978-01-17 |
| FR2345460A1 (fr) | 1977-10-21 |
| IT1076016B (it) | 1985-04-22 |
| NL188169C (nl) | 1992-04-16 |
| SU743600A3 (ru) | 1980-06-25 |
| BE852791A (fr) | 1977-09-23 |
| DE2612726B2 (de) | 1978-07-06 |
| CH629535A5 (de) | 1982-04-30 |
| JPS52117488A (en) | 1977-10-01 |
| AU509593B2 (en) | 1980-05-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM | Patent lapsed | ||
| MM | Patent lapsed |
Owner name: BOEHRINGER MANNHEIM GMBH |