FI3642202T3 - Dihydro-pyrrolo-pyridiinijohdannaisia - Google Patents

Dihydro-pyrrolo-pyridiinijohdannaisia Download PDF

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Publication number
FI3642202T3
FI3642202T3 FIEP18743584.7T FI18743584T FI3642202T3 FI 3642202 T3 FI3642202 T3 FI 3642202T3 FI 18743584 T FI18743584 T FI 18743584T FI 3642202 T3 FI3642202 T3 FI 3642202T3
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FI
Finland
Prior art keywords
alkyl
group
oxide
compound
cycloalkyl
Prior art date
Application number
FIEP18743584.7T
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Inventor
Elizabeth Mary Beck
Michael Aaron Brodney
Matthew Frank Brown
Christopher Ryan Butler
Adam Matthew Gilbert
Erik Alphie Lachapelle
Laura Ann Mcallister
Daniel Paul Uccello
Lei Zhang
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application granted granted Critical
Publication of FI3642202T3 publication Critical patent/FI3642202T3/fi

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Addiction (AREA)
  • Hospice & Palliative Care (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychology (AREA)
  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
FIEP18743584.7T 2017-06-22 2018-06-14 Dihydro-pyrrolo-pyridiinijohdannaisia FI3642202T3 (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762523306P 2017-06-22 2017-06-22
PCT/IB2018/054390 WO2018234953A1 (en) 2017-06-22 2018-06-14 Dihydro-pyrrolo-pyridine derivatives

Publications (1)

Publication Number Publication Date
FI3642202T3 true FI3642202T3 (fi) 2023-03-01

Family

ID=62981279

Family Applications (1)

Application Number Title Priority Date Filing Date
FIEP18743584.7T FI3642202T3 (fi) 2017-06-22 2018-06-14 Dihydro-pyrrolo-pyridiinijohdannaisia

Country Status (19)

Country Link
US (1) US11198692B2 (enExample)
EP (1) EP3642202B1 (enExample)
JP (1) JP7263266B2 (enExample)
KR (1) KR20200013783A (enExample)
CN (1) CN110944998B (enExample)
AU (1) AU2018287787A1 (enExample)
BR (1) BR112019026955A2 (enExample)
CA (1) CA3066986A1 (enExample)
DK (1) DK3642202T3 (enExample)
ES (1) ES2937236T3 (enExample)
FI (1) FI3642202T3 (enExample)
HU (1) HUE060914T2 (enExample)
IL (1) IL271290B2 (enExample)
MX (1) MX2019015371A (enExample)
PL (1) PL3642202T3 (enExample)
PT (1) PT3642202T (enExample)
SG (1) SG11201913014YA (enExample)
TW (1) TWI680128B (enExample)
WO (1) WO2018234953A1 (enExample)

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JP2025534061A (ja) * 2022-10-28 2025-10-09 紐欧申医薬（上海）有限公司 窒素含有複素環化合物、その薬学的に許容される塩及びその調製方法と使用
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CN120641421A (zh) * 2022-12-16 2025-09-12 卡鲁娜治疗学有限公司 经取代的二氢吡咯并[3,4-d]嘧啶化合物及其在治疗医学病状中的用途
KR20250130620A (ko) * 2022-12-16 2025-09-02 카루나 세러퓨틱스 인코포레이티드 치환된 테트라하이드로피롤로-피리디논 화합물 및 의학적 병태 치료에서의 이의 용도
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Also Published As

Publication number Publication date
US20200262833A1 (en) 2020-08-20
CA3066986A1 (en) 2018-12-27
WO2018234953A1 (en) 2018-12-27
NZ760036A (en) 2025-05-30
AU2018287787A1 (en) 2020-01-16
IL271290B1 (en) 2023-07-01
ES2937236T3 (es) 2023-03-27
DK3642202T3 (da) 2023-01-30
HUE060914T2 (hu) 2023-04-28
CN110944998A (zh) 2020-03-31
PL3642202T3 (pl) 2023-03-13
JP2020524687A (ja) 2020-08-20
TWI680128B (zh) 2019-12-21
IL271290A (en) 2020-01-30
KR20200013783A (ko) 2020-02-07
US11198692B2 (en) 2021-12-14
SG11201913014YA (en) 2020-01-30
BR112019026955A2 (pt) 2020-06-30
CN110944998B (zh) 2022-08-16
IL271290B2 (en) 2023-11-01
EP3642202A1 (en) 2020-04-29
JP7263266B2 (ja) 2023-04-24
MX2019015371A (es) 2020-07-20
TW201920166A (zh) 2019-06-01
EP3642202B1 (en) 2022-11-02
PT3642202T (pt) 2023-02-02

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