JP7263266B2 - ジヒドロ－ピロロ－ピリジン誘導体 - Google Patents

ジヒドロ－ピロロ－ピリジン誘導体 Download PDF

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JP7263266B2
JP7263266B2 JP2019570547A JP2019570547A JP7263266B2 JP 7263266 B2 JP7263266 B2 JP 7263266B2 JP 2019570547 A JP2019570547 A JP 2019570547A JP 2019570547 A JP2019570547 A JP 2019570547A JP 7263266 B2 JP7263266 B2 JP 7263266B2
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pyridin
pyrrolo
dihydro
optionally substituted
dimethyl
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JP2020524687A5 (enExample
JP2020524687A (ja
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エリザベス メアリー ベック，
マイケル アーロン ブロドニー，
マシュー フランク ブラウン，
クリストファー ライアン バトラー，
アダム マシュー ギルバート，
エリック アルフィー ラシャペル，
ローラ アン マカリスター，
ダニエル ポール ウッチェロ，
レイ ジャン，
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ファイザー・インク
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Addiction (AREA)
  • Hospice & Palliative Care (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychology (AREA)
  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2019570547A 2017-06-22 2018-06-14 ジヒドロ－ピロロ－ピリジン誘導体 Active JP7263266B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762523306P 2017-06-22 2017-06-22
US62/523,306 2017-06-22
PCT/IB2018/054390 WO2018234953A1 (en) 2017-06-22 2018-06-14 Dihydro-pyrrolo-pyridine derivatives

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JP2020524687A JP2020524687A (ja) 2020-08-20
JP2020524687A5 JP2020524687A5 (enExample) 2021-07-26
JP7263266B2 true JP7263266B2 (ja) 2023-04-24

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US (1) US11198692B2 (enExample)
EP (1) EP3642202B1 (enExample)
JP (1) JP7263266B2 (enExample)
KR (1) KR20200013783A (enExample)
CN (1) CN110944998B (enExample)
AU (1) AU2018287787A1 (enExample)
BR (1) BR112019026955A2 (enExample)
CA (1) CA3066986A1 (enExample)
DK (1) DK3642202T3 (enExample)
ES (1) ES2937236T3 (enExample)
FI (1) FI3642202T3 (enExample)
HU (1) HUE060914T2 (enExample)
IL (1) IL271290B2 (enExample)
MX (1) MX2019015371A (enExample)
PL (1) PL3642202T3 (enExample)
PT (1) PT3642202T (enExample)
SG (1) SG11201913014YA (enExample)
TW (1) TWI680128B (enExample)
WO (1) WO2018234953A1 (enExample)

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CN114728964A (zh) * 2019-11-22 2022-07-08 豪夫迈·罗氏有限公司 吡咯烷衍生物
CN112174869B (zh) * 2020-10-12 2023-04-25 蔡霈 N-苯乙酰基-2-羟甲基吡咯烷-2-甲酰胺的制备方法及其药用用途
TW202432557A (zh) * 2022-10-28 2024-08-16 大陸商紐歐申醫藥（上海）有限公司 一種含氮雜環化合物、其藥學上可接受的鹽及其製備方法與應用
CN120641414A (zh) * 2022-12-16 2025-09-12 卡鲁娜治疗学有限公司 经取代的四氢吡咯并-吡啶酮化合物及其在治疗医学病状中的用途
JP2025541363A (ja) * 2022-12-16 2025-12-18 カルナ セラピューティクス，インコーポレイテッド 置換ジヒドロピロロ［３，４－ｄ］ピリミジン化合物及び医学的状態の治療におけるその使用
KR20250121123A (ko) 2022-12-16 2025-08-11 카루나 세러퓨틱스 인코포레이티드 치환된 테트라히드로피롤로-피리디논 화합물 및 의학적 병태를 치료하는 데 있어서의 이의 용도
KR20250114139A (ko) * 2022-12-16 2025-07-28 카루나 세러퓨틱스 인코포레이티드 치환된 테트라하이드로피롤로-피리디논 화합물 및 의학적 병태 치료에서의 이의 용도
EP4634194A1 (en) * 2022-12-16 2025-10-22 Karuna Therapeutics, Inc. Substituted dihydropyrrolo [3, 4-d] pyrimidine compounds and their use in treating medical conditions
WO2024260386A1 (zh) * 2023-06-20 2024-12-26 西藏海思科制药有限公司 毒蕈碱m4受体激动剂及其用途
WO2025055970A1 (zh) * 2023-09-15 2025-03-20 江苏恩华药业股份有限公司 氮杂环丁烷衍生物、其制备方法及其医药用途
WO2025083630A1 (en) 2023-10-19 2025-04-24 Suven Life Sciences Limited Heteroaromatic compounds as muscarinic m4 receptor positive allosteric modulators (m4 pams)
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WO2025103475A1 (zh) * 2023-11-17 2025-05-22 上海翰森生物医药科技有限公司 杂环羰基类衍生物调节剂、其制备方法和应用
WO2025122809A1 (en) * 2023-12-07 2025-06-12 Acadia Pharmaceuticals Inc. M4 positive allosteric modulators
WO2025131049A1 (en) * 2023-12-21 2025-06-26 Ignis Therapeutics (Suzhou) Limited Dihydro-pyrrolo-pyridine derivatives and uses thereof
WO2025134078A1 (en) 2023-12-22 2025-06-26 Suven Life Sciences Limited Organic compounds as muscarinic m4 receptor positive allosteric modulators (m4 pams)

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