FI3512955T3 - Muunneltuja glukosyylitransferaaseja - Google Patents
Muunneltuja glukosyylitransferaaseja Download PDFInfo
- Publication number
- FI3512955T3 FI3512955T3 FIEP17772809.4T FI17772809T FI3512955T3 FI 3512955 T3 FI3512955 T3 FI 3512955T3 FI 17772809 T FI17772809 T FI 17772809T FI 3512955 T3 FI3512955 T3 FI 3512955T3
- Authority
- FI
- Finland
- Prior art keywords
- amino acid
- seq
- seo
- residues
- residue
- Prior art date
Links
- 102000000340 Glucosyltransferases Human genes 0.000 title claims 28
- 108010055629 Glucosyltransferases Proteins 0.000 title claims 28
- 125000003275 alpha amino acid group Chemical group 0.000 claims 24
- 125000000539 amino acid group Chemical group 0.000 claims 19
- 238000006467 substitution reaction Methods 0.000 claims 19
- 229920000310 Alpha glucan Polymers 0.000 claims 9
- 230000003197 catalytic effect Effects 0.000 claims 5
- DXALOGXSFLZLLN-WTZPKTTFSA-N (3s,4s,5r)-1,3,4,6-tetrahydroxy-5-[(2r,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyhexan-2-one Chemical compound OCC(=O)[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O DXALOGXSFLZLLN-WTZPKTTFSA-N 0.000 claims 2
- JPFGFRMPGVDDGE-UHFFFAOYSA-N Leucrose Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)(CO)OC1 JPFGFRMPGVDDGE-UHFFFAOYSA-N 0.000 claims 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims 2
- 229930006000 Sucrose Natural products 0.000 claims 2
- 239000002773 nucleotide Substances 0.000 claims 2
- 125000003729 nucleotide group Chemical group 0.000 claims 2
- 230000001105 regulatory effect Effects 0.000 claims 2
- 239000005720 sucrose Substances 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 238000006116 polymerization reaction Methods 0.000 claims 1
- 239000002157 polynucleotide Substances 0.000 claims 1
- 102000040430 polynucleotide Human genes 0.000 claims 1
- 108091033319 polynucleotide Proteins 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
- C12N9/1051—Hexosyltransferases (2.4.1)
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
- C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/18—Preparation of compounds containing saccharide radicals produced by the action of a glycosyl transferase, e.g. alpha-, beta- or gamma-cyclodextrins
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Materials Engineering (AREA)
- Polymers & Plastics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662394354P | 2016-09-14 | 2016-09-14 | |
| PCT/US2017/051279 WO2018052942A1 (en) | 2016-09-14 | 2017-09-13 | Engineered glucosyltransferases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| FI3512955T3 true FI3512955T3 (fi) | 2023-07-18 |
Family
ID=59969237
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FIEP17772809.4T FI3512955T3 (fi) | 2016-09-14 | 2017-09-13 | Muunneltuja glukosyylitransferaaseja |
Country Status (9)
| Country | Link |
|---|---|
| US (4) | US10301604B2 (enExample) |
| EP (1) | EP3512955B1 (enExample) |
| JP (1) | JP7136783B2 (enExample) |
| CN (1) | CN109715818A (enExample) |
| AU (1) | AU2017326168B2 (enExample) |
| BR (1) | BR112019004213A2 (enExample) |
| CA (1) | CA3033369A1 (enExample) |
| FI (1) | FI3512955T3 (enExample) |
| WO (1) | WO2018052942A1 (enExample) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112019020201A2 (pt) | 2017-05-23 | 2020-06-30 | E. I. Du Pont De Nemours And Company | método de produção de alfa-1,3-glucano e composições |
| CN111344400B (zh) | 2017-09-13 | 2025-05-09 | 营养与生物科学美国4公司 | 工程化的葡糖基转移酶 |
| AU2018334514B2 (en) * | 2017-09-13 | 2025-01-30 | Nutrition & Biosciences USA 4, Inc. | Engineered glucosyltransferases |
| JP7343490B2 (ja) | 2017-10-13 | 2023-09-12 | ニュートリション・アンド・バイオサイエンシーズ・ユーエスエー・フォー，インコーポレイテッド | 流動性バルク粒状多糖 |
| US11098334B2 (en) | 2017-12-14 | 2021-08-24 | Nutrition & Biosciences USA 4, Inc. | Alpha-1,3-glucan graft copolymers |
| WO2019173580A1 (en) * | 2018-03-09 | 2019-09-12 | E. I. Du Pont De Nemours And Company | Engineered glucosyltransferases |
| WO2020009893A1 (en) * | 2018-07-05 | 2020-01-09 | Dupont Nutrition Biosciences Aps | Use of glucosyl transferase to provide improved texture in fermented milk based products |
| US11859022B2 (en) | 2018-10-25 | 2024-01-02 | Nutrition & Biosciences USA 4, Inc. | Alpha-1,3-glucan graft copolymers |
| WO2020131711A1 (en) | 2018-12-17 | 2020-06-25 | Dupont Industrial Biosciences Usa, Llc | Polysaccharide derivatives and compositions comprising same |
| WO2021007264A1 (en) * | 2019-07-09 | 2021-01-14 | Nutrition & Biosciences USA 4, Inc. | Engineered alpha-1,3 branching enzymes |
| EP4013241A1 (en) | 2019-08-16 | 2022-06-22 | Nutrition & Biosciences USA 4, Inc. | Flour- and meal-based food products comprising insoluble alpha-1,3-glucan |
| CA3159763A1 (en) | 2019-11-06 | 2021-05-14 | Nutrition & Biosciences USA 4, Inc. | Highly crystalline alpha-1,3-glucan |
| WO2021158543A1 (en) | 2020-02-04 | 2021-08-12 | Nutrition & Biosciences USA 4, Inc. | Aqueous dispersions of insoluble alpha-glucan comprising alpha-1,3 glycosidic linkages |
| CN116134054A (zh) | 2020-06-04 | 2023-05-16 | 营养与生物科学美国4公司 | 右旋糖酐-α-葡聚糖接枝共聚物及其衍生物 |
| CN116134055A (zh) | 2020-06-10 | 2023-05-16 | 营养与生物科学美国4公司 | 聚α-1,6-葡聚糖衍生物和包含其的组合物 |
| US20240199766A1 (en) | 2021-02-19 | 2024-06-20 | Nutrition & Biosciences USA 4, Inc. | Oxidized polysaccharide derivatives |
| CN117337308A (zh) | 2021-05-04 | 2024-01-02 | 营养与生物科学美国4公司 | 包含氧化的不溶性α-葡聚糖的组合物 |
| CN117242102A (zh) | 2021-05-04 | 2023-12-15 | 营养与生物科学美国4公司 | 包含不溶性α-葡聚糖的组合物 |
| JP2024525685A (ja) | 2021-07-13 | 2024-07-12 | ニュートリション・アンド・バイオサイエンシーズ・ユーエスエー・フォー，インコーポレイテッド | カチオン性グルカンエステル誘導体 |
| MX2024004006A (es) | 2021-09-30 | 2024-04-22 | Int N&H Denmark Aps | Metodo para reducir azucar en productos alimenticios. |
| WO2023081341A1 (en) | 2021-11-05 | 2023-05-11 | Nutrition & Biosciences USA 4, Inc. | Compositions comprising one cationic alpha- 1,6-glucan derivative and one alpha- 1,3-glucan |
| US20250092606A1 (en) | 2022-01-12 | 2025-03-20 | Nutrition & Biosciences USA 4, Inc. | Paper coating compositions comprising rubber and insoluble alpha-glucan |
| KR20240167661A (ko) | 2022-03-21 | 2024-11-27 | 뉴트리션 앤드 바이오사이언시스 유에스에이 4, 인크. | 불용성 알파-글루칸을 포함하는 조성물 |
| CN114717213B (zh) * | 2022-05-05 | 2023-09-22 | 广西科学院 | 一种葡聚糖蔗糖酶的n端截短突变酶及其制备方法 |
| JP2025523007A (ja) | 2022-07-11 | 2025-07-17 | ニュートリション・アンド・バイオサイエンシーズ・ユーエスエー・フォー，インコーポレイテッド | 両親媒性グルカンエステル誘導体 |
| AU2023365666A1 (en) | 2022-10-17 | 2025-03-27 | Danisco Us Inc. | Method for improving flavor in plant-based food stuff |
| EP4611720A1 (en) | 2022-11-02 | 2025-09-10 | Nutrition & Biosciences USA 4, Inc. | Compositions comprising xanthan gum and crystalline alpha-1,3-glucan |
| CN120957606A (zh) | 2023-03-29 | 2025-11-14 | 国际营养与健康丹麦有限公司 | 经由优选原位产生的α-葡聚糖改变食料质地的方法 |
| CN121398902A (zh) | 2023-06-30 | 2026-01-23 | 营养与生物科学美国第四公司 | 多孔α-1,3-葡聚糖组合物 |
| WO2025072416A1 (en) | 2023-09-29 | 2025-04-03 | Nutrition & Biosciences USA 4, Inc. | Polysaccharide derivatives |
| WO2025072417A1 (en) | 2023-09-29 | 2025-04-03 | Nutrition & Biosciences USA 4, Inc. | Polysaccharide derivatives |
| WO2025072419A1 (en) | 2023-09-29 | 2025-04-03 | Nutrition & Biosciences Usa 1, Llc | Crosslinked alpha-glucan derivatives |
| WO2025198996A1 (en) | 2024-03-19 | 2025-09-25 | Danisco Us Inc. | Method for improving flavor in foodstuff |
| WO2026015598A2 (en) | 2024-07-11 | 2026-01-15 | International N&H Denmark Aps | Method to provide improved texture and stable sucrose levels in foodstuff with glucosyltransferase |
| WO2026024663A1 (en) | 2024-07-24 | 2026-01-29 | Nutrition & Biosciences USA 4, Inc. | Compositions comprising alpha-glucan with alpha-1,3 glycosidic linkages |
| WO2026039397A1 (en) | 2024-08-13 | 2026-02-19 | Nutrition & Biosciences USA 4, Inc. | Alpha-glucan graft copolymer derivatives |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU4550897A (en) | 1996-10-11 | 1998-05-11 | Novo Nordisk A/S | Starch binding domains (sbds) for oral care products |
| US5952205A (en) | 1998-02-06 | 1999-09-14 | Neose Technologies, Inc. | Process for processing sucrose into glucose and fructose |
| JP2000175694A (ja) | 1998-12-17 | 2000-06-27 | Lion Corp | 酵素合成によるムタンの製造方法 |
| EP1165867B1 (en) | 1999-01-25 | 2004-04-14 | E.I. Du Pont De Nemours And Company | Polysaccharide fibers |
| US6867026B2 (en) | 2000-05-25 | 2005-03-15 | Nederlandse Organisatie Voor Toegepast Natuurwetenschappelijk Onderzoek Tno | Glucosyltransferases |
| JP3709435B2 (ja) * | 2001-10-03 | 2005-10-26 | 独立行政法人食品総合研究所 | 改変デキストランスクラーゼ、その遺伝子組み換え体、グルカンの製造法 |
| WO2003075845A2 (en) * | 2002-03-07 | 2003-09-18 | The Forsyth Institute | Immunogenicity of glucan binding protein |
| EP1530642B1 (en) | 2002-08-06 | 2009-12-30 | Danisco A/S | Use of lactobacillus to produce exopolysaccharides in food and pharmaceutical compositions |
| US7524645B2 (en) | 2004-12-14 | 2009-04-28 | Centre National De La Recherche Scientifique (Cnrs) | Fully active alternansucrases partially deleted in its carboxy-terminal and amino-terminal domains and mutants thereof |
| EP1679374A1 (en) | 2005-01-10 | 2006-07-12 | Bayer CropScience GmbH | Transformed plant expressing a mutansucrase and synthesizing a modified starch |
| FR2897069B1 (fr) | 2006-02-08 | 2012-06-08 | Centre Nat Rech Scient | Construction de nouveaux variants de l'enzyme dextrane-saccharase dsr-s par ingienerie moleculaire. |
| EP2100966A1 (en) | 2008-03-12 | 2009-09-16 | Institut Pasteur | Mutants of glycoside hydrolases and uses thereof for synthesizing complex oligosaccharides and disaccharide intermediates |
| JP5680860B2 (ja) * | 2009-01-30 | 2015-03-04 | サントリーホールディングス株式会社 | フラボノイド３位ガラクトース・グルコース転移酵素、及びそれをコードするポリヌクレオチド |
| JP2011206273A (ja) | 2010-03-30 | 2011-10-20 | Terumo Corp | 注射針組立体および薬剤注射装置 |
| US20130096511A1 (en) | 2010-05-04 | 2013-04-18 | Sanofi-Aventis Deutschland Gmbh | Tactile identification of drug filled cartridge |
| JP5015287B2 (ja) | 2010-05-11 | 2012-08-29 | シャープ株式会社 | 加熱調理器 |
| JP5851149B2 (ja) | 2011-08-08 | 2016-02-03 | 株式会社ニューフレアテクノロジー | 成膜装置および成膜方法 |
| US8642757B2 (en) | 2011-09-09 | 2014-02-04 | E I Du Pont De Nemours And Company | High titer production of highly linear poly (α 1,3 glucan) |
| US9080195B2 (en) | 2011-09-09 | 2015-07-14 | E I Du Pont De Nemours And Company | High titer production of poly (α 1,3 glucan) |
| CA2884950C (en) | 2012-09-25 | 2020-09-08 | E. I. Du Pont De Nemours And Company | Glucosyltransferase enzymes for production of glucan polymers |
| CN104968781A (zh) * | 2012-12-24 | 2015-10-07 | 诺维信公司 | 具有内切葡聚糖酶活性的多肽以及对其进行编码的多核苷酸 |
| US9169506B2 (en) | 2013-09-05 | 2015-10-27 | E I Du Pont De Nemours And Company | Process for producing alpha-1,3-glucan polymer with reduced molecular weight |
| US9644190B2 (en) | 2014-02-06 | 2017-05-09 | The United States Of America, As Represented By The Secretary Of Agriculture | Modified glucansucrase and related methods |
| US20150232785A1 (en) | 2014-02-14 | 2015-08-20 | E I Du Pont De Nemours And Company | Polysaccharides for viscosity modification |
| CN105980413B (zh) | 2014-02-14 | 2020-11-10 | 纳幕尔杜邦公司 | 用于制备葡聚糖聚合物的葡糖基转移酶 |
| WO2015183726A1 (en) | 2014-05-29 | 2015-12-03 | E. I. Du Pont De Nemours And Company | Enzymatic synthesis of soluble glucan fiber |
| WO2015183722A1 (en) | 2014-05-29 | 2015-12-03 | E. I. Du Pont De Nemours And Company | Enzymatic synthesis of soluble glucan fiber |
| WO2015183729A1 (en) | 2014-05-29 | 2015-12-03 | E. I. Du Pont De Nemours And Company | Enzymatic synthesis of soluble glucan fiber |
| EP3149185A1 (en) | 2014-05-29 | 2017-04-05 | E. I. du Pont de Nemours and Company | Enzymatic synthesis of soluble glucan fiber |
| EP3149186A1 (en) | 2014-05-29 | 2017-04-05 | E. I. du Pont de Nemours and Company | Enzymatic synthesis of soluble glucan fiber |
| WO2015183714A1 (en) | 2014-05-29 | 2015-12-03 | E. I. Du Pont De Nemours And Company | Enzymatic synthesis of soluble glucan fiber |
| AU2015342990B2 (en) | 2014-11-05 | 2019-08-29 | Nutrition & Biosciences USA 4, Inc. | Enzymatically polymerized gelling dextrans |
| JP2018518179A (ja) | 2015-06-17 | 2018-07-12 | イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニーＥ．Ｉ．Ｄｕ Ｐｏｎｔ Ｄｅ Ｎｅｍｏｕｒｓ Ａｎｄ Ｃｏｍｐａｎｙ | 直鎖状ポリα−１，３−グルカンを生成するためのグルコシルトランスフェラーゼアミノ酸配列モチーフ |
-
2017
- 2017-09-13 US US15/702,893 patent/US10301604B2/en active Active
- 2017-09-13 FI FIEP17772809.4T patent/FI3512955T3/fi active
- 2017-09-13 EP EP17772809.4A patent/EP3512955B1/en active Active
- 2017-09-13 CA CA3033369A patent/CA3033369A1/en not_active Abandoned
- 2017-09-13 BR BR112019004213A patent/BR112019004213A2/pt not_active IP Right Cessation
- 2017-09-13 AU AU2017326168A patent/AU2017326168B2/en active Active
- 2017-09-13 CN CN201780055064.3A patent/CN109715818A/zh active Pending
- 2017-09-13 WO PCT/US2017/051279 patent/WO2018052942A1/en not_active Ceased
- 2017-09-13 JP JP2019535206A patent/JP7136783B2/ja active Active
-
2019
- 2019-04-11 US US16/381,010 patent/US11028373B2/en active Active
-
2021
- 2021-06-04 US US17/338,842 patent/US11952598B2/en active Active
-
2024
- 2024-04-05 US US18/628,140 patent/US12378535B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP3512955B1 (en) | 2023-04-19 |
| US12378535B2 (en) | 2025-08-05 |
| CA3033369A1 (en) | 2018-03-22 |
| CN109715818A (zh) | 2019-05-03 |
| US10301604B2 (en) | 2019-05-28 |
| US11028373B2 (en) | 2021-06-08 |
| BR112019004213A2 (pt) | 2019-06-25 |
| JP2019530474A (ja) | 2019-10-24 |
| JP7136783B2 (ja) | 2022-09-13 |
| EP3512955A1 (en) | 2019-07-24 |
| AU2017326168A1 (en) | 2019-02-21 |
| US20240417702A1 (en) | 2024-12-19 |
| US20180072998A1 (en) | 2018-03-15 |
| US11952598B2 (en) | 2024-04-09 |
| WO2018052942A1 (en) | 2018-03-22 |
| US20190292528A1 (en) | 2019-09-26 |
| US20210395705A1 (en) | 2021-12-23 |
| AU2017326168B2 (en) | 2022-02-24 |
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