FI3408292T3 - Jaettuja inteiinejä, joilla on poikkeuksellinen silmukoitumisaktiivisuus - Google Patents
Jaettuja inteiinejä, joilla on poikkeuksellinen silmukoitumisaktiivisuus Download PDFInfo
- Publication number
- FI3408292T3 FI3408292T3 FIEP17745022.8T FI17745022T FI3408292T3 FI 3408292 T3 FI3408292 T3 FI 3408292T3 FI 17745022 T FI17745022 T FI 17745022T FI 3408292 T3 FI3408292 T3 FI 3408292T3
- Authority
- FI
- Finland
- Prior art keywords
- intein
- fragment
- split intein
- compound
- fragment according
- Prior art date
Links
- 230000017730 intein-mediated protein splicing Effects 0.000 title claims 38
- 239000012634 fragment Substances 0.000 claims 30
- 150000001875 compounds Chemical class 0.000 claims 13
- 108090000765 processed proteins & peptides Proteins 0.000 claims 10
- 239000002773 nucleotide Substances 0.000 claims 8
- 125000003729 nucleotide group Chemical group 0.000 claims 8
- 125000003275 alpha amino acid group Chemical group 0.000 claims 7
- 108091034117 Oligonucleotide Proteins 0.000 claims 4
- 231100000433 cytotoxic Toxicity 0.000 claims 4
- 230000001472 cytotoxic effect Effects 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- 229940079593 drug Drugs 0.000 claims 4
- 229920001184 polypeptide Polymers 0.000 claims 4
- 102000004196 processed proteins & peptides Human genes 0.000 claims 4
- 239000000412 dendrimer Substances 0.000 claims 3
- 229920000736 dendritic polymer Polymers 0.000 claims 3
- 108090000623 proteins and genes Proteins 0.000 claims 3
- 230000004927 fusion Effects 0.000 claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- 239000012038 nucleophile Substances 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 150000000179 1,2-aminoalcohols Chemical class 0.000 claims 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- 239000003153 chemical reaction reagent Substances 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- GNBHRKFJIUUOQI-UHFFFAOYSA-N fluorescein Chemical class O1C(=O)C2=CC=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 GNBHRKFJIUUOQI-UHFFFAOYSA-N 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 150000002431 hydrogen Chemical class 0.000 claims 1
- 230000000269 nucleophilic effect Effects 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 239000013612 plasmid Substances 0.000 claims 1
- 108091033319 polynucleotide Proteins 0.000 claims 1
- 239000002157 polynucleotide Substances 0.000 claims 1
- 102000040430 polynucleotide Human genes 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 239000011593 sulfur Substances 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/93—Ligases (6)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/32—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bacillus (G)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2851—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
- C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/90—Fusion polypeptide containing a motif for post-translational modification
- C07K2319/92—Fusion polypeptide containing a motif for post-translational modification containing an intein ("protein splicing")domain
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- General Chemical & Material Sciences (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662288661P | 2016-01-29 | 2016-01-29 | |
| PCT/US2017/015455 WO2017132580A2 (en) | 2016-01-29 | 2017-01-27 | Split inteins with exceptional splicing activity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| FI3408292T3 true FI3408292T3 (fi) | 2023-06-30 |
Family
ID=59398921
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FIEP17745022.8T FI3408292T3 (fi) | 2016-01-29 | 2017-01-27 | Jaettuja inteiinejä, joilla on poikkeuksellinen silmukoitumisaktiivisuus |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US11142550B2 (enExample) |
| EP (2) | EP3408292B1 (enExample) |
| JP (1) | JP7290305B2 (enExample) |
| CN (1) | CN108884154A (enExample) |
| AU (1) | AU2017211395B2 (enExample) |
| CA (1) | CA3051195A1 (enExample) |
| DK (1) | DK3408292T3 (enExample) |
| ES (1) | ES2949163T3 (enExample) |
| FI (1) | FI3408292T3 (enExample) |
| HU (1) | HUE062276T2 (enExample) |
| PL (1) | PL3408292T3 (enExample) |
| PT (1) | PT3408292T (enExample) |
| SI (1) | SI3408292T1 (enExample) |
| WO (1) | WO2017132580A2 (enExample) |
Families Citing this family (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2734621B1 (en) | 2011-07-22 | 2019-09-04 | President and Fellows of Harvard College | Evaluation and improvement of nuclease cleavage specificity |
| EP2986635B1 (en) | 2013-04-18 | 2018-10-03 | Fondazione Telethon | Effective delivery of large genes by dual aav vectors |
| US20150044192A1 (en) | 2013-08-09 | 2015-02-12 | President And Fellows Of Harvard College | Methods for identifying a target site of a cas9 nuclease |
| US9359599B2 (en) | 2013-08-22 | 2016-06-07 | President And Fellows Of Harvard College | Engineered transcription activator-like effector (TALE) domains and uses thereof |
| US9340800B2 (en) | 2013-09-06 | 2016-05-17 | President And Fellows Of Harvard College | Extended DNA-sensing GRNAS |
| US9526784B2 (en) | 2013-09-06 | 2016-12-27 | President And Fellows Of Harvard College | Delivery system for functional nucleases |
| US9840699B2 (en) | 2013-12-12 | 2017-12-12 | President And Fellows Of Harvard College | Methods for nucleic acid editing |
| WO2016022363A2 (en) | 2014-07-30 | 2016-02-11 | President And Fellows Of Harvard College | Cas9 proteins including ligand-dependent inteins |
| WO2017011550A1 (en) | 2015-07-13 | 2017-01-19 | University Of Utah Research Foundation | Methods of making red blood cells and platelets in vitro and uses thereof |
| IL258821B (en) | 2015-10-23 | 2022-07-01 | Harvard College | Nucleobase editors and their uses |
| PL3408292T3 (pl) * | 2016-01-29 | 2023-10-02 | The Trustees Of Princeton University | Podzielone inteiny o wyjątkowej aktywności splicingu |
| KR20250103795A (ko) | 2016-08-03 | 2025-07-07 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 아데노신 핵염기 편집제 및 그의 용도 |
| CA3033327A1 (en) | 2016-08-09 | 2018-02-15 | President And Fellows Of Harvard College | Programmable cas9-recombinase fusion proteins and uses thereof |
| WO2018039438A1 (en) | 2016-08-24 | 2018-03-01 | President And Fellows Of Harvard College | Incorporation of unnatural amino acids into proteins using base editing |
| JP7588390B2 (ja) | 2016-10-14 | 2024-11-22 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 核酸塩基エディターのａａｖ送達 |
| WO2018119359A1 (en) | 2016-12-23 | 2018-06-28 | President And Fellows Of Harvard College | Editing of ccr5 receptor gene to protect against hiv infection |
| CN110662556A (zh) | 2017-03-09 | 2020-01-07 | 哈佛大学的校长及成员们 | 癌症疫苗 |
| WO2018165504A1 (en) | 2017-03-09 | 2018-09-13 | President And Fellows Of Harvard College | Suppression of pain by gene editing |
| JP2020510439A (ja) | 2017-03-10 | 2020-04-09 | プレジデント アンド フェローズ オブ ハーバード カレッジ | シトシンからグアニンへの塩基編集因子 |
| BR112019019655A2 (pt) | 2017-03-23 | 2020-04-22 | Harvard College | editores de nucleobase que compreendem proteínas de ligação a dna programáveis por ácido nucleico |
| WO2018209320A1 (en) | 2017-05-12 | 2018-11-15 | President And Fellows Of Harvard College | Aptazyme-embedded guide rnas for use with crispr-cas9 in genome editing and transcriptional activation |
| JP2020534795A (ja) | 2017-07-28 | 2020-12-03 | プレジデント アンド フェローズ オブ ハーバード カレッジ | ファージによって支援される連続的進化（ｐａｃｅ）を用いて塩基編集因子を進化させるための方法および組成物 |
| US11319532B2 (en) | 2017-08-30 | 2022-05-03 | President And Fellows Of Harvard College | High efficiency base editors comprising Gam |
| KR20250107288A (ko) | 2017-10-16 | 2025-07-11 | 더 브로드 인스티튜트, 인코퍼레이티드 | 아데노신 염기 편집제의 용도 |
| WO2019118949A1 (en) | 2017-12-15 | 2019-06-20 | The Broad Institute, Inc. | Systems and methods for predicting repair outcomes in genetic engineering |
| WO2019226953A1 (en) | 2018-05-23 | 2019-11-28 | The Broad Institute, Inc. | Base editors and uses thereof |
| KR102894715B1 (ko) | 2018-08-03 | 2025-12-03 | 빔 테라퓨틱스, 인크. | 핵산 표적 서열을 변형시키기 위한 다중-이펙터 핵염기 편집기 및 이를 이용하는 방법 |
| US11530245B2 (en) * | 2018-08-31 | 2022-12-20 | Washington University | Split intein mediated polymerization and production of mussel foot adhesive protein materials |
| WO2020051562A2 (en) | 2018-09-07 | 2020-03-12 | Beam Therapeutics Inc. | Compositions and methods for improving base editing |
| IL320368A (en) * | 2018-10-15 | 2025-06-01 | Fond Telethon Ets | Intein proteins and their uses |
| WO2020092453A1 (en) | 2018-10-29 | 2020-05-07 | The Broad Institute, Inc. | Nucleobase editors comprising geocas9 and uses thereof |
| US12351837B2 (en) | 2019-01-23 | 2025-07-08 | The Broad Institute, Inc. | Supernegatively charged proteins and uses thereof |
| LU101118B1 (en) * | 2019-02-06 | 2020-08-06 | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) | Method for detecting a specific splice event of a gene of interest |
| EP3942042A1 (en) | 2019-03-19 | 2022-01-26 | The Broad Institute, Inc. | Methods and compositions for editing nucleotide sequences |
| EP3956349A1 (en) | 2019-04-17 | 2022-02-23 | The Broad Institute, Inc. | Adenine base editors with reduced off-target effects |
| CN110714020B (zh) * | 2019-05-22 | 2021-08-03 | 北京理工大学 | 一种高效简便纯化蛋白的方法 |
| WO2021016075A1 (en) | 2019-07-19 | 2021-01-28 | Flagship Pioneering Innovations Vi, Llc | Recombinase compositions and methods of use |
| WO2021040703A1 (en) * | 2019-08-28 | 2021-03-04 | The Trustees Of Princeton University | Atypical split inteins and uses thereof |
| WO2021047559A1 (zh) * | 2019-09-09 | 2021-03-18 | 武汉友芝友生物制药有限公司 | 一种断裂型内含肽、使用其的重组多肽的制备方法 |
| KR20220070481A (ko) * | 2019-10-01 | 2022-05-31 | 유타대학연구재단 | 순환 종양 세포를 표적화하기 위한 혈소판 조작 방법 |
| US12435330B2 (en) | 2019-10-10 | 2025-10-07 | The Broad Institute, Inc. | Methods and compositions for prime editing RNA |
| GB201917046D0 (en) * | 2019-11-22 | 2020-01-08 | Ge Healthcare Bioprocess R&D Ab | Improved protein production |
| MX2022010991A (es) | 2020-03-04 | 2023-02-09 | Flagship Pioneering Innovations Vi Llc | Metodos y composiciones para modular un genoma. |
| CN111235174A (zh) * | 2020-03-11 | 2020-06-05 | 梦芊科技知识产权有限公司 | 利用枯草芽孢杆菌和核酸内切酶制备人碱性成纤维细胞生长因子 |
| EP3885440A1 (en) * | 2020-03-26 | 2021-09-29 | Splicebio, S.L. | Split inteins and their uses |
| WO2021226558A1 (en) | 2020-05-08 | 2021-11-11 | The Broad Institute, Inc. | Methods and compositions for simultaneous editing of both strands of a target double-stranded nucleotide sequence |
| US20230227508A1 (en) | 2020-06-12 | 2023-07-20 | Massachusetts Institute Of Technology | Split intein-based selection for peptide binders |
| US20250282815A1 (en) * | 2021-05-12 | 2025-09-11 | Cytiva Bioprocess R&D Ab | Improved protein purification |
| CN113735941B (zh) * | 2021-08-13 | 2024-01-30 | 江南大学 | 一种蛋白纯化方法及其应用 |
| KR102663243B1 (ko) * | 2021-08-30 | 2024-05-03 | 국립순천대학교산학협력단 | 트립신 특이적 형광 프로브 및 이의 용도 |
| JP2024533311A (ja) | 2021-09-08 | 2024-09-12 | フラッグシップ パイオニアリング イノベーションズ シックス，エルエルシー | ゲノムを調節するための方法及び組成物 |
| WO2023081714A1 (en) * | 2021-11-02 | 2023-05-11 | Cornell University | Intein systems and uses thereof |
| CN119630796A (zh) * | 2022-05-26 | 2025-03-14 | 国立大学法人山形大学 | 异二聚体蛋白质的制造方法、二聚体蛋白质、单体蛋白质，以及靶标反应性异二聚体蛋白质的筛选方法 |
| EP4594486A2 (en) * | 2022-09-26 | 2025-08-06 | Beam Therapeutics Inc. | Synthetic polypeptides and uses thereof |
| WO2024097763A1 (en) * | 2022-11-01 | 2024-05-10 | Memorial Sloan-Kettering Cancer Center | Intein-based sorting system and modular chimeric polypeptides |
| WO2024170051A1 (en) * | 2023-02-13 | 2024-08-22 | Kutzner Christoph | Fusion polypeptides for manufacturing of cyclic peptides |
| WO2024258785A1 (en) | 2023-06-11 | 2024-12-19 | Regeneron Pharmaceuticals, Inc. | Circularized antibody molecules |
| WO2025051758A1 (en) | 2023-09-04 | 2025-03-13 | Splicebio, Sl | Use of split intein for the treatment of scn1a associated disease |
| WO2025153705A1 (en) | 2024-01-18 | 2025-07-24 | Splicebio, Sl | Use of split intein for the treatment of myo7a-associated disease |
| WO2025194124A1 (en) | 2024-03-14 | 2025-09-18 | Tessera Therapeutics, Inc. | Modified st1cas9 guide nucleic acids |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2618632T3 (es) * | 2011-09-28 | 2017-06-21 | Zera Intein Protein Solutions, S.L. | Inteínas divididas y usos de éstas |
| JP2015522020A (ja) | 2012-06-27 | 2015-08-03 | ザ・トラスティーズ・オブ・プリンストン・ユニバーシティＴｈｅ Ｔｒｕｓｔｅｅｓ Ｏｆ Ｐｒｉｎｃｅｔｏｎ Ｕｎｉｖｅｒｓｉｔｙ | スプリットインテイン、複合体およびそれらの使用 |
| US10087213B2 (en) * | 2013-01-11 | 2018-10-02 | The Texas A&M University System | Intein mediated purification of protein |
| PL3408292T3 (pl) * | 2016-01-29 | 2023-10-02 | The Trustees Of Princeton University | Podzielone inteiny o wyjątkowej aktywności splicingu |
-
2017
- 2017-01-27 PL PL17745022.8T patent/PL3408292T3/pl unknown
- 2017-01-27 CN CN201780021267.0A patent/CN108884154A/zh active Pending
- 2017-01-27 EP EP17745022.8A patent/EP3408292B1/en active Active
- 2017-01-27 WO PCT/US2017/015455 patent/WO2017132580A2/en not_active Ceased
- 2017-01-27 DK DK17745022.8T patent/DK3408292T3/da active
- 2017-01-27 AU AU2017211395A patent/AU2017211395B2/en active Active
- 2017-01-27 FI FIEP17745022.8T patent/FI3408292T3/fi active
- 2017-01-27 JP JP2018539361A patent/JP7290305B2/ja active Active
- 2017-01-27 HU HUE17745022A patent/HUE062276T2/hu unknown
- 2017-01-27 SI SI201731373T patent/SI3408292T1/sl unknown
- 2017-01-27 CA CA3051195A patent/CA3051195A1/en active Pending
- 2017-01-27 ES ES17745022T patent/ES2949163T3/es active Active
- 2017-01-27 EP EP23168286.5A patent/EP4234689A3/en active Pending
- 2017-01-27 PT PT177450228T patent/PT3408292T/pt unknown
- 2017-01-27 US US16/073,602 patent/US11142550B2/en active Active
-
2021
- 2021-06-30 US US17/363,698 patent/US12297472B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP3408292A4 (en) | 2019-09-18 |
| CA3051195A1 (en) | 2017-08-03 |
| JP2019506163A (ja) | 2019-03-07 |
| PL3408292T3 (pl) | 2023-10-02 |
| EP4234689A2 (en) | 2023-08-30 |
| US20210371467A1 (en) | 2021-12-02 |
| AU2017211395B2 (en) | 2024-04-18 |
| DK3408292T3 (da) | 2023-06-12 |
| EP3408292A2 (en) | 2018-12-05 |
| WO2017132580A3 (en) | 2017-09-14 |
| SI3408292T1 (sl) | 2023-09-29 |
| EP3408292B1 (en) | 2023-04-26 |
| EP4234689A3 (en) | 2023-09-13 |
| CN108884154A (zh) | 2018-11-23 |
| JP7290305B2 (ja) | 2023-06-13 |
| US11142550B2 (en) | 2021-10-12 |
| HUE062276T2 (hu) | 2023-10-28 |
| PT3408292T (pt) | 2023-07-19 |
| US12297472B2 (en) | 2025-05-13 |
| US20200055900A1 (en) | 2020-02-20 |
| WO2017132580A2 (en) | 2017-08-03 |
| ES2949163T3 (es) | 2023-09-26 |
| AU2017211395A1 (en) | 2018-09-06 |
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