FI2970868T3 - Menetelmä metaboliitin tuotannon säätelemiseksi mikrobifermentaatiossa - Google Patents

Menetelmä metaboliitin tuotannon säätelemiseksi mikrobifermentaatiossa Download PDF

Info

Publication number
FI2970868T3
FI2970868T3 FIEP14768693.5T FI14768693T FI2970868T3 FI 2970868 T3 FI2970868 T3 FI 2970868T3 FI 14768693 T FI14768693 T FI 14768693T FI 2970868 T3 FI2970868 T3 FI 2970868T3
Authority
FI
Finland
Prior art keywords
dissolved
amount
bioreactor
pyruvate
derived
Prior art date
Application number
FIEP14768693.5T
Other languages
English (en)
Finnish (fi)
Inventor
Sean Simpson
Michael Koepke
Kathleen Smart
Loan Tran
Paul Sechrist
Original Assignee
Lanzatech Nz Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lanzatech Nz Inc filed Critical Lanzatech Nz Inc
Application granted granted Critical
Publication of FI2970868T3 publication Critical patent/FI2970868T3/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C12P7/18—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic polyhydric
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/38—Chemical stimulation of growth or activity by addition of chemical compounds which are not essential growth factors; Stimulation of growth by removal of a chemical compound
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C12P7/06—Ethanol, i.e. non-beverage
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C12P7/16—Butanols
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/24—Preparation of oxygen-containing organic compounds containing a carbonyl group
    • C12P7/26—Ketones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/44—Polycarboxylic acids
    • C12P7/46—Dicarboxylic acids having four or less carbon atoms, e.g. fumaric acid, maleic acid
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/56—Lactic acid
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/30—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
    • C12M41/34—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of gas
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/145—Clostridium
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E50/00—Technologies for the production of fuel of non-fossil origin
    • Y02E50/10—Biofuels, e.g. bio-diesel
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E50/00—Technologies for the production of fuel of non-fossil origin
    • Y02E50/30—Fuel from waste, e.g. synthetic alcohol or diesel

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Processing Of Solid Wastes (AREA)
  • Mycology (AREA)
FIEP14768693.5T 2013-03-15 2014-03-12 Menetelmä metaboliitin tuotannon säätelemiseksi mikrobifermentaatiossa FI2970868T3 (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361791065P 2013-03-15 2013-03-15
PCT/US2014/025128 WO2014151158A1 (en) 2013-03-15 2014-03-12 A system and method for controlling metabolite production in a microbial fermentation

Publications (1)

Publication Number Publication Date
FI2970868T3 true FI2970868T3 (fi) 2024-11-29

Family

ID=51528790

Family Applications (1)

Application Number Title Priority Date Filing Date
FIEP14768693.5T FI2970868T3 (fi) 2013-03-15 2014-03-12 Menetelmä metaboliitin tuotannon säätelemiseksi mikrobifermentaatiossa

Country Status (15)

Country Link
US (2) US20140273115A1 (https=)
EP (2) EP4424833A3 (https=)
JP (4) JP6813354B2 (https=)
KR (1) KR102157256B1 (https=)
CN (1) CN105051178B (https=)
BR (2) BR122022024140B1 (https=)
CA (1) CA2903462C (https=)
DK (1) DK2970868T3 (https=)
EA (1) EA033028B1 (https=)
ES (1) ES2998491T3 (https=)
FI (1) FI2970868T3 (https=)
MY (3) MY194094A (https=)
SG (1) SG11201507071YA (https=)
WO (1) WO2014151158A1 (https=)
ZA (1) ZA201506621B (https=)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10113194B2 (en) * 2014-10-22 2018-10-30 Lanzatech New Zealand Limited Gas testing unit and method
FI3209786T3 (fi) * 2014-10-22 2023-06-13 Lanzatech Nz Inc Monivaiheisia bioreaktoriprosesseja
US9873859B2 (en) * 2015-08-20 2018-01-23 H R D Corporation Microorganism growth and products recovery
GB201601558D0 (en) * 2016-01-28 2016-03-16 Verdant Bioproducts Ltd Method for producing 3-hydroxypropionamide
WO2017155478A1 (en) * 2016-03-09 2017-09-14 Ptt Public Company Limited Method for producing biochemicals from co2 fermentation
WO2017200884A1 (en) * 2016-05-14 2017-11-23 Lanzatech, Inc. Microorganism with modified aldehyde:ferredoxin oxidoreductase activity and related methods
AU2017330155B2 (en) * 2016-09-26 2022-02-03 Sk Innovation Co., Ltd. Process of converting carbon dioxide using combination of carbon dioxide mineralization process and metabolism of sulfur-oxidizing microorganisms
WO2020245197A1 (en) * 2019-06-07 2020-12-10 Unibio A/S Method for optimizing a fermentation process
KR102273179B1 (ko) * 2019-09-04 2021-07-02 한국해양과학기술원 클로스트리디움 속 신균주 awrp 및 이를 이용한 바이오 알코올의 선택적 생산방법
KR102443037B1 (ko) * 2020-10-23 2022-09-14 한국과학기술연구원 에탄올을 포함하는 합성 가스로부터 2,3-부탄디올 제조용 배지 조성물 및 이를 이용한 2,3-부탄디올 생산 방법
CN112746008B (zh) * 2021-02-05 2024-04-05 清华大学 含一氧化碳原料气发酵制含氧有机物的发酵反应器及方法
CN117280040A (zh) * 2021-04-09 2023-12-22 朗泽科技有限公司 控制气体发酵平台以提高二氧化碳转化为产物的方法
JP2025504620A (ja) * 2022-02-01 2025-02-13 コリピ・ゲーエムベーハー バイオ生成物のバイオテクノロジー的製造のためのプロセス
CN115814592A (zh) * 2022-12-19 2023-03-21 河北首朗新能源科技有限公司 一种提高工业尾气发酵利用率的方法和系统

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4533211A (en) 1983-01-31 1985-08-06 International Business Machines Corporation Frequency multiplexed optical spatial filter based upon photochemical hole burning
US5173429A (en) 1990-11-09 1992-12-22 The Board Of Trustees Of The University Of Arkansas Clostridiumm ljungdahlii, an anaerobic ethanol and acetate producing microorganism
US5593886A (en) 1992-10-30 1997-01-14 Gaddy; James L. Clostridium stain which produces acetic acid from waste gases
US6136577A (en) 1992-10-30 2000-10-24 Bioengineering Resources, Inc. Biological production of ethanol from waste gases with Clostridium ljungdahlii
US5821111A (en) 1994-03-31 1998-10-13 Bioengineering Resources, Inc. Bioconversion of waste biomass to useful products
US5807722A (en) 1992-10-30 1998-09-15 Bioengineering Resources, Inc. Biological production of acetic acid from waste gases with Clostridium ljungdahlii
KR100387301B1 (ko) 1996-07-01 2003-06-12 바이오 엔지니어링 리소스 인코포레이티드 폐가스로부터의 생성물의 생물학적 제조방법
UA72220C2 (uk) 1998-09-08 2005-02-15 Байоенджініерінг Рісорсиз, Інк. Незмішувана з водою суміш розчинник/співрозчинник для екстрагування оцтової кислоти, спосіб одержання оцтової кислоти (варіанти), спосіб анаеробного мікробного бродіння для одержання оцтової кислоти (варіанти), модифікований розчинник та спосіб його одержання
WO2000068407A1 (en) 1999-05-07 2000-11-16 Bioengineering Resources, Inc. Clostridium strains which produce ethanol from substrate-containing gases
WO2002008438A2 (en) * 2000-07-25 2002-01-31 Bioengineering Resources, Inc. Methods for increasing the production of ethanol from microbial fermentation
US7078201B2 (en) 2004-12-01 2006-07-18 Burmaster Brian M Ethanol fermentation using oxidation reduction potential
NZ546496A (en) 2006-04-07 2008-09-26 Lanzatech New Zealand Ltd Gas treatment process
US7704723B2 (en) 2006-08-31 2010-04-27 The Board Of Regents For Oklahoma State University Isolation and characterization of novel clostridial species
NZ553984A (en) 2007-03-19 2009-07-31 Lanzatech New Zealand Ltd Alcohol production process
US7923227B2 (en) * 2007-06-08 2011-04-12 Coskata, Inc. Method of conversion of syngas using microorganism on hydrophilic membrane
CN102016052B (zh) 2007-08-15 2015-04-29 朗泽科技新西兰有限公司 生产醇的工艺
JP5600296B2 (ja) * 2007-11-13 2014-10-01 ランザテク・ニュージーランド・リミテッド 新規細菌及びその使用法
EA019266B1 (ru) * 2008-03-12 2014-02-28 Ланзатек Нью Зиленд Лимитед Микробиологический способ производства спирта
CN102317463B (zh) * 2008-06-09 2014-12-03 蓝瑟科技纽西兰有限公司 厌氧微生物发酵生产丁二醇
WO2010064933A1 (en) 2008-12-01 2010-06-10 Lanzatech New Zealand Limited Optimised fermentation media
DE102009002583A1 (de) * 2009-04-23 2010-10-28 Evonik Degussa Gmbh Zellen und Verfahren zur Herstellung von Aceton
NZ598279A (en) * 2009-09-06 2012-12-21 Lanzatech New Zealand Ltd Improved fermentation of gaseous substrates
WO2011112103A1 (en) * 2010-03-10 2011-09-15 Lanzatech New Zealand Limited Acid production by fermentation
US8143037B2 (en) 2010-03-19 2012-03-27 Coskata, Inc. Ethanologenic Clostridium species, Clostridium coskatii
CA2836686C (en) * 2010-10-22 2015-11-17 Lanzatech New Zealand Limited Methods and systems for the production of alcohols and/or acids
AU2011349523B2 (en) * 2010-12-20 2014-07-17 Lanzatech Nz, Inc. A fermentation method
US20110256600A1 (en) * 2011-02-02 2011-10-20 Lanzatech New Zealand Limited Recombinant Microorganisms and Methods of Use Thereof
CN103582703A (zh) * 2011-03-31 2014-02-12 新西兰郎泽科技公司 一种用于控制丁二醇生产的发酵方法

Also Published As

Publication number Publication date
EA201591547A1 (ru) 2016-01-29
JP2019122387A (ja) 2019-07-25
JP2016511009A (ja) 2016-04-14
MY194095A (en) 2022-11-11
EA033028B1 (ru) 2019-08-30
SG11201507071YA (en) 2015-10-29
CA2903462A1 (en) 2014-09-25
JP2022160489A (ja) 2022-10-19
EP4424833A3 (en) 2025-09-24
BR122022024140B1 (pt) 2023-05-16
CN105051178A (zh) 2015-11-11
US20140273115A1 (en) 2014-09-18
EP4424833A2 (en) 2024-09-04
CA2903462C (en) 2016-11-01
KR102157256B1 (ko) 2020-09-18
KR20150128730A (ko) 2015-11-18
DK2970868T3 (da) 2024-12-02
US20170342446A1 (en) 2017-11-30
JP6813354B2 (ja) 2021-01-13
WO2014151158A1 (en) 2014-09-25
JP7110283B2 (ja) 2022-08-01
EP2970868A1 (en) 2016-01-20
JP2020195383A (ja) 2020-12-10
EP2970868A4 (en) 2016-09-28
CN105051178B (zh) 2018-08-03
MY194094A (en) 2022-11-11
EP2970868B1 (en) 2024-09-04
BR112015022736B1 (pt) 2023-02-23
MY183766A (en) 2021-03-12
WO2014151158A9 (en) 2015-02-26
ES2998491T3 (en) 2025-02-20
BR112015022736A2 (https=) 2017-08-22
ZA201506621B (en) 2017-03-26

Similar Documents

Publication Publication Date Title
FI2970868T3 (fi) Menetelmä metaboliitin tuotannon säätelemiseksi mikrobifermentaatiossa
WO2008055200A3 (en) Model predictive control of a fermentation feed in biofuel production
Kantzow et al. Effects of hydrogen partial pressure on autotrophic growth and product formation of Acetobacterium woodii
JP2016524927A5 (https=)
Zeng et al. Biosynthesis of keto acids by fed-batch culture of Yarrowia lipolytica WSH-Z06
Fan et al. Kinetic model of continuous ethanol fermentation in closed-circulating process with pervaporation membrane bioreactor by Saccharomyces cerevisiae
JP2011522563A5 (https=)
NZ594329A (en) Microbial alcohol fermentation production process wherein the substrate supply is regulated by the amount of CO converted to CO2
WO2010048421A3 (en) Process to sequence bioreactor modules for serial gas flow and uniform gas velocity
WO2012177619A3 (en) Microorganisms for producing 1,3-butanediol and methods related thereto
WO2010016943A3 (en) Nutrient monitoring and feedback control for increased bioproduct production
WO2012024522A3 (en) A process for producing chemicals using microbial fermentation of substrates comprising carbon monoxide
NZ589632A (en) Production of butanediol by anaerobic microbial fermentation
Qi et al. A protocol for optimization vinegar fermentation according to the ratio of oxygen consumption versus acid yield
Yan et al. Fermentation process for continuous production of succinic acid in a fibrous bed bioreactor
EA201891857A1 (ru) Способ регулирования концентрации этанола во время ферментации синтез-газа
NZ611186A (en) Fermentation process involving adjusting specific co-uptake
Chan et al. Process optimization on micro-aeration supply for high production yield of 2, 3-butanediol from maltodextrin by metabolically-engineered Klebsiella oxytoca
Zhang et al. Improving lactic acid production via bio-augmentation with acid-tolerant isolates from source-sorted organic household waste
Mariano et al. Optimisation of a continuous flash fermentation for butanol production using the response surface methodology
Thangprompan et al. Production of ethanol from sweet sorghum juice using VHG technology: a simulation case study
Chan et al. Using a combined oxygen‐supply and substrate‐feeding strategy to improve 2, 3‐butanediol production by metabolically engineered Klebsiella oxytoca KMS005
Liu et al. Ageing vessel configuration for continuous redox potential-controlled very-high-gravity fermentation
Velazquez-Sanchez et al. Modelling of the pH dynamic and its effect over the Isopropanol-Butanol-Ethanol fermentation by Clostridium acetobutylicum pIPA3-Cm2
Kazemi et al. Modeling and control of dissolved oxygen concentration in the fermentation of glucose to gluconic acid