FI20030014A0 - Prolyylioligopeptidaasia inhiboivaa aktiivisuutta omaavia yhdisteitä - Google Patents

Prolyylioligopeptidaasia inhiboivaa aktiivisuutta omaavia yhdisteitä

Info

Publication number
FI20030014A0
FI20030014A0 FI20030014A FI20030014A FI20030014A0 FI 20030014 A0 FI20030014 A0 FI 20030014A0 FI 20030014 A FI20030014 A FI 20030014A FI 20030014 A FI20030014 A FI 20030014A FI 20030014 A0 FI20030014 A0 FI 20030014A0
Authority
FI
Finland
Prior art keywords
compositions
inhibitory action
prolyl oligopeptidase
oligopeptidase
prolyl
Prior art date
Application number
FI20030014A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Inventor
Jukka Gynther
Erik Wallen
Elina Jarho
Pekka Maennistoe
Markus Forsberg
Antti Poso
Johannes A M Christiaans
Jarkko Venaelaeinen
Jouko Vepsaelaeinen
Taija Saarinen
Tomi Jaervinen
Original Assignee
Orion Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Orion Corp filed Critical Orion Corp
Priority to FI20030014A priority Critical patent/FI20030014A0/fi
Publication of FI20030014A0 publication Critical patent/FI20030014A0/fi
Priority to EP04700047A priority patent/EP1581489A2/en
Priority to US10/541,387 priority patent/US20060229254A1/en
Priority to MXPA05007262A priority patent/MXPA05007262A/es
Priority to EA200501083A priority patent/EA010022B1/ru
Priority to JP2006500146A priority patent/JP2006516557A/ja
Priority to KR1020057012201A priority patent/KR20060027789A/ko
Priority to BR0406618-9A priority patent/BRPI0406618A/pt
Priority to PL378329A priority patent/PL378329A1/pl
Priority to YUP-2005/0514A priority patent/RS20050514A/sr
Priority to CNA2004800034680A priority patent/CN1747930A/zh
Priority to AU2004203788A priority patent/AU2004203788A1/en
Priority to CA002511856A priority patent/CA2511856A1/en
Priority to PCT/FI2004/000001 priority patent/WO2004060862A2/en
Priority to ZA200505183A priority patent/ZA200505183B/en
Priority to IS7963A priority patent/IS7963A/is
Priority to HR20050693A priority patent/HRP20050693A2/hr
Priority to NO20053726A priority patent/NO20053726L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
FI20030014A 2003-01-03 2003-01-03 Prolyylioligopeptidaasia inhiboivaa aktiivisuutta omaavia yhdisteitä FI20030014A0 (fi)

Priority Applications (18)

Application Number Priority Date Filing Date Title
FI20030014A FI20030014A0 (fi) 2003-01-03 2003-01-03 Prolyylioligopeptidaasia inhiboivaa aktiivisuutta omaavia yhdisteitä
PCT/FI2004/000001 WO2004060862A2 (en) 2003-01-03 2004-01-02 Compounds having prolyl oligopeptidase inhibitory activity
PL378329A PL378329A1 (pl) 2003-01-03 2004-01-02 Związki o aktywności hamującej wobec oligopeptydazy prolilowej
CNA2004800034680A CN1747930A (zh) 2003-01-03 2004-01-02 具有脯氨酰基寡肽酶抑制活性的化合物
MXPA05007262A MXPA05007262A (es) 2003-01-03 2004-01-02 Compuestos que tienen actividad anhibidora de prolil oligopeptidasa.
EA200501083A EA010022B1 (ru) 2003-01-03 2004-01-02 Соединения, активные в ингибировании пролилолигопептидазы
JP2006500146A JP2006516557A (ja) 2003-01-03 2004-01-02 プロリルオリゴペプチダーゼ阻害活性を有する化合物
KR1020057012201A KR20060027789A (ko) 2003-01-03 2004-01-02 프롤릴 올리고펩티다제 억제 활성을 가지는 화합물
BR0406618-9A BRPI0406618A (pt) 2003-01-03 2004-01-02 Compostos possuindo atividade inibitória da propil oligopeptidase
EP04700047A EP1581489A2 (en) 2003-01-03 2004-01-02 Compounds having prolyl oligopeptidase inhibitory activity
YUP-2005/0514A RS20050514A (en) 2003-01-03 2004-01-02 Compounds having prolyl oligopeptidase inhibitory activity
US10/541,387 US20060229254A1 (en) 2003-01-03 2004-01-02 Compounds having prolyl oligopeptidase inhibitory activity
AU2004203788A AU2004203788A1 (en) 2003-01-03 2004-01-02 Compounds having prolyl oligopeptidase inhibitory activity
CA002511856A CA2511856A1 (en) 2003-01-03 2004-01-02 Compounds having prolyl oligopeptidase inhibitory activity
ZA200505183A ZA200505183B (en) 2003-01-03 2005-06-27 Compounds having prolyl oligopeptidase inhibitory activity
IS7963A IS7963A (is) 2003-01-03 2005-07-28 Efnasambönd með hamlandi virkni gegn prólýlólígópeptíðasa
HR20050693A HRP20050693A2 (en) 2003-01-03 2005-08-02 Compounds having prolyl oligopeptidase inhibitory activity
NO20053726A NO20053726L (no) 2003-01-03 2005-08-03 Forbindelser med prolyloligopeptidase-hemmende aktivitet

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FI20030014A FI20030014A0 (fi) 2003-01-03 2003-01-03 Prolyylioligopeptidaasia inhiboivaa aktiivisuutta omaavia yhdisteitä

Publications (1)

Publication Number Publication Date
FI20030014A0 true FI20030014A0 (fi) 2003-01-03

Family

ID=8565256

Family Applications (1)

Application Number Title Priority Date Filing Date
FI20030014A FI20030014A0 (fi) 2003-01-03 2003-01-03 Prolyylioligopeptidaasia inhiboivaa aktiivisuutta omaavia yhdisteitä

Country Status (18)

Country Link
US (1) US20060229254A1 (no)
EP (1) EP1581489A2 (no)
JP (1) JP2006516557A (no)
KR (1) KR20060027789A (no)
CN (1) CN1747930A (no)
AU (1) AU2004203788A1 (no)
BR (1) BRPI0406618A (no)
CA (1) CA2511856A1 (no)
EA (1) EA010022B1 (no)
FI (1) FI20030014A0 (no)
HR (1) HRP20050693A2 (no)
IS (1) IS7963A (no)
MX (1) MXPA05007262A (no)
NO (1) NO20053726L (no)
PL (1) PL378329A1 (no)
RS (1) RS20050514A (no)
WO (1) WO2004060862A2 (no)
ZA (1) ZA200505183B (no)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112012018374B1 (pt) 2009-12-18 2021-09-21 Epics Therapeutics Derivados de ácido carboxílico de pirrolidina ou tiazolidina para distúrbios metabólicos como agonistas de receptor 43 acoplado à proteína g (gpr43), seu processo de preparação e composição farmacêutica
EP2730571A1 (en) * 2012-11-12 2014-05-14 Universitat De Barcelona 1-[1-(benzoyl)-pyrrolidine-2-carbonyl]-pyrrolidine-2-carbonitrile derivatives
KR102259934B1 (ko) * 2013-11-27 2021-06-03 에픽스 테라퓨틱스 염증 질환의 치료에 사용되기 위한 화합물, 의약 조성물 및 방법
KR101913506B1 (ko) * 2017-07-18 2018-10-30 경상대학교산학협력단 프롤릴 올리고펩티다아제 억제제를 유효성분으로 함유하는 퇴행성 뇌질환 예방 또는 치료용 조성물
TW202216689A (zh) 2020-07-07 2022-05-01 西班牙商阿庫勒療法有限公司 １－［１－（４－苄氧基－３，５－二氟－苯甲醯）－４－氟－吡咯烷－２－羰基］－吡咯烷－２－腈

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4483991A (en) * 1983-01-17 1984-11-20 American Home Products Corporation Hypotensive agents
DE3680578D1 (de) * 1985-04-16 1991-09-05 Suntory Ltd Dipeptid-derivate, verfahren zur herstellung, pharmazeutische zusammensetzungen und ihre anwendung.
CA1320734C (en) * 1986-02-04 1993-07-27 Suntory Limited Pyrrolidineamide derivative of acylamino acid and pharmaceutical composition containing the same
JPH0696563B2 (ja) * 1986-02-04 1994-11-30 サントリー株式会社 アシルアミノ酸誘導体、その製法並びに用途
WO1991018891A1 (en) * 1990-06-04 1991-12-12 Pfizer Inc. Aromatic pyrrolidine and thiazolidine amides
AU643300B2 (en) * 1990-06-07 1993-11-11 Zeria Pharmaceutical Co., Ltd. Novel arylalkanoylamine derivative and drug containing the same
SI0915088T1 (en) * 1997-10-31 2002-12-31 F. Hoffmann-La Roche Ag D-proline derivatives

Also Published As

Publication number Publication date
NO20053726L (no) 2005-09-28
EP1581489A2 (en) 2005-10-05
RS20050514A (en) 2007-12-31
BRPI0406618A (pt) 2005-12-06
CA2511856A1 (en) 2004-07-22
EA200501083A1 (ru) 2006-02-24
WO2004060862A3 (en) 2004-11-25
NO20053726D0 (no) 2005-08-03
HRP20050693A2 (en) 2005-10-31
KR20060027789A (ko) 2006-03-28
JP2006516557A (ja) 2006-07-06
PL378329A1 (pl) 2006-03-20
AU2004203788A1 (en) 2004-07-22
IS7963A (is) 2005-07-28
EA010022B1 (ru) 2008-06-30
WO2004060862A2 (en) 2004-07-22
MXPA05007262A (es) 2005-09-08
ZA200505183B (en) 2006-04-26
CN1747930A (zh) 2006-03-15
US20060229254A1 (en) 2006-10-12

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