FI126143B - Polymyksiinijohdannainen ja sen käytöt - Google Patents
Polymyksiinijohdannainen ja sen käytöt Download PDFInfo
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- FI126143B FI126143B FI20155027A FI20155027A FI126143B FI 126143 B FI126143 B FI 126143B FI 20155027 A FI20155027 A FI 20155027A FI 20155027 A FI20155027 A FI 20155027A FI 126143 B FI126143 B FI 126143B
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- FI
- Finland
- Prior art keywords
- polymyxin
- pharmaceutical composition
- dab
- nab815
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- 108010040201 Polymyxins Proteins 0.000 title description 36
- 150000001875 compounds Chemical class 0.000 claims description 44
- 241000894006 Bacteria Species 0.000 claims description 26
- -1 fluoroketolides Chemical compound 0.000 claims description 15
- 239000003242 anti bacterial agent Substances 0.000 claims description 14
- 238000011282 treatment Methods 0.000 claims description 13
- 239000008194 pharmaceutical composition Substances 0.000 claims description 12
- 150000003839 salts Chemical class 0.000 claims description 11
- ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 claims description 8
- 241000588724 Escherichia coli Species 0.000 claims description 8
- 239000003112 inhibitor Substances 0.000 claims description 8
- 125000002801 octanoyl group Chemical group C(CCCCCCC)(=O)* 0.000 claims description 7
- 241000589517 Pseudomonas aeruginosa Species 0.000 claims description 6
- 239000004480 active ingredient Substances 0.000 claims description 6
- 230000015572 biosynthetic process Effects 0.000 claims description 6
- 239000003814 drug Substances 0.000 claims description 6
- 241000588747 Klebsiella pneumoniae Species 0.000 claims description 5
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- COLNVLDHVKWLRT-MRVPVSSYSA-N D-phenylalanine Chemical compound OC(=O)[C@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-MRVPVSSYSA-N 0.000 claims description 4
- IECPWNUMDGFDKC-UHFFFAOYSA-N Fusicsaeure Natural products C12C(O)CC3C(=C(CCC=C(C)C)C(O)=O)C(OC(C)=O)CC3(C)C1(C)CCC1C2(C)CCC(O)C1C IECPWNUMDGFDKC-UHFFFAOYSA-N 0.000 claims description 4
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- ONUMZHGUFYIKPM-MXNFEBESSA-N telavancin Chemical compound O1[C@@H](C)[C@@H](O)[C@](NCCNCCCCCCCCCC)(C)C[C@@H]1O[C@H]1[C@H](OC=2C3=CC=4[C@H](C(N[C@H]5C(=O)N[C@H](C(N[C@@H](C6=CC(O)=C(CNCP(O)(O)=O)C(O)=C6C=6C(O)=CC=C5C=6)C(O)=O)=O)[C@H](O)C5=CC=C(C(=C5)Cl)O3)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](NC(=O)[C@@H](CC(C)C)NC)[C@H](O)C3=CC=C(C(=C3)Cl)OC=2C=4)O[C@H](CO)[C@@H](O)[C@@H]1O ONUMZHGUFYIKPM-MXNFEBESSA-N 0.000 claims description 3
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- 108010001478 Bacitracin Proteins 0.000 claims description 2
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
- C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
- C07K7/60—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation occurring through the 4-amino group of 2,4-diamino-butanoic acid
- C07K7/62—Polymyxins; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/14—Peptides containing saccharide radicals; Derivatives thereof, e.g. bleomycin, phleomycin, muramylpeptides or vancomycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
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- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
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- Epidemiology (AREA)
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- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Claims (10)
1. Yhdiste, jolla on yleinen kaava (I)
missä R1 on Dab R2 on Thr R3 on DThr R4 on Dab R5 on Dab R6 on DPhe R7 on Leu R8 on Abu R9 on Dab; R10 on Thr; ja R(FA) on oktanoyyli; tai sen farmaseuttisesti hyväksyttävä suola.
2. Patenttivaatimuksen 1 mukainen yhdiste tai sen farmaseuttisesti hyväksyttävä suola, missä R1-R10 on SEQ ID NO 1.
3. Farmaseuttinen koostumus, joka käsittää tehokkaan määrän patenttivaatimuksen 1 tai 2 mukaista yhdistettä tai sen farmaseuttisesti hyväksyttävää suolaa ja ainakin yhtä farmaseuttisesti hyväksyttävää kantaja-ainetta ja/tai täyteainetta.
4. Patenttivaatimuksen 3 mukainen farmaseuttinen koostumus, joka käsittää lisäksi yhtä tai useampaa muuta aktiivista ainesosaa.
5. Patenttivaatimuksen 4 mukainen farmaseuttinen koostumus, missä mainittu muu aktiivinen ainesosa on antibakteerinen aine, joka on valittu joukosta, joka koostuu klaritromysiinistä, atsitromysiinistä, erytromysiinistä ja muista makrolideistä, ketolideistä, fluoroketolideistä, klindamysiinistä ja muista linkosamiineista, streptogramiineista, rifampiinistä, rifabutiinistä, rifalatsiilistä ja muista rifamysiineistä, fusidiinihaposta, mupirosiinistä, oksatsolidinoneista, van-komysiinistä, dalbavansiinista, telavansiinista, oritavansiinista ja muista glyko-peptidiantibiooteista, fluorokinoloneista, basitrasiinista, tetrasykliinistä ja fluoro-sykliinijohdannaisista, beetalaktaamiantibiooteista, novobiosiinistä, pleuromuti-liineistä, folaattisynteesin estäjistä, deformylaasin estäjistä ja bakteerisen ef-fluksipumpun estäjistä.
6. Patenttivaatimuksen 5 mukainen farmaseuttinen koostumus, missä mainittu antibakteerinen aine on valittu joukosta, joka koostuu: klaritromysiinistä, atsitromysiinistä, erytromysiinistä, telitromysiinistä, solitromysiinistä, klindamysiinistä, streptogramiiniyhdistelmästä kinupristiini-dalfopristiini, eravasyk-liinistä, minosykliinistä, omadasykliinistä, rifampiinistä, rifabutiinistä, rifalatsiilistä, fusidiinihaposta, musiprosiinistä, oksatsolidoneista telitsolidi ja linetsolidi, vankomysiinistä, dalbavansiinista, oritavansiinista, telavansiinista, fluorokinoloneista moksifloksasiini, delafloksasiini ja avarafloksasiini ja folaattisynteesin estäjästä trimetopriimi.
7. Patenttivaatimuksen 1 tai 2 mukainen yhdiste tai jonkin patenttivaatimuksen 3-6 mukainen farmaseuttinen koostumus käytettäväksi lääkkeenä.
8. Patenttivaatimuksen 1 tai 2 mukainen yhdiste tai jonkin patenttivaatimuksen 3-6 mukainen farmaseuttinen koostumus käytettäväksi bakteeri-infektion hoidossa.
9. Patenttivaatimuksen 1 tai 2 mukainen yhdiste tai jonkin patenttivaatimuksen 3-6 mukainen farmaseuttinen koostumus käytettäväksi patenttivaatimuksen 8 mukaisesti, missä bakteeri on gramnegatiivinen bakteeri.
10. Patenttivaatimuksen 1 tai 2 mukainen yhdiste tai jonkin patenttivaatimuksen 3-6 mukainen farmaseuttinen koostumus käytettäväksi patenttivaatimuksen 8 mukaisesti, missä mainitut bakteerit on valittu joukosta, joka koostuu seuraavista: Escherichia coli, Klebsiella pneumoniae, Klebsiella oxytoca, Enterobacter cloacae, Citrobacter freundii, Pseudomonas aeruginosa
Priority Applications (20)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FI20155027A FI126143B (fi) | 2015-01-15 | 2015-01-15 | Polymyksiinijohdannainen ja sen käytöt |
| MX2017009094A MX2017009094A (es) | 2015-01-15 | 2016-01-15 | Derivado de polimixina y usos del mismo. |
| HUE16151398A HUE035778T2 (hu) | 2015-01-15 | 2016-01-15 | Polimixin származék és alkalmazásai |
| ES16151398.1T ES2656562T3 (es) | 2015-01-15 | 2016-01-15 | Derivado de polimixina y usos del mismo |
| EP16151398.1A EP3045469B1 (en) | 2015-01-15 | 2016-01-15 | Polymyxin derivative and uses thereof |
| CA2972743A CA2972743C (en) | 2015-01-15 | 2016-01-15 | Polymyxin derivative and uses thereof |
| BR112017014670-3A BR112017014670B1 (pt) | 2015-01-15 | 2016-01-15 | Derivado de polimixina e usos do mesmo |
| AU2016207942A AU2016207942B2 (en) | 2015-01-15 | 2016-01-15 | Polymyxin derivative and uses thereof |
| DK16151398.1T DK3045469T3 (en) | 2015-01-15 | 2016-01-15 | Polymyxin derivative and uses thereof |
| SG11201705125UA SG11201705125UA (en) | 2015-01-15 | 2016-01-15 | Polymyxin derivative and uses thereof |
| PT161513981T PT3045469T (pt) | 2015-01-15 | 2016-01-15 | Derivado da polimixina e seus usos |
| RU2017127011A RU2675819C1 (ru) | 2015-01-15 | 2016-01-15 | Производные полимиксина и их применение |
| JP2017536921A JP6471236B2 (ja) | 2015-01-15 | 2016-01-15 | ポリミキシン誘導体およびその使用 |
| KR1020177022255A KR102020886B1 (ko) | 2015-01-15 | 2016-01-15 | 폴리믹신 유도체 및 이의 용도 |
| TW105101251A TWI694087B (zh) | 2015-01-15 | 2016-01-15 | 多黏桿菌素衍生物及其用途 |
| NO16151398A NO3045469T3 (fi) | 2015-01-15 | 2016-01-15 | |
| CN201680005506.9A CN107207569B (zh) | 2015-01-15 | 2016-01-15 | 多黏菌素衍生物及其用途 |
| PCT/FI2016/050016 WO2016113470A1 (en) | 2015-01-15 | 2016-01-15 | Polymyxin derivative and uses thereof |
| IL25345717A IL253457B (en) | 2015-01-15 | 2017-07-12 | Polymyxin derivatives, preparations containing them and their uses |
| HRP20180180TT HRP20180180T1 (hr) | 2015-01-15 | 2018-01-31 | Derivat polimiksina i njegova uporaba |
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| FI20155027A FI126143B (fi) | 2015-01-15 | 2015-01-15 | Polymyksiinijohdannainen ja sen käytöt |
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| JP (1) | JP6471236B2 (fi) |
| KR (1) | KR102020886B1 (fi) |
| CN (1) | CN107207569B (fi) |
| AU (1) | AU2016207942B2 (fi) |
| CA (1) | CA2972743C (fi) |
| DK (1) | DK3045469T3 (fi) |
| ES (1) | ES2656562T3 (fi) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| EP3556769B1 (en) * | 2016-12-16 | 2023-06-14 | Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences | Polymyxin derivative, preparation method and application thereof |
| GB201703898D0 (en) | 2017-03-10 | 2017-04-26 | Helperby Therapeautics Ltd | Method |
| GB201704620D0 (en) | 2017-03-23 | 2017-05-10 | Helperby Therapeautics Ltd | Combinations |
| CN107661349A (zh) * | 2017-11-24 | 2018-02-06 | 刘晓峰 | 一种治疗小儿高热的联合用药物 |
| CN110179967A (zh) * | 2019-05-28 | 2019-08-30 | 中国医药集团总公司四川抗菌素工业研究所 | 多粘菌素母核和一种抗生素的组合物及其应用 |
| IT201900025414A1 (it) | 2019-12-23 | 2021-06-23 | Univ Bologna Alma Mater Studiorum | Composto per il trattamento della sindrome emolitico uremica |
| WO2022206826A1 (zh) * | 2021-03-31 | 2022-10-06 | 江苏奥赛康药业有限公司 | 一种多粘菌素衍生物的硫酸盐及其药物组合物 |
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| BE754411A (fr) * | 1969-08-05 | 1971-02-04 | Rhone Poulenc Sa | Cyclopeptides derives des polymyxines et leur |
| TW274552B (fi) * | 1992-05-26 | 1996-04-21 | Hoechst Ag | |
| US20060004185A1 (en) * | 2004-07-01 | 2006-01-05 | Leese Richard A | Peptide antibiotics and peptide intermediates for their prepartion |
| EP3078672A1 (en) * | 2006-08-11 | 2016-10-12 | Northern Antibiotics Oy | Polymyxin derivatives and uses thereof |
| US7807637B2 (en) | 2006-08-11 | 2010-10-05 | Northern Antibiotics Oy | Polymyxin derivatives and uses thereof |
| FI20085469A0 (fi) * | 2008-02-08 | 2008-05-16 | Northern Antibiotics Oy | Polymyksiinijohdannaiset, joissa on lyhyt rasvahappohäntä, ja niiden käyttöjä |
| MX355217B (es) | 2011-11-18 | 2018-04-10 | New Pharma Licence Holdings Ltd | Derivados de polimixina. |
| CA2895910C (en) * | 2013-01-11 | 2021-12-21 | Xellia Pharmaceuticals Aps | Polymyxins, compositions, methods of making and methods of use |
| PL2999711T3 (pl) | 2013-05-22 | 2022-09-26 | Spero Therapeutics, Inc. | Pochodne polimyksyny i ich zastosowanie w terapii skojarzonej razem z różnymi antybiotykami |
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| SG11201705125UA (en) | 2017-07-28 |
| KR102020886B1 (ko) | 2019-09-16 |
| TWI694087B (zh) | 2020-05-21 |
| EP3045469B1 (en) | 2017-11-29 |
| FI20155027A (fi) | 2016-07-15 |
| RU2675819C1 (ru) | 2018-12-25 |
| JP6471236B2 (ja) | 2019-02-13 |
| NO3045469T3 (fi) | 2018-04-28 |
| AU2016207942A1 (en) | 2017-08-10 |
| CA2972743A1 (en) | 2016-07-21 |
| MX2017009094A (es) | 2018-03-01 |
| ES2656562T3 (es) | 2018-02-27 |
| BR112017014670A2 (pt) | 2018-03-13 |
| IL253457B (en) | 2019-10-31 |
| CN107207569A (zh) | 2017-09-26 |
| EP3045469A1 (en) | 2016-07-20 |
| HRP20180180T1 (hr) | 2018-03-09 |
| HUE035778T2 (hu) | 2018-08-28 |
| CN107207569B (zh) | 2020-11-03 |
| AU2016207942B2 (en) | 2018-05-10 |
| TW201630930A (zh) | 2016-09-01 |
| JP2018505868A (ja) | 2018-03-01 |
| KR20170102005A (ko) | 2017-09-06 |
| IL253457A0 (en) | 2017-09-28 |
| DK3045469T3 (en) | 2018-03-05 |
| WO2016113470A1 (en) | 2016-07-21 |
| CA2972743C (en) | 2020-06-09 |
| PT3045469T (pt) | 2018-02-08 |
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