FI119473B - Menetelmä HIV-proteaasi-inhibiittoreiden valmistamiseksi - Google Patents

Menetelmä HIV-proteaasi-inhibiittoreiden valmistamiseksi Download PDF

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Publication number
FI119473B
FI119473B FI960184A FI960184A FI119473B FI 119473 B FI119473 B FI 119473B FI 960184 A FI960184 A FI 960184A FI 960184 A FI960184 A FI 960184A FI 119473 B FI119473 B FI 119473B
Authority
FI
Finland
Prior art keywords
alkyl
substituted
unsubstituted
aryl
alkoxy
Prior art date
Application number
FI960184A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI960184A (fi
FI960184A0 (fi
Inventor
David Askin
Kan K Eng
Ralph P Volante
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/187,664 external-priority patent/US5463067A/en
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of FI960184A0 publication Critical patent/FI960184A0/fi
Publication of FI960184A publication Critical patent/FI960184A/fi
Application granted granted Critical
Publication of FI119473B publication Critical patent/FI119473B/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Epoxy Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
FI960184A 1993-07-16 1996-01-15 Menetelmä HIV-proteaasi-inhibiittoreiden valmistamiseksi FI119473B (fi)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US9322593A 1993-07-16 1993-07-16
US9322593 1993-07-16
US18766494 1994-01-26
US08/187,664 US5463067A (en) 1993-07-16 1994-01-26 Process for making HIV protease inhibitors
PCT/US1994/007706 WO1995002584A2 (en) 1993-07-16 1994-07-11 Process for making hiv protease inhibitors
US9407706 1994-07-11

Publications (3)

Publication Number Publication Date
FI960184A0 FI960184A0 (fi) 1996-01-15
FI960184A FI960184A (fi) 1996-03-14
FI119473B true FI119473B (fi) 2008-11-28

Family

ID=26787287

Family Applications (1)

Application Number Title Priority Date Filing Date
FI960184A FI119473B (fi) 1993-07-16 1996-01-15 Menetelmä HIV-proteaasi-inhibiittoreiden valmistamiseksi

Country Status (22)

Country Link
US (2) US5491238A (de)
EP (1) EP0708762B1 (de)
JP (1) JP3547136B2 (de)
CN (2) CN1066723C (de)
AT (1) ATE200079T1 (de)
AU (1) AU676079B2 (de)
CZ (1) CZ293953B6 (de)
DE (1) DE69426979T2 (de)
DK (1) DK0708762T3 (de)
ES (1) ES2155091T3 (de)
FI (1) FI119473B (de)
GR (1) GR3035645T3 (de)
HU (1) HUT74583A (de)
IL (1) IL110342A (de)
LV (1) LV12825B (de)
NO (1) NO306297B1 (de)
NZ (1) NZ269904A (de)
PL (1) PL179039B1 (de)
PT (1) PT708762E (de)
RU (1) RU2125561C1 (de)
SK (1) SK282616B6 (de)
WO (1) WO1995002584A2 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL110255A (en) * 1993-07-16 1998-12-06 Merck & Co Inc Creation and resolution of 2 tert-butylcarboxamidopiprazine
IL111584A0 (en) * 1993-11-18 1995-01-24 Merck & Co Inc Prodrugs of an inhibitor of hiv protease and pharmaceutical compositions containing them
ES2116029T3 (es) * 1994-11-04 1998-07-01 Yamakawa Chemical Ind Procedimiento para preparar derivados de piperazina opticamente activos e intermedios para prepararlos.
DE4446025A1 (de) * 1994-12-22 1996-06-27 Basf Ag 2-Caroxamido-1,4,5,6-tetrahydropyrazine
ATE209190T1 (de) * 1995-05-23 2001-12-15 Lonza Ag Verfahren zur herstellung von optisch aktiven 2- piperazincarbonsäurederivaten
EP1125930A1 (de) * 1995-05-23 2001-08-22 Lonza Ag Optisch aktive 2-Piperazincarbonsäurederivate und Verfahren zu ihrer Herstellung
CA2201218C (en) * 1996-04-23 2004-09-28 Rudolf Fuchs Process for the preparation of optically active piperazine-2-carboxylic acid derivatives
US6645961B1 (en) 1997-03-07 2003-11-11 Merck & Co., Inc. Dry granulation formulation for an HIV protease inhibitor
US6482952B2 (en) 2000-06-20 2002-11-19 Merck & Co., Inc. Process for preparing acetonides
US7218837B2 (en) 2000-09-25 2007-05-15 Victor Company Of Japan, Ltd. Program-signal recording and reproducing apparatus

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2052907A1 (en) * 1990-10-11 1992-04-12 Joseph P. Vacca Hiv protease inhibitors having symmetrical structure
CA2072237A1 (en) * 1991-07-02 1993-01-03 Merck & Co., Inc. Stereoselective production of hydroxyamide compounds from chiral –-amino epoxides
US5169952A (en) * 1991-07-02 1992-12-08 Merck & Co., Inc. Stereoselective production of hydroxyamide compounds from chiral α-amino epoxides

Also Published As

Publication number Publication date
US5496948A (en) 1996-03-05
CN1192014C (zh) 2005-03-09
ATE200079T1 (de) 2001-04-15
EP0708762A1 (de) 1996-05-01
IL110342A (en) 1998-12-27
AU7358894A (en) 1995-02-13
CN1130380A (zh) 1996-09-04
US5491238A (en) 1996-02-13
DE69426979D1 (de) 2001-05-03
CN1066723C (zh) 2001-06-06
CZ293953B6 (cs) 2004-08-18
RU2125561C1 (ru) 1999-01-27
PL179039B1 (pl) 2000-07-31
NO960168L (no) 1996-03-15
WO1995002584A3 (en) 1995-03-09
HUT74583A (en) 1997-01-28
DE69426979T2 (de) 2001-09-20
GR3035645T3 (en) 2001-06-29
CN1252402A (zh) 2000-05-10
AU676079B2 (en) 1997-02-27
JP3547136B2 (ja) 2004-07-28
NZ269904A (en) 1997-11-24
PT708762E (pt) 2001-07-31
HU9600077D0 (en) 1996-03-28
ES2155091T3 (es) 2001-05-01
NO306297B1 (no) 1999-10-18
PL312613A1 (en) 1996-04-29
SK5596A3 (en) 1997-01-08
EP0708762B1 (de) 2001-03-28
SK282616B6 (sk) 2002-10-08
IL110342A0 (en) 1994-10-21
NO960168D0 (no) 1996-01-15
FI960184A (fi) 1996-03-14
LV12825A (en) 2002-05-20
WO1995002584A2 (en) 1995-01-26
CZ13196A3 (en) 1996-04-17
FI960184A0 (fi) 1996-01-15
LV12825B (en) 2002-09-20
DK0708762T3 (da) 2001-04-30
JPH08509985A (ja) 1996-10-22

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Publication Publication Date Title
FI119473B (fi) Menetelmä HIV-proteaasi-inhibiittoreiden valmistamiseksi
EP0708763B1 (de) Verfahren zur herstellung von hiv protease inhibitoren
US5463067A (en) Process for making HIV protease inhibitors
US5489685A (en) Method of synthesizing furo[2,3-b]pyridine carboxylic acid esters
KR100337579B1 (ko) 사람 면역결핍성 바이러스(hiv) 프로테아제 억제제를 제조하는 방법
EP0748319A1 (de) Verfahren zur herstellung von epoxiden
CA2167183C (en) Process for making hiv protease inhibitors

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