IL110342A - Process for making intermediates for crixiban and certain new compounds for it - Google Patents

Process for making intermediates for crixiban and certain new compounds for it

Info

Publication number
IL110342A
IL110342A IL11034294A IL11034294A IL110342A IL 110342 A IL110342 A IL 110342A IL 11034294 A IL11034294 A IL 11034294A IL 11034294 A IL11034294 A IL 11034294A IL 110342 A IL110342 A IL 110342A
Authority
IL
Israel
Prior art keywords
substituted
alkyl
unsubstituted
aryl
alkoxy
Prior art date
Application number
IL11034294A
Other languages
English (en)
Hebrew (he)
Other versions
IL110342A0 (en
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/187,664 external-priority patent/US5463067A/en
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of IL110342A0 publication Critical patent/IL110342A0/xx
Publication of IL110342A publication Critical patent/IL110342A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Epoxy Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
IL11034294A 1993-07-16 1994-07-17 Process for making intermediates for crixiban and certain new compounds for it IL110342A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9322593A 1993-07-16 1993-07-16
US08/187,664 US5463067A (en) 1993-07-16 1994-01-26 Process for making HIV protease inhibitors

Publications (2)

Publication Number Publication Date
IL110342A0 IL110342A0 (en) 1994-10-21
IL110342A true IL110342A (en) 1998-12-27

Family

ID=26787287

Family Applications (1)

Application Number Title Priority Date Filing Date
IL11034294A IL110342A (en) 1993-07-16 1994-07-17 Process for making intermediates for crixiban and certain new compounds for it

Country Status (22)

Country Link
US (2) US5491238A (de)
EP (1) EP0708762B1 (de)
JP (1) JP3547136B2 (de)
CN (2) CN1066723C (de)
AT (1) ATE200079T1 (de)
AU (1) AU676079B2 (de)
CZ (1) CZ293953B6 (de)
DE (1) DE69426979T2 (de)
DK (1) DK0708762T3 (de)
ES (1) ES2155091T3 (de)
FI (1) FI119473B (de)
GR (1) GR3035645T3 (de)
HU (1) HUT74583A (de)
IL (1) IL110342A (de)
LV (1) LV12825B (de)
NO (1) NO306297B1 (de)
NZ (1) NZ269904A (de)
PL (1) PL179039B1 (de)
PT (1) PT708762E (de)
RU (1) RU2125561C1 (de)
SK (1) SK282616B6 (de)
WO (1) WO1995002584A2 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL110255A (en) * 1993-07-16 1998-12-06 Merck & Co Inc Creation and resolution of 2 tert-butylcarboxamidopiprazine
IL111584A0 (en) * 1993-11-18 1995-01-24 Merck & Co Inc Prodrugs of an inhibitor of hiv protease and pharmaceutical compositions containing them
ES2116029T3 (es) * 1994-11-04 1998-07-01 Yamakawa Chemical Ind Procedimiento para preparar derivados de piperazina opticamente activos e intermedios para prepararlos.
DE4446025A1 (de) * 1994-12-22 1996-06-27 Basf Ag 2-Caroxamido-1,4,5,6-tetrahydropyrazine
ATE209190T1 (de) * 1995-05-23 2001-12-15 Lonza Ag Verfahren zur herstellung von optisch aktiven 2- piperazincarbonsäurederivaten
EP1125930A1 (de) * 1995-05-23 2001-08-22 Lonza Ag Optisch aktive 2-Piperazincarbonsäurederivate und Verfahren zu ihrer Herstellung
CA2201218C (en) * 1996-04-23 2004-09-28 Rudolf Fuchs Process for the preparation of optically active piperazine-2-carboxylic acid derivatives
US6645961B1 (en) 1997-03-07 2003-11-11 Merck & Co., Inc. Dry granulation formulation for an HIV protease inhibitor
US6482952B2 (en) 2000-06-20 2002-11-19 Merck & Co., Inc. Process for preparing acetonides
US7218837B2 (en) 2000-09-25 2007-05-15 Victor Company Of Japan, Ltd. Program-signal recording and reproducing apparatus

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2052907A1 (en) * 1990-10-11 1992-04-12 Joseph P. Vacca Hiv protease inhibitors having symmetrical structure
CA2072237A1 (en) * 1991-07-02 1993-01-03 Merck & Co., Inc. Stereoselective production of hydroxyamide compounds from chiral –-amino epoxides
US5169952A (en) * 1991-07-02 1992-12-08 Merck & Co., Inc. Stereoselective production of hydroxyamide compounds from chiral α-amino epoxides

Also Published As

Publication number Publication date
FI119473B (fi) 2008-11-28
US5496948A (en) 1996-03-05
CN1192014C (zh) 2005-03-09
ATE200079T1 (de) 2001-04-15
EP0708762A1 (de) 1996-05-01
AU7358894A (en) 1995-02-13
CN1130380A (zh) 1996-09-04
US5491238A (en) 1996-02-13
DE69426979D1 (de) 2001-05-03
CN1066723C (zh) 2001-06-06
CZ293953B6 (cs) 2004-08-18
RU2125561C1 (ru) 1999-01-27
PL179039B1 (pl) 2000-07-31
NO960168L (no) 1996-03-15
WO1995002584A3 (en) 1995-03-09
HUT74583A (en) 1997-01-28
DE69426979T2 (de) 2001-09-20
GR3035645T3 (en) 2001-06-29
CN1252402A (zh) 2000-05-10
AU676079B2 (en) 1997-02-27
JP3547136B2 (ja) 2004-07-28
NZ269904A (en) 1997-11-24
PT708762E (pt) 2001-07-31
HU9600077D0 (en) 1996-03-28
ES2155091T3 (es) 2001-05-01
NO306297B1 (no) 1999-10-18
PL312613A1 (en) 1996-04-29
SK5596A3 (en) 1997-01-08
EP0708762B1 (de) 2001-03-28
SK282616B6 (sk) 2002-10-08
IL110342A0 (en) 1994-10-21
NO960168D0 (no) 1996-01-15
FI960184A (fi) 1996-03-14
LV12825A (en) 2002-05-20
WO1995002584A2 (en) 1995-01-26
CZ13196A3 (en) 1996-04-17
FI960184A0 (fi) 1996-01-15
LV12825B (en) 2002-09-20
DK0708762T3 (da) 2001-04-30
JPH08509985A (ja) 1996-10-22

Similar Documents

Publication Publication Date Title
EP0708762B1 (de) Verfahren zur herstellung von hiv-proteasehemmern
CA2183976C (en) Process for making an epoxide
EP0708763B1 (de) Verfahren zur herstellung von hiv protease inhibitoren
US5463067A (en) Process for making HIV protease inhibitors
US5489685A (en) Method of synthesizing furo[2,3-b]pyridine carboxylic acid esters
US5663341A (en) Process for making HIV protease inhibitors
CA2167183C (en) Process for making hiv protease inhibitors

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees