FI116056B - N-(2-pyrrolidinyyli-1)-1-fenyylietyyli)asetamideja kappareseptoriantagonisteina - Google Patents

N-(2-pyrrolidinyyli-1)-1-fenyylietyyli)asetamideja kappareseptoriantagonisteina Download PDF

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Publication number
FI116056B
FI116056B FI970746A FI970746A FI116056B FI 116056 B FI116056 B FI 116056B FI 970746 A FI970746 A FI 970746A FI 970746 A FI970746 A FI 970746A FI 116056 B FI116056 B FI 116056B
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FI
Finland
Prior art keywords
phenyl
phenylethyl
dichlorophenyl
compound
alkyl
Prior art date
Application number
FI970746A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI970746A (fi
FI970746A0 (fi
Inventor
Fumitaka Ito
Original Assignee
Pfizer
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Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of FI970746A publication Critical patent/FI970746A/fi
Publication of FI970746A0 publication Critical patent/FI970746A0/fi
Application granted granted Critical
Publication of FI116056B publication Critical patent/FI116056B/fi

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/335—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrrole Compounds (AREA)
FI970746A 1994-08-24 1997-02-21 N-(2-pyrrolidinyyli-1)-1-fenyylietyyli)asetamideja kappareseptoriantagonisteina FI116056B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
PCT/JP1994/001399 WO1996006078A1 (en) 1994-08-24 1994-08-24 N-(2-(pyrrolidinyl-1)-1-phenylethyl)acetamides as kappa receptor antagonists
JP9401399 1994-08-24
IB9500374 1995-05-18
PCT/IB1995/000374 WO1996006077A1 (en) 1994-08-24 1995-05-18 N-[2-(pyrrolidinyl-1)-1-phenylethyl]acetamides as kappa receptor antagonists

Publications (3)

Publication Number Publication Date
FI970746A FI970746A (fi) 1997-02-21
FI970746A0 FI970746A0 (fi) 1997-02-21
FI116056B true FI116056B (fi) 2005-09-15

Family

ID=14098616

Family Applications (1)

Application Number Title Priority Date Filing Date
FI970746A FI116056B (fi) 1994-08-24 1997-02-21 N-(2-pyrrolidinyyli-1)-1-fenyylietyyli)asetamideja kappareseptoriantagonisteina

Country Status (17)

Country Link
US (1) US5837720A (de)
EP (1) EP0777649B1 (de)
JP (1) JP2935899B2 (de)
AT (1) ATE182138T1 (de)
AU (1) AU2350695A (de)
BR (1) BR9503775A (de)
CA (1) CA2196885C (de)
CO (1) CO4410322A1 (de)
DE (1) DE69510802T2 (de)
DK (1) DK0777649T3 (de)
ES (1) ES2133767T3 (de)
FI (1) FI116056B (de)
GR (1) GR3031133T3 (de)
IL (1) IL114969A0 (de)
MX (1) MX9701367A (de)
TR (1) TR199501055A2 (de)
WO (2) WO1996006078A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6239154B1 (en) 1996-03-08 2001-05-29 Adolor Corporation Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith
US5763445A (en) 1996-03-08 1998-06-09 Adolor Corporation Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith
US6133307A (en) * 1997-04-30 2000-10-17 Warner-Lambert Company Certain benzofuranyl-N-[pyrrolidin-1-YL]-N-methyl-acetamide derivatives useful as opioid agonists
US5760023A (en) * 1997-07-14 1998-06-02 Adolor Corporation Kappa agonist anti-pruritic pharmaceutical formulations and method of treating pruritus therewith
MXPA99011298A (es) * 1997-07-14 2004-10-28 Adolor Corp Formulaciones farmaceuticas antiprurito de agonista kappa y metodo para tratar prurito con las mismas.
US6284769B1 (en) 1999-12-03 2001-09-04 The Board Of Trustees Of The University Of Illinois Nonpeptide kappa opioid receptor antagonists
JP6275517B2 (ja) * 2013-03-22 2018-02-07 あゆみ製薬株式会社 Ｉｌ−２産生抑制
WO2014210436A2 (en) * 2013-06-28 2014-12-31 Nektar Therapeutics Kappa opioid agonists and uses thereof
JP2017503799A (ja) * 2014-01-24 2017-02-02 カディラ ヘルスケア リミテッド カッパオピオイドアゴニストとしての複素二環式化合物
CA2983927A1 (en) 2015-05-06 2016-11-10 The Regents Of The University Of California K-ras modulators
CN110785414A (zh) 2017-04-20 2020-02-11 加利福尼亚大学董事会 K-Ras调节剂

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4034785A1 (de) * 1990-11-02 1992-05-07 Merck Patent Gmbh 1-(2-arylethyl)-pyrrolidine
US5232978A (en) * 1988-12-23 1993-08-03 Merck Patent Gesellschaft Mit Beschrankter Haftung 1-(2-arylethyl)-pyrrolidines
DE4215213A1 (de) * 1992-05-09 1993-11-11 Merck Patent Gmbh Arylacetamide

Also Published As

Publication number Publication date
DK0777649T3 (da) 1999-11-29
MX9701367A (es) 1997-05-31
WO1996006078A1 (en) 1996-02-29
EP0777649A1 (de) 1997-06-11
CA2196885A1 (en) 1996-02-29
JPH09510731A (ja) 1997-10-28
GR3031133T3 (en) 1999-12-31
FI970746A (fi) 1997-02-21
CO4410322A1 (es) 1997-01-09
JP2935899B2 (ja) 1999-08-16
DE69510802D1 (de) 1999-08-19
AU2350695A (en) 1996-03-14
TR199501055A2 (tr) 1996-07-21
BR9503775A (pt) 1996-04-16
IL114969A0 (en) 1995-12-08
CA2196885C (en) 2001-01-23
FI970746A0 (fi) 1997-02-21
ATE182138T1 (de) 1999-07-15
DE69510802T2 (de) 1999-11-04
WO1996006077A1 (en) 1996-02-29
US5837720A (en) 1998-11-17
EP0777649B1 (de) 1999-07-14
ES2133767T3 (es) 1999-09-16

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