CO4410322A1 - Nuevos compuestos de carboxamida, sus sales farmaceuticamente aceptables y composiciones farmaceuticas que los contienen - Google Patents

Nuevos compuestos de carboxamida, sus sales farmaceuticamente aceptables y composiciones farmaceuticas que los contienen

Info

Publication number
CO4410322A1
CO4410322A1 CO95037814A CO95037814A CO4410322A1 CO 4410322 A1 CO4410322 A1 CO 4410322A1 CO 95037814 A CO95037814 A CO 95037814A CO 95037814 A CO95037814 A CO 95037814A CO 4410322 A1 CO4410322 A1 CO 4410322A1
Authority
CO
Colombia
Prior art keywords
pct
pharmaceutically acceptable
unsubstituted
pharmaceutical compositions
acceptable salts
Prior art date
Application number
CO95037814A
Other languages
English (en)
Inventor
Ito Fumitaka
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of CO4410322A1 publication Critical patent/CO4410322A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/335—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)

Abstract

UN COMPUESTO DE LA FORMULA (I) Y SUS SALES FARMACEUTICAMENTE ACEPTABLES, EN LA QUE R ES HIDROGENO O HIDROXI; Ar ES FENILO NO SUBSTITUIDO O SUBSTITUIDO; X ES FENILO O HETERO- CICLICO NO SUBSTITUIDO O SUBSTITUIDO, MONO-, DI- O TRIHALOMETILO, CIANO O LOS SIMILARES; Y X1 ES FENILO, NAFTILO, FURILO, TIENILO, PIRIDILO, TIAZO- LILO, BENZOFURILO, BENZOTIENILO O LOS SIMILARES. ESTOS COMPUESTOS TIENEN ACTIVIDAD AGONISTA HACIA EL RECEPTOR OPIACEO KAPPA Y POR TANTO SON UTILES COMO AGENTES ANALGESICOS, ANTIINFLAMATORIOS, DIU- RETICOS Y NEUROPROTECTORES. FIGURA 1
CO95037814A 1994-08-24 1995-08-23 Nuevos compuestos de carboxamida, sus sales farmaceuticamente aceptables y composiciones farmaceuticas que los contienen CO4410322A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/JP1994/001399 WO1996006078A1 (en) 1994-08-24 1994-08-24 N-(2-(pyrrolidinyl-1)-1-phenylethyl)acetamides as kappa receptor antagonists

Publications (1)

Publication Number Publication Date
CO4410322A1 true CO4410322A1 (es) 1997-01-09

Family

ID=14098616

Family Applications (1)

Application Number Title Priority Date Filing Date
CO95037814A CO4410322A1 (es) 1994-08-24 1995-08-23 Nuevos compuestos de carboxamida, sus sales farmaceuticamente aceptables y composiciones farmaceuticas que los contienen

Country Status (17)

Country Link
US (1) US5837720A (es)
EP (1) EP0777649B1 (es)
JP (1) JP2935899B2 (es)
AT (1) ATE182138T1 (es)
AU (1) AU2350695A (es)
BR (1) BR9503775A (es)
CA (1) CA2196885C (es)
CO (1) CO4410322A1 (es)
DE (1) DE69510802T2 (es)
DK (1) DK0777649T3 (es)
ES (1) ES2133767T3 (es)
FI (1) FI116056B (es)
GR (1) GR3031133T3 (es)
IL (1) IL114969A0 (es)
MX (1) MX9701367A (es)
TR (1) TR199501055A2 (es)
WO (2) WO1996006078A1 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6239154B1 (en) 1996-03-08 2001-05-29 Adolor Corporation Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith
US5763445A (en) 1996-03-08 1998-06-09 Adolor Corporation Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith
WO1998049141A1 (en) * 1997-04-30 1998-11-05 Warner-Lambert Company Kappa opioid agonists
US5760023A (en) * 1997-07-14 1998-06-02 Adolor Corporation Kappa agonist anti-pruritic pharmaceutical formulations and method of treating pruritus therewith
CA2288828A1 (en) * 1997-07-14 1999-01-28 Adolor Corporation Kappa agonist anti-pruritic pharmaceutical formulations and method of treating pruritus therewith
US6284769B1 (en) 1999-12-03 2001-09-04 The Board Of Trustees Of The University Of Illinois Nonpeptide kappa opioid receptor antagonists
CA2907921C (en) * 2013-03-22 2021-09-07 Ayumi Pharmaceutical Corporation Inhibition of il-2 production
WO2014210436A2 (en) * 2013-06-28 2014-12-31 Nektar Therapeutics Kappa opioid agonists and uses thereof
EP3097093A1 (en) * 2014-01-24 2016-11-30 Cadila Healthcare Limited Novel heterobicyclic compounds as kappa opioid agonists
AU2016258192B2 (en) 2015-05-06 2021-07-29 Leidos Biomedical Research, Inc. K-Ras modulators
WO2018195439A2 (en) 2017-04-20 2018-10-25 The Regents Of The University Of California K-ras modulators

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4034785A1 (de) * 1990-11-02 1992-05-07 Merck Patent Gmbh 1-(2-arylethyl)-pyrrolidine
US5232978A (en) * 1988-12-23 1993-08-03 Merck Patent Gesellschaft Mit Beschrankter Haftung 1-(2-arylethyl)-pyrrolidines
DE4215213A1 (de) * 1992-05-09 1993-11-11 Merck Patent Gmbh Arylacetamide

Also Published As

Publication number Publication date
DE69510802D1 (de) 1999-08-19
ATE182138T1 (de) 1999-07-15
JPH09510731A (ja) 1997-10-28
GR3031133T3 (en) 1999-12-31
US5837720A (en) 1998-11-17
WO1996006077A1 (en) 1996-02-29
FI116056B (fi) 2005-09-15
FI970746A (fi) 1997-02-21
CA2196885A1 (en) 1996-02-29
DK0777649T3 (da) 1999-11-29
MX9701367A (es) 1997-05-31
ES2133767T3 (es) 1999-09-16
CA2196885C (en) 2001-01-23
FI970746A0 (fi) 1997-02-21
DE69510802T2 (de) 1999-11-04
BR9503775A (pt) 1996-04-16
EP0777649B1 (en) 1999-07-14
AU2350695A (en) 1996-03-14
IL114969A0 (en) 1995-12-08
EP0777649A1 (en) 1997-06-11
WO1996006078A1 (en) 1996-02-29
JP2935899B2 (ja) 1999-08-16
TR199501055A2 (tr) 1996-07-21

Similar Documents

Publication Publication Date Title
DK0889877T3 (da) Meta-substituerede phenylenderivater og deres anvendelse som alfav-beta3-integrin-antagonister eller -inhibitorer
DK0889876T3 (da) Meta-substituerede phenylensulfonamidderivater
EA200000731A1 (ru) Альфа-аминоамидные производные, полезные в качестве анальгетических агентов
ATE297203T1 (de) Antithrombotische mitteln
FI954609A (fi) 1-amidinofenyyli-pyrrolidoneja, -piperidinoneja ja -atsetinoneja verihiutaleiden kasaantumisen inhibiittoreina
ATE202337T1 (de) Cyclopropylalkansäurederivate
RU94045846A (ru) Применение производных бензотиофена для ингибирования тромбина
CO4410322A1 (es) Nuevos compuestos de carboxamida, sus sales farmaceuticamente aceptables y composiciones farmaceuticas que los contienen
RU94044436A (ru) Способы подавления атрофии кожи и влагалища
KR950016731A (ko) 지루 및 좌창의 억제 방법
ATE148108T1 (de) Beta,beta-dimethyl-4-piperidinethanamin-derivat als inhibitoren der cholesterin-biosynthese
RU94045271A (ru) Применение 2-фенил-3-ароилбензотиофенов для ингибирования синдрома тернера
HUP0300298A2 (hu) 4-[Piperazinil-8-(kinolinil-metil)]benzamid-származékok, alkalmazásuk és ezeket tartalmazó gyógyszerkészítmények
ES2104370T3 (es) Derivados de (arilalquilaminobencil)aminopropionamidas sustituidas, su preparacion y utilizacion.
AR019474A1 (es) Compuestos 1-sustituidos de piperidina, utiles como antagonistas de los receptores 5-ht(1f), composiciones farmaceuticas formuladas con dichos compuestosy metodos para reducir la activacion de dichos receptores
KR930021203A (ko) 죽상동맥경화 치료제로서의 독사조신의 히드록실화된 대사산물 및 유도체
ATE248163T1 (de) Neuartige, pharmazeutisch aktive verbindung
EA200401617A1 (ru) Комбинация nmda-антагониста и ингибиторов ацетилхолинэстеразы для лечения болезни альцгеймера
SE9302334D0 (sv) New compounds
ATE228359T1 (de) Hemmung der leukotrienbiosynthese mittels harnstoffderivaten
AR011138A1 (es) Compuestos derivados de 4-aminoalcoxi-1,3-dihidrobenzomidazol-2-onas, composicion farmaceutica que los comprende y uso de los mismos para lafabricacion de un medicamento util, agonistas del autorreceptor de la dopamina.
TH25615A (th) วิธียับยั้งความว่องไวของไมอิโลเปอร์ออกซิเดส
MX9701529A (es) Uso de (e)-1-[4'-(2-alquilaminoetoxi)fenil]-1-(3'-hidroxifenil)-2-f enilbut-1-enos para inhibir trastornos patologicos.