FI115135B - Substituoidut alkyylidiamiinijohdannaiset ja niiden käyttö takykiniinin antagonisteina - Google Patents

Substituoidut alkyylidiamiinijohdannaiset ja niiden käyttö takykiniinin antagonisteina Download PDF

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Publication number
FI115135B
FI115135B FI965097A FI965097A FI115135B FI 115135 B FI115135 B FI 115135B FI 965097 A FI965097 A FI 965097A FI 965097 A FI965097 A FI 965097A FI 115135 B FI115135 B FI 115135B
Authority
FI
Finland
Prior art keywords
methyl
ethylamino
benzyl
indol
butoxycarbonyl
Prior art date
Application number
FI965097A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI965097A0 (fi
FI965097A (fi
Inventor
Tieu-Binh Le
Timothy P Burkholder
Elizabeth Kudlacz
Original Assignee
Merrell Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Pharma Inc filed Critical Merrell Pharma Inc
Publication of FI965097A0 publication Critical patent/FI965097A0/fi
Publication of FI965097A publication Critical patent/FI965097A/fi
Application granted granted Critical
Publication of FI115135B publication Critical patent/FI115135B/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/77—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
    • C07C233/78—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/20—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/52—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the nitrogen atom of at least one of the carboxamide groups further acylated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
FI965097A 1994-06-20 1996-12-18 Substituoidut alkyylidiamiinijohdannaiset ja niiden käyttö takykiniinin antagonisteina FI115135B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US26220994 1994-06-20
US08/262,209 US5597845A (en) 1994-06-20 1994-06-20 Substituted alkyldiamine derivatives
PCT/US1995/006317 WO1995035279A1 (en) 1994-06-20 1995-05-19 Substituted alkyldiamine derivatives and their use as tachykinin antagonists
US9506317 1995-05-19

Publications (3)

Publication Number Publication Date
FI965097A0 FI965097A0 (fi) 1996-12-18
FI965097A FI965097A (fi) 1996-12-18
FI115135B true FI115135B (fi) 2005-03-15

Family

ID=22996631

Family Applications (1)

Application Number Title Priority Date Filing Date
FI965097A FI115135B (fi) 1994-06-20 1996-12-18 Substituoidut alkyylidiamiinijohdannaiset ja niiden käyttö takykiniinin antagonisteina

Country Status (20)

Country Link
US (1) US5597845A (zh)
EP (1) EP0767783B1 (zh)
JP (1) JP3920916B2 (zh)
KR (1) KR100371981B1 (zh)
CN (1) CN1083429C (zh)
AT (1) ATE169905T1 (zh)
AU (1) AU691619B2 (zh)
CA (1) CA2193348C (zh)
DE (1) DE69504198T2 (zh)
DK (1) DK0767783T3 (zh)
ES (1) ES2121389T3 (zh)
FI (1) FI115135B (zh)
HU (1) HUT75965A (zh)
IL (1) IL114185A (zh)
MX (1) MX9606654A (zh)
NO (1) NO307458B1 (zh)
NZ (1) NZ287291A (zh)
TW (1) TW442451B (zh)
WO (1) WO1995035279A1 (zh)
ZA (1) ZA954947B (zh)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW541295B (en) * 1999-01-05 2003-07-11 Nippon Zoki Pharmaceutical Co A novel substituted alkylteraamine derivative for use as tachykinin antagonist
US6613801B2 (en) * 2000-05-30 2003-09-02 Transtech Pharma, Inc. Method for the synthesis of compounds of formula I and their uses thereof
US7423177B2 (en) 2001-03-05 2008-09-09 Transtech Pharma, Inc. Carboxamide derivatives as therapeutic agents
JP2004523565A (ja) 2001-03-05 2004-08-05 トランス　テック　ファーマ，インコーポレイテッド 治療因子としてのベンゾイミダゾール誘導体
EP2324830A1 (en) 2002-03-05 2011-05-25 TransTech Pharma Inc. Process for the preparation of a monocyclic azole derivative that inhibits the interaction of ligands with rage
US20090263370A1 (en) * 2006-11-30 2009-10-22 Guoliang Tao Methods for treating tachykinin-mediated diseases with cholinesterase
TWI517850B (zh) 2009-09-30 2016-01-21 Ｖｔｖ治療有限責任公司 經取代之咪唑衍生物及其使用方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5164372A (en) * 1989-04-28 1992-11-17 Fujisawa Pharmaceutical Company, Ltd. Peptide compounds having substance p antagonism, processes for preparation thereof and pharmaceutical composition comprising the same
WO1993001169A2 (en) * 1991-07-05 1993-01-21 Merck Sharp & Dohme Limited Aromatic compounds, pharmaceutical compositions containing them and their use in therapy
NZ255721A (en) * 1992-08-13 1997-06-24 Warner Lambert Co Hetarylmethoxy carbonyl substituted tryptophan amides, esters, analogues and pharmaceutical compositions thereof

Also Published As

Publication number Publication date
AU2596195A (en) 1996-01-15
ZA954947B (en) 1996-01-31
FI965097A0 (fi) 1996-12-18
DK0767783T3 (da) 1999-05-25
NZ287291A (en) 1998-10-28
NO307458B1 (no) 2000-04-10
FI965097A (fi) 1996-12-18
CN1083429C (zh) 2002-04-24
WO1995035279A1 (en) 1995-12-28
DE69504198T2 (de) 1999-04-29
CN1155883A (zh) 1997-07-30
NO965469L (no) 1997-02-19
IL114185A (en) 1999-07-14
IL114185A0 (zh) 1995-10-31
DE69504198D1 (de) 1998-09-24
CA2193348A1 (en) 1995-12-28
US5597845A (en) 1997-01-28
JP3920916B2 (ja) 2007-05-30
HUT75965A (en) 1997-05-28
ES2121389T3 (es) 1998-11-16
ATE169905T1 (de) 1998-09-15
AU691619B2 (en) 1998-05-21
TW442451B (en) 2001-06-23
EP0767783B1 (en) 1998-08-19
CA2193348C (en) 1999-08-24
HU9603540D0 (en) 1997-02-28
NO965469D0 (no) 1996-12-19
KR100371981B1 (ko) 2003-06-12
JPH10501551A (ja) 1998-02-10
MX9606654A (es) 1997-12-31
EP0767783A1 (en) 1997-04-16

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