FI114094B - Förfarande för framställning av substituerade indolonderivat - Google Patents

Förfarande för framställning av substituerade indolonderivat Download PDF

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Publication number
FI114094B
FI114094B FI953361A FI953361A FI114094B FI 114094 B FI114094 B FI 114094B FI 953361 A FI953361 A FI 953361A FI 953361 A FI953361 A FI 953361A FI 114094 B FI114094 B FI 114094B
Authority
FI
Finland
Prior art keywords
compounds
compound
dihydro
formula
indol
Prior art date
Application number
FI953361A
Other languages
English (en)
Finnish (fi)
Other versions
FI953361A0 (sv
FI953361A (sv
Inventor
Timothy Charles Walsgrove
Joseph Marian Fortunak
Norman John Lewis
Paul Oxley
Andrew S Wells
Original Assignee
Smithkline Beecham Plc
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Plc, Smithkline Beecham Corp filed Critical Smithkline Beecham Plc
Publication of FI953361A0 publication Critical patent/FI953361A0/sv
Publication of FI953361A publication Critical patent/FI953361A/sv
Application granted granted Critical
Publication of FI114094B publication Critical patent/FI114094B/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Claims (3)

1. Förfarande för framställning av en förening med formeln (I) 5 (PUNK1 R där n är 1 - 3; 10 varje grupp R är oberoende väte eller Ci_4-alkyl; och R1 är väte, hydroxi eller Cx^-alkoxi, kännetecknat av att en förening med formeln (II) redu-ceras i närvaro av Raney-nickel: (OUNRj (a: Il H
15 R · 1 där n, R och R är enligt vad som är definierat för for- i mein (I), varefter valbart - föreningen med formeln (I) omvandlas tili en annan före-20 ning med formeln (I) - ett sait bildas. * »
2. Förfarande enligt patentkrav 1, kännetecknat j av att bäda grupperna R är Ci_4-alkyl och n är 2 .
3. Förfarande enligt patentkrav 1, kännetecknat ,,· 25 av att den framställda föreningen med formeln (I) är: 4- • ’1 [2-(di-n-propylamino)etyl]-1,3-dihydro-2H-indol-2-onhydro- * 1 klorid (INN:ropinirol).
FI953361A 1993-01-08 1995-07-07 Förfarande för framställning av substituerade indolonderivat FI114094B (sv)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB939300309A GB9300309D0 (en) 1993-01-08 1993-01-08 Process
GB9300309 1993-01-08
PCT/EP1993/003706 WO1994015918A1 (en) 1993-01-08 1993-12-27 Process for the preparation of substituted indolone derivatives
EP9303706 1993-12-27

Publications (3)

Publication Number Publication Date
FI953361A0 FI953361A0 (sv) 1995-07-07
FI953361A FI953361A (sv) 1995-07-07
FI114094B true FI114094B (sv) 2004-08-13

Family

ID=10728465

Family Applications (1)

Application Number Title Priority Date Filing Date
FI953361A FI114094B (sv) 1993-01-08 1995-07-07 Förfarande för framställning av substituerade indolonderivat

Country Status (7)

Country Link
FI (1) FI114094B (sv)
GB (1) GB9300309D0 (sv)
HU (1) HUT72075A (sv)
MA (1) MA23081A1 (sv)
NO (1) NO305363B1 (sv)
PL (1) PL176152B1 (sv)
WO (1) WO1994015918A1 (sv)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2237307B1 (es) * 2003-10-14 2006-11-01 Urquima, S.A. Procedimiento para la preparacion de ropinirol.
WO2005074387A2 (en) * 2003-12-30 2005-08-18 Sun Pharmaceutical Industries Limited Novel crystal forms of 4-[2-di-n-propylamino)ethyl]-2 (3h)- indolone hydrochloride
WO2005105741A1 (en) * 2004-02-11 2005-11-10 Sun Pharmaceutical Industries Limited Substantially pure 4-[2-(di-n-propylamino)ethyl]-2(3h)-indolone hydrochloride
WO2005080333A1 (en) * 2004-02-19 2005-09-01 Torrent Pharmaceuticals Ltd Process for purification of ropinirole
WO2008075169A2 (en) * 2006-12-15 2008-06-26 Orchid Chemicals & Pharmaceuticals Limited A process for the purification of ropinirole hydrochloride
WO2011030330A2 (en) * 2009-09-09 2011-03-17 Taro Pharmaceutical Industries Ltd. Process for the purification of ropinirole hydrochloride
WO2018227553A1 (zh) 2017-06-16 2018-12-20 浙江华海立诚药业有限公司 盐酸罗匹尼罗的纯化方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3882236A (en) * 1973-12-26 1975-05-06 Lilly Co Eli Pharmaceutical compositions containing substituted 2-oxo-indolines and the use thereof to treat anxiety and tension
US4314944A (en) * 1980-08-22 1982-02-09 Smithkline Corporation 4-Aminoalkyl-7-hydroxy-2(3H)-indolones
US4452808A (en) * 1982-12-07 1984-06-05 Smithkline Beckman Corporation 4-Aminoalkyl-2(3H)-indolones
US4593106A (en) * 1984-06-04 1986-06-03 Smithkline Beckman Corporation 4-[2-(dialkylamino)ethyl]-7-hydroxyisatins
GB8712073D0 (en) * 1987-05-21 1987-06-24 Smith Kline French Lab Medicament
GB8714371D0 (en) * 1987-06-19 1987-07-22 Smith Kline French Lab Process
GB9008605D0 (en) * 1990-04-17 1990-06-13 Smith Kline French Lab Process

Also Published As

Publication number Publication date
HUT72075A (en) 1996-03-28
FI953361A0 (sv) 1995-07-07
NO952713D0 (no) 1995-07-07
NO305363B1 (no) 1999-05-18
NO952713L (no) 1995-07-07
FI953361A (sv) 1995-07-07
WO1994015918A1 (en) 1994-07-21
GB9300309D0 (en) 1993-03-03
PL309645A1 (en) 1995-10-30
PL176152B1 (pl) 1999-04-30
MA23081A1 (fr) 1994-10-01

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