FI113264B - Trisyklisiä pyratsolijohdannaisia - Google Patents
Trisyklisiä pyratsolijohdannaisia Download PDFInfo
- Publication number
- FI113264B FI113264B FI953827A FI953827A FI113264B FI 113264 B FI113264 B FI 113264B FI 953827 A FI953827 A FI 953827A FI 953827 A FI953827 A FI 953827A FI 113264 B FI113264 B FI 113264B
- Authority
- FI
- Finland
- Prior art keywords
- mmol
- disorders
- dihydroindeno
- methoxy
- pyrazol
- Prior art date
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- 150000003217 pyrazoles Chemical class 0.000 title abstract description 4
- 150000003839 salts Chemical class 0.000 claims abstract description 24
- 125000000217 alkyl group Chemical group 0.000 claims abstract description 17
- 125000003545 alkoxy group Chemical group 0.000 claims abstract description 7
- 150000001875 compounds Chemical class 0.000 claims description 54
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 claims description 51
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims description 32
- -1 trifluoroacetylamino group Chemical group 0.000 claims description 31
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- 239000001257 hydrogen Substances 0.000 claims description 11
- 238000002360 preparation method Methods 0.000 claims description 11
- 239000002253 acid Substances 0.000 claims description 10
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- 230000002265 prevention Effects 0.000 claims description 7
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- 125000000738 acetamido group Chemical group [H]C([H])([H])C(=O)N([H])[*] 0.000 claims description 6
- IVRMZWNICZWHMI-UHFFFAOYSA-N azide group Chemical group [N-]=[N+]=[N-] IVRMZWNICZWHMI-UHFFFAOYSA-N 0.000 claims description 6
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- DJMNDMNLFDORLV-PBBCPHEYSA-N (e)-but-2-enedioic acid;(2s)-1-(5-methoxy-8,8-dimethylindeno[2,1-c]pyrazol-3-yl)propan-2-amine Chemical compound OC(=O)\C=C\C(O)=O.CC1(C)C=CC(OC)=C2C=C(N(C[C@H](C)N)N=C3)C3=C21 DJMNDMNLFDORLV-PBBCPHEYSA-N 0.000 claims 1
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Classifications
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- C—CHEMISTRY; METALLURGY
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- C07D—HETEROCYCLIC COMPOUNDS
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- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
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- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Reproductive Health (AREA)
- Hospice & Palliative Care (AREA)
- Pregnancy & Childbirth (AREA)
- Diabetes (AREA)
- Child & Adolescent Psychology (AREA)
- Addiction (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Gynecology & Obstetrics (AREA)
- Obesity (AREA)
- Anesthesiology (AREA)
- Endocrinology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Cephalosporin Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH249094 | 1994-08-12 | ||
| CH249094 | 1994-08-12 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI953827A0 FI953827A0 (fi) | 1995-08-11 |
| FI953827L FI953827L (fi) | 1996-02-13 |
| FI113264B true FI113264B (fi) | 2004-03-31 |
Family
ID=4234975
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI953827A FI113264B (fi) | 1994-08-12 | 1995-08-11 | Trisyklisiä pyratsolijohdannaisia |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US5561150A (cs) |
| EP (1) | EP0700905B1 (cs) |
| JP (1) | JP2755560B2 (cs) |
| KR (1) | KR100385384B1 (cs) |
| CN (1) | CN1056607C (cs) |
| AT (1) | ATE207905T1 (cs) |
| AU (1) | AU691310B2 (cs) |
| BR (1) | BR9503630A (cs) |
| CA (1) | CA2153937C (cs) |
| CO (1) | CO4410331A1 (cs) |
| CZ (1) | CZ289027B6 (cs) |
| DE (1) | DE59509777D1 (cs) |
| DK (1) | DK0700905T3 (cs) |
| ES (1) | ES2164730T3 (cs) |
| FI (1) | FI113264B (cs) |
| HU (1) | HUT72066A (cs) |
| IL (1) | IL114849A (cs) |
| MA (1) | MA23643A1 (cs) |
| MY (1) | MY133619A (cs) |
| NO (1) | NO305026B1 (cs) |
| NZ (1) | NZ272731A (cs) |
| PE (1) | PE34096A1 (cs) |
| PH (1) | PH31424A (cs) |
| PL (1) | PL182480B1 (cs) |
| PT (1) | PT700905E (cs) |
| RU (1) | RU2152388C1 (cs) |
| TR (1) | TR199500977A2 (cs) |
| TW (1) | TW403738B (cs) |
| UY (1) | UY24016A1 (cs) |
| ZA (1) | ZA956553B (cs) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU727654B2 (en) * | 1997-06-13 | 2000-12-21 | Yamanouchi Pharmaceutical Co., Ltd. | Tricyclic pyrazole derivative |
| US7189753B1 (en) | 1997-11-06 | 2007-03-13 | Cady Roger K | Preemptive prophylaxis of migraine |
| US6960579B1 (en) | 1998-05-19 | 2005-11-01 | Alcon Manufacturing, Ltd. | Serotonergic 5HT7 receptor compounds for treating ocular and CNS disorders |
| GB9819019D0 (en) * | 1998-09-01 | 1998-10-28 | Cerebrus Ltd | Chemical compounds II |
| GB9820767D0 (en) * | 1998-09-23 | 1998-11-18 | Cerebrus Ltd | Chemical compounds VIII |
| GB9918965D0 (en) | 1999-08-11 | 1999-10-13 | Cerebrus Ltd | Chemical compounds xxi |
| GB9918962D0 (en) | 1999-08-11 | 1999-10-13 | Cerebrus Ltd | Chemical compounds xxii |
| US20040048844A1 (en) * | 1999-10-20 | 2004-03-11 | Bristol-Myers Squibb Pharma Company | Acylsemicarbazides as cyclin dependent kinase inhibitors useful as anti-cancer and anti-proliferative agents |
| US6291504B1 (en) * | 1999-10-20 | 2001-09-18 | Dupont Pharmaceuticals Company | Acylsemicarbazides and their uses |
| EP1132389A1 (en) | 2000-03-06 | 2001-09-12 | Vernalis Research Limited | New aza-indolyl derivatives for the treatment of obesity |
| EP1268493B1 (en) * | 2000-03-31 | 2006-02-15 | Purdue Research Foundation | Phosphoramidate prodrugs |
| WO2004098807A1 (en) * | 2000-11-21 | 2004-11-18 | Barsplice Products, Inc. | Method of making steel couplers for joining concrete reinforcing bars |
| HUP0303316A2 (hu) | 2000-12-20 | 2004-01-28 | Bristol-Myers Squibb Pharma Company | Aril- és amino-aril-szubsztituált szerotoninreceptor agonista és antagonista ligandumok és ezeket tartalmazó gyógyszerkészítmények |
| PL366636A1 (en) * | 2001-06-01 | 2005-02-07 | Alcon, Inc. | Pyranoindazoles and their use for the treatment of glaucoma |
| CA2447156A1 (en) * | 2001-06-01 | 2002-12-12 | Alcon, Inc. | Novel fused indazoles and indoles and their use for the treatment of glaucoma |
| US6884816B2 (en) * | 2001-08-31 | 2005-04-26 | Alcon, Inc. | Hydroxy substituted fused naphthyl-azoles and fused indeno-azoles and their use for the treatment of glaucoma |
| US20070197664A1 (en) * | 2001-11-29 | 2007-08-23 | Steiner Mitchell S | Prevention and treatment of androgen-deprivation induced osteoporosis |
| US20040214898A1 (en) * | 2001-11-29 | 2004-10-28 | Steiner Mitchell S. | Methods for treating hot flashes |
| US20050080143A1 (en) * | 2001-11-29 | 2005-04-14 | Steiner Mitchell S. | Treatment of androgen-deprivation induced osteoporosis |
| US20080249183A1 (en) * | 2001-11-29 | 2008-10-09 | Steiner Mitchell S | Treatment of androgen-deprivation induced osteoporosis |
| US20060269611A1 (en) * | 2001-11-29 | 2006-11-30 | Steiner Mitchell S | Prevention and treatment of androgen-deprivation induced osteoporosis |
| TW593302B (en) * | 2001-12-20 | 2004-06-21 | Alcon Inc | Novel benzodifuranimidazoline and benzofuranimidazoline derivatives and their use for the treatment of glaucoma |
| WO2003057673A1 (en) * | 2001-12-28 | 2003-07-17 | Bayer Pharmaceuticals Corporation | 1h-pyrazolyl derivative compounds, for use in diseases associated with the 5-ht2c receptor |
| MXPA04005847A (es) * | 2001-12-28 | 2004-09-13 | Bayer Pharmaceuticals Corp | Compuestos derivados de 4-sulfuro/sulfoxido/sulfonil-1h-pirazolilo, para uso en enfermedades asociadas con el receptor 5-ht2c. |
| WO2003057161A2 (en) * | 2001-12-28 | 2003-07-17 | Bayer Pharmaceuticals Corporation | BENZOTHIENO [3,2-c]PYRAZOLYL AND BENZOFURANO [3,2-c] PYRAZOLYL COMPOUNDS, THEIR USE IN DISEASES ASSOCIATED WITH THE 5-HT2C RECEPTOR AND INTERMEDIATE COMPOUNDS THEREOF |
| BR0314419A (pt) * | 2002-08-30 | 2005-07-19 | Alcon Inc | Compostos de 5-croman-5-il-etilamina substituìdos, seu uso e composição farmacêutica incluindo-o |
| BR0316775A (pt) * | 2002-12-13 | 2005-11-01 | Alcon Inc | Novos análogos de benzopirano e seu uso para o tratamento de glaucoma |
| WO2005053688A1 (en) * | 2003-11-26 | 2005-06-16 | Alcon, Inc. | Substituted furo[2,3-g] indazoles for the treatment of glaucoma |
| US7338972B1 (en) | 2003-12-15 | 2008-03-04 | Alcon, Inc. | Substituted 1-alkylamino-1H-indazoles for the treatment of glaucoma |
| US7129257B1 (en) * | 2003-12-15 | 2006-10-31 | Alcon, Inc. | Pyrazolo[3,4- e]benzoxazoles for the treatment of glaucoma |
| WO2005058911A2 (en) * | 2003-12-15 | 2005-06-30 | Alcon, Inc. | Substituted [1,4]oxazino[2,3-g]indazoles for the treatment of glaucoma |
| FR2870239B1 (fr) * | 2004-05-11 | 2006-06-16 | Sanofi Synthelabo | Derives de carbamate de 2h- ou 3h-benzo[e]indazol-1-yle, leur preparation et leur application en therapeutique. |
| US7425572B2 (en) * | 2004-12-08 | 2008-09-16 | Alcon, Inc. | Use of dioxindoindazoles and dioxoloindazoles for treating glaucoma |
| TW200744567A (en) * | 2005-09-23 | 2007-12-16 | Alcon Inc | Phenylethylamine analogs and their use for treating glaucoma |
| US20070293475A1 (en) * | 2006-06-20 | 2007-12-20 | Alcon Manufacturing Ltd. | Aryl and heteroaryl tetrahydrobenzazepine derivatives and their use for treating glaucoma |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US392430A (en) * | 1888-11-06 | Tubular lantern | ||
| GB1228792A (cs) * | 1967-07-20 | 1971-04-21 | ||
| BE789948A (fr) * | 1971-10-13 | 1973-04-11 | Sandoz Sa | Nouveaux derives du pyrazole, leur preparation et leur application comme medicaments |
| US3957816A (en) * | 1973-01-31 | 1976-05-18 | Sandoz, Inc. | Substituted naphtho pyrazoles |
| SU1676453A3 (ru) * | 1987-09-18 | 1991-09-07 | Фармиталиа Карло Эрба С.Р.Л.(Фирма) | Способ получени конденсированных производных пиразола или их фармацевтически приемлемых солей |
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1995
- 1995-07-10 TW TW084107125A patent/TW403738B/zh not_active IP Right Cessation
- 1995-07-14 CA CA002153937A patent/CA2153937C/en not_active Expired - Fee Related
- 1995-08-02 US US08/510,153 patent/US5561150A/en not_active Expired - Lifetime
- 1995-08-04 ZA ZA956553A patent/ZA956553B/xx unknown
- 1995-08-04 EP EP95112270A patent/EP0700905B1/de not_active Expired - Lifetime
- 1995-08-04 HU HU9502310A patent/HUT72066A/hu unknown
- 1995-08-04 AT AT95112270T patent/ATE207905T1/de not_active IP Right Cessation
- 1995-08-04 DE DE59509777T patent/DE59509777D1/de not_active Expired - Fee Related
- 1995-08-04 ES ES95112270T patent/ES2164730T3/es not_active Expired - Lifetime
- 1995-08-04 DK DK95112270T patent/DK0700905T3/da active
- 1995-08-04 PT PT95112270T patent/PT700905E/pt unknown
- 1995-08-07 AU AU28382/95A patent/AU691310B2/en not_active Ceased
- 1995-08-07 IL IL11484995A patent/IL114849A/xx not_active IP Right Cessation
- 1995-08-07 NZ NZ272731A patent/NZ272731A/en unknown
- 1995-08-07 CZ CZ19952013A patent/CZ289027B6/cs not_active IP Right Cessation
- 1995-08-08 MA MA23984A patent/MA23643A1/fr unknown
- 1995-08-08 RU RU95113149/04A patent/RU2152388C1/ru not_active IP Right Cessation
- 1995-08-08 PE PE1995275579A patent/PE34096A1/es not_active Application Discontinuation
- 1995-08-08 TR TR95/00977A patent/TR199500977A2/xx unknown
- 1995-08-09 JP JP7203040A patent/JP2755560B2/ja not_active Expired - Fee Related
- 1995-08-10 CN CN95115544A patent/CN1056607C/zh not_active Expired - Fee Related
- 1995-08-10 MY MYPI95002335A patent/MY133619A/en unknown
- 1995-08-10 PL PL95309974A patent/PL182480B1/pl unknown
- 1995-08-10 CO CO95035750A patent/CO4410331A1/es unknown
- 1995-08-10 KR KR1019950024636A patent/KR100385384B1/ko not_active Expired - Fee Related
- 1995-08-10 PH PH51087A patent/PH31424A/en unknown
- 1995-08-11 NO NO953162A patent/NO305026B1/no unknown
- 1995-08-11 BR BR9503630A patent/BR9503630A/pt not_active IP Right Cessation
- 1995-08-11 FI FI953827A patent/FI113264B/fi not_active IP Right Cessation
- 1995-08-11 UY UY24016A patent/UY24016A1/es unknown
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| MA | Patent expired |