PE34096A1 - Derivado triciclico del pirazol - Google Patents

Derivado triciclico del pirazol

Info

Publication number
PE34096A1
PE34096A1 PE1995275579A PE27557995A PE34096A1 PE 34096 A1 PE34096 A1 PE 34096A1 PE 1995275579 A PE1995275579 A PE 1995275579A PE 27557995 A PE27557995 A PE 27557995A PE 34096 A1 PE34096 A1 PE 34096A1
Authority
PE
Peru
Prior art keywords
pyrazole
lower alkyl
tricyclic derivative
tricyclic
alkoxy
Prior art date
Application number
PE1995275579A
Other languages
English (en)
Inventor
Jurgen Wichmann
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of PE34096A1 publication Critical patent/PE34096A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Reproductive Health (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Gynecology & Obstetrics (AREA)
  • Addiction (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

SE REFIERE A UN COMPUESTO DE FORMULA I DONDE: R1 A R4 SIGNIFICAN CADA UNO HIDROGENO, HIDROXILO, HALOGENO, ALQUILO INFERIOR, ALCOXILO INFERIOR O FENILO, R2 ES DE PREFERENCIA METILO O METOXILO; R1, R3, R4 Y R6 SON DE PREFERENCIA HIDROGENO; R5 SIGNIFICA HIDROGENO o ALQUILO INFERIOR, DE PREFERENCIA METILO; R6 SIGNIFICA HIDROGENO, ALQUILO INFERIOR o ALCOXILO INFERIOR; X SIGNIFICA -(CR7R8)n o -CH=CH-, DE PREFERENCIA -CH2-; R7 y R8 SIGNIFICAN HIDROGENO o ALQUILO INFERIOR; n SIGNIFICA 1 o 2; ADEMAS SE REFIERE AL PROCEDIMIENTO DE OBTENCION QUE COMPRENDE LA CONVERSION DE UN COMPUESTO DE FORMULA GENERAL IIa, DONDE DE R1 A R6 y X YA ESTAN DEFINIDOS y R91 SIGNIFICA UN GRUPO CONVERTIBLE EN UN GRUPO AMINO, EN EL CORRESPONDIENTE COMPUESTO AMINO DE FORMULA I. ESTE COMPUESTO ES UTILIZADO EN EL TRATAMIENTO O PREVENCION DE TRANSTORNOS DEL S.N.C
PE1995275579A 1994-08-12 1995-08-08 Derivado triciclico del pirazol PE34096A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH249094 1994-08-12

Publications (1)

Publication Number Publication Date
PE34096A1 true PE34096A1 (es) 1996-10-04

Family

ID=4234975

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1995275579A PE34096A1 (es) 1994-08-12 1995-08-08 Derivado triciclico del pirazol

Country Status (31)

Country Link
US (1) US5561150A (es)
EP (1) EP0700905B1 (es)
JP (1) JP2755560B2 (es)
KR (1) KR100385384B1 (es)
CN (1) CN1056607C (es)
AT (1) ATE207905T1 (es)
AU (1) AU691310B2 (es)
BR (1) BR9503630A (es)
CA (1) CA2153937C (es)
CO (1) CO4410331A1 (es)
CZ (1) CZ289027B6 (es)
DE (1) DE59509777D1 (es)
DK (1) DK0700905T3 (es)
ES (1) ES2164730T3 (es)
FI (1) FI113264B (es)
HK (1) HK1012342A1 (es)
HU (1) HUT72066A (es)
IL (1) IL114849A (es)
MA (1) MA23643A1 (es)
MY (1) MY133619A (es)
NO (1) NO305026B1 (es)
NZ (1) NZ272731A (es)
PE (1) PE34096A1 (es)
PH (1) PH31424A (es)
PL (1) PL182480B1 (es)
PT (1) PT700905E (es)
RU (1) RU2152388C1 (es)
TR (1) TR199500977A2 (es)
TW (1) TW403738B (es)
UY (1) UY24016A1 (es)
ZA (1) ZA956553B (es)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU727654B2 (en) * 1997-06-13 2000-12-21 Yamanouchi Pharmaceutical Co., Ltd. Tricyclic pyrazole derivative
US7189753B1 (en) 1997-11-06 2007-03-13 Cady Roger K Preemptive prophylaxis of migraine
US6960579B1 (en) 1998-05-19 2005-11-01 Alcon Manufacturing, Ltd. Serotonergic 5HT7 receptor compounds for treating ocular and CNS disorders
GB9819019D0 (en) * 1998-09-01 1998-10-28 Cerebrus Ltd Chemical compounds II
GB9820767D0 (en) * 1998-09-23 1998-11-18 Cerebrus Ltd Chemical compounds VIII
GB9918965D0 (en) * 1999-08-11 1999-10-13 Cerebrus Ltd Chemical compounds xxi
GB9918962D0 (en) * 1999-08-11 1999-10-13 Cerebrus Ltd Chemical compounds xxii
US20040048844A1 (en) * 1999-10-20 2004-03-11 Bristol-Myers Squibb Pharma Company Acylsemicarbazides as cyclin dependent kinase inhibitors useful as anti-cancer and anti-proliferative agents
US6291504B1 (en) * 1999-10-20 2001-09-18 Dupont Pharmaceuticals Company Acylsemicarbazides and their uses
EP1132389A1 (en) 2000-03-06 2001-09-12 Vernalis Research Limited New aza-indolyl derivatives for the treatment of obesity
DE60117247D1 (de) * 2000-03-31 2006-04-20 Purdue Research Foundation West Lafayette Phosphoramidat-prodrugs
WO2004098807A1 (en) * 2000-11-21 2004-11-18 Barsplice Products, Inc. Method of making steel couplers for joining concrete reinforcing bars
JP2005506280A (ja) 2000-12-20 2005-03-03 ブリストル−マイヤーズ・スクイブ・ファーマ・カンパニー アリールおよびアミノアリール置換セロトニン受容体アゴニストおよびアンタゴニストリガンド
EP1392658A4 (en) * 2001-06-01 2004-10-13 Alcon Inc NOVEL FUSED INDAZOLES AND INDOLES AND THEIR USE IN THE TREATMENT OF GLAUCOMES
JP2004535418A (ja) * 2001-06-01 2004-11-25 アルコン，インコーポレイテッド ピラノインダゾールおよび緑内障治療への使用
US6884816B2 (en) * 2001-08-31 2005-04-26 Alcon, Inc. Hydroxy substituted fused naphthyl-azoles and fused indeno-azoles and their use for the treatment of glaucoma
US20060269611A1 (en) * 2001-11-29 2006-11-30 Steiner Mitchell S Prevention and treatment of androgen-deprivation induced osteoporosis
US20080249183A1 (en) * 2001-11-29 2008-10-09 Steiner Mitchell S Treatment of androgen-deprivation induced osteoporosis
US20070197664A1 (en) * 2001-11-29 2007-08-23 Steiner Mitchell S Prevention and treatment of androgen-deprivation induced osteoporosis
US20040214898A1 (en) * 2001-11-29 2004-10-28 Steiner Mitchell S. Methods for treating hot flashes
US20050080143A1 (en) * 2001-11-29 2005-04-14 Steiner Mitchell S. Treatment of androgen-deprivation induced osteoporosis
TW593302B (en) * 2001-12-20 2004-06-21 Alcon Inc Novel benzodifuranimidazoline and benzofuranimidazoline derivatives and their use for the treatment of glaucoma
WO2003057161A2 (en) * 2001-12-28 2003-07-17 Bayer Pharmaceuticals Corporation BENZOTHIENO [3,2-c]PYRAZOLYL AND BENZOFURANO [3,2-c] PYRAZOLYL COMPOUNDS, THEIR USE IN DISEASES ASSOCIATED WITH THE 5-HT2C RECEPTOR AND INTERMEDIATE COMPOUNDS THEREOF
WO2003057673A1 (en) * 2001-12-28 2003-07-17 Bayer Pharmaceuticals Corporation 1h-pyrazolyl derivative compounds, for use in diseases associated with the 5-ht2c receptor
WO2003057674A1 (en) * 2001-12-28 2003-07-17 Bayer Pharmaceuticals Corporation 4-sulfide / sulfoxide / sulfonyl-1h-pyrazolyl derivative compounds, for use in diseases associated with the 5-ht2c receptor
PL375564A1 (en) * 2002-08-30 2005-11-28 Alcon, Inc. Substituted 5-chroman-5-yl-ethylamine compounds and their use for the treatment of glaucoma
WO2004054572A2 (en) * 2002-12-13 2004-07-01 Alcon, Inc. Novel benzopyran analogs and their use for the treatment of glaucoma
WO2005053688A1 (en) * 2003-11-26 2005-06-16 Alcon, Inc. Substituted furo[2,3-g] indazoles for the treatment of glaucoma
US7129257B1 (en) 2003-12-15 2006-10-31 Alcon, Inc. Pyrazolo[3,4- e]benzoxazoles for the treatment of glaucoma
US7338972B1 (en) 2003-12-15 2008-03-04 Alcon, Inc. Substituted 1-alkylamino-1H-indazoles for the treatment of glaucoma
AR046890A1 (es) * 2003-12-15 2005-12-28 Alcon Inc [1,4] oxazino [2,3-g] indazoles sustituidos para el tratamiento del glaucoma.
WO2006062839A1 (en) * 2004-12-08 2006-06-15 Alcon, Inc. Use of dioxindoindazoles and dioxoloindazoles for treating glaucoma
TW200744567A (en) * 2005-09-23 2007-12-16 Alcon Inc Phenylethylamine analogs and their use for treating glaucoma
WO2007149728A2 (en) * 2006-06-20 2007-12-27 Alcon Research, Ltd. Aryl and heteroaryl tetrahydrobenzazepine derivatives and their use for treating glaucoma

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US392430A (en) * 1888-11-06 Tubular lantern
GB1228792A (es) * 1967-07-20 1971-04-21
BE789948A (fr) * 1971-10-13 1973-04-11 Sandoz Sa Nouveaux derives du pyrazole, leur preparation et leur application comme medicaments

Also Published As

Publication number Publication date
FI113264B (fi) 2004-03-31
PT700905E (pt) 2002-04-29
UY24016A1 (es) 2000-12-29
ATE207905T1 (de) 2001-11-15
IL114849A0 (en) 1995-12-08
FI953827A (fi) 1996-02-13
US5561150A (en) 1996-10-01
JP2755560B2 (ja) 1998-05-20
MA23643A1 (fr) 1996-04-01
MY133619A (en) 2007-11-30
DK0700905T3 (da) 2002-02-18
NO953162D0 (no) 1995-08-11
AU2838295A (en) 1996-02-22
AU691310B2 (en) 1998-05-14
RU2152388C1 (ru) 2000-07-10
EP0700905A1 (de) 1996-03-13
KR960007568A (ko) 1996-03-22
CO4410331A1 (es) 1997-01-09
CZ9502013A3 (en) 1996-03-13
CN1131666A (zh) 1996-09-25
FI953827A0 (fi) 1995-08-11
CA2153937C (en) 2007-04-10
PL182480B1 (pl) 2002-01-31
HK1012342A1 (en) 1999-07-30
TR199500977A2 (tr) 1996-06-21
PL309974A1 (en) 1996-02-19
DE59509777D1 (de) 2001-12-06
NO305026B1 (no) 1999-03-22
TW403738B (en) 2000-09-01
NZ272731A (en) 1996-09-25
PH31424A (en) 1998-10-29
JPH0859623A (ja) 1996-03-05
CA2153937A1 (en) 1996-02-13
HUT72066A (en) 1996-03-28
CZ289027B6 (cs) 2001-10-17
EP0700905B1 (de) 2001-10-31
BR9503630A (pt) 1996-05-28
ZA956553B (en) 1996-02-12
NO953162L (no) 1996-02-13
ES2164730T3 (es) 2002-03-01
CN1056607C (zh) 2000-09-20
IL114849A (en) 1999-11-30
KR100385384B1 (ko) 2003-09-19

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Legal Events

Date Code Title Description
FG Grant, registration
FD Application declared void or lapsed