ES2164730T3 - Derivados triciclicos de pirazol. - Google Patents

Derivados triciclicos de pirazol.

Info

Publication number
ES2164730T3
ES2164730T3 ES95112270T ES95112270T ES2164730T3 ES 2164730 T3 ES2164730 T3 ES 2164730T3 ES 95112270 T ES95112270 T ES 95112270T ES 95112270 T ES95112270 T ES 95112270T ES 2164730 T3 ES2164730 T3 ES 2164730T3
Authority
ES
Spain
Prior art keywords
pirazol
lower alkyl
tricycle
derivatives
tricycle derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95112270T
Other languages
English (en)
Inventor
Jurgen Wichmann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Application granted granted Critical
Publication of ES2164730T3 publication Critical patent/ES2164730T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Reproductive Health (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Diabetes (AREA)
  • Addiction (AREA)
  • Anesthesiology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

LA INVENCION SE REFIERE A DERIVADOS PIRAZOL TRICICLICOS DE LA FORMULA GENERAL DONDE R{SUB, 1} HASTA R{SUB, 4} SIGNIFICAN HIDROGENO, HIDROXI, HALOGENO, ALQUILO INFERIOR, ALCOXI INFERIOR O FENILO; R{SUB, 5} ES HIDROGENO O ALQUILO INFERIOR; R{SUB, 6} ES HIDROGENO, ALQUILO INFERIOR O ALCOXI INFERIOR; X ES - (CR{SUB, 7}R{SUB, 8}){SUB, N} - O - CH=CH - ; R{SUB, 7} Y R{SUB, 8} SON HIDROGENO O ALQUILO INFERIOR Y N ES 1 O 2, ASI COMO SALES ACEPTABLES FARMACEUTICAMENTE DE LOS COMPUESTOS BASICOS DE LA FORMULA GENERAL I. ESTOS COMPUESTOS Y SALES SON APROPIADOS PARA SU UTILIZACION COMO SUSTANCIAS ACTIVAS TERAPEUTICAS, EN PARTICULAR PARA TRATAMIENTO O PREVENCION DE PERTURBACIONES NERVIOSAS CENTRALES, COMO DEPRESIONES, PERTURBACIONES BIPOLARES, ESTADOS DE ANGUSTIA, PERTURBACIONES SEXUALES Y DEL SUEÑO, PSICOSIS, ESQUIZOFRENIA, MIGRAÑA Y DOLORES DE CABEZA O DOLORES DE OTRO TIPO LIGADOS A DIFERENTES SITUACIONES, PERTURBACIONES DE LA PERSONALIDAD O PERTURBACIONES OBSESIVO COMPULSIVAS, FOBIA SOCIAL O CASOS DEPANICO, PERTURBACIONES ORGANICAS MENTALES, PERTURBACIONES MENTALES EN VEJEZ INFANTIL, AGRESIVIDAD, PERTURBACIONES DEL PENSAMIENTO LIGADAS A LA VEJEZ Y PERTURBACIONES DE COMPORTAMIENTO, ANSIEDAD, OBESIDAD, BULIMIA, ETC. DAÑOS DEL SISTEMA NERVIOSO DEBIDO A SITUACIONES TRAUMATICAS, APOPLEJIA, ENFERMEDADES NEURODEGENERATIVAS ETC., PERTURBACIONES CARDIOVASCULARES, COMO ALTA PRESION ARTERIAL, TROMBOSIS, ATAQUE DE APOPLEJIA ETC. Y PERTURBACIONES GASTROINTESTINALES COMO DISFUNCIONES DE LA MOVILIDAD DEL TRACTO GASTROINTESTINAL.
ES95112270T 1994-08-12 1995-08-04 Derivados triciclicos de pirazol. Expired - Lifetime ES2164730T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH249094 1994-08-12

Publications (1)

Publication Number Publication Date
ES2164730T3 true ES2164730T3 (es) 2002-03-01

Family

ID=4234975

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95112270T Expired - Lifetime ES2164730T3 (es) 1994-08-12 1995-08-04 Derivados triciclicos de pirazol.

Country Status (31)

Country Link
US (1) US5561150A (es)
EP (1) EP0700905B1 (es)
JP (1) JP2755560B2 (es)
KR (1) KR100385384B1 (es)
CN (1) CN1056607C (es)
AT (1) ATE207905T1 (es)
AU (1) AU691310B2 (es)
BR (1) BR9503630A (es)
CA (1) CA2153937C (es)
CO (1) CO4410331A1 (es)
CZ (1) CZ289027B6 (es)
DE (1) DE59509777D1 (es)
DK (1) DK0700905T3 (es)
ES (1) ES2164730T3 (es)
FI (1) FI113264B (es)
HK (1) HK1012342A1 (es)
HU (1) HUT72066A (es)
IL (1) IL114849A (es)
MA (1) MA23643A1 (es)
MY (1) MY133619A (es)
NO (1) NO305026B1 (es)
NZ (1) NZ272731A (es)
PE (1) PE34096A1 (es)
PH (1) PH31424A (es)
PL (1) PL182480B1 (es)
PT (1) PT700905E (es)
RU (1) RU2152388C1 (es)
TR (1) TR199500977A2 (es)
TW (1) TW403738B (es)
UY (1) UY24016A1 (es)
ZA (1) ZA956553B (es)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU727654B2 (en) 1997-06-13 2000-12-21 Yamanouchi Pharmaceutical Co., Ltd. Tricyclic pyrazole derivative
US7189753B1 (en) 1997-11-06 2007-03-13 Cady Roger K Preemptive prophylaxis of migraine
US6960579B1 (en) 1998-05-19 2005-11-01 Alcon Manufacturing, Ltd. Serotonergic 5HT7 receptor compounds for treating ocular and CNS disorders
GB9819019D0 (en) * 1998-09-01 1998-10-28 Cerebrus Ltd Chemical compounds II
GB9820767D0 (en) * 1998-09-23 1998-11-18 Cerebrus Ltd Chemical compounds VIII
GB9918965D0 (en) * 1999-08-11 1999-10-13 Cerebrus Ltd Chemical compounds xxi
GB9918962D0 (en) 1999-08-11 1999-10-13 Cerebrus Ltd Chemical compounds xxii
US6291504B1 (en) * 1999-10-20 2001-09-18 Dupont Pharmaceuticals Company Acylsemicarbazides and their uses
US20040048844A1 (en) * 1999-10-20 2004-03-11 Bristol-Myers Squibb Pharma Company Acylsemicarbazides as cyclin dependent kinase inhibitors useful as anti-cancer and anti-proliferative agents
EP1132389A1 (en) 2000-03-06 2001-09-12 Vernalis Research Limited New aza-indolyl derivatives for the treatment of obesity
JP2004538240A (ja) * 2000-03-31 2004-12-24 パーデュー・リサーチ・ファウンデーション ホスホラミデートおよびそのための方法
WO2004098807A1 (en) * 2000-11-21 2004-11-18 Barsplice Products, Inc. Method of making steel couplers for joining concrete reinforcing bars
JP2005506280A (ja) 2000-12-20 2005-03-03 ブリストル−マイヤーズ・スクイブ・ファーマ・カンパニー アリールおよびアミノアリール置換セロトニン受容体アゴニストおよびアンタゴニストリガンド
CA2447156A1 (en) * 2001-06-01 2002-12-12 Alcon, Inc. Novel fused indazoles and indoles and their use for the treatment of glaucoma
PT1392292E (pt) * 2001-06-01 2006-05-31 Alcon Inc Piranoindazoles e sua utilizacao para o tratamento de glaucoma
US6884816B2 (en) * 2001-08-31 2005-04-26 Alcon, Inc. Hydroxy substituted fused naphthyl-azoles and fused indeno-azoles and their use for the treatment of glaucoma
US20040214898A1 (en) * 2001-11-29 2004-10-28 Steiner Mitchell S. Methods for treating hot flashes
US20080249183A1 (en) * 2001-11-29 2008-10-09 Steiner Mitchell S Treatment of androgen-deprivation induced osteoporosis
US20060269611A1 (en) * 2001-11-29 2006-11-30 Steiner Mitchell S Prevention and treatment of androgen-deprivation induced osteoporosis
US20070197664A1 (en) * 2001-11-29 2007-08-23 Steiner Mitchell S Prevention and treatment of androgen-deprivation induced osteoporosis
US20050080143A1 (en) * 2001-11-29 2005-04-14 Steiner Mitchell S. Treatment of androgen-deprivation induced osteoporosis
TW593302B (en) * 2001-12-20 2004-06-21 Alcon Inc Novel benzodifuranimidazoline and benzofuranimidazoline derivatives and their use for the treatment of glaucoma
WO2003057673A1 (en) * 2001-12-28 2003-07-17 Bayer Pharmaceuticals Corporation 1h-pyrazolyl derivative compounds, for use in diseases associated with the 5-ht2c receptor
US20050119489A1 (en) * 2001-12-28 2005-06-02 Ladouceur Gaetan H. 4-Sulfide/sulfoxide/sulfonyl-1h-pyrazolyl derivative compounds, for use in diseases associated with the 5-ht2c receptor
AU2002367323A1 (en) * 2001-12-28 2003-07-24 Bayer Pharmaceuticals Corporation Benzothieno (3,2-
JP2006501245A (ja) * 2002-08-30 2006-01-12 アルコン，インコーポレイテッド 置換された５−クロマン−５−イル−エチルアミン化合物および緑内障の治療のためのその使用
CA2506204A1 (en) * 2002-12-13 2004-07-01 Alcon, Inc. Novel benzopyran analogs and their use for the treatment of glaucoma
WO2005053688A1 (en) * 2003-11-26 2005-06-16 Alcon, Inc. Substituted furo[2,3-g] indazoles for the treatment of glaucoma
WO2005058911A2 (en) * 2003-12-15 2005-06-30 Alcon, Inc. Substituted [1,4]oxazino[2,3-g]indazoles for the treatment of glaucoma
US7129257B1 (en) 2003-12-15 2006-10-31 Alcon, Inc. Pyrazolo[3,4- e]benzoxazoles for the treatment of glaucoma
US7338972B1 (en) 2003-12-15 2008-03-04 Alcon, Inc. Substituted 1-alkylamino-1H-indazoles for the treatment of glaucoma
WO2006062839A1 (en) * 2004-12-08 2006-06-15 Alcon, Inc. Use of dioxindoindazoles and dioxoloindazoles for treating glaucoma
TW200744567A (en) * 2005-09-23 2007-12-16 Alcon Inc Phenylethylamine analogs and their use for treating glaucoma
US20070293475A1 (en) * 2006-06-20 2007-12-20 Alcon Manufacturing Ltd. Aryl and heteroaryl tetrahydrobenzazepine derivatives and their use for treating glaucoma

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US392430A (en) * 1888-11-06 Tubular lantern
GB1228792A (es) * 1967-07-20 1971-04-21
BE789948A (fr) * 1971-10-13 1973-04-11 Sandoz Sa Nouveaux derives du pyrazole, leur preparation et leur application comme medicaments

Also Published As

Publication number Publication date
IL114849A0 (en) 1995-12-08
NO953162L (no) 1996-02-13
RU2152388C1 (ru) 2000-07-10
JPH0859623A (ja) 1996-03-05
KR100385384B1 (ko) 2003-09-19
NO305026B1 (no) 1999-03-22
FI953827A (fi) 1996-02-13
EP0700905A1 (de) 1996-03-13
ZA956553B (en) 1996-02-12
CZ9502013A3 (en) 1996-03-13
UY24016A1 (es) 2000-12-29
BR9503630A (pt) 1996-05-28
ATE207905T1 (de) 2001-11-15
JP2755560B2 (ja) 1998-05-20
PH31424A (en) 1998-10-29
CO4410331A1 (es) 1997-01-09
CA2153937C (en) 2007-04-10
NZ272731A (en) 1996-09-25
PE34096A1 (es) 1996-10-04
PL309974A1 (en) 1996-02-19
FI953827A0 (fi) 1995-08-11
KR960007568A (ko) 1996-03-22
NO953162D0 (no) 1995-08-11
CN1056607C (zh) 2000-09-20
TW403738B (en) 2000-09-01
CN1131666A (zh) 1996-09-25
CA2153937A1 (en) 1996-02-13
AU691310B2 (en) 1998-05-14
DK0700905T3 (da) 2002-02-18
EP0700905B1 (de) 2001-10-31
PT700905E (pt) 2002-04-29
IL114849A (en) 1999-11-30
FI113264B (fi) 2004-03-31
MY133619A (en) 2007-11-30
HUT72066A (en) 1996-03-28
PL182480B1 (pl) 2002-01-31
AU2838295A (en) 1996-02-22
CZ289027B6 (cs) 2001-10-17
TR199500977A2 (tr) 1996-06-21
DE59509777D1 (de) 2001-12-06
MA23643A1 (fr) 1996-04-01
US5561150A (en) 1996-10-01
HK1012342A1 (en) 1999-07-30

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