FI112868B - Terapiassa käyttökelpoiset spiro[1-atsabisyklo[2.2.2]oktaani- tai -[2.2.1]heptaani-3,5'-oksatsolidiini-2'-oniyhdisteet ja menetelmä niiden valmistamiseksi sekä välituotteet - Google Patents
Terapiassa käyttökelpoiset spiro[1-atsabisyklo[2.2.2]oktaani- tai -[2.2.1]heptaani-3,5'-oksatsolidiini-2'-oniyhdisteet ja menetelmä niiden valmistamiseksi sekä välituotteet Download PDFInfo
- Publication number
- FI112868B FI112868B FI970762A FI970762A FI112868B FI 112868 B FI112868 B FI 112868B FI 970762 A FI970762 A FI 970762A FI 970762 A FI970762 A FI 970762A FI 112868 B FI112868 B FI 112868B
- Authority
- FI
- Finland
- Prior art keywords
- enantiomer
- compound
- formula
- pharmaceutically acceptable
- azabicyclo
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9417084A GB9417084D0 (en) | 1994-08-24 | 1994-08-24 | Compounds useful in therapy |
GB9417084 | 1994-08-24 | ||
GB9504627 | 1995-03-08 | ||
GBGB9504627.2A GB9504627D0 (en) | 1995-03-08 | 1995-03-08 | Compounds for use in therapy |
PCT/SE1995/000937 WO1996006098A1 (en) | 1994-08-24 | 1995-08-22 | Spiro-azabicyclic compounds useful in therapy |
SE9500937 | 1995-08-22 |
Publications (3)
Publication Number | Publication Date |
---|---|
FI970762A FI970762A (fi) | 1997-02-24 |
FI970762A0 FI970762A0 (fi) | 1997-02-24 |
FI112868B true FI112868B (fi) | 2004-01-30 |
Family
ID=26305509
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI970762A FI112868B (fi) | 1994-08-24 | 1997-02-24 | Terapiassa käyttökelpoiset spiro[1-atsabisyklo[2.2.2]oktaani- tai -[2.2.1]heptaani-3,5'-oksatsolidiini-2'-oniyhdisteet ja menetelmä niiden valmistamiseksi sekä välituotteet |
Country Status (34)
Country | Link |
---|---|
US (2) | US5902814A (de) |
EP (1) | EP0777671B1 (de) |
JP (1) | JP3708962B2 (de) |
KR (1) | KR100366331B1 (de) |
CN (2) | CN1056846C (de) |
AR (1) | AR031828A2 (de) |
AT (1) | ATE192157T1 (de) |
AU (1) | AU690735B2 (de) |
BR (1) | BR9508751A (de) |
CA (1) | CA2196995C (de) |
CZ (1) | CZ289512B6 (de) |
DE (1) | DE69516524T2 (de) |
DK (1) | DK0777671T3 (de) |
EE (1) | EE03399B1 (de) |
EG (1) | EG24222A (de) |
ES (1) | ES2145922T3 (de) |
FI (1) | FI112868B (de) |
GR (1) | GR3033878T3 (de) |
HK (1) | HK1010370A1 (de) |
HU (1) | HUT77352A (de) |
IL (1) | IL115039A (de) |
IS (1) | IS1852B (de) |
MX (1) | MX9701292A (de) |
NO (1) | NO307707B1 (de) |
NZ (1) | NZ292289A (de) |
PL (1) | PL183933B1 (de) |
PT (1) | PT777671E (de) |
RU (1) | RU2148058C1 (de) |
SA (1) | SA95160370B1 (de) |
SK (1) | SK282366B6 (de) |
TR (1) | TR199501053A2 (de) |
TW (1) | TW397837B (de) |
UA (1) | UA54375C2 (de) |
WO (1) | WO1996006098A1 (de) |
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US5977144A (en) * | 1992-08-31 | 1999-11-02 | University Of Florida | Methods of use and compositions for benzylidene- and cinnamylidene-anabaseines |
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US6277870B1 (en) * | 1998-05-04 | 2001-08-21 | Astra Ab | Use |
SE9900100D0 (sv) | 1999-01-15 | 1999-01-15 | Astra Ab | New compounds |
JP4564135B2 (ja) * | 1999-07-26 | 2010-10-20 | 住友化学株式会社 | 高純度フェノチアジン化合物とその製造方法、およびその中間体の製造方法、並びにその中間体の原料の水和物と新規結晶 |
WO2001066546A1 (fr) * | 2000-03-09 | 2001-09-13 | Mitsubishi Pharma Corporation | Composes spiro, leur procede de preparation et leur utilisation comme medicaments |
US8914114B2 (en) | 2000-05-23 | 2014-12-16 | The Feinstein Institute For Medical Research | Inhibition of inflammatory cytokine production by cholinergic agonists and vagus nerve stimulation |
JP2004507549A (ja) * | 2000-08-28 | 2004-03-11 | コロラド ステート ユニバーシティー リサーチ ファウンデーション | オキサゾリジノン部分を含む化合物およびその使用方法 |
US6569865B2 (en) | 2001-06-01 | 2003-05-27 | Astrazeneca Ab | Spiro 1-azabicyclo[2.2.2]octane-3,2′(3′h)-furo[2,3-b]pyridine |
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DE10164139A1 (de) | 2001-12-27 | 2003-07-10 | Bayer Ag | 2-Heteroarylcarbonsäureamide |
WO2003072135A2 (en) * | 2002-02-26 | 2003-09-04 | North Shore-Long Island Jewish Research Insitute | Inhibition of inflammatory cytokine production by stimulation of brain muscarinic receptors |
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JP4750421B2 (ja) * | 2002-12-06 | 2011-08-17 | ノース ショア−ロング アイランド ジュ−イッシュ リサ−チ インスティチュ−ト | α7受容体結合コリン作動性アゴニストを用いる炎症の阻害 |
US7238715B2 (en) * | 2002-12-06 | 2007-07-03 | The Feinstein Institute For Medical Research | Treatment of pancreatitis using alpha 7 receptor-binding cholinergic agonists |
CN1829721A (zh) * | 2003-07-08 | 2006-09-06 | 阿斯利康(瑞典)有限公司 | 对α7烟碱乙酰胆碱受体具有亲和力的螺[1-氮杂二环[2.2.2]辛烷-3,5’-噁唑烷]-2’-酮衍生物 |
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EP2258359A3 (de) | 2005-08-26 | 2011-04-06 | Braincells, Inc. | Neurogenese durch Modulation des Muscarinrezeptors mit Sabcomelin |
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CH601304A5 (de) * | 1974-02-12 | 1978-07-14 | Buskine Sa | |
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-
1995
- 1995-08-22 JP JP50799596A patent/JP3708962B2/ja not_active Expired - Fee Related
- 1995-08-22 AT AT95930755T patent/ATE192157T1/de not_active IP Right Cessation
- 1995-08-22 DE DE69516524T patent/DE69516524T2/de not_active Expired - Fee Related
- 1995-08-22 DK DK95930755T patent/DK0777671T3/da active
- 1995-08-22 EE EE9700039A patent/EE03399B1/xx not_active IP Right Cessation
- 1995-08-22 CZ CZ1997392A patent/CZ289512B6/cs not_active IP Right Cessation
- 1995-08-22 NZ NZ292289A patent/NZ292289A/en not_active IP Right Cessation
- 1995-08-22 BR BR9508751A patent/BR9508751A/pt not_active IP Right Cessation
- 1995-08-22 US US08/525,575 patent/US5902814A/en not_active Expired - Fee Related
- 1995-08-22 EP EP95930755A patent/EP0777671B1/de not_active Expired - Lifetime
- 1995-08-22 MX MX9701292A patent/MX9701292A/es unknown
- 1995-08-22 KR KR1019970701159A patent/KR100366331B1/ko not_active IP Right Cessation
- 1995-08-22 RU RU97104165A patent/RU2148058C1/ru not_active IP Right Cessation
- 1995-08-22 HU HU9701965A patent/HUT77352A/hu unknown
- 1995-08-22 WO PCT/SE1995/000937 patent/WO1996006098A1/en active IP Right Grant
- 1995-08-22 SK SK216-97A patent/SK282366B6/sk not_active IP Right Cessation
- 1995-08-22 CN CN95195518A patent/CN1056846C/zh not_active Expired - Fee Related
- 1995-08-22 CA CA002196995A patent/CA2196995C/en not_active Expired - Fee Related
- 1995-08-22 UA UA97031329A patent/UA54375C2/uk unknown
- 1995-08-22 PT PT95930755T patent/PT777671E/pt unknown
- 1995-08-22 AU AU34018/95A patent/AU690735B2/en not_active Ceased
- 1995-08-22 PL PL95318760A patent/PL183933B1/pl not_active IP Right Cessation
- 1995-08-22 ES ES95930755T patent/ES2145922T3/es not_active Expired - Lifetime
- 1995-08-23 EG EG70395A patent/EG24222A/xx active
- 1995-08-23 IL IL11503995A patent/IL115039A/xx not_active IP Right Cessation
- 1995-08-24 TW TW084108836A patent/TW397837B/zh not_active IP Right Cessation
- 1995-08-24 TR TR95/01053A patent/TR199501053A2/xx unknown
- 1995-11-08 SA SA95160370A patent/SA95160370B1/ar unknown
-
1997
- 1997-02-03 IS IS4424A patent/IS1852B/is unknown
- 1997-02-21 NO NO970800A patent/NO307707B1/no not_active IP Right Cessation
- 1997-02-24 FI FI970762A patent/FI112868B/fi active
-
1998
- 1998-09-26 HK HK98110995A patent/HK1010370A1/xx not_active IP Right Cessation
- 1998-11-09 US US09/188,099 patent/US6051581A/en not_active Expired - Fee Related
-
1999
- 1999-11-08 CN CN99123574A patent/CN1099419C/zh not_active Expired - Fee Related
-
2000
- 2000-04-10 AR ARP000101632A patent/AR031828A2/es unknown
- 2000-07-04 GR GR20000401563T patent/GR3033878T3/el not_active IP Right Cessation
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