FI112116B - Menetelmä proteiinin 3-ulotteisen rakenneinformaation määrittämiseksi ja ravintoväliaine - Google Patents

Menetelmä proteiinin 3-ulotteisen rakenneinformaation määrittämiseksi ja ravintoväliaine Download PDF

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Publication number
FI112116B
FI112116B FI943745A FI943745A FI112116B FI 112116 B FI112116 B FI 112116B FI 943745 A FI943745 A FI 943745A FI 943745 A FI943745 A FI 943745A FI 112116 B FI112116 B FI 112116B
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Prior art keywords
protein
amino acids
nutrient medium
labeled
substituted
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FI943745A
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English (en)
Finnish (fi)
Swedish (sv)
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FI943745A (fi
FI943745A0 (fi
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Jonathan Miles Brown
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Martek Biosciences Corp
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/001—Acyclic or carbocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/12—Unicellular algae; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/04—Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/534—Production of labelled immunochemicals with radioactive label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
    • Y10T436/105831—Protein or peptide standard or control [e.g., hemoglobin, etc.]

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Botany (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
FI943745A 1993-02-05 1994-08-15 Menetelmä proteiinin 3-ulotteisen rakenneinformaation määrittämiseksi ja ravintoväliaine FI112116B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US1424393 1993-02-05
US08/014,243 US5393669A (en) 1993-02-05 1993-02-05 Compositions and methods for protein structural determinations
US9401329 1994-02-07
PCT/US1994/001329 WO1994018339A1 (en) 1993-02-05 1994-02-07 Compositions and methods for protein structural determinations

Publications (3)

Publication Number Publication Date
FI943745A FI943745A (fi) 1994-08-15
FI943745A0 FI943745A0 (fi) 1994-08-15
FI112116B true FI112116B (fi) 2003-10-31

Family

ID=21764312

Family Applications (1)

Application Number Title Priority Date Filing Date
FI943745A FI112116B (fi) 1993-02-05 1994-08-15 Menetelmä proteiinin 3-ulotteisen rakenneinformaation määrittämiseksi ja ravintoväliaine

Country Status (13)

Country Link
US (3) US5393669A (no)
EP (3) EP0636183B1 (no)
JP (4) JPH07506192A (no)
AT (1) ATE221918T1 (no)
AU (2) AU678446B2 (no)
CA (1) CA2129904A1 (no)
DE (1) DE69431142T2 (no)
DK (1) DK0636183T3 (no)
ES (1) ES2181715T3 (no)
FI (1) FI112116B (no)
NO (1) NO943703L (no)
PT (1) PT636183E (no)
WO (1) WO1994018339A1 (no)

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US5393669A (en) * 1993-02-05 1995-02-28 Martek Biosciences Corp. Compositions and methods for protein structural determinations
US5989827A (en) * 1995-11-14 1999-11-23 Abbott Laboratories Use of nuclear magnetic resonance to design ligands to target biomolecules
US5891643A (en) * 1995-11-14 1999-04-06 Abbott Laboratories Use of nuclear magnetic resonance to design ligands to target biomolecules
ATE201768T1 (de) * 1995-11-14 2001-06-15 Abbott Lab Verwendung von kernspinresonanz zur bestimmung von liganden für zielbiomoleküle
WO1997018321A1 (en) * 1995-11-15 1997-05-22 Martek Corporation Photosynthetic production of stable isotopically labeled recombinant proteins
US6168912B1 (en) 1996-01-23 2001-01-02 Martek Biosciences Corporation Method and kit for making a multidimensional combinatorial chemical library
US6111066A (en) * 1997-09-02 2000-08-29 Martek Biosciences Corporation Peptidic molecules which have been isotopically substituted with 13 C, 15 N and 2 H in the backbone but not in the sidechains
US20030220234A1 (en) * 1998-11-02 2003-11-27 Selvaraj Naicker Deuterated cyclosporine analogs and their use as immunodulating agents
JP2002534687A (ja) * 1998-12-30 2002-10-15 アメルシャム・パブリック・リミテッド・カンパニー 過分極を使用したｎｍｒ分光学アッセイ
AU5880800A (en) * 1999-06-25 2001-01-31 Battelle Memorial Institute Use of non-lossy solvents as a means to improve the high-field nmr sensitivity of biological samples
EP1311858B1 (en) * 2000-05-05 2006-11-02 Purdue Research Foundation Affinity selected signature peptides for protein identification and quantification
US6762041B2 (en) 2000-05-15 2004-07-13 Ajinomoto Co., Inc. Method for isotope labeling of protein with enzyme
WO2002035239A1 (en) * 2000-10-20 2002-05-02 Martek Biosciences Corporation Rapid determination of protein global folds
US6882939B2 (en) * 2000-10-20 2005-04-19 Prospect Pharma Rapid determination of protein global folds
US20030068831A1 (en) * 2001-03-12 2003-04-10 Aled Edwards Proteins and druggable regions of proteins
US7256047B2 (en) * 2001-05-01 2007-08-14 Board Of Regents, The University Of Texas System Measurement of gluconeogenesis and intermediary metabolism using stable isotopes
WO2003006488A1 (en) * 2001-07-13 2003-01-23 The Regents Of The University Of California In-cell nmr spectroscopy
CA2460819A1 (en) * 2001-09-18 2003-03-27 Affinium Pharmaceuticals, Inc. Methods and apparatuses for purification
CA2461587C (en) * 2001-09-27 2011-04-26 Purdue Research Foundation Materials and methods for controlling isotope effects during fractionation of analytes
ATE425178T1 (de) * 2001-10-19 2009-03-15 Isotechnika Inc Synthese von cyclosporinanalogen
WO2003053910A1 (fr) * 2001-12-19 2003-07-03 Japan Science And Technology Agency Amino acide marque par isotope stable, technique d'integration de cet amino acide dans une proteine cible, technique d'analyse structurelle par irm de proteine et technique de production d'acide fumarique et d'acide tartrique marques par isotope stable a selection de site
AU2003247276A1 (en) * 2002-02-20 2003-09-09 Affinium Pharmaceuticals, Inc. Methods and apparatuses for characterizing stability of biological molecules
US20050079526A1 (en) * 2002-02-20 2005-04-14 Affinium Pharmaceuticals, Inc. Methods and apparatuses for characterizing refolding and aggregation of biological molecules
US20050181464A1 (en) * 2002-04-04 2005-08-18 Affinium Pharmaceuticals, Inc. Novel purified polypeptides from bacteria
WO2003087834A2 (en) * 2002-04-08 2003-10-23 Affinium Pharmaceuticals, Inc. High throughput analysis of recombinant proteins in multi-well plates
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US20060154323A1 (en) * 2002-06-10 2006-07-13 Prospect Pharma Method for obtaining dynamic and structural data pertaining to proteins and protein/ligand complexes
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JP4836786B2 (ja) * 2003-07-11 2011-12-14 − ツァチェルニュウク、タティアナ、アー． エゴロワ 生体化合物の安定同位体標識のための組成物及び方法
EP1678198A4 (en) * 2003-10-07 2007-12-05 Prospect Pharma SIDE CHAIN DEUTERATED AMINO ACIDS AND METHOD OF USE
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CN104030942B (zh) * 2014-06-09 2016-08-24 浙江普洛医药科技有限公司 一种L-α-氨基丁酰胺盐酸盐的制备方法
JP2019521083A (ja) * 2016-05-02 2019-07-25 レトロトップ、 インコーポレイテッドＲｅｔｒｏｔｏｐｅ， Ｉｎｃ． 同位体修飾された組成物およびその治療的使用
CN107793209A (zh) * 2016-08-30 2018-03-13 泰生科技香港有限公司 稳定性同位素标记植物的专用培养基、其制备方法及用途
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Also Published As

Publication number Publication date
EP1193271A3 (en) 2004-03-24
JPH07506192A (ja) 1995-07-06
ATE221918T1 (de) 2002-08-15
US5393669A (en) 1995-02-28
CA2129904A1 (en) 1994-08-18
FI943745A (fi) 1994-08-15
AU711468B2 (en) 1999-10-14
DK0636183T3 (da) 2002-12-02
DE69431142T2 (de) 2003-10-09
EP1193271A2 (en) 2002-04-03
EP0636183A4 (en) 1997-01-22
AU678446B2 (en) 1997-05-29
EP0636183A1 (en) 1995-02-01
AU3608797A (en) 1997-12-04
PT636183E (pt) 2002-11-29
JP2004113248A (ja) 2004-04-15
WO1994018339A1 (en) 1994-08-18
US5817474A (en) 1998-10-06
FI943745A0 (fi) 1994-08-15
NO943703L (no) 1994-11-23
EP1191033A3 (en) 2003-07-30
JP2004125801A (ja) 2004-04-22
AU6236394A (en) 1994-08-29
EP0636183B1 (en) 2002-08-07
JP2004115528A (ja) 2004-04-15
EP1191033A2 (en) 2002-03-27
ES2181715T3 (es) 2003-03-01
US5627044A (en) 1997-05-06
NO943703D0 (no) 1994-10-04
DE69431142D1 (de) 2002-09-12

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