ES2181715T3 - Composiciones y procedimientos para la determinacion de estructuras de proteinas. - Google Patents

Composiciones y procedimientos para la determinacion de estructuras de proteinas.

Info

Publication number
ES2181715T3
ES2181715T3 ES94909555T ES94909555T ES2181715T3 ES 2181715 T3 ES2181715 T3 ES 2181715T3 ES 94909555 T ES94909555 T ES 94909555T ES 94909555 T ES94909555 T ES 94909555T ES 2181715 T3 ES2181715 T3 ES 2181715T3
Authority
ES
Spain
Prior art keywords
labeled
protein
amino acid
acid mixture
subjecting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94909555T
Other languages
English (en)
Inventor
Jonathan Miles Brown
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Martek Biosciences Corp
Original Assignee
Martek Biosciences Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21764312&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2181715(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Martek Biosciences Corp filed Critical Martek Biosciences Corp
Application granted granted Critical
Publication of ES2181715T3 publication Critical patent/ES2181715T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/001—Acyclic or carbocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/12—Unicellular algae; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/04—Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/534—Production of labelled immunochemicals with radioactive label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
    • Y10T436/105831—Protein or peptide standard or control [e.g., hemoglobin, etc.]

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Botany (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

UN METODO PARA DETERMINAR LA INFORMACION ESTRUCTURAL TRIDIMENSIONAL DE UNA PROTEINA ATAÑE A PRODUCIR LA PROTEINA EN UNA FORMA SUSTANCIALMENTE MARCADA CON 13C O 15N O AMBAS O MARCADA SUSTANCIALMENTE CON 15N Y 13C Y PARCIALMENTE MARCADA CON 2H Y SOMETER A LA PROTEINA A ANALISIS ESPECTROSCOPICO DE RESONANCIA MAGNETICA NUCLEAR. LA PROTEINA MARCADA ISOTOPICAMENTE ES PRODUCIDA POR UN METODO QUE ATAÑE PRODUCIR UN HIDROLISATO DE PROTEINA MICROBIAL MARCADA SUSTANCIALMENTE, SOMETIENDO AL HIDROLISATO DE PROTEINA A CROMATOGRAFIA DE CAMBIO DE CATION PARA PRODUCIR UNA MEZCLA DE ACIDO AMINO MARCADA PARCIALMENTE PURIFICADA, SOMETIENDO LA MEZCLA DE ACIDO AMINO MARCADA PARCIALMENTE PURIFICADA A CROMATOGRAFIA DE CAMBIO DE ANION PARA PRODUCIR UNA MEZCLA DE ACIDO AMINO MARCADA PURIFICADA Y SUPLEMENTAR LA MEZCLA DE ACIDO AMINO MARCADA PURIFICADA CON CISTEINA MARCADA ISOTOPICAMENTE Y OPCIONALMENTE CON GLUTAMINA Y ASPARAGINA MARCADAS ISOTOPICAMENTE.
ES94909555T 1993-02-05 1994-02-07 Composiciones y procedimientos para la determinacion de estructuras de proteinas. Expired - Lifetime ES2181715T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/014,243 US5393669A (en) 1993-02-05 1993-02-05 Compositions and methods for protein structural determinations

Publications (1)

Publication Number Publication Date
ES2181715T3 true ES2181715T3 (es) 2003-03-01

Family

ID=21764312

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94909555T Expired - Lifetime ES2181715T3 (es) 1993-02-05 1994-02-07 Composiciones y procedimientos para la determinacion de estructuras de proteinas.

Country Status (13)

Country Link
US (3) US5393669A (es)
EP (3) EP1193271A3 (es)
JP (4) JPH07506192A (es)
AT (1) ATE221918T1 (es)
AU (2) AU678446B2 (es)
CA (1) CA2129904A1 (es)
DE (1) DE69431142T2 (es)
DK (1) DK0636183T3 (es)
ES (1) ES2181715T3 (es)
FI (1) FI112116B (es)
NO (1) NO943703L (es)
PT (1) PT636183E (es)
WO (1) WO1994018339A1 (es)

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DK0870197T4 (da) * 1995-11-14 2007-02-26 Abbott Lab Anvendelse af nuclear magnetisk resonans til design af ligander rettet mod biomolekyler
US5989827A (en) * 1995-11-14 1999-11-23 Abbott Laboratories Use of nuclear magnetic resonance to design ligands to target biomolecules
US5891643A (en) * 1995-11-14 1999-04-06 Abbott Laboratories Use of nuclear magnetic resonance to design ligands to target biomolecules
AU7731696A (en) * 1995-11-15 1997-06-05 Martek Corporation Photosynthetic production of stable isotopically labeled recombinant proteins
US6168912B1 (en) 1996-01-23 2001-01-02 Martek Biosciences Corporation Method and kit for making a multidimensional combinatorial chemical library
US6111066A (en) 1997-09-02 2000-08-29 Martek Biosciences Corporation Peptidic molecules which have been isotopically substituted with 13 C, 15 N and 2 H in the backbone but not in the sidechains
US20030220234A1 (en) * 1998-11-02 2003-11-27 Selvaraj Naicker Deuterated cyclosporine analogs and their use as immunodulating agents
IL143927A0 (en) * 1998-12-30 2002-04-21 Nycomed Amersham Plc Nmr spectroscopic in vitro assay using hyperpolarization
WO2001001165A1 (en) * 1999-06-25 2001-01-04 Battelle Memorial Institute Use of non-lossy solvents as a means to improve the high-field nmr sensitivity of biological samples
CA2402871C (en) 2000-05-05 2011-08-23 Purdue Research Foundation Affinity selected signature peptides for protein identification and quantification
US6762041B2 (en) 2000-05-15 2004-07-13 Ajinomoto Co., Inc. Method for isotope labeling of protein with enzyme
AU2002224440A1 (en) * 2000-10-20 2002-05-06 Martek Biosciences Corporation Rapid determination of protein global folds
US6882939B2 (en) * 2000-10-20 2005-04-19 Prospect Pharma Rapid determination of protein global folds
CA2441208A1 (en) * 2001-03-12 2003-01-09 John D. Mendlein Proteins, druggable regions of proteins and target analysis for chemistry of therapeutics
US7256047B2 (en) * 2001-05-01 2007-08-14 Board Of Regents, The University Of Texas System Measurement of gluconeogenesis and intermediary metabolism using stable isotopes
WO2003006488A1 (en) * 2001-07-13 2003-01-23 The Regents Of The University Of California In-cell nmr spectroscopy
CA2460819A1 (en) * 2001-09-18 2003-03-27 Affinium Pharmaceuticals, Inc. Methods and apparatuses for purification
AU2002341862C1 (en) * 2001-09-27 2009-01-29 Purdue Research Foundation Controlling isotope effects during fractionation of analytes
SI1436321T1 (sl) 2001-10-19 2006-12-31 Isotechnika Inc Sinteza analogov ciklosporina
EP1457482B9 (en) * 2001-12-19 2012-10-24 Japan Science and Technology Agency Stable isotope-labeled amino acid, method of integrating the same into target protein, method of NMR structural analysis of protein
US20050079526A1 (en) * 2002-02-20 2005-04-14 Affinium Pharmaceuticals, Inc. Methods and apparatuses for characterizing refolding and aggregation of biological molecules
WO2003071269A2 (en) * 2002-02-20 2003-08-28 Affinium Pharmaceuticals, Inc. Methods and apparatuses for characterizing stability of biological molecules
US20050181464A1 (en) * 2002-04-04 2005-08-18 Affinium Pharmaceuticals, Inc. Novel purified polypeptides from bacteria
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AU2003245433A1 (en) * 2002-06-10 2003-12-22 Prospect Pharma Method for obtaining dynamic and structural data pertaining to proteins and protein/ligand complexes
US20040121445A1 (en) * 2002-07-31 2004-06-24 Fabien Marino Cell cultures
US20070184455A1 (en) * 2003-05-16 2007-08-09 Cheryl Arrowsmith Evaluation of spectra
US20070082399A1 (en) * 2003-07-11 2007-04-12 Tatiana A Egorova-Zachernyuk Compositions and method for stable isotope labelling of biological compounds
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CA2544305C (en) * 2003-10-31 2011-07-12 Japan Science And Technology Agency Stable isotope-labeled aromatic amino acids, method for incorporating the same in target protein and method for nmr-structural analysis of proteins
CN104745486B (zh) 2005-06-07 2018-01-16 帝斯曼营养品股份公司 生产脂质和抗氧化剂的真核微生物
GB0604647D0 (en) 2006-03-08 2006-04-19 Shchepinov Mikhail Stabilized food supplements and their derivatives
WO2008004088A2 (en) * 2006-07-05 2008-01-10 Centre National De La Recherche Scientifique (C.N.R.S.) Iron-copper co-catalyzed process for carbon-carbon or carbon-heteroatom bonding
ES2572833T3 (es) * 2006-08-01 2016-06-02 Dsm Nutritional Products Ag Proceso de producción de aceite microbiano que contiene ácidos grasos poliinsaturados
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CN104030942B (zh) * 2014-06-09 2016-08-24 浙江普洛医药科技有限公司 一种L-α-氨基丁酰胺盐酸盐的制备方法
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Also Published As

Publication number Publication date
US5393669A (en) 1995-02-28
US5627044A (en) 1997-05-06
DK0636183T3 (da) 2002-12-02
EP1193271A3 (en) 2004-03-24
DE69431142D1 (de) 2002-09-12
EP1191033A2 (en) 2002-03-27
NO943703L (no) 1994-11-23
EP0636183A1 (en) 1995-02-01
AU711468B2 (en) 1999-10-14
EP1193271A2 (en) 2002-04-03
FI112116B (fi) 2003-10-31
EP0636183B1 (en) 2002-08-07
ATE221918T1 (de) 2002-08-15
WO1994018339A1 (en) 1994-08-18
EP0636183A4 (en) 1997-01-22
PT636183E (pt) 2002-11-29
AU3608797A (en) 1997-12-04
JPH07506192A (ja) 1995-07-06
FI943745A (fi) 1994-08-15
JP2004113248A (ja) 2004-04-15
JP2004125801A (ja) 2004-04-22
US5817474A (en) 1998-10-06
EP1191033A3 (en) 2003-07-30
AU678446B2 (en) 1997-05-29
NO943703D0 (no) 1994-10-04
DE69431142T2 (de) 2003-10-09
AU6236394A (en) 1994-08-29
CA2129904A1 (en) 1994-08-18
JP2004115528A (ja) 2004-04-15
FI943745A0 (fi) 1994-08-15

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