ES2104558T3 - Glicoesfingolipidos con un grupo acoplable en la porcion esfingoide, su preparacion y utilizacion. - Google Patents

Glicoesfingolipidos con un grupo acoplable en la porcion esfingoide, su preparacion y utilizacion.

Info

Publication number
ES2104558T3
ES2104558T3 ES89121788T ES89121788T ES2104558T3 ES 2104558 T3 ES2104558 T3 ES 2104558T3 ES 89121788 T ES89121788 T ES 89121788T ES 89121788 T ES89121788 T ES 89121788T ES 2104558 T3 ES2104558 T3 ES 2104558T3
Authority
ES
Spain
Prior art keywords
glycosphingolipids
sphingoid
preparation
group
coupling
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89121788T
Other languages
English (en)
Inventor
Herbert Prof Dr Wiegand
Silke Bosslet
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Siemens Healthcare Diagnostics GmbH Germany
Original Assignee
Behringwerke AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Behringwerke AG filed Critical Behringwerke AG
Application granted granted Critical
Publication of ES2104558T3 publication Critical patent/ES2104558T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C07H15/10—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical containing unsaturated carbon-to-carbon bonds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)

Abstract

EL INVENTO SE REFIERE A LA MODIFICACION QUIMICA DE LA FRACCION ESTINGUIDA DE GLICOSFRUGOLIPIDOS. A TRAVES DE UNA SERIE DE REACCIONES PUEDE INTRODUCIRSE UN GRUPO AMINO EN LA POSICION DE DOBLE ENLACE ENTRE CARBONOS DE LA FRACCION DE ESTINGUIDA DESPUES DEL DESDOBLAMIENTO DE ALDEHIDOS DE LARGA CADENA. LAS GLICOSFRUGOLIPIDAS SON DE FORMULA (II) Y (III). SIENDO: X E Y GRUPOS DE ACOPLAMIENTO A OTRAS MOLECULAS (PROTEINAS) COMO EL RADICAL DE FORMULA (I) O NH2.
ES89121788T 1988-11-27 1989-11-25 Glicoesfingolipidos con un grupo acoplable en la porcion esfingoide, su preparacion y utilizacion. Expired - Lifetime ES2104558T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3840044A DE3840044A1 (de) 1988-11-27 1988-11-27 Glykosphingolipide mit kopplungsfaehiger gruppe im sphingoidanteil, ihre herstellung und verwendung

Publications (1)

Publication Number Publication Date
ES2104558T3 true ES2104558T3 (es) 1997-10-16

Family

ID=6367998

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89121788T Expired - Lifetime ES2104558T3 (es) 1988-11-27 1989-11-25 Glicoesfingolipidos con un grupo acoplable en la porcion esfingoide, su preparacion y utilizacion.

Country Status (11)

Country Link
US (2) US5599914A (es)
EP (1) EP0371414B1 (es)
JP (1) JP2919881B2 (es)
KR (1) KR0147845B1 (es)
AT (1) ATE155141T1 (es)
AU (1) AU621688B2 (es)
CA (1) CA2003662C (es)
DE (2) DE3840044A1 (es)
DK (2) DK592489A (es)
ES (1) ES2104558T3 (es)
PT (1) PT92403B (es)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3837623A1 (de) * 1988-11-05 1990-05-10 Behringwerke Ag Neoglykoproteine, ihre herstellung und verwendung
US6720184B1 (en) 1991-08-05 2004-04-13 Emory University Method of altering sphingolipid metabolism and detecting fumonisin ingestion and contamination
US5936076A (en) * 1991-08-29 1999-08-10 Kirin Beer Kabushiki Kaisha αgalactosylceramide derivatives
JPH0559081A (ja) * 1991-08-29 1993-03-09 Kirin Brewery Co Ltd 新規スフインゴ糖脂質、その製造法および使用
TW261533B (es) * 1992-07-16 1995-11-01 Kirin Brewery
EP0666268B1 (en) * 1992-10-22 2000-04-19 Kirin Beer Kabushiki Kaisha Novel sphingoglycolipid and use thereof
EP1360963B1 (en) * 1993-01-22 2007-09-12 Sloan-Kettering Institute For Cancer Research Ganglioside-KLH conjugate vaccines with QS-21 for delaying recurrence of melanoma
EP0694558B1 (en) * 1993-04-15 1999-01-27 Kirin Beer Kabushiki Kaisha Novel sphingoglycolipid and use thereof
US5612030A (en) * 1995-01-17 1997-03-18 University Of Kentucky Research Foundation Anti-idiotype monoclonal antibody 1A7 and use for the treatment of melanoma and small cell carcinoma
US5977316A (en) * 1995-01-17 1999-11-02 The Board Of Trustees Of The University Of Kentucky Monoclonal antibody 1A7 and related polypeptides
US5935821A (en) * 1995-01-17 1999-08-10 Board Of Trustees Of The University Of Kentucky Polynucleotides related to monoclonal antibody 1A7 and use for the treatment of melanoma and small cell carcinoma
CA2284606A1 (en) * 1997-03-26 1998-10-01 Brigham And Women's Hospital, Inc. Method for generating saccharide fragments
JP3390965B2 (ja) * 1997-09-12 2003-03-31 理化学研究所 糖結合スフィンゴシンを含有するポリマー化合物
US6355244B1 (en) 1997-11-17 2002-03-12 University Of Kentucky Research Foundation Methods and compositions for the treatment of psoriasis
DE69943314D1 (de) * 1998-02-12 2011-05-12 Kapil N Bhalla Sphingolipid-derivate und verfahren zu deren verwendung
CA2335617C (en) 1998-06-24 2009-12-15 Emory University Use of 3'-azido-2',3'-dideoxyuridine in combination with further anti-hiv drugs for the manufacture of a medicament for the treatment of hiv
EP2217250A4 (en) 2007-11-09 2011-01-05 California Inst Of Techn IMMUNOREGULATORY COMPOUNDS AND RELATED COMPOSITIONS AND METHODS
DK2555753T3 (en) 2010-04-07 2018-11-26 California Inst Of Techn Vesicle for delivering a compound to a mucosal membrane as well as corresponding compositions, methods and systems
WO2011146910A1 (en) 2010-05-20 2011-11-24 Round June L Antigen specific tregs and related compositions, methods and systems
US9539281B2 (en) 2011-07-12 2017-01-10 The Brigham And Women's Hospital, Inc. Lipid-containing PSA compositions, methods of isolation and methods of use thereof
JP2016521284A (ja) 2013-05-10 2016-07-21 カリフォルニア インスティチュート オブ テクノロジー 大腸ガンのプロバイオティクスによる防止および処置
WO2016201342A1 (en) 2015-06-10 2016-12-15 California Institute Of Technology Sepsis treatment and related compositions methods and systems
WO2017031431A1 (en) 2015-08-19 2017-02-23 President And Fellows Of Harvard College Lipidated psa compositions and methods
US11491181B2 (en) 2016-07-15 2022-11-08 President And Fellows Of Harvard College Glycolipid compositions and methods of use

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2403098A1 (fr) * 1977-09-19 1979-04-13 Merieux Inst Nouveau materiau capable de fixer de facon reversible des macromolecules biologiques, sa preparation et son application
JPS6057254A (ja) * 1983-09-09 1985-04-03 Dainabotsuto Kk 免疫学的測定法による糖脂質の定量方法
DE3410238A1 (de) * 1984-03-21 1985-10-03 Bayer Ag, 5090 Leverkusen Glycolipid-aehnliche substanzen in liposomenform
IT1199116B (it) * 1984-07-03 1988-12-30 Fidia Farmaceutici Derivati di gangliosidi
DK17885D0 (da) * 1985-01-14 1985-01-14 Karlsson Karl Anders Antiviralt middel
JP2782069B2 (ja) * 1988-08-12 1998-07-30 和光純薬工業株式会社 ガングリオシド類の新規な製造法
DE3837623A1 (de) * 1988-11-05 1990-05-10 Behringwerke Ag Neoglykoproteine, ihre herstellung und verwendung

Also Published As

Publication number Publication date
EP0371414A3 (de) 1991-05-29
EP0371414B1 (de) 1997-07-09
PT92403B (pt) 1995-08-09
DK592489A (da) 1990-05-28
DK592489D0 (da) 1989-11-24
ATE155141T1 (de) 1997-07-15
CA2003662C (en) 2000-02-29
KR900007861A (ko) 1990-06-02
DK16196A (da) 1996-02-15
CA2003662A1 (en) 1990-05-27
EP0371414A2 (de) 1990-06-06
JP2919881B2 (ja) 1999-07-19
AU4548189A (en) 1990-05-31
DE3840044A1 (de) 1990-06-07
AU621688B2 (en) 1992-03-19
PT92403A (pt) 1990-05-31
US5599914A (en) 1997-02-04
JPH02184700A (ja) 1990-07-19
US5571900A (en) 1996-11-05
DE58909806D1 (de) 1997-08-14
KR0147845B1 (ko) 1998-08-01

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