ATE10845T1 - Verfahren zur herstellung von n-(4-(((2,4-diamino-6-pteridinyl)methyl)methyla ino)benzoyl)- glutaminsaeure. - Google Patents

Verfahren zur herstellung von n-(4-(((2,4-diamino-6-pteridinyl)methyl)methyla ino)benzoyl)- glutaminsaeure.

Info

Publication number
ATE10845T1
ATE10845T1 AT81107198T AT81107198T ATE10845T1 AT E10845 T1 ATE10845 T1 AT E10845T1 AT 81107198 T AT81107198 T AT 81107198T AT 81107198 T AT81107198 T AT 81107198T AT E10845 T1 ATE10845 T1 AT E10845T1
Authority
AT
Austria
Prior art keywords
benzoyl
methyl
glutamic acid
pteridinyl
diamino
Prior art date
Application number
AT81107198T
Other languages
English (en)
Inventor
Jens Karl Jensen
Karol Alster
Bjoern Svendsen
Original Assignee
Farmos Group Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farmos Group Ltd. filed Critical Farmos Group Ltd.
Application granted granted Critical
Publication of ATE10845T1 publication Critical patent/ATE10845T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
    • C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D241/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/06—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4
    • C07D475/08—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4 with a nitrogen atom directly attached in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT81107198T 1980-09-12 1981-09-11 Verfahren zur herstellung von n-(4-(((2,4-diamino-6-pteridinyl)methyl)methyla ino)benzoyl)- glutaminsaeure. ATE10845T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK390380 1980-09-12
EP81107198A EP0048001B1 (de) 1980-09-12 1981-09-11 Verfahren zur Herstellung von N-(4-(((2,4-Diamino-6-pteridinyl)methyl)methylamino)benzoyl)-glutaminsäure

Publications (1)

Publication Number Publication Date
ATE10845T1 true ATE10845T1 (de) 1985-01-15

Family

ID=8128060

Family Applications (1)

Application Number Title Priority Date Filing Date
AT81107198T ATE10845T1 (de) 1980-09-12 1981-09-11 Verfahren zur herstellung von n-(4-(((2,4-diamino-6-pteridinyl)methyl)methyla ino)benzoyl)- glutaminsaeure.

Country Status (5)

Country Link
EP (1) EP0048001B1 (de)
AT (1) ATE10845T1 (de)
CA (1) CA1179338A (de)
DE (1) DE3167839D1 (de)
FI (1) FI812773A7 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3009486A1 (de) * 1980-03-12 1981-09-17 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung von 1,1-dichlor-alkenen
US5140104A (en) * 1982-03-09 1992-08-18 Cytogen Corporation Amine derivatives of folic acid analogs
US4781200A (en) * 1985-10-04 1988-11-01 Baker Donald A Ambulatory non-invasive automatic fetal monitoring system

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4057548A (en) * 1975-11-11 1977-11-08 Jacek Wiecko Process for preparing methotrexate or an N-substituted derivative thereof and/or a di (lower) alkyl ester thereof and precursor therefor

Also Published As

Publication number Publication date
EP0048001B1 (de) 1984-12-19
EP0048001A1 (de) 1982-03-24
CA1179338A (en) 1984-12-11
FI812773L (fi) 1982-03-13
FI812773A7 (fi) 1982-03-13
DE3167839D1 (en) 1985-01-31

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee