FI111719B - Uudet D-vitamiinianalogit - Google Patents

Uudet D-vitamiinianalogit Download PDF

Info

Publication number
FI111719B
FI111719B FI956108A FI956108A FI111719B FI 111719 B FI111719 B FI 111719B FI 956108 A FI956108 A FI 956108A FI 956108 A FI956108 A FI 956108A FI 111719 B FI111719 B FI 111719B
Authority
FI
Finland
Prior art keywords
compound
formula
hydroxy
compounds
process according
Prior art date
Application number
FI956108A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI956108A0 (fi
FI956108A (fi
Inventor
Gunnar Grue-Soerensen
Original Assignee
Leo Pharm Prod Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Leo Pharm Prod Ltd filed Critical Leo Pharm Prod Ltd
Publication of FI956108A0 publication Critical patent/FI956108A0/fi
Publication of FI956108A publication Critical patent/FI956108A/fi
Application granted granted Critical
Publication of FI111719B publication Critical patent/FI111719B/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Dermatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Dental Preparations (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
FI956108A 1993-07-12 1995-12-19 Uudet D-vitamiinianalogit FI111719B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB9314400 1993-07-12
GB939314400A GB9314400D0 (en) 1993-07-12 1993-07-12 Produktionsaktieselskab) chemical compounds
PCT/DK1994/000271 WO1995002577A1 (en) 1993-07-12 1994-07-01 Novel vitamin d analogues
DK9400271 1994-07-01

Publications (3)

Publication Number Publication Date
FI956108A0 FI956108A0 (fi) 1995-12-19
FI956108A FI956108A (fi) 1995-12-19
FI111719B true FI111719B (fi) 2003-09-15

Family

ID=10738689

Family Applications (1)

Application Number Title Priority Date Filing Date
FI956108A FI111719B (fi) 1993-07-12 1995-12-19 Uudet D-vitamiinianalogit

Country Status (15)

Country Link
US (1) US5716945A (de)
EP (1) EP0708755B1 (de)
JP (1) JP3773253B2 (de)
KR (1) KR100317869B1 (de)
CN (1) CN1048241C (de)
AT (1) ATE165346T1 (de)
AU (1) AU690564B2 (de)
CA (1) CA2162040A1 (de)
DE (1) DE69409811T2 (de)
ES (1) ES2117281T3 (de)
FI (1) FI111719B (de)
GB (1) GB9314400D0 (de)
NZ (1) NZ268567A (de)
RU (1) RU2130926C1 (de)
WO (1) WO1995002577A1 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6407082B1 (en) * 1996-09-13 2002-06-18 New Life Pharmaceuticals Inc. Prevention of ovarian cancer by administration of a vitamin D compound
US20040167106A1 (en) * 1993-06-04 2004-08-26 Rodriguez Gustavo C. Prevention of ovarian cancer by administration of a Vitamin D compound
DE19619036A1 (de) 1996-04-30 1997-11-13 Schering Ag Neue Vitamin D-Derivate mit carbo- oder heterocyclischen Substituenten an C-25, Verfahren zu ihrer Herstellung und die Verwendung zur Herstellung von Arzneimitteln
WO1998001135A1 (fr) * 1996-07-03 1998-01-15 Sanwa Kagaku Kenkyusho Co., Ltd. Agents d'elimination du phosphore, inhibiteurs augmentant le taux serique de parathormone et inhibiteurs de l'osteodystrophie
KR20010012770A (ko) 1997-05-22 2001-02-26 세파론, 인코포레이티드 비타민 ｄ 유사체 및 그 뉴런 효과
WO1999003828A1 (en) * 1997-07-17 1999-01-28 F.Hoffmann-La Roche Ag Dihomo-seco-cholestanes with two unsaturated bones in the side chain
EP1178808B2 (de) * 1999-04-23 2019-06-12 Leo Pharma A/S Nicht-wässrige pharmazeutische zusammensetzung zur anwendung auf der haut für die behandlung von psoriasis enthaltend ein vitamin d, ein corticosteroid und eine lösungsmittelkomponente
US6703380B2 (en) 1999-09-29 2004-03-09 Colotech A/S Prevention of cancer
DK1220676T3 (da) 1999-09-29 2005-09-05 Colotech As Forebyggelse af colorektal cancer
US6989377B2 (en) 1999-12-21 2006-01-24 Wisconsin Alumni Research Foundation Treating vitamin D responsive diseases
US6358939B1 (en) 1999-12-21 2002-03-19 Northern Lights Pharmaceuticals, Llc Use of biologically active vitamin D compounds for the prevention and treatment of inflammatory bowel disease
US20020183277A1 (en) * 2001-05-15 2002-12-05 Lise Binderup Combination of vitamin D analogue and pyrimidine nucleoside analogue
AR041696A1 (es) 2002-10-23 2005-05-26 Leo Pharm Prod Ltd Compuestos analogos de vitamina d, composiciones que comprenden dichos compuestos analogos y su uso
JP4512490B2 (ja) * 2002-10-23 2010-07-28 レオ ファーマ アクティーゼルスカブ ビタミンｄ類似体、該類似体を含んで成る組成物およびその使用
AU2003291810A1 (en) * 2002-11-18 2004-06-15 Teva Pharmaceutical Industries Ltd. A crystallization method for purification of calcipotriene
ES2234423B1 (es) * 2003-12-05 2006-03-01 Laboratorios Viñas, S.A. Procedimiento para la obtencion de derivados de vitamina d a partir de compuestos monohalogenovinilicos.
WO2006051106A1 (en) 2004-11-12 2006-05-18 Bioxell Spa Combined use of vitamin d derivatives and anti-proliferative agents for treating bladder cancer
SG173119A1 (en) * 2009-01-27 2011-08-29 Berg Biosystems Llc Vitamin d3 and analogs thereof for alleviating side effects associated with chemotherapy
BR112012003372A2 (pt) 2009-08-14 2019-09-24 Berg Biosystems Llc vitamina d3 e análogos da mesma para o tratamento de alopecia.
EP3003497B1 (de) 2013-05-29 2024-02-14 BPGbio, Inc. Verhinderung oder verringerung von chemotherapieinduzierter alopezie mit vitamin d
CN103508999B (zh) * 2013-10-12 2015-05-13 浙江海正药业股份有限公司 马沙骨化醇的合成中间体及其制备方法和用途

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5145846A (en) * 1988-01-20 1992-09-08 Hoffmann-La Roche Inc. Vitamin D3 analogs
US4804502A (en) * 1988-01-20 1989-02-14 Hoffmann-La Roche Inc. Vitamin D compounds
JP2711161B2 (ja) * 1988-04-21 1998-02-10 レオ・ファーマシューティカル・プロダクツ・リミテッド・エイ／エス（レーベンス・ケミスケ・ファブリック・プロデュクチオンスアクチーセルスカブ） 新規ビタミンｄ類似体
US5378695A (en) * 1989-02-23 1995-01-03 Leo Pharmaceutical Products Ltd. A/S (Lovens Kemiske Fabrik Produktionsaktieselskab) Vitamin D analogues
GB8915770D0 (en) * 1989-07-10 1989-08-31 Leo Pharm Prod Ltd Chemical compounds
GB9007236D0 (en) * 1990-03-30 1990-05-30 Leo Pharm Prod Ltd Chemical compounds
GB9223061D0 (en) * 1992-11-04 1992-12-16 Leo Pharm Prod Ltd Chemical compounds
GB9226877D0 (en) * 1992-12-23 1993-02-17 Leo Pharm Prod Ltd Chemical compounds
US5449668A (en) * 1993-06-04 1995-09-12 Duphar International Research B.V. Vitamin D compounds and method of preparing these compounds

Also Published As

Publication number Publication date
JPH08512327A (ja) 1996-12-24
FI956108A0 (fi) 1995-12-19
FI956108A (fi) 1995-12-19
KR960702436A (ko) 1996-04-27
CN1048241C (zh) 2000-01-12
EP0708755A1 (de) 1996-05-01
AU690564B2 (en) 1998-04-30
ES2117281T3 (es) 1998-08-01
US5716945A (en) 1998-02-10
GB9314400D0 (en) 1993-08-25
ATE165346T1 (de) 1998-05-15
AU7182994A (en) 1995-02-13
CN1125941A (zh) 1996-07-03
EP0708755B1 (de) 1998-04-22
RU2130926C1 (ru) 1999-05-27
JP3773253B2 (ja) 2006-05-10
CA2162040A1 (en) 1995-01-26
KR100317869B1 (ko) 2002-09-27
DE69409811T2 (de) 1999-01-07
WO1995002577A1 (en) 1995-01-26
DE69409811D1 (de) 1998-05-28
NZ268567A (en) 1997-11-24

Similar Documents

Publication Publication Date Title
FI111719B (fi) Uudet D-vitamiinianalogit
FI103791B (fi) Menetelmä ja välituote uusien D-vitamiinianalogien valmistamiseksi
FI92929C (fi) Menetelmä uusien farmaseuttisesti vaikuttavien vitamiini D analogien valmistamiseksi
FI106120B (fi) Menetelmä uusien D-vitamiinianalogien valmistamiseksi
KR100209179B1 (ko) 비타민 d 동족체, 이의 제조방법 및 이를 함유하는 약제학적 조성물
FI109687B (fi) Menetelmä uusien D-vitamiinianalogien valmistamiseksi
FI108225B (fi) Menetelmä uusien D-vitamiinianalogien valmistamiseksi
JP3553591B2 (ja) 新規ビタミンｄ類似体
US5401732A (en) Vitamin D analogues
RU2165923C2 (ru) Аналоги витамина d, способ их получения, фармацевтическая композиция
EP0865428B1 (de) Vitamin d analoge
FI108224B (fi) Menetelmä uusien D-vitamiinianalogien valmistamiseksi
KR20000057417A (ko) 비타민 ｄ3 유도체
MXPA06001248A (en) 2-methylene-19-nor-vitamin d2 compounds

Legal Events

Date Code Title Description
MA Patent expired