FI111368B - Menetelmä terapeuttisesti käyttökelpoisten [[(tieno- tai furo) [3,2-b]pyridin-5-yyli)] (etenyyli tai etyyli)fenyyli]-(3-fenyylipropyyli) - (tio tai oksi)metyylisyklopropaanietikkahappojohdannaisten valmistamiseksi - Google Patents

Menetelmä terapeuttisesti käyttökelpoisten [[(tieno- tai furo) [3,2-b]pyridin-5-yyli)] (etenyyli tai etyyli)fenyyli]-(3-fenyylipropyyli) - (tio tai oksi)metyylisyklopropaanietikkahappojohdannaisten valmistamiseksi Download PDF

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Publication number
FI111368B
FI111368B FI953104A FI953104A FI111368B FI 111368 B FI111368 B FI 111368B FI 953104 A FI953104 A FI 953104A FI 953104 A FI953104 A FI 953104A FI 111368 B FI111368 B FI 111368B
Authority
FI
Finland
Prior art keywords
phenyl
mmol
methyl
compound
added
Prior art date
Application number
FI953104A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI953104A (fi
FI953104A0 (fi
Inventor
Yves Leblanc
Marc Labelle
Yves Gareau
Robert N Young
Claude Dufresne
Cheuk L Lau
Yi Bin Xiang
Original Assignee
Merck Frosst Canada Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Frosst Canada Inc filed Critical Merck Frosst Canada Inc
Publication of FI953104A publication Critical patent/FI953104A/fi
Publication of FI953104A0 publication Critical patent/FI953104A0/fi
Application granted granted Critical
Publication of FI111368B publication Critical patent/FI111368B/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pulmonology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyridine Compounds (AREA)
FI953104A 1992-12-22 1995-06-21 Menetelmä terapeuttisesti käyttökelpoisten [[(tieno- tai furo) [3,2-b]pyridin-5-yyli)] (etenyyli tai etyyli)fenyyli]-(3-fenyylipropyyli) - (tio tai oksi)metyylisyklopropaanietikkahappojohdannaisten valmistamiseksi FI111368B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US99486992A 1992-12-22 1992-12-22
US99486992 1992-12-22
CA9300541 1993-12-15
PCT/CA1993/000541 WO1994014815A1 (fr) 1992-12-22 1993-12-15 Acides di-aryle 5,6 fusionnes heterocycliques en tant qu'antagonistes des leucotrienes

Publications (3)

Publication Number Publication Date
FI953104A FI953104A (fi) 1995-06-21
FI953104A0 FI953104A0 (fi) 1995-06-21
FI111368B true FI111368B (fi) 2003-07-15

Family

ID=25541163

Family Applications (1)

Application Number Title Priority Date Filing Date
FI953104A FI111368B (fi) 1992-12-22 1995-06-21 Menetelmä terapeuttisesti käyttökelpoisten [[(tieno- tai furo) [3,2-b]pyridin-5-yyli)] (etenyyli tai etyyli)fenyyli]-(3-fenyylipropyyli) - (tio tai oksi)metyylisyklopropaanietikkahappojohdannaisten valmistamiseksi

Country Status (23)

Country Link
EP (1) EP0604114B1 (fr)
KR (1) KR100310552B1 (fr)
CN (1) CN1040213C (fr)
AT (1) ATE192448T1 (fr)
AU (1) AU672837B2 (fr)
CA (1) CA2111372C (fr)
CZ (1) CZ290829B6 (fr)
DE (1) DE69328540T2 (fr)
DK (1) DK0604114T3 (fr)
ES (1) ES2145765T3 (fr)
FI (1) FI111368B (fr)
GR (1) GR3033985T3 (fr)
HU (1) HU222274B1 (fr)
IL (1) IL108050A (fr)
MX (1) MX9400022A (fr)
NO (1) NO313831B1 (fr)
NZ (1) NZ258835A (fr)
PL (1) PL177967B1 (fr)
PT (1) PT604114E (fr)
RU (1) RU2154065C2 (fr)
SK (1) SK282409B6 (fr)
WO (1) WO1994014815A1 (fr)
ZA (1) ZA939560B (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5472964A (en) * 1992-12-22 1995-12-05 Merck Frosst Canada, Inc. Diaryl 5,6-fused heterocyclic acids as leukotriene antagonists
US5350760A (en) * 1993-08-04 1994-09-27 Merck Frosst Canada, Inc. Aza-5,5-fused hetrocyclic acids as leukotriene antagonists
TW448160B (en) * 1993-12-28 2001-08-01 Merck & Co Inc Novel dicyclohexylamine salt and process for the preparation of leukotriene antagonists
US5427933A (en) * 1994-07-20 1995-06-27 Merck & Co., Inc. Reduction of phenylalkyl ketones to the corresponding (S)-hydroxy derivatives using mucor hiemalis IFO 5834
US5491077A (en) * 1994-07-20 1996-02-13 Merck & Co., Inc. Microbial method
US5523477A (en) * 1995-01-23 1996-06-04 Merck & Co., Inc. Process for the preparation of 1-(thiomethyl)-cyclopropaneacetic acid
US5750539A (en) * 1995-06-07 1998-05-12 Merck Frosst Canada Heteroaryl diol acids as leukotriene antagonists
JP4308667B2 (ja) * 2002-02-06 2009-08-05 デルマー ケミカルズ インコーポレーテッド １−（メルカプトメチル）−シクロプロパン酢酸の調製方法
US7271268B1 (en) 2006-12-22 2007-09-18 Formosa Laboratories Inc. Process for preparation of [1-(mercaptomethyl)cyclopropyl]acetic acid and related derivatives
RU2449807C2 (ru) * 2009-11-16 2012-05-10 Государственное образовательное учреждение высшего профессионального образования "Дагестанская государственная медицинская академия федерального агентства по здравоохранению и социальному развитию" Способ лечения эндотоксикоза при хроническом пиелонефрите

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4957932A (en) * 1987-11-25 1990-09-18 Merck Frosst Canada, Inc. Benzoheterazoles
HU222344B1 (hu) * 1990-10-12 2003-06-28 Merck Frosst Canada & Co. Eljárás telítetlen hidroxi-alkil-kinolinsavak, és ezeket tartalmazó gyógyszerkészítmények előállítására
CA2053216C (fr) * 1990-10-12 2003-04-08 Michel L. Belley Derives acides d'hyroxyalkylquinoline saturee comme antagonistes des leucotrienes
US5308850A (en) * 1991-09-30 1994-05-03 Merck Frosst Canada, Inc. (Bicyclic-hetero-arylmethoxy)indoles as inhibitors of leukotriene biosynthesis

Also Published As

Publication number Publication date
ATE192448T1 (de) 2000-05-15
CN1040213C (zh) 1998-10-14
KR100310552B1 (ko) 2001-12-17
NO313831B1 (no) 2002-12-09
CA2111372C (fr) 2007-01-16
IL108050A (en) 1998-06-15
PL309408A1 (en) 1995-10-02
PL177967B1 (pl) 2000-02-29
DE69328540D1 (de) 2000-06-08
EP0604114B1 (fr) 2000-05-03
MX9400022A (es) 1995-01-31
NZ258835A (en) 1997-06-24
CZ165395A3 (en) 1996-01-17
ZA939560B (en) 1994-08-11
CA2111372A1 (fr) 1994-06-23
ES2145765T3 (es) 2000-07-16
PT604114E (pt) 2000-09-29
DE69328540T2 (de) 2001-01-04
CN1094051A (zh) 1994-10-26
AU5257993A (en) 1994-07-07
GR3033985T3 (en) 2000-11-30
SK282409B6 (sk) 2002-01-07
WO1994014815A1 (fr) 1994-07-07
NO952495L (no) 1995-08-22
HUT71810A (en) 1996-02-28
HU9501842D0 (en) 1995-08-28
HU222274B1 (hu) 2003-05-28
SK82295A3 (en) 1995-12-06
DK0604114T3 (da) 2000-08-07
FI953104A (fi) 1995-06-21
IL108050A0 (en) 1994-04-12
CZ290829B6 (cs) 2002-10-16
RU2154065C2 (ru) 2000-08-10
KR950704325A (ko) 1995-11-17
FI953104A0 (fi) 1995-06-21
EP0604114A1 (fr) 1994-06-29
AU672837B2 (en) 1996-10-17
NO952495D0 (no) 1995-06-21
RU95113598A (ru) 1997-06-10

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Owner name: MERCK FROSST CANADA & CO.