FI110781B - Välituote atsitromysiiniä varten, menetelmä välituotteen ja atsitromysiinin valmistamiseksi - Google Patents

Välituote atsitromysiiniä varten, menetelmä välituotteen ja atsitromysiinin valmistamiseksi Download PDF

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Publication number
FI110781B
FI110781B FI942313A FI942313A FI110781B FI 110781 B FI110781 B FI 110781B FI 942313 A FI942313 A FI 942313A FI 942313 A FI942313 A FI 942313A FI 110781 B FI110781 B FI 110781B
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FI
Finland
Prior art keywords
compound
formula
iii
azithromycin
process according
Prior art date
Application number
FI942313A
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English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI942313A (fi
FI942313A0 (fi
Inventor
Bingwei V Yang
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
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Publication of FI942313A0 publication Critical patent/FI942313A0/fi
Publication of FI942313A publication Critical patent/FI942313A/fi
Application granted granted Critical
Publication of FI110781B publication Critical patent/FI110781B/fi

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
FI942313A 1993-05-19 1994-05-18 Välituote atsitromysiiniä varten, menetelmä välituotteen ja atsitromysiinin valmistamiseksi FI110781B (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6461093A 1993-05-19 1993-05-19
US6461093 1993-05-19

Publications (3)

Publication Number Publication Date
FI942313A0 FI942313A0 (fi) 1994-05-18
FI942313A FI942313A (fi) 1994-11-20
FI110781B true FI110781B (fi) 2003-03-31

Family

ID=22057118

Family Applications (1)

Application Number Title Priority Date Filing Date
FI942313A FI110781B (fi) 1993-05-19 1994-05-18 Välituote atsitromysiiniä varten, menetelmä välituotteen ja atsitromysiinin valmistamiseksi

Country Status (12)

Country Link
US (1) US5686587A (sl)
EP (1) EP0699207B1 (sl)
JP (1) JP2696608B2 (sl)
AT (1) ATE154806T1 (sl)
CA (1) CA2162401C (sl)
DE (1) DE69403963T2 (sl)
DK (1) DK0699207T3 (sl)
ES (1) ES2104386T3 (sl)
FI (1) FI110781B (sl)
GR (1) GR3024297T3 (sl)
HR (1) HRP940271B1 (sl)
WO (1) WO1994026758A1 (sl)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP20020231A2 (en) 2002-03-18 2003-12-31 Pliva D D ISOSTRUCTURAL PSEUDOPOLYMORPHS OF 9-DEOXO-9a-AZA-9a-METHYL-9a-HOMOERYTHROMYCIN A
ES2122905B1 (es) * 1996-07-11 1999-11-16 Astur Pharma Sa Sintesis de 11,12-hidrogenoortoborato de 9-desoxo-9a-aza-11,12-desoxi-9a-metil-9a-homoeritromicina a. un procedimiento para la preparacion de 9-desoxo-9a-aza-9a-metil-9a-homoeritromicina a dihidrato (azitromicina dihidrato).
GB9705323D0 (en) * 1997-03-14 1997-04-30 Biochemie Sa Organic compounds
PT102006B (pt) * 1997-05-19 2000-06-30 Hovione Sociedade Quimica S A Novo processo de preparacao de azitromicina
HRP980189B1 (en) * 1998-04-06 2004-04-30 Pliva Pharm & Chem Works Novel 15-membered lactams ketolides
GB9824580D0 (en) * 1998-11-10 1999-01-06 Biochemie Sa Organic compounds
US6764996B1 (en) 1999-08-24 2004-07-20 Abbott Laboratories 9a-azalides with antibacterial activity
AU6748500A (en) * 1999-08-24 2001-03-19 Abbott Laboratories 9a-azalides with antibacterial activity
ES2177373B1 (es) * 1999-11-26 2003-11-01 Astur Pharma Sa Preparacion de azitromicina en su forma no cristalina
ATE320441T1 (de) 2000-07-25 2006-04-15 Silanes Sa De Cv Lab Einstufiges verfahren zur herstellung von 7,16-
CA2419873A1 (en) * 2000-08-23 2002-02-28 Wockhardt Limited Process for preparation of anhydrous azithromycin
ES2179756B1 (es) * 2000-11-30 2004-10-01 Ercros Industrial, S.A. Procedimiento de obtencion de azaeritromicina.
EP1671979B1 (en) 2001-05-22 2008-08-13 Pfizer Products Inc. New Cristal Form of Azithromycin
YU8804A (sh) * 2001-08-21 2006-08-17 Pfizer Products Inc. Jedno-dozni azitromicin
HRP20020614A2 (en) 2002-07-22 2004-06-30 PLIVA-ISTRAŽIVAČKI INSTITUT d.o.o. Rhombic pseudopolymorph of 9-deoxo-9a-aza-9a-methyl-9a-homoerythromycin a
US6645941B1 (en) * 2003-03-26 2003-11-11 Enanta Pharmaceuticals, Inc. 6,11-3C-bicyclic 9a-azalide derivatives
US7276487B2 (en) * 2003-09-23 2007-10-02 Enanta Pharmaceuticals, Inc. 9a, 11-3C-bicyclic 9a-azalide derivatives
US7265094B2 (en) * 2004-01-09 2007-09-04 Enanta Pharmaceuticals, Inc. 9N-substituted 6-11 bicyclic erythromycin derivatives
US7468428B2 (en) 2004-03-17 2008-12-23 App Pharmaceuticals, Llc Lyophilized azithromycin formulation
WO2006011160A1 (en) 2004-06-28 2006-02-02 Alembic Limited Process for the preparation of azithromycin monohydrate isopropanol clathrate
US7384922B2 (en) * 2005-05-04 2008-06-10 Enanta Pharmaceuticals, Inc. 6-11 bridged oxime erythromycin derivatives
WO2007015265A2 (en) * 2005-05-24 2007-02-08 Kopran Research Laboratories Ltd A process for preparing 6,9-imino ether
US7407942B2 (en) * 2006-03-29 2008-08-05 Emata Pharmaceuticals, Inc 3,6-bridged 9,12-oxolides
CN102863486A (zh) * 2012-09-18 2013-01-09 太仓市运通化工厂 一种9-脱氧-9a-氮杂-9a-高红霉素的合成方法
CN104262429A (zh) * 2014-10-03 2015-01-07 菏泽市方明制药有限公司 一种阿奇霉素的纯化方法
CN108530494B (zh) * 2018-06-29 2021-03-30 宜昌东阳光生化制药有限公司 一种阿奇霉素重排杂质r的合成方法

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
YU43116B (en) * 1979-04-02 1989-04-30 Pliva Pharm & Chem Works Process for preparing 11-aza-4-o-cladinosyl-6-o-desosaminyl-15-ethyl-7,13,14-trihydroxy-3,5,7,9,12,14-hexamethyl-oxacyclopentadecane-2-one(11-aza-10-deox
SI8110592A8 (en) * 1981-03-06 1996-06-30 Pliva Pharm & Chem Works Process for preparing of n-methyl-11-aza-10-deoxo-10-dihydroerythromycine a and derivatives thereof
US4382085A (en) * 1982-03-01 1983-05-03 Pfizer Inc. 4"-Epi erythromycin A and derivatives thereof as useful antibacterial agents
US4474768A (en) * 1982-07-19 1984-10-02 Pfizer Inc. N-Methyl 11-aza-10-deoxo-10-dihydro-erytromycin A, intermediates therefor
US4526889A (en) * 1982-11-15 1985-07-02 Pfizer Inc. Epimeric azahomoerythromycin A derivative, intermediates and method of use
US4464527A (en) * 1983-06-30 1984-08-07 Pfizer Inc. Antibacterial 9-deoxo-9a-alkyl-9a-aza-9a-homoerythromycin A derivatives and intermediates therefore
SI8311553A8 (en) * 1983-07-18 1995-06-30 Pliva Pharm & Chem Works Process for preparing 7,16-dioxa-2-aza-10-0-cladynosil-12-0-desosaminyl-4,5-dihydroxy-6- ethyl-3,5,9,11,13,15-hexamethylbicyclo (11.2.1.) hexadeca-1(2)-ene-8-ones
US4512982A (en) * 1984-04-13 1985-04-23 Pfizer Inc. 9α-Aza-9α-homoerythromycin compounds, pharmaceutical composition and therapeutic method
US4518590A (en) * 1984-04-13 1985-05-21 Pfizer Inc. 9α-Aza-9α-homoerythromycin compounds, pharmaceutical compositions and therapeutic method
US5912331A (en) * 1991-03-15 1999-06-15 Merck & Co., Inc. Process for the preparation of 9-deoxo-9(Z)-hydroxyiminoerythromycin A
DE69227713D1 (de) * 1991-03-15 1999-01-14 Merck & Co Inc 9-Deoxo-9(Z)-hydroxyiminoerythromycin A und O-Derivate hiervon
CA2064634C (en) * 1991-04-04 1998-08-04 James V. Heck 9-deoxo-8a-aza-8a-homoerythromycin a derivatives modified at the 4"- and8a-positions
US5202434A (en) * 1991-04-05 1993-04-13 Merck & Co., Inc. 8a-aza-8a-homoerythromycin lactams
CA2065222A1 (en) * 1991-04-09 1992-10-10 Robert R. Wilkening Process for the preparation of 8a-aza-8a-homoerythromycin cyclic iminoethers
US5189159A (en) * 1992-04-02 1993-02-23 Merck & Co., Inc. 8a-AZA-8a-homoerythromycin cyclic iminoethers
CA2065674A1 (en) * 1991-04-10 1992-10-11 Robert R. Wilkening 8a-aza-8a-homoerythromycin cyclic iminoethers
CA2065218A1 (en) * 1991-04-11 1992-10-12 Robert R. Wilkening Process for the preparation of 9-deoxo-8a-aza-8a-homoerythromycin a and its 8a-alkyl derivatives

Also Published As

Publication number Publication date
DK0699207T3 (da) 1997-12-08
ATE154806T1 (de) 1997-07-15
ES2104386T3 (es) 1997-10-01
CA2162401A1 (en) 1994-11-24
FI942313A (fi) 1994-11-20
HRP940271B1 (en) 2000-02-29
DE69403963D1 (de) 1997-07-31
HRP940271A2 (en) 1996-12-31
GR3024297T3 (en) 1997-10-31
WO1994026758A1 (en) 1994-11-24
CA2162401C (en) 1998-11-03
EP0699207A1 (en) 1996-03-06
JPH08506596A (ja) 1996-07-16
DE69403963T2 (de) 1997-11-20
JP2696608B2 (ja) 1998-01-14
EP0699207B1 (en) 1997-06-25
US5686587A (en) 1997-11-11
FI942313A0 (fi) 1994-05-18

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