FI110438B - Menetelmä mutanttiherpesviruksen valmistamiseksi - Google Patents
Menetelmä mutanttiherpesviruksen valmistamiseksi Download PDFInfo
- Publication number
- FI110438B FI110438B FI931309A FI931309A FI110438B FI 110438 B FI110438 B FI 110438B FI 931309 A FI931309 A FI 931309A FI 931309 A FI931309 A FI 931309A FI 110438 B FI110438 B FI 110438B
- Authority
- FI
- Finland
- Prior art keywords
- virus
- att
- gene
- viral
- mutant
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims description 50
- 241001529453 unidentified herpesvirus Species 0.000 title claims description 10
- 241000700605 Viruses Species 0.000 claims abstract description 177
- 108090000623 proteins and genes Proteins 0.000 claims abstract description 108
- 208000015181 infectious disease Diseases 0.000 claims abstract description 55
- 229960005486 vaccine Drugs 0.000 claims abstract description 48
- 238000004519 manufacturing process Methods 0.000 claims abstract description 32
- 102000004169 proteins and genes Human genes 0.000 claims abstract description 32
- 230000002458 infectious effect Effects 0.000 claims abstract description 27
- 230000002163 immunogen Effects 0.000 claims abstract description 16
- 108700005077 Viral Genes Proteins 0.000 claims abstract description 9
- 230000002950 deficient Effects 0.000 claims abstract description 8
- 241000894007 species Species 0.000 claims abstract description 5
- 230000007547 defect Effects 0.000 claims abstract 2
- 210000004027 cell Anatomy 0.000 claims description 101
- 230000003612 virological effect Effects 0.000 claims description 54
- 241000700584 Simplexvirus Species 0.000 claims description 36
- 239000002245 particle Substances 0.000 claims description 25
- 108091007433 antigens Proteins 0.000 claims description 15
- 238000002360 preparation method Methods 0.000 claims description 13
- 108091026890 Coding region Proteins 0.000 claims description 12
- 108090000288 Glycoproteins Proteins 0.000 claims description 12
- 230000000295 complement effect Effects 0.000 claims description 12
- 230000010076 replication Effects 0.000 claims description 11
- 108700039887 Essential Genes Proteins 0.000 claims description 10
- 230000028993 immune response Effects 0.000 claims description 10
- 208000032420 Latent Infection Diseases 0.000 claims description 9
- 208000037771 disease arising from reactivation of latent virus Diseases 0.000 claims description 9
- 239000002773 nucleotide Substances 0.000 claims description 9
- 125000003729 nucleotide group Chemical group 0.000 claims description 9
- 239000000203 mixture Substances 0.000 claims description 5
- 238000009472 formulation Methods 0.000 claims description 4
- 230000001225 therapeutic effect Effects 0.000 claims description 4
- 238000012258 culturing Methods 0.000 claims description 3
- 238000004806 packaging method and process Methods 0.000 claims description 3
- 206010061598 Immunodeficiency Diseases 0.000 claims description 2
- 208000029462 Immunodeficiency disease Diseases 0.000 claims description 2
- 230000007813 immunodeficiency Effects 0.000 claims description 2
- 230000007812 deficiency Effects 0.000 claims 10
- 239000003086 colorant Substances 0.000 claims 3
- 238000004113 cell culture Methods 0.000 claims 2
- 230000001413 cellular effect Effects 0.000 claims 2
- 210000004072 lung Anatomy 0.000 claims 2
- 108010026228 mRNA guanylyltransferase Proteins 0.000 claims 2
- 230000003449 preventive effect Effects 0.000 claims 2
- MGSRCZKZVOBKFT-UHFFFAOYSA-N thymol Chemical compound CC(C)C1=CC=C(C)C=C1O MGSRCZKZVOBKFT-UHFFFAOYSA-N 0.000 claims 2
- 208000035484 Cellulite Diseases 0.000 claims 1
- 208000035473 Communicable disease Diseases 0.000 claims 1
- 108090000626 DNA-directed RNA polymerases Proteins 0.000 claims 1
- 102000004163 DNA-directed RNA polymerases Human genes 0.000 claims 1
- 208000019693 Lung disease Diseases 0.000 claims 1
- 241000721701 Lynx Species 0.000 claims 1
- 241001529936 Murinae Species 0.000 claims 1
- RYXPMWYHEBGTRV-UHFFFAOYSA-N Omeprazole sodium Chemical compound [Na+].N=1C2=CC(OC)=CC=C2[N-]C=1S(=O)CC1=NC=C(C)C(OC)=C1C RYXPMWYHEBGTRV-UHFFFAOYSA-N 0.000 claims 1
- 206010049752 Peau d'orange Diseases 0.000 claims 1
- 230000004913 activation Effects 0.000 claims 1
- 230000004397 blinking Effects 0.000 claims 1
- 230000036232 cellulite Effects 0.000 claims 1
- 210000004748 cultured cell Anatomy 0.000 claims 1
- 238000003384 imaging method Methods 0.000 claims 1
- 230000005847 immunogenicity Effects 0.000 claims 1
- 208000000509 infertility Diseases 0.000 claims 1
- 230000036512 infertility Effects 0.000 claims 1
- 231100000535 infertility Toxicity 0.000 claims 1
- 230000003362 replicative effect Effects 0.000 claims 1
- 239000013598 vector Substances 0.000 abstract description 11
- 230000001717 pathogenic effect Effects 0.000 abstract description 8
- 244000052769 pathogen Species 0.000 abstract description 7
- 230000021633 leukocyte mediated immunity Effects 0.000 abstract 1
- 239000013612 plasmid Substances 0.000 description 29
- 108020004414 DNA Proteins 0.000 description 23
- 239000012634 fragment Substances 0.000 description 15
- 239000000427 antigen Substances 0.000 description 14
- 102000036639 antigens Human genes 0.000 description 14
- 101150055782 gH gene Proteins 0.000 description 12
- 238000002255 vaccination Methods 0.000 description 12
- 230000002238 attenuated effect Effects 0.000 description 10
- 241000701022 Cytomegalovirus Species 0.000 description 9
- 102000003886 Glycoproteins Human genes 0.000 description 8
- 238000012217 deletion Methods 0.000 description 8
- 230000037430 deletion Effects 0.000 description 8
- 239000000047 product Substances 0.000 description 8
- 241000700588 Human alphaherpesvirus 1 Species 0.000 description 7
- 108091034117 Oligonucleotide Proteins 0.000 description 7
- 101100145155 Escherichia phage lambda cIII gene Proteins 0.000 description 6
- 241000725303 Human immunodeficiency virus Species 0.000 description 6
- 241001465754 Metazoa Species 0.000 description 6
- 108010067390 Viral Proteins Proteins 0.000 description 6
- 108010005774 beta-Galactosidase Proteins 0.000 description 6
- 230000003053 immunization Effects 0.000 description 6
- 241000282412 Homo Species 0.000 description 5
- 241000700618 Vaccinia virus Species 0.000 description 5
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 5
- 239000002953 phosphate buffered saline Substances 0.000 description 5
- 239000011550 stock solution Substances 0.000 description 5
- 239000013603 viral vector Substances 0.000 description 5
- 241000282693 Cercopithecidae Species 0.000 description 4
- 241000699666 Mus <mouse, genus> Species 0.000 description 4
- 241000699670 Mus sp. Species 0.000 description 4
- 101900350318 Simian immunodeficiency virus Surface protein gp120 Proteins 0.000 description 4
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 4
- 230000001154 acute effect Effects 0.000 description 4
- 238000013459 approach Methods 0.000 description 4
- 238000003556 assay Methods 0.000 description 4
- 230000007969 cellular immunity Effects 0.000 description 4
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 description 4
- 230000006378 damage Effects 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 238000002649 immunization Methods 0.000 description 4
- 238000001727 in vivo Methods 0.000 description 4
- 238000011282 treatment Methods 0.000 description 4
- 210000003501 vero cell Anatomy 0.000 description 4
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 3
- OPIFSICVWOWJMJ-AEOCFKNESA-N 5-bromo-4-chloro-3-indolyl beta-D-galactoside Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1OC1=CNC2=CC=C(Br)C(Cl)=C12 OPIFSICVWOWJMJ-AEOCFKNESA-N 0.000 description 3
- 229920001817 Agar Polymers 0.000 description 3
- 241000588724 Escherichia coli Species 0.000 description 3
- 108700002232 Immediate-Early Genes Proteins 0.000 description 3
- 108020004511 Recombinant DNA Proteins 0.000 description 3
- 108020005202 Viral DNA Proteins 0.000 description 3
- 208000036142 Viral infection Diseases 0.000 description 3
- 239000008272 agar Substances 0.000 description 3
- VEZXCJBBBCKRPI-UHFFFAOYSA-N beta-propiolactone Chemical compound O=C1CCO1 VEZXCJBBBCKRPI-UHFFFAOYSA-N 0.000 description 3
- 238000005119 centrifugation Methods 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 3
- 238000003776 cleavage reaction Methods 0.000 description 3
- 238000010276 construction Methods 0.000 description 3
- 230000029087 digestion Effects 0.000 description 3
- 108700004025 env Genes Proteins 0.000 description 3
- 101150030339 env gene Proteins 0.000 description 3
- 230000012010 growth Effects 0.000 description 3
- 210000000987 immune system Anatomy 0.000 description 3
- 238000000338 in vitro Methods 0.000 description 3
- 238000012545 processing Methods 0.000 description 3
- 229960000380 propiolactone Drugs 0.000 description 3
- 230000001681 protective effect Effects 0.000 description 3
- 230000006798 recombination Effects 0.000 description 3
- 238000005215 recombination Methods 0.000 description 3
- 230000002829 reductive effect Effects 0.000 description 3
- 239000000523 sample Substances 0.000 description 3
- 230000007017 scission Effects 0.000 description 3
- FLNVBBPBGKOJHN-KKAOYSRWSA-N sivmac Chemical compound O=C([C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CS)NC(=O)[C@@H](N)CCCNC(N)=N)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O)[C@@H](C)CC)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(O)=O FLNVBBPBGKOJHN-KKAOYSRWSA-N 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 210000001519 tissue Anatomy 0.000 description 3
- 238000011144 upstream manufacturing Methods 0.000 description 3
- 230000029812 viral genome replication Effects 0.000 description 3
- 230000009385 viral infection Effects 0.000 description 3
- 229960004854 viral vaccine Drugs 0.000 description 3
- 101100296182 Caenorhabditis elegans paf-2 gene Proteins 0.000 description 2
- 208000002177 Cataract Diseases 0.000 description 2
- 241000991587 Enterovirus C Species 0.000 description 2
- 241000701074 Human alphaherpesvirus 2 Species 0.000 description 2
- 241000701024 Human betaherpesvirus 5 Species 0.000 description 2
- 241000519995 Stachys sylvatica Species 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 150000007513 acids Chemical class 0.000 description 2
- 239000002671 adjuvant Substances 0.000 description 2
- 230000000890 antigenic effect Effects 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 102000005936 beta-Galactosidase Human genes 0.000 description 2
- 239000001506 calcium phosphate Substances 0.000 description 2
- 229910000389 calcium phosphate Inorganic materials 0.000 description 2
- 235000011010 calcium phosphates Nutrition 0.000 description 2
- 210000004889 cervical nerve Anatomy 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 238000010367 cloning Methods 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 210000005069 ears Anatomy 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 230000002068 genetic effect Effects 0.000 description 2
- 210000005260 human cell Anatomy 0.000 description 2
- 230000036039 immunity Effects 0.000 description 2
- 230000002779 inactivation Effects 0.000 description 2
- 238000011081 inoculation Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000010369 molecular cloning Methods 0.000 description 2
- 210000005036 nerve Anatomy 0.000 description 2
- 210000002569 neuron Anatomy 0.000 description 2
- 230000037361 pathway Effects 0.000 description 2
- 239000000546 pharmaceutical excipient Substances 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 230000004044 response Effects 0.000 description 2
- 108091008146 restriction endonucleases Proteins 0.000 description 2
- 238000010561 standard procedure Methods 0.000 description 2
- 230000000638 stimulation Effects 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 238000013518 transcription Methods 0.000 description 2
- 230000035897 transcription Effects 0.000 description 2
- 238000001890 transfection Methods 0.000 description 2
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 2
- 241000701161 unidentified adenovirus Species 0.000 description 2
- 241001430294 unidentified retrovirus Species 0.000 description 2
- 230000017613 viral reproduction Effects 0.000 description 2
- 210000002845 virion Anatomy 0.000 description 2
- 239000012224 working solution Substances 0.000 description 2
- 102000040650 (ribonucleotides)n+m Human genes 0.000 description 1
- 102100022717 Atypical chemokine receptor 1 Human genes 0.000 description 1
- 101000583086 Bunodosoma granuliferum Delta-actitoxin-Bgr2b Proteins 0.000 description 1
- 108020004705 Codon Proteins 0.000 description 1
- 108020004635 Complementary DNA Proteins 0.000 description 1
- 241000699800 Cricetinae Species 0.000 description 1
- 102000053602 DNA Human genes 0.000 description 1
- 241000450599 DNA viruses Species 0.000 description 1
- 101710177291 Gag polyprotein Proteins 0.000 description 1
- 108010093031 Galactosidases Proteins 0.000 description 1
- 206010061978 Genital lesion Diseases 0.000 description 1
- 241000700321 Herpes simplex virus (type 1 / strain SC16) Species 0.000 description 1
- 102000008949 Histocompatibility Antigens Class I Human genes 0.000 description 1
- 101000678879 Homo sapiens Atypical chemokine receptor 1 Proteins 0.000 description 1
- 241001135569 Human adenovirus 5 Species 0.000 description 1
- 101150027427 ICP4 gene Proteins 0.000 description 1
- XQFRJNBWHJMXHO-RRKCRQDMSA-N IDUR Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(I)=C1 XQFRJNBWHJMXHO-RRKCRQDMSA-N 0.000 description 1
- 108060003951 Immunoglobulin Proteins 0.000 description 1
- 108091054437 MHC class I family Proteins 0.000 description 1
- 241000282553 Macaca Species 0.000 description 1
- 101710125418 Major capsid protein Proteins 0.000 description 1
- 229930193140 Neomycin Natural products 0.000 description 1
- 208000012902 Nervous system disease Diseases 0.000 description 1
- 241000700629 Orthopoxvirus Species 0.000 description 1
- 241001631646 Papillomaviridae Species 0.000 description 1
- 108010033276 Peptide Fragments Proteins 0.000 description 1
- 102000007079 Peptide Fragments Human genes 0.000 description 1
- 102000004160 Phosphoric Monoester Hydrolases Human genes 0.000 description 1
- 108090000608 Phosphoric Monoester Hydrolases Proteins 0.000 description 1
- 241000125945 Protoparvovirus Species 0.000 description 1
- 108020004682 Single-Stranded DNA Proteins 0.000 description 1
- 238000002105 Southern blotting Methods 0.000 description 1
- 108091081024 Start codon Proteins 0.000 description 1
- 101710172711 Structural protein Proteins 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- 230000005867 T cell response Effects 0.000 description 1
- 101800000385 Transmembrane protein Proteins 0.000 description 1
- 101800003344 Vaccinia growth factor Proteins 0.000 description 1
- 206010046865 Vaccinia virus infection Diseases 0.000 description 1
- 241000700647 Variola virus Species 0.000 description 1
- 108010003533 Viral Envelope Proteins Proteins 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- MKUXAQIIEYXACX-UHFFFAOYSA-N aciclovir Chemical compound N1C(N)=NC(=O)C2=C1N(COCCO)C=N2 MKUXAQIIEYXACX-UHFFFAOYSA-N 0.000 description 1
- 229960004150 aciclovir Drugs 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 230000005875 antibody response Effects 0.000 description 1
- 210000000612 antigen-presenting cell Anatomy 0.000 description 1
- 229940031567 attenuated vaccine Drugs 0.000 description 1
- 210000003719 b-lymphocyte Anatomy 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 208000025698 brain inflammatory disease Diseases 0.000 description 1
- 238000010804 cDNA synthesis Methods 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 239000013553 cell monolayer Substances 0.000 description 1
- 108091092356 cellular DNA Proteins 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000002512 chemotherapy Methods 0.000 description 1
- 238000000975 co-precipitation Methods 0.000 description 1
- 239000002299 complementary DNA Substances 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 230000001086 cytosolic effect Effects 0.000 description 1
- 230000006735 deficit Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 241001493065 dsRNA viruses Species 0.000 description 1
- 238000001493 electron microscopy Methods 0.000 description 1
- 206010014599 encephalitis Diseases 0.000 description 1
- 230000001815 facial effect Effects 0.000 description 1
- 101150036031 gD gene Proteins 0.000 description 1
- 238000012224 gene deletion Methods 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 101150118163 h gene Proteins 0.000 description 1
- 210000002443 helper t lymphocyte Anatomy 0.000 description 1
- 244000144980 herd Species 0.000 description 1
- 238000000265 homogenisation Methods 0.000 description 1
- 230000004727 humoral immunity Effects 0.000 description 1
- 230000008348 humoral response Effects 0.000 description 1
- 210000002865 immune cell Anatomy 0.000 description 1
- 230000009851 immunogenic response Effects 0.000 description 1
- 102000018358 immunoglobulin Human genes 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 239000000411 inducer Substances 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 239000010410 layer Substances 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 229940124590 live attenuated vaccine Drugs 0.000 description 1
- 229940023012 live-attenuated vaccine Drugs 0.000 description 1
- 230000033001 locomotion Effects 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 210000004779 membrane envelope Anatomy 0.000 description 1
- 230000034217 membrane fusion Effects 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 230000035772 mutation Effects 0.000 description 1
- 229960004927 neomycin Drugs 0.000 description 1
- 208000003154 papilloma Diseases 0.000 description 1
- 231100000255 pathogenic effect Toxicity 0.000 description 1
- 230000007918 pathogenicity Effects 0.000 description 1
- 238000003752 polymerase chain reaction Methods 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- 230000007420 reactivation Effects 0.000 description 1
- 230000000306 recurrent effect Effects 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 238000012163 sequencing technique Methods 0.000 description 1
- 238000002741 site-directed mutagenesis Methods 0.000 description 1
- 238000000527 sonication Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 238000000856 sucrose gradient centrifugation Methods 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 238000004448 titration Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 230000009261 transgenic effect Effects 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
- 241000712461 unidentified influenza virus Species 0.000 description 1
- 208000007089 vaccinia Diseases 0.000 description 1
- 230000006656 viral protein synthesis Effects 0.000 description 1
- 230000009278 visceral effect Effects 0.000 description 1
- 238000001262 western blot Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/245—Herpetoviridae, e.g. herpes simplex virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5252—Virus inactivated (killed)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5254—Virus avirulent or attenuated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16611—Simplexvirus, e.g. human herpesvirus 1, 2
- C12N2710/16622—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16611—Simplexvirus, e.g. human herpesvirus 1, 2
- C12N2710/16634—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16611—Simplexvirus, e.g. human herpesvirus 1, 2
- C12N2710/16641—Use of virus, viral particle or viral elements as a vector
- C12N2710/16643—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16611—Simplexvirus, e.g. human herpesvirus 1, 2
- C12N2710/16661—Methods of inactivation or attenuation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
- C12N2740/15022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- General Engineering & Computer Science (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Gastroenterology & Hepatology (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Plant Pathology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB909020799A GB9020799D0 (en) | 1990-09-25 | 1990-09-25 | Viral vaccines |
GB9020799 | 1990-09-25 | ||
GB919104903A GB9104903D0 (en) | 1991-03-08 | 1991-03-08 | Viral vaccines |
GB9104903 | 1991-03-08 | ||
GB9101632 | 1991-09-23 | ||
PCT/GB1991/001632 WO1992005263A1 (en) | 1990-09-25 | 1991-09-23 | Viral defective vaccine produced by transcomplementing cell line |
Publications (3)
Publication Number | Publication Date |
---|---|
FI931309A0 FI931309A0 (fi) | 1993-03-24 |
FI931309A FI931309A (fi) | 1993-03-24 |
FI110438B true FI110438B (fi) | 2003-01-31 |
Family
ID=26297693
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI931309A FI110438B (fi) | 1990-09-25 | 1993-03-24 | Menetelmä mutanttiherpesviruksen valmistamiseksi |
Country Status (19)
Country | Link |
---|---|
US (1) | US6541009B1 (no) |
EP (2) | EP0550553B1 (no) |
JP (1) | JP3895366B2 (no) |
KR (1) | KR100372934B1 (no) |
AT (1) | ATE194657T1 (no) |
AU (1) | AU658836B2 (no) |
BR (1) | BR9106879A (no) |
CA (1) | CA2091678C (no) |
DE (1) | DE69132311T2 (no) |
DK (1) | DK0550553T3 (no) |
ES (1) | ES2150416T3 (no) |
FI (1) | FI110438B (no) |
GB (1) | GB2263480B (no) |
GR (1) | GR3034484T3 (no) |
HK (1) | HK1001656A1 (no) |
MX (1) | MX9203717A (no) |
NO (1) | NO314550B1 (no) |
OA (1) | OA09777A (no) |
WO (1) | WO1992005263A1 (no) |
Families Citing this family (81)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10399032I1 (de) * | 1987-08-28 | 2004-01-29 | Health Research Inc | Rekombinante Viren. |
AT400955B (de) * | 1989-03-08 | 1996-05-28 | Health Research Inc | Rekombinantes pockenvirus-wirtsselektionssystem |
US5665362A (en) * | 1990-09-25 | 1997-09-09 | Cantab Pharmaceuticals Research Limited | Viral vaccines |
US5837261A (en) * | 1990-09-25 | 1998-11-17 | Cantab Pharmaceuticals Research Limited | Viral vaccines |
US7374768B1 (en) | 1990-09-25 | 2008-05-20 | Xenova Research Limited | Viral vaccines |
EP0550553B1 (en) | 1990-09-25 | 2000-07-12 | Cantab Pharmaceuticals Research Limited | Viral defective vaccine produced by transcomplementing cell line |
ATE181108T1 (de) | 1991-08-26 | 1999-06-15 | Immuno Ag | Direkt molekuläre klonierung eines modifizierten genoms eines chordopocken-virus |
TW289731B (no) * | 1992-07-09 | 1996-11-01 | Akzo Nv | |
EP0606437B1 (en) * | 1992-07-30 | 2005-02-02 | Akzo Nobel N.V. | Non-shedding live herpesvirus vaccine |
EP0652772B2 (en) * | 1992-07-31 | 2008-07-23 | The President and Fellows of Harvard College | Herpesvirus vaccines |
US7223411B1 (en) | 1992-07-31 | 2007-05-29 | Dana-Farber Cancer Institute | Herpesvirus replication defective mutants |
EP0689603A1 (en) * | 1993-03-19 | 1996-01-03 | Cantab Pharmaceuticals Research Limited | Defective mutant non-retroviral virus (e.g. hsv) as vaccine |
WO1995003399A2 (en) * | 1993-07-19 | 1995-02-02 | Cantab Pharmaceuticals Research Limited | Production method for preparation of disabled viruses |
WO1995004546A1 (en) * | 1993-08-06 | 1995-02-16 | Kai Juhani Ernst Krohn | Novel mutated human and simian immunodeficiency viruses and vaccines containing said viruses |
EP0659885A1 (en) * | 1993-12-21 | 1995-06-28 | Akzo Nobel N.V. | Vaccine against viruses associated with antibody-dependent-enhancement of viral infectivity |
DK0758397T3 (da) * | 1994-04-29 | 2005-10-10 | Baxter Healthcare Sa | Rekombinante poxvira med fremmede polynucleotider i essentielle regioner |
US5807557A (en) * | 1994-07-25 | 1998-09-15 | The Trustees Of The University Of Pennsylvania | Soluble herpesvirus glycoprotein complex |
US6156319A (en) | 1994-07-25 | 2000-12-05 | The Trustees Of The University Of Pennsylvania | Soluble herpesvirus glycoprotein complex vaccine |
GB9415319D0 (en) * | 1994-07-29 | 1994-09-21 | Medical Res Council | HSV viral vector |
GB9415369D0 (en) * | 1994-07-29 | 1994-09-21 | Lynxvale Ltd | Mutant virus |
GB9423663D0 (en) * | 1994-11-23 | 1995-01-11 | Cantab Pharma Res | Viral preparations, immunogens, and vaccines |
WO1996026267A1 (en) * | 1995-02-21 | 1996-08-29 | Cantab Pharmaceuticals Research Limited | Viral preparations, vectors, immunogens, and vaccines |
JPH11502222A (ja) * | 1995-03-23 | 1999-02-23 | キャンタブ ファーマシューティカルズ リサーチ リミティド | 遺伝子供給用ベクター |
EP0828823A4 (en) * | 1995-06-01 | 1999-02-10 | Merck & Co Inc | HERPES SIMPLEX TYPE 1 VIRUS PROTEASE MUTANTS AND VECTORS THEREOF |
CA2234877A1 (en) * | 1995-10-19 | 1997-04-24 | St. Jude Children's Research Hospital | Herpesvirus vectors and their uses |
DE19709148C1 (de) * | 1997-03-06 | 1998-09-03 | Evotec Biosystems Gmbh | Verfahren zur Herstellung eines Impfstoffes gegen infektiöse Erreger |
US6638502B1 (en) | 1997-04-28 | 2003-10-28 | Gencell Sas | Adenovirus-mediated intratumoral delivery of an angiogenesis antagonist for the treatment of tumors |
EP0884382A3 (en) * | 1997-06-10 | 2000-10-25 | Pfizer Products Inc. | Processes for preparation of marek's disease virus using continuous mammalian cell lines |
US6875606B1 (en) | 1997-10-23 | 2005-04-05 | The United States Of America As Represented By The Department Of Veterans Affairs | Human α-7 nicotinic receptor promoter |
GB9804632D0 (en) | 1998-03-05 | 1998-04-29 | Cantab Pharma Res | Virus preparations and methods |
GB9808922D0 (en) | 1998-04-24 | 1998-06-24 | Cantab Pharmaceuticals Res Ltd | Virus preparations |
US6225456B1 (en) | 1998-05-07 | 2001-05-01 | University Technololy Corporation | Ras suppressor SUR-5 |
US6506889B1 (en) | 1998-05-19 | 2003-01-14 | University Technology Corporation | Ras suppressor SUR-8 and related compositions and methods |
GB9816761D0 (en) | 1998-07-31 | 1998-09-30 | Phogen Limited | Herpesvirus preparations and their uses |
US6399354B1 (en) | 1998-07-31 | 2002-06-04 | President And Fellows Of Harvard College | Replication-competent virus expressing a detectable fusion protein |
EP1153136A2 (en) | 1998-12-09 | 2001-11-14 | The General Hospital Corporation | Enhanced packaging of herpes virus amplicons and generation of recombinant virus vectors |
US6441156B1 (en) * | 1998-12-30 | 2002-08-27 | The United States Of America As Represented By The Department Of Health And Human Services | Calcium channel compositions and methods of use thereof |
GB9927353D0 (en) * | 1999-11-19 | 2000-01-19 | Cantab Pharma Res | Virus preparation and use |
GB0018307D0 (en) | 2000-07-26 | 2000-09-13 | Aventis Pharm Prod Inc | Polypeptides |
CA2399940A1 (en) | 2000-04-13 | 2001-10-25 | The Rockefeller University | Enhancement of antibody-mediated immune responses |
CA2901451C (en) | 2000-05-10 | 2020-04-07 | Moses Rodriguez | Human igm antibodies with the capability of inducing remyelination, and diagnostic and therapeutic uses thereof particularly in the central nervous system |
CA2421938A1 (en) | 2000-09-14 | 2002-03-21 | Mount Sinai School Of Medicine | Screening methods to identify g-proteins and other compounds which modulate phosphodiesterase (pde) activity |
US7060442B2 (en) | 2000-10-30 | 2006-06-13 | Regents Of The University Of Michigan | Modulators on Nod2 signaling |
CA2432426A1 (en) | 2000-12-28 | 2002-07-11 | Wyeth | Recombinant protective protein from streptococcus pneumoniae |
ATE448793T1 (de) | 2001-03-02 | 2009-12-15 | Univ Rockefeller | Rekombinante hybrid-allergenkonstrukte mit verringerter allergenität unter beibehaltung der immunogenität des natürlichen allergens |
US7803982B2 (en) | 2001-04-20 | 2010-09-28 | The Mount Sinai School Of Medicine Of New York University | T1R3 transgenic animals, cells and related methods |
MX339524B (es) | 2001-10-11 | 2016-05-30 | Wyeth Corp | Composiciones inmunogenicas novedosas para la prevencion y tratamiento de enfermedad meningococica. |
US7785608B2 (en) | 2002-08-30 | 2010-08-31 | Wyeth Holdings Corporation | Immunogenic compositions for the prevention and treatment of meningococcal disease |
US7432057B2 (en) | 2004-01-30 | 2008-10-07 | Michigan State University | Genetic test for PSE-susceptible turkeys |
GB0716992D0 (en) | 2007-08-31 | 2007-10-10 | Immune Targeting Systems Its L | Influenza antigen delivery vectors and constructs |
GB0408164D0 (en) | 2004-04-13 | 2004-05-19 | Immune Targeting Systems Ltd | Antigen delivery vectors and constructs |
US7604798B2 (en) | 2004-07-15 | 2009-10-20 | Northwestern University | Methods and compositions for importing nucleic acids into cell nuclei |
AU2005274948B2 (en) | 2004-07-16 | 2011-09-22 | Genvec, Inc. | Vaccines against aids comprising CMV/R-nucleic acid constructs |
GB2421025A (en) * | 2004-12-09 | 2006-06-14 | Oxxon Therapeutics Ltd | HSV vaccination vectors |
US7439327B2 (en) | 2005-01-18 | 2008-10-21 | Nuvelo, Inc. | Stem cell factor-like proteins and uses thereof |
WO2007005898A2 (en) | 2005-07-05 | 2007-01-11 | Cornell Research Foundation, Inc. | Blocking leukocyte emigration and inflammation by interfering with cd99l2 |
WO2007016239A2 (en) * | 2005-07-29 | 2007-02-08 | President And Fellows Of Harvard College | Herpes simplex virus mutant and uses therefore |
AR064642A1 (es) | 2006-12-22 | 2009-04-15 | Wyeth Corp | Polinucleotido vector que lo comprende celula recombinante que comprende el vector polipeptido , anticuerpo , composicion que comprende el polinucleotido , vector , celula recombinante polipeptido o anticuerpo , uso de la composicion y metodo para preparar la composicion misma y preparar una composi |
US8093043B2 (en) | 2008-06-04 | 2012-01-10 | New York University | β-TrCP1, β-TrCP2 and RSK1 or RSK2 inhibitors and methods for sensitizing target cells to apoptosis |
WO2009155484A2 (en) | 2008-06-20 | 2009-12-23 | Wyeth | Compositions and methods of use of orf1358 from beta-hemolytic streptococcal strains |
US8425898B2 (en) | 2008-06-20 | 2013-04-23 | Duke University | Compositions, methods, and kits for eliciting an immune response |
DK2356135T3 (en) | 2008-11-05 | 2017-12-04 | Wyeth Llc | IMMUNOGEN MULTICOMPONENT COMPOSITION FOR THE PREVENTION OF BETA-HAEMOLYTIC STRUCTURAL TOC (BHS) DISEASE |
WO2010096561A1 (en) | 2009-02-18 | 2010-08-26 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Synthetic hiv/siv gag proteins and uses thereof |
WO2011116351A2 (en) | 2010-03-19 | 2011-09-22 | University Of South Alabama | Methods and compositions for the treatment of cancer |
RU2580620C2 (ru) | 2010-08-23 | 2016-04-10 | ВАЙЕТ ЭлЭлСи | СТАБИЛЬНЫЕ КОМПОЗИЦИИ АНТИГЕНОВ Neisseria meningitidis rLP2086 |
EP3056212B1 (en) | 2010-09-10 | 2019-04-03 | Wyeth LLC | Non-lipidated variants of neisseria meningitidis orf2086 antigens |
US9458456B2 (en) | 2011-04-01 | 2016-10-04 | University Of South Alabama | Methods and compositions for the diagnosis, classification, and treatment of cancer |
HUE037408T2 (hu) | 2011-06-10 | 2018-08-28 | Univ Oregon Health & Science | CMV glikoproteinek és rekombináns vektorok |
US9464291B2 (en) | 2012-01-06 | 2016-10-11 | University Of South Alabama | Methods and compositions for the treatment of cancer |
SA115360586B1 (ar) | 2012-03-09 | 2017-04-12 | فايزر انك | تركيبات لعلاج الالتهاب السحائي البكتيري وطرق لتحضيرها |
BR122016004924A2 (pt) | 2012-03-09 | 2019-07-30 | Pfizer Inc. | Polipeptídeo isolado e composições imunogênicas compreendendo os mesmos |
CA2903716C (en) | 2013-03-08 | 2019-04-09 | Pfizer Inc. | Immunogenic fusion polypeptides |
US10981961B2 (en) | 2013-03-11 | 2021-04-20 | University Of Florida Research Foundation, Incorporated | Delivery of card protein as therapy for occular inflammation |
RU2662968C2 (ru) | 2013-09-08 | 2018-07-31 | Пфайзер Инк. | Иммуногенная композиция против neisseria meningitidis (варианты) |
WO2015047901A1 (en) | 2013-09-24 | 2015-04-02 | Duke University | Compositions, methods and kits for eliciting an immune response |
BE1023557B1 (fr) | 2014-02-10 | 2017-05-03 | Univercells Sa | Systeme, appareil et procede pour la production de biomolecules |
EP3107939B1 (en) | 2014-02-19 | 2020-06-17 | University of Florida Research Foundation, Inc. | Delivery of nrf2 as therapy for protection against reactive oxygen species |
KR20190049940A (ko) | 2015-02-19 | 2019-05-09 | 화이자 인코포레이티드 | 나이세리아 메닌지티디스 조성물 및 그의 방법 |
CN110234658B (zh) | 2017-01-31 | 2024-03-12 | 辉瑞大药厂 | 脑膜炎奈瑟菌组合物及其使用方法 |
CA3062549A1 (en) | 2017-05-15 | 2018-11-22 | Janssen Vaccines & Prevention B.V. | Stable virus-containing composition |
CA3061678A1 (en) | 2017-05-15 | 2018-11-22 | Janssen Vaccines & Prevention B.V. | Stable virus-containing composition |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5338683A (en) * | 1981-12-24 | 1994-08-16 | Health Research Incorporated | Vaccinia virus containing DNA sequences encoding herpesvirus glycoproteins |
EP0213894A3 (en) * | 1985-08-23 | 1987-10-21 | Advanced Genetics Research Institute | Defective viral particle vaccines and methods for their use |
US4996152A (en) * | 1987-12-04 | 1991-02-26 | The United States Of America, As Represented By The Secretary Of Agriculture | Avian herpesvirus amplicon as a eucaryotic expression vector |
JPH03504079A (ja) * | 1988-03-21 | 1991-09-12 | カイロン コーポレイション | 組換えレトロウィルス |
EP0441897A4 (en) * | 1988-11-14 | 1992-06-24 | Us Health | Parvovirus capsids |
JP3140757B2 (ja) * | 1989-02-06 | 2001-03-05 | デイナ・フアーバー・キヤンサー・インステイテユート | パッケージング欠陥hivプロウイルス、細胞系及びその使用 |
AT400955B (de) | 1989-03-08 | 1996-05-28 | Health Research Inc | Rekombinantes pockenvirus-wirtsselektionssystem |
FR2663228A2 (fr) * | 1989-09-29 | 1991-12-20 | Agronomique Inst Nat Rech | Composition immunisante contre la maladie de newcastle et procede de preparation. |
CA2039921A1 (en) * | 1990-04-16 | 1991-10-17 | Xandra O. Breakefield | Transfer and expression of gene sequences into central nervous system cells using herpes simplex virus mutants with deletions in genes for viral replication |
EP0550553B1 (en) | 1990-09-25 | 2000-07-12 | Cantab Pharmaceuticals Research Limited | Viral defective vaccine produced by transcomplementing cell line |
EP0575491B1 (en) * | 1991-03-07 | 2003-08-13 | Virogenetics Corporation | Genetically engineered vaccine strain |
EP0652772B2 (en) | 1992-07-31 | 2008-07-23 | The President and Fellows of Harvard College | Herpesvirus vaccines |
-
1991
- 1991-09-23 EP EP19910917033 patent/EP0550553B1/en not_active Expired - Lifetime
- 1991-09-23 ES ES91917033T patent/ES2150416T3/es not_active Expired - Lifetime
- 1991-09-23 EP EP19990106514 patent/EP0953648A3/en not_active Withdrawn
- 1991-09-23 AT AT91917033T patent/ATE194657T1/de not_active IP Right Cessation
- 1991-09-23 WO PCT/GB1991/001632 patent/WO1992005263A1/en active IP Right Grant
- 1991-09-23 CA CA 2091678 patent/CA2091678C/en not_active Expired - Lifetime
- 1991-09-23 DE DE69132311T patent/DE69132311T2/de not_active Expired - Lifetime
- 1991-09-23 AU AU86489/91A patent/AU658836B2/en not_active Ceased
- 1991-09-23 KR KR1019930700913A patent/KR100372934B1/ko active
- 1991-09-23 JP JP51739991A patent/JP3895366B2/ja not_active Expired - Fee Related
- 1991-09-23 DK DK91917033T patent/DK0550553T3/da active
- 1991-09-23 BR BR9106879A patent/BR9106879A/pt not_active Application Discontinuation
-
1992
- 1992-06-29 MX MX9203717A patent/MX9203717A/es unknown
-
1993
- 1993-03-23 GB GB9306044A patent/GB2263480B/en not_active Expired - Fee Related
- 1993-03-23 NO NO19931057A patent/NO314550B1/no not_active IP Right Cessation
- 1993-03-24 FI FI931309A patent/FI110438B/fi active
- 1993-03-25 OA OA60354A patent/OA09777A/en unknown
-
1995
- 1995-06-05 US US08/462,632 patent/US6541009B1/en not_active Expired - Fee Related
-
1998
- 1998-01-27 HK HK98100722A patent/HK1001656A1/xx not_active IP Right Cessation
-
2000
- 2000-09-26 GR GR20000402173T patent/GR3034484T3/el not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
EP0953648A3 (en) | 2007-09-12 |
NO314550B1 (no) | 2003-04-07 |
US6541009B1 (en) | 2003-04-01 |
FI931309A0 (fi) | 1993-03-24 |
CA2091678C (en) | 2003-04-22 |
WO1992005263A1 (en) | 1992-04-02 |
JPH06504194A (ja) | 1994-05-19 |
CA2091678A1 (en) | 1992-03-26 |
AU8648991A (en) | 1992-04-15 |
MX9203717A (es) | 1992-09-01 |
KR100372934B1 (ko) | 2003-12-24 |
NO931057L (no) | 1993-05-03 |
OA09777A (en) | 1993-11-30 |
EP0953648A2 (en) | 1999-11-03 |
DE69132311T2 (de) | 2000-12-14 |
GB9306044D0 (en) | 1993-06-02 |
JP3895366B2 (ja) | 2007-03-22 |
GR3034484T3 (en) | 2000-12-29 |
HK1001656A1 (en) | 1998-07-03 |
EP0550553A1 (en) | 1993-07-14 |
AU658836B2 (en) | 1995-05-04 |
BR9106879A (pt) | 1993-07-20 |
FI931309A (fi) | 1993-03-24 |
EP0550553B1 (en) | 2000-07-12 |
GB2263480B (en) | 1994-07-20 |
DK0550553T3 (da) | 2000-10-23 |
DE69132311D1 (de) | 2000-08-17 |
GB2263480A (en) | 1993-07-28 |
NO931057D0 (no) | 1993-03-23 |
ATE194657T1 (de) | 2000-07-15 |
ES2150416T3 (es) | 2000-12-01 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
FI110438B (fi) | Menetelmä mutanttiherpesviruksen valmistamiseksi | |
US5665362A (en) | Viral vaccines | |
JP3602530B2 (ja) | 遺伝子操作したワクチン菌株 | |
JP5926804B2 (ja) | Cmv用ワクチンとしての条件付き複製サイトメガロウイルス | |
EP3407910B1 (en) | Recombinant modified vaccinia virus ankara (mva) equine encephalitis virus vaccine | |
JP2002514885A (ja) | ポックスウイルス−イヌジステンパーウイルス(cdv)組み換え体類および組成物類および前記組み換え体類を用いる方法 | |
US7645455B2 (en) | Chimeric lyssavirus nucleic acids and polypeptides | |
CN105555958A (zh) | 水疱性口炎病毒的改性基质蛋白 | |
JP3034025B2 (ja) | 自己アセンブルド欠損非自己増殖性ウイルス粒子 | |
JP2007254489A (ja) | Htlv抗原を発現する組換え弱毒化ポックスウイルスを含有する免疫原性組成物 | |
EP1439856B1 (en) | Recombinant rabies vaccine and methods of preparation and use | |
Vlastos et al. | VP1 pseudocapsids, but not a glutathione‐S‐transferase VP1 fusion protein, prevent polyomavirus infection in a T‐cell immune deficient experimental mouse model | |
JPH11511961A (ja) | 組換えポックスウイルス−カリシウイルス[ウサギ出血疾患ウイルス(rhdv)]組成物および使用 | |
Van der Ryst et al. | Study of the immunogenicity of different recombinant Mengo viruses expressing HIV1 and SIV epitopes | |
CA2370278C (en) | Chimeric lyssavirus nucleic acids and polypeptides | |
RU2236256C2 (ru) | Вакцина, содержащая мутантный вирус герпеса | |
US7374768B1 (en) | Viral vaccines | |
US7238672B1 (en) | Chimeric lyssavirus nucleic acids and polypeptides | |
CN1062601C (zh) | 病毒疫苗 | |
Morghen et al. | Virus vectors for immunoprophylaxis | |
Xiang et al. | A simple method to test the ability of individual viral proteins to induce immune responses | |
CZ127394A3 (en) | Replication-capable recombinant virus, process of obtaining thereof and vaccine composition |