FI109694B - Menetelmä terapeuttisesti käyttökelpoisen (1)-(-)-2-(aminokarbonyyli)-N-(4-amino-2,6-dikloorifenyyli)-4-[5,5-bis-(4-fluorifenyyli)pentyyli]-1-piperatsiiniasetamidin valmistamiseksi - Google Patents

Menetelmä terapeuttisesti käyttökelpoisen (1)-(-)-2-(aminokarbonyyli)-N-(4-amino-2,6-dikloorifenyyli)-4-[5,5-bis-(4-fluorifenyyli)pentyyli]-1-piperatsiiniasetamidin valmistamiseksi Download PDF

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Publication number
FI109694B
FI109694B FI913433A FI913433A FI109694B FI 109694 B FI109694 B FI 109694B FI 913433 A FI913433 A FI 913433A FI 913433 A FI913433 A FI 913433A FI 109694 B FI109694 B FI 109694B
Authority
FI
Finland
Prior art keywords
bis
fluorophenyl
formula
compound
aminocarbonyl
Prior art date
Application number
FI913433A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI913433A0 (fi
Inventor
Laerhoven Willy Joannes Ca Van
Belle Herman Van
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of FI913433A0 publication Critical patent/FI913433A0/fi
Application granted granted Critical
Publication of FI109694B publication Critical patent/FI109694B/fi

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/164—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • A61K38/166—Streptokinase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/49—Urokinase; Tissue plasminogen activator
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Protection Of Pipes Against Damage, Friction, And Corrosion (AREA)
  • Dicing (AREA)
  • Branch Pipes, Bends, And The Like (AREA)
  • Golf Clubs (AREA)
  • Professional, Industrial, Or Sporting Protective Garments (AREA)
  • Suspension Of Electric Lines Or Cables (AREA)
  • External Artificial Organs (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Paper (AREA)
  • Production Of Liquid Hydrocarbon Mixture For Refining Petroleum (AREA)
FI913433A 1989-11-22 1991-07-16 Menetelmä terapeuttisesti käyttökelpoisen (1)-(-)-2-(aminokarbonyyli)-N-(4-amino-2,6-dikloorifenyyli)-4-[5,5-bis-(4-fluorifenyyli)pentyyli]-1-piperatsiiniasetamidin valmistamiseksi FI109694B (fi)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US44014289A 1989-11-22 1989-11-22
US44014289 1989-11-22
PCT/EP1990/001985 WO1991007967A2 (en) 1989-11-22 1990-11-19 Method of preventing or limiting reperfusion damage
EP9001985 1990-11-19
SG118494A SG118494G (en) 1989-11-22 1994-08-20 Method of preventing or limiting reperfusion damage
SG118494 1994-08-20

Publications (2)

Publication Number Publication Date
FI913433A0 FI913433A0 (fi) 1991-07-16
FI109694B true FI109694B (fi) 2002-09-30

Family

ID=26664237

Family Applications (1)

Application Number Title Priority Date Filing Date
FI913433A FI109694B (fi) 1989-11-22 1991-07-16 Menetelmä terapeuttisesti käyttökelpoisen (1)-(-)-2-(aminokarbonyyli)-N-(4-amino-2,6-dikloorifenyyli)-4-[5,5-bis-(4-fluorifenyyli)pentyyli]-1-piperatsiiniasetamidin valmistamiseksi

Country Status (22)

Country Link
EP (2) EP0577171B1 (hu)
JP (1) JP2574585B2 (hu)
KR (1) KR0165686B1 (hu)
AT (2) ATE102831T1 (hu)
AU (1) AU632888B2 (hu)
CA (1) CA2044143C (hu)
CY (1) CY1869A (hu)
DE (2) DE69007471T2 (hu)
DK (2) DK0577171T3 (hu)
ES (2) ES2053208T3 (hu)
FI (1) FI109694B (hu)
HK (1) HK115095A (hu)
HU (1) HU215847B (hu)
IE (1) IE65121B1 (hu)
IL (1) IL96390A (hu)
NO (2) NO304519B1 (hu)
NZ (1) NZ236168A (hu)
PT (2) PT95959B (hu)
RU (1) RU2093156C1 (hu)
SG (1) SG118494G (hu)
WO (1) WO1991007967A2 (hu)
ZA (1) ZA909345B (hu)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9202266D0 (sv) * 1992-07-31 1992-07-31 Kabi Pharmacia Ab Novel piperazine carboxamides
SE9504661D0 (sv) 1995-12-22 1995-12-22 Astra Pharma Inc New compounds
US6683100B2 (en) 1999-01-19 2004-01-27 Novartis Ag Organic compounds
US6194181B1 (en) 1998-02-19 2001-02-27 Novartis Ag Fermentative preparation process for and crystal forms of cytostatics
SE9904673D0 (sv) 1999-12-20 1999-12-20 Astra Pharma Inc Novel compounds
SE9904674D0 (sv) 1999-12-20 1999-12-20 Astra Pharma Inc Novel compounds
SE0001209D0 (sv) 2000-04-04 2000-04-04 Astrazeneca Canada Inc Novel compounds
BR0209678A (pt) 2001-05-18 2004-09-14 Astrazeneca Ab Composto, processo para preparar e uso do mesmo, composição farmacêutica, e, métodos para o tratamento da dor e de distúrbios gastrintestinais funcionais
SE0203302D0 (sv) 2002-11-07 2002-11-07 Astrazeneca Ab Novel Compounds
SE0203300D0 (sv) 2002-11-07 2002-11-07 Astrazeneca Ab Novel Compounds
SE0203303D0 (sv) 2002-11-07 2002-11-07 Astrazeneca Ab Novel Compounds
CA2575975A1 (en) * 2003-11-12 2005-05-26 Dr. Reddy's Laboratories, Inc. Preparation of escitalopram
DK1781631T3 (da) 2004-08-02 2012-05-14 Astrazeneca Ab Diarylmethylpiperazinderivater, præparater dermed og anvendelser deraf
FR2946340B1 (fr) 2009-06-05 2011-06-24 Galderma Res & Dev Nouveaux n-phenyl acetamie, inhibiteurs de l'enzyme soat-1, compositions pharmaceutiques et cosmetiques les contenant.
KR101900124B1 (ko) 2014-06-25 2018-09-18 전남대학교산학협력단 전복 박리용 조성물
KR101644299B1 (ko) 2014-07-22 2016-08-02 주식회사 엔바이로젠 오미자 및 삼채 추출물을 유효성분으로 포함하는 전복 박리용 조성물

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4766125A (en) * 1981-06-23 1988-08-23 Janssen Pharmaceutica N.V. N-aryl-piperazinealkanamides useful for protecting hearts from myocardial injury caused by ischaemia, anoxia or hypoxia
NZ223847A (en) * 1987-04-01 1989-12-21 Janssen Pharmaceutica Nv Substituted piperazine derivatives and pharmaceutical compositions

Also Published As

Publication number Publication date
DE69033926T2 (de) 2002-10-24
ATE102831T1 (de) 1994-04-15
SG118494G (en) 1994-11-25
FI913433A0 (fi) 1991-07-16
HK115095A (en) 1995-07-21
RU2093156C1 (ru) 1997-10-20
EP0455789A1 (en) 1991-11-13
PT102145A (pt) 1999-10-29
IE904209A1 (en) 1991-05-22
AU632888B2 (en) 1993-01-14
CA2044143C (en) 2002-11-19
JP2574585B2 (ja) 1997-01-22
AU6876391A (en) 1991-06-26
PT95959A (pt) 1991-09-13
KR920700644A (ko) 1992-08-10
ZA909345B (en) 1992-08-26
NZ236168A (en) 1993-05-26
CA2044143A1 (en) 1991-05-23
EP0577171A3 (en) 1994-06-29
PT102145B (pt) 2002-06-28
PT95959B (pt) 1998-08-31
EP0455789B1 (en) 1994-03-16
IL96390A (en) 1995-06-29
DE69007471T2 (de) 1994-06-23
DK0577171T3 (da) 2002-06-03
NO912511L (no) 1991-08-26
WO1991007967A3 (en) 1991-07-11
CY1869A (en) 1996-04-05
NO311701B1 (no) 2002-01-14
DE69007471D1 (de) 1994-04-21
DE69033926D1 (de) 2002-04-11
IE65121B1 (en) 1995-10-04
WO1991007967A2 (en) 1991-06-13
HUT58709A (en) 1992-03-30
HU215847B (hu) 1999-04-28
EP0577171A2 (en) 1994-01-05
NO982078L (no) 1991-08-26
IL96390A0 (en) 1991-08-16
DK0455789T3 (da) 1994-04-05
ES2053208T3 (es) 1994-07-16
NO304519B1 (no) 1999-01-04
NO912511D0 (no) 1991-06-26
ES2173883T3 (es) 2002-11-01
HU9102436D0 (en) 1991-12-30
ATE213943T1 (de) 2002-03-15
EP0577171B1 (en) 2002-03-06
NO982078D0 (no) 1998-05-07
KR0165686B1 (ko) 1999-01-15

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