FI106031B - Menetelmä uusien syklisten farmaseuttisesti käytettävien heksapeptidien valmistamiseksi - Google Patents

Menetelmä uusien syklisten farmaseuttisesti käytettävien heksapeptidien valmistamiseksi Download PDF

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Publication number
FI106031B
FI106031B FI923619A FI923619A FI106031B FI 106031 B FI106031 B FI 106031B FI 923619 A FI923619 A FI 923619A FI 923619 A FI923619 A FI 923619A FI 106031 B FI106031 B FI 106031B
Authority
FI
Finland
Prior art keywords
asp
leu
trp
added
residue
Prior art date
Application number
FI923619A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI923619A0 (fi
FI923619A (fi
Inventor
Mitsuhiro Wakimasu
Takashi Kikuchi
Akira Kawada
Hideo Shirahuji
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of FI923619A0 publication Critical patent/FI923619A0/fi
Publication of FI923619A publication Critical patent/FI923619A/fi
Application granted granted Critical
Publication of FI106031B publication Critical patent/FI106031B/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/57536—Endothelin, vasoactive intestinal contractor [VIC]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Reproductive Health (AREA)
  • Rheumatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
FI923619A 1991-08-13 1992-08-12 Menetelmä uusien syklisten farmaseuttisesti käytettävien heksapeptidien valmistamiseksi FI106031B (fi)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
JP20303291 1991-08-13
JP20303291 1991-08-13
JP30363591 1991-11-19
JP30363591 1991-11-19
JP3543692 1992-02-21
JP3543692 1992-02-21
JP11179292 1992-04-30
JP11179292 1992-04-30

Publications (3)

Publication Number Publication Date
FI923619A0 FI923619A0 (fi) 1992-08-12
FI923619A FI923619A (fi) 1993-02-14
FI106031B true FI106031B (fi) 2000-11-15

Family

ID=27460093

Family Applications (1)

Application Number Title Priority Date Filing Date
FI923619A FI106031B (fi) 1991-08-13 1992-08-12 Menetelmä uusien syklisten farmaseuttisesti käytettävien heksapeptidien valmistamiseksi

Country Status (11)

Country Link
US (2) US5616684A (de)
EP (1) EP0528312B1 (de)
JP (2) JP2677489B2 (de)
AT (1) ATE155486T1 (de)
CA (1) CA2075878C (de)
DE (1) DE69220861T2 (de)
DK (1) DK0528312T3 (de)
ES (1) ES2103857T3 (de)
FI (1) FI106031B (de)
GR (1) GR3024495T3 (de)
NO (1) NO310295B1 (de)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5767310A (en) * 1993-03-19 1998-06-16 Merck & Co., Inc. Phenoxyphenylacetic acid derivatives
CA2121724A1 (en) * 1993-04-21 1994-10-22 Toshifumi Watanabe Methods and compositions for the prophylactic and/or therapeutic treatment of organ hypofunction
US6087324A (en) * 1993-06-24 2000-07-11 Takeda Chemical Industries, Ltd. Sustained-release preparation
CA2126619A1 (en) * 1993-06-24 1994-12-25 Yasutaka Igari Sustained-release preparation of anti-endothelin substance
US5811218A (en) * 1993-07-28 1998-09-22 Hitachi Chemical Company, Ltd. Photoinitiator compositions including amino acids, coumarin and titanocene and photosensitive materials using the same
CA2135151A1 (en) * 1993-11-08 1995-05-09 Mitsuhiro Wakimasu Cyclic hexapeptides, their production and use
US5521156A (en) * 1994-02-03 1996-05-28 Merrell Pharmaceuticals Inc. Cyclic neurokinin A antagonists
US5538991A (en) * 1994-09-14 1996-07-23 Merck & Co., Inc. Endothelin antagonists bearing 5-membered heterocyclic amides
US5559135A (en) * 1994-09-14 1996-09-24 Merck & Co., Inc. Endothelin antagonists bearing pyridyl amides
EP0714909A1 (de) * 1994-12-01 1996-06-05 Takeda Chemical Industries, Ltd. Zusammensetzung zur Vorbeugung und Behandlung von Lungen-Kreislauferkrankungen
WO1996034012A1 (en) * 1995-04-28 1996-10-31 Takeda Chemical Industries, Ltd. Cyclic pentapeptide lh-rh receptor antagonists
US6251861B1 (en) 1996-06-27 2001-06-26 Takeda Chemical Industries, Ltd. Treatment of cerebral infarction using cyclic hexapeptides
IT1304888B1 (it) * 1998-08-05 2001-04-05 Menarini Ricerche Spa Composti monociclici ad azione nk-2 antagonista e formulazioni che licontengono
CZ20013407A3 (cs) 1999-03-29 2002-02-13 The Procter & Gamble Company Cyklický peptidový analog a jeho výroba
WO2003006041A1 (fr) * 2001-07-12 2003-01-23 Takeda Chemical Industries, Ltd. Agents prophylactiques/therapeutiques contre les tumeurs malignes
GB0326632D0 (en) 2003-11-14 2003-12-17 Jagotec Ag Dry powder formulations
WO2005085277A1 (en) * 2004-02-06 2005-09-15 Concepcion Gisela P Cyclic hexapeptides, process and use thereof
US7838102B2 (en) * 2004-10-28 2010-11-23 E. I. Du Pont De Nemours And Company Filled polyvinyl butyral sheeting for decorative laminated glass and a process for making same
SG174050A1 (en) * 2006-04-13 2011-09-29 Actelion Pharmaceuticals Ltd Endothelin receptor antagonists for early stage idiopathic pulmonary fibrosis
CA2939778C (en) 2007-01-31 2019-01-29 Dana-Farber Cancer Institute, Inc. Stabilized p53 peptides and uses thereof
EP3159352B1 (de) 2007-03-28 2023-08-02 President and Fellows of Harvard College Geheftete polypeptide
WO2012021876A2 (en) 2010-08-13 2012-02-16 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
US20130177651A1 (en) 2010-09-03 2013-07-11 Pharmaterials Limited Pharmaceutical Composition Suitable for Use in a Dry Powder Inhaler
US9480525B2 (en) 2011-01-21 2016-11-01 Kardium, Inc. High-density electrode-based medical device system
WO2013059525A1 (en) 2011-10-18 2013-04-25 Aileron Therapeutics, Inc. Peptidomimetic macrocyles
CN104144695A (zh) 2012-02-15 2014-11-12 爱勒让治疗公司 三唑交联的和硫醚交联的拟肽大环化合物
CA2862038C (en) 2012-02-15 2021-05-25 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
US9605047B2 (en) 2012-04-04 2017-03-28 The Brigham And Womens's Hospital, Inc. Compositions and methods for treating hypertension
SG11201503052RA (en) 2012-11-01 2015-05-28 Aileron Therapeutics Inc Disubstituted amino acids and methods of preparation and use thereof
CA2961258A1 (en) 2014-09-24 2016-03-31 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
MX2017003819A (es) 2014-09-24 2017-06-15 Aileron Therapeutics Inc Macrociclos peptidomimeticos y formulaciones de los mismos.
CA2979847A1 (en) 2015-03-20 2016-09-29 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
US10023613B2 (en) 2015-09-10 2018-07-17 Aileron Therapeutics, Inc. Peptidomimetic macrocycles as modulators of MCL-1
KR102389725B1 (ko) * 2020-02-14 2022-04-25 서울대학교산학협력단 피페라진산을 함유하는 사이클릭 펩티드 화합물, 이의 생산 방법, 및 이의 용도
WO2024114782A1 (en) * 2022-12-01 2024-06-06 National Institute Of Biological Sciences, Beijing Small-molecule modulators of spike protein

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2032559C (en) * 1989-12-28 2001-11-06 Kiyofumi Ishikawa Endothelin antagonistic cyclic pentapeptides
IT1241761B (it) * 1990-08-03 1994-02-01 Menarini Farma Ind Peptidi di sintesi antagonisti della neurochinina a, loro sali e relativi procedimenti di fabbricazione
US5260276A (en) * 1991-06-14 1993-11-09 Warner-Lambert Company Linear and monocyclic endothelin antagonists

Also Published As

Publication number Publication date
EP0528312B1 (de) 1997-07-16
JPH08225595A (ja) 1996-09-03
EP0528312A2 (de) 1993-02-24
ES2103857T3 (es) 1997-10-01
ATE155486T1 (de) 1997-08-15
EP0528312A3 (de) 1993-04-14
NO923142D0 (no) 1992-08-12
FI923619A0 (fi) 1992-08-12
NO923142L (no) 1993-02-15
US5616684A (en) 1997-04-01
DE69220861D1 (de) 1997-08-21
NO310295B1 (no) 2001-06-18
CA2075878C (en) 2002-12-24
DE69220861T2 (de) 1997-11-20
JP2726647B2 (ja) 1998-03-11
CA2075878A1 (en) 1993-02-14
DK0528312T3 (da) 1997-12-29
JP2677489B2 (ja) 1997-11-17
FI923619A (fi) 1993-02-14
US5883075A (en) 1999-03-16
JPH069689A (ja) 1994-01-18
GR3024495T3 (en) 1997-11-28

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