FI105918B - Menetelmä 5-metyyli-tetrahydrofoolihapon enantiomeerien erottamiseksi - Google Patents

Menetelmä 5-metyyli-tetrahydrofoolihapon enantiomeerien erottamiseksi Download PDF

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Publication number
FI105918B
FI105918B FI942161A FI942161A FI105918B FI 105918 B FI105918 B FI 105918B FI 942161 A FI942161 A FI 942161A FI 942161 A FI942161 A FI 942161A FI 105918 B FI105918 B FI 105918B
Authority
FI
Finland
Prior art keywords
acid
ethyl
methyl
aminomethylpyrrolidine
salt
Prior art date
Application number
FI942161A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI942161A (fi
FI942161A0 (fi
Inventor
Klaus Scheib
Peter Klein
Robert Carter
Original Assignee
Knoll Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Knoll Ag filed Critical Knoll Ag
Publication of FI942161A publication Critical patent/FI942161A/fi
Publication of FI942161A0 publication Critical patent/FI942161A0/fi
Application granted granted Critical
Publication of FI105918B publication Critical patent/FI105918B/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
    • C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
FI942161A 1991-11-11 1994-05-10 Menetelmä 5-metyyli-tetrahydrofoolihapon enantiomeerien erottamiseksi FI105918B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE4136921 1991-11-11
DE4136921A DE4136921A1 (de) 1991-11-11 1991-11-11 Verfahren zur trennung von 5-methyl-tetrahydrofolsaeure
PCT/EP1992/002515 WO1993010118A1 (de) 1991-11-11 1992-11-03 Verfahren zur trennung von 5-methyl-tetrahydrofolsäure
EP9202515 1992-11-03

Publications (3)

Publication Number Publication Date
FI942161A FI942161A (fi) 1994-05-10
FI942161A0 FI942161A0 (fi) 1994-05-10
FI105918B true FI105918B (fi) 2000-10-31

Family

ID=6444446

Family Applications (1)

Application Number Title Priority Date Filing Date
FI942161A FI105918B (fi) 1991-11-11 1994-05-10 Menetelmä 5-metyyli-tetrahydrofoolihapon enantiomeerien erottamiseksi

Country Status (16)

Country Link
US (1) US5457202A (no)
EP (1) EP0612322B1 (no)
JP (1) JP3162390B2 (no)
KR (1) KR100211915B1 (no)
AT (1) ATE177100T1 (no)
AU (1) AU664051B2 (no)
CA (1) CA2121351C (no)
DE (2) DE4136921A1 (no)
DK (1) DK0612322T3 (no)
ES (1) ES2127765T3 (no)
FI (1) FI105918B (no)
GR (1) GR3029552T3 (no)
NO (1) NO305175B1 (no)
TW (1) TW221293B (no)
WO (1) WO1993010118A1 (no)
ZA (1) ZA928643B (no)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4136921A1 (de) * 1991-11-11 1993-05-13 Knoll Ag Verfahren zur trennung von 5-methyl-tetrahydrofolsaeure
GB9222253D0 (en) * 1992-10-23 1992-12-09 Celltech Ltd Chemical compounds
GB9304919D0 (en) * 1993-03-10 1993-04-28 Celltech Ltd Chemical compounds
GB9304920D0 (en) * 1993-03-10 1993-04-28 Celltech Ltd Chemical compounds
EP0738268B1 (en) * 1993-12-22 2004-03-03 Celltech R&D Limited Trisubstituted phenyl derivatives, processes for their preparation and their use as phosphodiesterase (type iv) inhibitors
GB9326600D0 (en) * 1993-12-22 1994-03-02 Celltech Ltd Chemical compounds
IT1270185B (it) * 1994-06-08 1997-04-29 Bracco Spa Processo per l'ottenimento e la separazione dei sali diastereoisomeri dell'acido folinico
US6245774B1 (en) 1994-06-21 2001-06-12 Celltech Therapeutics Limited Tri-substituted phenyl or pyridine derivatives
US5786354A (en) * 1994-06-21 1998-07-28 Celltech Therapeutics, Limited Tri-substituted phenyl derivatives and processes for their preparation
GB9412573D0 (en) 1994-06-22 1994-08-10 Celltech Ltd Chemical compounds
GB9412571D0 (en) 1994-06-22 1994-08-10 Celltech Ltd Chemical compounds
GB9523675D0 (en) * 1995-11-20 1996-01-24 Celltech Therapeutics Ltd Chemical compounds
GB9526245D0 (en) * 1995-12-21 1996-02-21 Celltech Therapeutics Ltd Chemical compounds
GB9526246D0 (en) * 1995-12-21 1996-02-21 Celltech Therapeutics Ltd Chemical compounds
GB9608435D0 (en) * 1996-04-24 1996-06-26 Celltech Therapeutics Ltd Chemical compounds
GB9619284D0 (en) * 1996-09-16 1996-10-30 Celltech Therapeutics Ltd Chemical compounds
GB9622363D0 (en) * 1996-10-28 1997-01-08 Celltech Therapeutics Ltd Chemical compounds
GB9625184D0 (en) * 1996-12-04 1997-01-22 Celltech Therapeutics Ltd Chemical compounds
US6057329A (en) * 1996-12-23 2000-05-02 Celltech Therapeutics Limited Fused polycyclic 2-aminopyrimidine derivatives
GB9705361D0 (en) * 1997-03-14 1997-04-30 Celltech Therapeutics Ltd Chemical compounds
GB9713087D0 (en) * 1997-06-20 1997-08-27 Celltech Therapeutics Ltd Chemical compounds
CH693905A5 (de) * 1999-04-15 2004-04-15 Eprova Ag Stabile kristalline Salze von 5-Methyltetrahydrofolsäure.
GB9914258D0 (en) 1999-06-18 1999-08-18 Celltech Therapeutics Ltd Chemical compounds
GB9924862D0 (en) 1999-10-20 1999-12-22 Celltech Therapeutics Ltd Chemical compounds
DE10022510A1 (de) * 2000-05-10 2001-11-15 Basf Ag Zusammensetzungen enthaltend Folsäure und reduziertes Folat
EP1392662B1 (de) 2001-05-29 2009-01-07 Bayer Schering Pharma Aktiengesellschaft Cdk inhibitorische pyrimidine, deren herstellung und verwendung als arzneimittel
CN101143863B (zh) * 2006-09-13 2010-08-11 南京莱因医药科技有限公司 5-甲基四氢叶酸的拆分及其成盐方法
CH698729B1 (de) * 2007-05-30 2009-10-15 Cerbios Pharma Sa Stabile, kristalline (6S)-N(5)-Methyl-5, 6,7,8-tetrahydrofolsäure.
CN101407518A (zh) * 2007-10-11 2009-04-15 南京莱尔生物化工有限公司 (6r,s)-5-甲酰-四氢叶酸的拆分及其成盐的方法
DK2254890T3 (da) * 2008-02-20 2015-07-13 Gnosis Spa Fremgangsmåde til diastereomerisk racematspaltning af methyltetrahydrofolsyre
CN104334561B (zh) 2012-04-13 2016-06-22 连云港金康和信药业有限公司 化合物jk12a及其制备
EP3609895A1 (en) 2017-03-31 2020-02-19 Merck Patent GmbH Crystalline sodium salt of 5-methyl-(6s)-tetrahydrofolic acid
CN108358928A (zh) * 2018-05-23 2018-08-03 浙江圣达生物药业股份有限公司 一种(6s)-5-甲基四氢叶酸钙的制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8621268D0 (en) * 1986-09-03 1986-10-08 Univ Strathclyde Separation of substances
CH673459A5 (no) * 1987-05-15 1990-03-15 Eprova Ag
DE3821875C1 (no) * 1988-06-29 1990-02-15 Eprova Ag, Forschungsinstitut, Schaffhausen, Ch
CH676981A5 (no) * 1988-11-11 1991-03-28 Eprova Ag
DE69027585T2 (de) * 1989-12-11 1997-01-16 American Cyanamid Co Verfahren zur Herstellung von optisch reinen Diastereoisomeren von Tetrahydrofolatverbindungen
FR2659330B1 (fr) * 1990-03-09 1994-02-11 Sapec Sa Composes diastereoisomeres derivant de l'acide tetrahydrofolique, procede de preparation et utilisation dans la synthese de diastereomeres 6s et 6r de folates reduits.
CH680731A5 (no) * 1990-04-12 1992-10-30 Sapec Fine Chemicals
CH681303A5 (no) * 1991-01-16 1993-02-26 Eprova Ag
CH683261A5 (it) * 1991-10-10 1994-02-15 Applied Pharma Res Procedimento per la preparazione dell'acido metiltetraidrofolico nella forma (6(R,S)(-))N-5 e separazione del diastereoisomero attivo (6(S)(-))N-5) sotto forma di sali.
DE4136921A1 (de) * 1991-11-11 1993-05-13 Knoll Ag Verfahren zur trennung von 5-methyl-tetrahydrofolsaeure

Also Published As

Publication number Publication date
FI942161A (fi) 1994-05-10
ZA928643B (en) 1994-05-11
JP3162390B2 (ja) 2001-04-25
WO1993010118A1 (de) 1993-05-27
EP0612322A1 (de) 1994-08-31
NO941756L (no) 1994-05-10
US5457202A (en) 1995-10-10
TW221293B (no) 1994-02-21
JPH07500842A (ja) 1995-01-26
CA2121351C (en) 2003-08-05
CA2121351A1 (en) 1993-05-27
DE4136921A1 (de) 1993-05-13
ES2127765T3 (es) 1999-05-01
EP0612322B1 (de) 1999-03-03
NO941756D0 (no) 1994-05-10
GR3029552T3 (en) 1999-06-30
FI942161A0 (fi) 1994-05-10
NO305175B1 (no) 1999-04-12
DE59209643D1 (de) 1999-04-08
KR100211915B1 (ko) 1999-08-02
AU2898392A (en) 1993-06-15
AU664051B2 (en) 1995-11-02
ATE177100T1 (de) 1999-03-15
DK0612322T3 (da) 1999-09-27

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