NO305175B1 - FremgangsmÕte for Õ skille enantiomerene av 5-metyl-tetrahydrofolsyre - Google Patents

FremgangsmÕte for Õ skille enantiomerene av 5-metyl-tetrahydrofolsyre

Info

Publication number
NO305175B1
NO305175B1 NO941756A NO941756A NO305175B1 NO 305175 B1 NO305175 B1 NO 305175B1 NO 941756 A NO941756 A NO 941756A NO 941756 A NO941756 A NO 941756A NO 305175 B1 NO305175 B1 NO 305175B1
Authority
NO
Norway
Prior art keywords
enantiomers
separating
methyl
pct
tetrahydrofolic acid
Prior art date
Application number
NO941756A
Other languages
English (en)
Other versions
NO941756L (no
NO941756D0 (no
Inventor
Klaus Scheib
Peter Klein
Robert Carter
Original Assignee
Knoll Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Knoll Ag filed Critical Knoll Ag
Publication of NO941756L publication Critical patent/NO941756L/no
Publication of NO941756D0 publication Critical patent/NO941756D0/no
Publication of NO305175B1 publication Critical patent/NO305175B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
    • C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
NO941756A 1991-11-11 1994-05-10 FremgangsmÕte for Õ skille enantiomerene av 5-metyl-tetrahydrofolsyre NO305175B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4136921A DE4136921A1 (de) 1991-11-11 1991-11-11 Verfahren zur trennung von 5-methyl-tetrahydrofolsaeure
PCT/EP1992/002515 WO1993010118A1 (de) 1991-11-11 1992-11-03 Verfahren zur trennung von 5-methyl-tetrahydrofolsäure

Publications (3)

Publication Number Publication Date
NO941756L NO941756L (no) 1994-05-10
NO941756D0 NO941756D0 (no) 1994-05-10
NO305175B1 true NO305175B1 (no) 1999-04-12

Family

ID=6444446

Family Applications (1)

Application Number Title Priority Date Filing Date
NO941756A NO305175B1 (no) 1991-11-11 1994-05-10 FremgangsmÕte for Õ skille enantiomerene av 5-metyl-tetrahydrofolsyre

Country Status (16)

Country Link
US (1) US5457202A (no)
EP (1) EP0612322B1 (no)
JP (1) JP3162390B2 (no)
KR (1) KR100211915B1 (no)
AT (1) ATE177100T1 (no)
AU (1) AU664051B2 (no)
CA (1) CA2121351C (no)
DE (2) DE4136921A1 (no)
DK (1) DK0612322T3 (no)
ES (1) ES2127765T3 (no)
FI (1) FI105918B (no)
GR (1) GR3029552T3 (no)
NO (1) NO305175B1 (no)
TW (1) TW221293B (no)
WO (1) WO1993010118A1 (no)
ZA (1) ZA928643B (no)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4136921A1 (de) * 1991-11-11 1993-05-13 Knoll Ag Verfahren zur trennung von 5-methyl-tetrahydrofolsaeure
GB9222253D0 (en) * 1992-10-23 1992-12-09 Celltech Ltd Chemical compounds
GB9304920D0 (en) * 1993-03-10 1993-04-28 Celltech Ltd Chemical compounds
GB9304919D0 (en) * 1993-03-10 1993-04-28 Celltech Ltd Chemical compounds
GB9326600D0 (en) * 1993-12-22 1994-03-02 Celltech Ltd Chemical compounds
JP3806144B2 (ja) * 1993-12-22 2006-08-09 セルテック セラピューティックス リミテッド 三置換フェニル誘導体、その調製方法とホスホジエステラーゼ（ｉｖ型）阻害剤としてのその使用
IT1270185B (it) * 1994-06-08 1997-04-29 Bracco Spa Processo per l'ottenimento e la separazione dei sali diastereoisomeri dell'acido folinico
US6245774B1 (en) 1994-06-21 2001-06-12 Celltech Therapeutics Limited Tri-substituted phenyl or pyridine derivatives
US5786354A (en) * 1994-06-21 1998-07-28 Celltech Therapeutics, Limited Tri-substituted phenyl derivatives and processes for their preparation
GB9412571D0 (en) 1994-06-22 1994-08-10 Celltech Ltd Chemical compounds
GB9412573D0 (en) 1994-06-22 1994-08-10 Celltech Ltd Chemical compounds
GB9523675D0 (en) * 1995-11-20 1996-01-24 Celltech Therapeutics Ltd Chemical compounds
GB9526245D0 (en) * 1995-12-21 1996-02-21 Celltech Therapeutics Ltd Chemical compounds
GB9526246D0 (en) * 1995-12-21 1996-02-21 Celltech Therapeutics Ltd Chemical compounds
GB9608435D0 (en) * 1996-04-24 1996-06-26 Celltech Therapeutics Ltd Chemical compounds
GB9619284D0 (en) * 1996-09-16 1996-10-30 Celltech Therapeutics Ltd Chemical compounds
GB9622363D0 (en) 1996-10-28 1997-01-08 Celltech Therapeutics Ltd Chemical compounds
GB9625184D0 (en) * 1996-12-04 1997-01-22 Celltech Therapeutics Ltd Chemical compounds
JP2001507349A (ja) 1996-12-23 2001-06-05 セルテック セラピューティックス リミテッド 縮合多環式２−アミノピリミジン誘導体、それらの製造およびたんぱく質チロシンキナーゼ抑制因子としてのそれらの使用
GB9705361D0 (en) 1997-03-14 1997-04-30 Celltech Therapeutics Ltd Chemical compounds
GB9713087D0 (en) * 1997-06-20 1997-08-27 Celltech Therapeutics Ltd Chemical compounds
CH693905A5 (de) * 1999-04-15 2004-04-15 Eprova Ag Stabile kristalline Salze von 5-Methyltetrahydrofolsäure.
GB9914258D0 (en) 1999-06-18 1999-08-18 Celltech Therapeutics Ltd Chemical compounds
GB9924862D0 (en) 1999-10-20 1999-12-22 Celltech Therapeutics Ltd Chemical compounds
DE10022510A1 (de) 2000-05-10 2001-11-15 Basf Ag Zusammensetzungen enthaltend Folsäure und reduziertes Folat
IL159120A0 (en) 2001-05-29 2004-05-12 Schering Ag Cdk inhibiting pyrimidines, production thereof and their use as medicaments
CN101143863B (zh) * 2006-09-13 2010-08-11 南京莱因医药科技有限公司 5-甲基四氢叶酸的拆分及其成盐方法
CH698729B1 (de) * 2007-05-30 2009-10-15 Cerbios Pharma Sa Stabile, kristalline (6S)-N(5)-Methyl-5, 6,7,8-tetrahydrofolsäure.
CN101407518A (zh) * 2007-10-11 2009-04-15 南京莱尔生物化工有限公司 (6r,s)-5-甲酰-四氢叶酸的拆分及其成盐的方法
PT2254890E (pt) * 2008-02-20 2015-07-31 Gnosis Spa Processo para a resolução diastereoisomérica do ácido 5- metiltetra-hidrofólico
KR101673979B1 (ko) 2012-04-13 2016-11-08 리안윤강 진강 해신 파머수티컬 코. 엘티디. 화합물 jk12a 및 그 제조
EP3609895B1 (en) 2017-03-31 2024-10-16 Merck Patent GmbH Crystalline sodium salt of 5-methyl-(6s)-tetrahydrofolic acid
CN108358928A (zh) * 2018-05-23 2018-08-03 浙江圣达生物药业股份有限公司 一种(6s)-5-甲基四氢叶酸钙的制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8621268D0 (en) * 1986-09-03 1986-10-08 Univ Strathclyde Separation of substances
CH673459A5 (no) * 1987-05-15 1990-03-15 Eprova Ag
DE3821875C1 (no) * 1988-06-29 1990-02-15 Eprova Ag, Forschungsinstitut, Schaffhausen, Ch
CH676981A5 (no) * 1988-11-11 1991-03-28 Eprova Ag
DK0432441T3 (da) * 1989-12-11 1996-07-29 American Cyanamid Co Fremgangsmåde til fremstilling af optisk rene diastereoisomere af tetrahydrofolatforbindelser
FR2659330B1 (fr) * 1990-03-09 1994-02-11 Sapec Sa Composes diastereoisomeres derivant de l'acide tetrahydrofolique, procede de preparation et utilisation dans la synthese de diastereomeres 6s et 6r de folates reduits.
CH680731A5 (no) * 1990-04-12 1992-10-30 Sapec Fine Chemicals
CH681303A5 (no) * 1991-01-16 1993-02-26 Eprova Ag
CH683261A5 (it) * 1991-10-10 1994-02-15 Applied Pharma Res Procedimento per la preparazione dell'acido metiltetraidrofolico nella forma (6(R,S)(-))N-5 e separazione del diastereoisomero attivo (6(S)(-))N-5) sotto forma di sali.
DE4136921A1 (de) * 1991-11-11 1993-05-13 Knoll Ag Verfahren zur trennung von 5-methyl-tetrahydrofolsaeure

Also Published As

Publication number Publication date
GR3029552T3 (en) 1999-06-30
ZA928643B (en) 1994-05-11
FI105918B (fi) 2000-10-31
AU664051B2 (en) 1995-11-02
NO941756L (no) 1994-05-10
EP0612322A1 (de) 1994-08-31
CA2121351A1 (en) 1993-05-27
TW221293B (no) 1994-02-21
DE4136921A1 (de) 1993-05-13
KR100211915B1 (ko) 1999-08-02
FI942161A (fi) 1994-05-10
ES2127765T3 (es) 1999-05-01
DK0612322T3 (da) 1999-09-27
DE59209643D1 (de) 1999-04-08
AU2898392A (en) 1993-06-15
NO941756D0 (no) 1994-05-10
JPH07500842A (ja) 1995-01-26
ATE177100T1 (de) 1999-03-15
EP0612322B1 (de) 1999-03-03
US5457202A (en) 1995-10-10
WO1993010118A1 (de) 1993-05-27
JP3162390B2 (ja) 2001-04-25
FI942161A0 (fi) 1994-05-10
CA2121351C (en) 2003-08-05

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