FI105100B - Menetelmä puolisynteettisten glykosaminoglykaanien valmistamiseksi, jotka sisältävät nukleofiilisillä radikaaleilla 3-asemassa substituoitua alfa-L-galakturonihappoa - Google Patents

Menetelmä puolisynteettisten glykosaminoglykaanien valmistamiseksi, jotka sisältävät nukleofiilisillä radikaaleilla 3-asemassa substituoitua alfa-L-galakturonihappoa Download PDF

Info

Publication number
FI105100B
FI105100B FI941432A FI941432A FI105100B FI 105100 B FI105100 B FI 105100B FI 941432 A FI941432 A FI 941432A FI 941432 A FI941432 A FI 941432A FI 105100 B FI105100 B FI 105100B
Authority
FI
Finland
Prior art keywords
acid
nucleophilic
nucleophilic reagent
glycosaminoglycans
heparin
Prior art date
Application number
FI941432A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI941432A0 (fi
FI941432A (fi
Inventor
Fabrizio Ungarelli
Silvano Piani
Original Assignee
Alfa Wassermann Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alfa Wassermann Spa filed Critical Alfa Wassermann Spa
Publication of FI941432A0 publication Critical patent/FI941432A0/fi
Publication of FI941432A publication Critical patent/FI941432A/fi
Application granted granted Critical
Publication of FI105100B publication Critical patent/FI105100B/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
FI941432A 1993-03-29 1994-03-28 Menetelmä puolisynteettisten glykosaminoglykaanien valmistamiseksi, jotka sisältävät nukleofiilisillä radikaaleilla 3-asemassa substituoitua alfa-L-galakturonihappoa FI105100B (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITBO930126 1993-03-29
IT93BO000126A IT1264102B1 (it) 1993-03-29 1993-03-29 Processo per la sintesi di glicosaminoglicani semisintetici contenenti acido alfa-l-galatturonico sostituito con radicali

Publications (3)

Publication Number Publication Date
FI941432A0 FI941432A0 (fi) 1994-03-28
FI941432A FI941432A (fi) 1994-09-30
FI105100B true FI105100B (fi) 2000-06-15

Family

ID=11338860

Family Applications (1)

Application Number Title Priority Date Filing Date
FI941432A FI105100B (fi) 1993-03-29 1994-03-28 Menetelmä puolisynteettisten glykosaminoglykaanien valmistamiseksi, jotka sisältävät nukleofiilisillä radikaaleilla 3-asemassa substituoitua alfa-L-galakturonihappoa

Country Status (18)

Country Link
US (1) US5410039A (el)
EP (1) EP0618235B1 (el)
JP (1) JP2726620B2 (el)
KR (1) KR100191885B1 (el)
AT (1) ATE155798T1 (el)
AU (1) AU664938B2 (el)
CA (1) CA2114863C (el)
DE (1) DE69404353T2 (el)
DK (1) DK0618235T3 (el)
ES (1) ES2105382T3 (el)
FI (1) FI105100B (el)
GR (1) GR3024710T3 (el)
IL (1) IL108690A (el)
IT (1) IT1264102B1 (el)
NO (1) NO305993B1 (el)
NZ (1) NZ250816A (el)
TW (1) TW266216B (el)
ZA (1) ZA94892B (el)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6255295B1 (en) 1996-12-23 2001-07-03 Nutramax Laboratories, Inc. Aminosugar, glycosaminoglycan or glycosaminoglycan-like compounds, and s-adenosylmethionine composition for the protection, treatment, repair, and reduction of inflammation of connective tissue
US7259152B2 (en) 2000-06-07 2007-08-21 Alfa Wasserman, Inc. Methods and compositions using sulodexide for the treatment of diabetic nephropathy
CA2435637A1 (en) 2001-01-23 2002-08-01 Massachusetts Institute Of Technology Solid- and solution -phase synthesis of heparin and other glycosaminoglycans
EP2402753A1 (en) * 2002-03-11 2012-01-04 Momenta Pharmaceuticals, Inc. Analysis of sulfated polysaccharides
US9139876B1 (en) 2007-05-03 2015-09-22 Momenta Pharmacueticals, Inc. Method of analyzing a preparation of a low molecular weight heparin
EP2526122B1 (en) * 2010-01-19 2020-06-10 Momenta Pharmaceuticals, Inc. Evaluating heparin preparations
WO2012115952A1 (en) 2011-02-21 2012-08-30 Momenta Pharmaceuticals, Inc. Evaluating heparin preparations
WO2017154938A1 (ja) * 2016-03-09 2017-09-14 株式会社糖鎖工学研究所 硫酸基および／またはリン酸基を有する糖の製造方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4987223A (en) * 1981-12-23 1991-01-22 Choay S.A. Derivatives of the uronic acid
IT1234508B (it) * 1988-06-10 1992-05-19 Alfa Wassermann Spa Derivati eparinici e procedimento per la loro preparazione
IT1234826B (it) * 1989-01-30 1992-05-29 Alfa Wassermann Spa Derivati eparinici e procedimento per la loro preparazione
IT1242604B (it) * 1990-11-13 1994-05-16 Alfa Wassermann Spa Sali di glicosaminoglicani con esteri di aminoacidi, loro preparazione e formulazioni farmaceutiche che li contengono.
IT1260136B (it) * 1992-04-17 1996-03-28 Alfa Wassermann Spa Glicosaminoglicani semisintetici contenenti acido alfa-l-galatturonicosostituito con radicali nucleofili in posizione 3
IT1260137B (it) * 1992-04-17 1996-03-28 Alfa Wassermann Spa Glicosaminoglicani semisintetici a struttura eparinica od eparanica modificati nella posizione 2 dell'acido alfa-l-iduronico-2-0-solfato
AU5504594A (en) * 1993-02-08 1994-08-11 Applied Sorting Technologies Pty Ltd Metal detection in highly mineralised ground

Also Published As

Publication number Publication date
NO941129L (no) 1994-09-30
ES2105382T3 (es) 1997-10-16
FI941432A0 (fi) 1994-03-28
DE69404353D1 (de) 1997-09-04
FI941432A (fi) 1994-09-30
NO941129D0 (no) 1994-03-28
ATE155798T1 (de) 1997-08-15
TW266216B (el) 1995-12-21
CA2114863C (en) 1999-07-20
IL108690A (en) 1998-02-22
DE69404353T2 (de) 1997-11-13
ITBO930126A1 (it) 1994-09-29
KR100191885B1 (ko) 1999-06-15
AU664938B2 (en) 1995-12-07
EP0618235B1 (en) 1997-07-23
AU5508494A (en) 1994-10-06
GR3024710T3 (en) 1997-12-31
ZA94892B (en) 1994-08-23
KR940021583A (ko) 1994-10-19
IL108690A0 (en) 1994-05-30
EP0618235A1 (en) 1994-10-05
JPH06322002A (ja) 1994-11-22
NZ250816A (en) 1996-02-27
ITBO930126A0 (it) 1993-03-29
CA2114863A1 (en) 1994-09-30
NO305993B1 (no) 1999-08-30
JP2726620B2 (ja) 1998-03-11
IT1264102B1 (it) 1996-09-10
DK0618235T3 (da) 1998-01-26
US5410039A (en) 1995-04-25

Similar Documents

Publication Publication Date Title
CA2093147C (en) Semi-synthetic glycosaminoglycans with heparin or heparan structure of –-l-iduronic-2-sulfate acid modified in position 2
EP2103631B1 (en) Mercapto-group modified macromolecule derivative and cross-linked material
FI105100B (fi) Menetelmä puolisynteettisten glykosaminoglykaanien valmistamiseksi, jotka sisältävät nukleofiilisillä radikaaleilla 3-asemassa substituoitua alfa-L-galakturonihappoa
KR0171623B1 (ko) 3-위치가 친핵성 래디칼로 치환된 알파-엘-갈락투론산을 함유하는 반-합성 글리코스아미노글리칸
AU664939B2 (en) Process for the synthesis of semi-synthetic glycosaminoglycans with heparin or heparan structure modified in position 2 of the alpha-L-iduronic-2-O-sulfate acid
WO2019102367A1 (en) METHOD OF SYNTHESISING 6-DEOXY-6-AMINO-β-D-GLUCOPYRANOSIDE-CONTAINING POLYMERS AND THEIR PRECURSORS
CN104592319A (zh) 一种糖胺聚糖类化合物n,o-同时硫酸化的方法及其反应中间体

Legal Events

Date Code Title Description
MA Patent expired